77 results about "Diabetic care" patented technology

The invention relates to the technical field of formula foods for special medical purposes, and discloses a low-GI formula food suitable for diabetics and a preparation method thereof, the low-GI formula food comprises the following raw materials by weight: 4-6% of protein, 2-4% of fat, 10-15% of carbohydrate, 2.5-4.5% of dietary fiber, 0.3-0.5% of mineral, 0.3-0.5% of vitamin, 3-5% of food additive, and the balance purified water. The full-nutrition formula food for the diabetes mellitus with special medical application meets the metabolic characteristics and nutritional requirements of people suffering from the diabetes mellitus in China, and provides a more scientific nutrition intervention means for people suffering from the diabetes mellitus in China.

The invention belongs to the technical field of medicines, and particularly relates to a fenerenone orally disintegrating tablet and a preparation method thereof. The active component of the fenerenone orally disintegrating tablet is fenerenone, and the fenerenone orally disintegrating tablet comprises the following components in percentage by weight: 10-15% of fenerenone, 10-15% of magnesium stearate, 10-15% of magnesium stearate and the balance of 70-80% of a filler; 5.5-10% of a disintegrating agent; 1-4% of a flow aid; and 1-4% of a lubricant. The finerenone orally disintegrating tablet disclosed by the invention is suitable for being taken by diabetics, and has the advantages of high disintegration and dissolution speed, stable finished product quality, no need of being taken with water and strong patient compliance; in addition, the finerenone orally disintegrating tablet disclosed by the invention is simple in preparation process, low in cost and suitable for large-scale production.

The invention provides a lactic acid bacteria composition for adjuvant treatment of diabetes, a compound lactic acid bacteria probiotic agent and application, and belongs to the technical field of functional microorganisms. The lactic acid bacteria composition provided by the invention is obtained by compounding eight specific lactic acid bacteria strains, has the effects of reducing blood sugar, blood fat and insulin level for people with high blood sugar and diabetics, and also has the effect of regulating gastrointestinal tract disorder. Therefore, the compound lactic acid bacteria probiotic agent prepared on the basis of the lactic acid bacteria composition has a good blood sugar control effect on people with high blood sugar and patients with type II diabetes mellitus. Meanwhile, the compound lactic acid bacteria probiotic agent has no side effect, and the purpose of safe prevention and treatment can be achieved.

The embodiment of the invention discloses a method for acquiring face spectral information of a type II diabetes patient; the face spectrum information is input into a pre-constructed model, corresponding traditional Chinese medicine constitution information is output, the traditional Chinese medicine constitution information comprises mild constitution, yin deficiency constitution, yang deficiency constitution, phlegm-dampness constitution, blood stasis constitution, qi deficiency constitution, qi depression constitution, specific intrinsic constitution and damp-heat constitution, and the pre-trained model is a model constructed based on a partial least square method. The purpose of non-contact judgment of the traditional Chinese medicine constitution information of the type II diabetes mellitus is achieved.

The invention belongs to the technical field of food processing, and particularly relates to a product with peony peptide and ginseng peptide as main raw materials and a preparation method of the product. According to the invention, leftovers such as ginseng root hair and peony seed meal are used as raw materials, so that the production cost is greatly reduced, and the prepared product is presented in the form of a solid beverage and is convenient to carry and drink; the ginseng peptide is prepared by adopting a steam explosion and biological enzymolysis technology, the peony peptide is prepared by adopting a microbial fermentation mode, the molecular weight of the polypeptide is reduced, digestion and absorption are facilitated, meanwhile, the yield and oxidation resistance of the peptide are improved by adopting the microbial fermentation mode, the highest yield can reach 45.5%, and the highest oxidation resistance can reach 72.5%; besides, isomaltulose is also added while the bovine bone collagen peptide powder, the ginseng peptide powder and the peony peptide powder are adopted, so that the taste of the product is improved, the reconstituability of the product is improved, the fluctuation of blood sugar and insulin level is not caused after the product is taken, and the product can also be drunk by diabetics.

Insulin therapy revolutionized the care of patients with diabetes, yet insulin-induced hypoglycemia remains a serious life-threatening complication of insulin therapy. Glucagon is a highly effective treatment for hypoglycemia; however, current dosage forms remain under-utilized due to poor patient compliance. High-density, readily soluble, and thermostable solid glucagon formulations applied with painless, application-specific microneedle-patches can treat hypoglycemia in type 1 diabetes patients who are awake or asleep. On-demand patches can prevent or treat mild hypoglycemia during the day, and enzyme-driven hypoglycemia-responsive patches can release glucagon autonomously during the night. These patches have excellent in vitro glucagon stability, loading, and release kinetics and can treat hypoglycemia in diabetic humans and animals. These delivery systems enable new modes of glucagon therapy, thereby expanding the clinical role of glucagon beyond the emergency setting.

The invention relates to the technical field of medicine, discloses a medical detection method, and particularly relates to a myocardial state detection method and system for a diabetic patient. Through combination of multiple groups of indexes and image group characteristic data, the cardiovascular disease, especially the cardiovascular disease of a diabetic patient, can be effectively evaluated, and score data reflecting the myocardial state of the diabetic patient can be obtained. And the incidence probability and the staging result degree of the myocardial disease of the diabetic patient are more intuitively determined through the score data, so that the overall automatic prediction of the incidence of the myocardial disease of the diabetic patient is realized.

The invention relates to the technical field of molecular biology, in particular to a methylation marker for diagnosis of diabetic nephropathy. Specifically, the methylation marker comprises a P site of a CAT gene promoter region and / or an E site of a CAT gene exon 1 region. Based on a detection system combining methylation sensitive restriction enzyme with quantitative PCR, the kit has the advantages of simplicity and convenience in operation, good repeatability, accuracy in quantification and easiness in standardization, and is suitable for low-invasive samples such as peripheral blood. By effectively distinguishing pure type 2 diabetes patients from diabetic nephropathy combined patients, a reliable technical means is provided for risk stratification, early intervention and dynamic monitoring of diabetic people, and the method has good clinical application prospects and popularization value.

The utility model relates to nursing instrument technical field, and disclose a kind of diabetic foot protection device, including protection device bottom pad, the top of protection device bottom pad is equipped with flexible protection body, the side of protection device bottom pad is equipped with rotating shaft, the side of rotating shaft is rotatably connected with hard protection body, the side of protection device bottom pad is fixedly connected with first connecting block, the side of hard protection body is fixedly connected with connecting plate, the top of first connecting block is equipped with the insertion slot, the top of connecting plate is fixedly connected with second connecting block, the one end of second connecting block is equipped with structure slot.The foot protection device for lower limb nursing of diabetic patient can make medical staff more conveniently observe and replace the wound dressing of affected side toe, help to prevent disease from getting worse, and improve the efficiency of nursing work, at the same time, it reduces the discomfort of patient suffered from repeatedly wearing protection device.

The invention provides a low-glycemic whole-grain food and a preparation method thereof, and belongs to the technical field of food processing. The low-glycemic whole-grain food comprises 60-80 parts of whole-grain mixed powder, 4-7 parts of inulin, 3-8 parts of resistant dextrin and 2-5 parts of konjaku flour, and the whole-grain mixed powder is obtained by solid-state fermentation of oats, quinoa and brown rice through compound microorganisms. The low-glycemic whole-grain food is prepared by low-temperature extrusion forming and drying. Test results show that the low-glycemic-index whole-grain food obtained by adopting the technical scheme is low in cooking loss, the texture characteristic and the sense of the cooked low-glycemic-index whole-grain food are close to those of northeast natural rice, the glycemic index is smaller than 55, and the low-glycemic-index whole-grain food is low in glycemic index and suitable for diabetics to eat.

The invention discloses noodles with the advantages of low GI value and quick cooking and a preparation method thereof. The noodles comprise the following components: purple highland barley whole flour, purple highland barley bran powder, wheat flour, vital gluten, high amylose corn starch and curdlan. The corresponding preparation method comprises the following steps: (1) preparing a plant lactobacillus suspension; (2) carrying out semi-solid state fermentation on composite purple highland barley powder (purple highland barley whole powder and purple highland barley bran powder) by adopting a plant lactic acid bacteria suspension; and (3) finely mixing dry and wet materials of the fermented composite purple highland barley powder and other materials, kneading dough, fermenting, calendering, cutting into strips, dehydrating and the like to prepare the purple highland barley noodles. Compared with conventional noodles, the obtained highland barley noodles belong to low-GI noodles (eGI = 44.9), can effectively control the postprandial blood sugar level of diabetics, are suitable for the diabetics to eat, are soft, elastic and smooth in taste, rich in dietary fibers and anthocyanin and high in nutritional value, and the cooking time is shortened by 30% or above.

The invention provides high-protein, low-fat and low-sugar ice cream as well as a preparation method and application thereof, and belongs to the technical field of food processing. The ice cream disclosed by the invention is prepared from the following raw materials in parts by weight: 20 to 40 parts of soybean protein isolate, 0.5 to 2.5 parts of vegetable oil, 3 to 10 parts of soybean dietary fiber, 2 to 10 parts of fructo-oligosaccharide, 3 to 10 parts of soybean oligosaccharide, 1 to 8 parts of resistant dextrin, 0.2 to 1.5 parts of L-arabinose, 0.2 to 1 part of vitamin B complex, 0.05 to 0.5 part of mulberry leaf extract and 2 to 10 parts of eggs. The prepared ice cream is high in protein, low in fat and low in carbon water, still keeps good stability under the condition that a stabilizer and an emulsifier are not added, keeps the taste and flavor of the ice cream, and is suitable for diabetics to eat.

The invention relates to the technical field of food formulas and processing, and discloses a formula and making method of flour special for diabetics, and the flour is composed of oat bran, wheat gluten, flaxseed, coconut powder, erythritol, white kidney bean extract, mulberry leaf polypeptide, beta glucan and L arabinose. According to the invention, the content of effective carbohydrates in the flour with the same weight is reduced, the white kidney bean extract, the mulberry leaf polypeptide and the beta glucan effectively inhibit the increase of blood sugar, and the L arabinose can hinder the absorption of glucose in large intestines and discharge redundant glucose through excrement, so that the burden of medication and kidneys is reduced; the product disclosed by the invention is balanced in nutrition and suitable for being eaten by the diabetic for a long time.

A drug combination kit for controlling blood sugar, comprising oral insulin enteric-coated capsules and ketone ester oral liquid or ketone ester capsules. The oral insulin enteric-coated capsules are taken before bedtime to achieve good control of fasting blood sugar at night and in the morning. The ketone ester oral liquid is taken before meals during the day, so that the human body enters a ketogenic state, not only lowering the blood sugar, but also avoiding postprandial blood sugar peaks. The combination of the two drugs can achieve better control of the blood sugar in the human body. Furthermore, ketone esters can further enhance insulin sensitivity and improve the cardiac function of diabetic patients. The kit has low cost and good sugar control effect, and is currently an ideal sugar control solution for diabetic patients.

The invention provides a preparation method of steamed buns capable of improving frozen storage quality and slowing down postprandial blood sugar generation. The preparation method comprises the following steps: (a) preparing the following raw materials in parts by weight: 103-187 parts of plain flour, 70-110 parts of pitaya, 35-55 parts of radix puerariae powder, 5-25 parts of hericium erinaceus powder, 3-7 parts of yeast and 20-60 parts of water; (b) mixing the plain flour, the kudzuvine root powder and the hericium erinaceus powder, adding the crushed pitaya, the activated yeast and the water, and performing dough kneading to obtain dough; and (c) sequentially performing primary fermentation, shaping, secondary fermentation and steaming on the dough to obtain the steamed bun. According to the present invention, the formula is matched with the preparation process, such that the prepared steamed bun has characteristics of thick taste, high resilience, low-temperature storage benefiting, low-temperature storage, low hardening rate after low-temperature storage and reheating, small moisture content change, and after-meal sugar increasing coefficient reducing; and the product is more suitable for being developed into long-term food for diabetics to eat.

The invention relates to the technical field of machine learning medical prediction, in particular to a diabetes-related pancreatic cancer risk prediction method based on a machine learning model and biological age, and the method comprises the steps: constructing a health reference population queue and a type 2 diabetes application verification queue; determining a core index panel through an automatic machine learning process, and training by adopting a regularization survival analysis model to obtain biological age and age acceleration; based on multi-modal features such as age acceleration, predicting a future pancreatic cancer absolute risk probability by using a machine learning competitive risk model, performing risk grade division, calculating an equal-risk age and supporting risk trajectory simulation according to the future pancreatic cancer absolute risk probability; and packaging the model into a risk prediction toolkit with an adaptive calibration function, and outputting a comprehensive risk assessment report. According to the method, the biological age is trained by adopting the pure health queue, so that the interference of the disease state on aging measurement is avoided, and the prediction precision of the pancreatic cancer risk of the type 2 diabetes mellitus population is improved.

The invention discloses stevia fiber healthy sugar suitable for diabetics to eat and a preparation method of the stevia fiber healthy sugar, and relates to the technical field of food. The healthy sugar disclosed by the invention is prepared from the following raw materials in parts by weight: 1-30 parts of stevioside and 70-99 parts of dietary fibers. An element for enhancing sweetness comes from a stevia rebaudiana aqueous extract stevioside, the natural dietary fiber is used as a carrier to simulate the overall characteristics of cane sugar, and the use of the carrier creates a synergistic effect in taste, so that the product is more like cane sugar, and the bad flavor of stevioside is also masked; the bad flavor of stevioside is masked by adopting the natural method, so that the quality of the product is very stable, and the shelf life can be up to 24 months; meanwhile, the dietary fiber in the product has the effects of reducing blood sugar, helping digestion, prebiotics and the like, and is very beneficial to the treatment of patients with hyperglycemia and diabetes mellitus.

The invention discloses a risk prediction method and system for type 2 diabetes mellitus complicated with mild cognitive impairment, and relates to the field of data processing. The method comprises the following steps: acquiring potential risk factor related data of type 2 diabetes subjects, and dividing the subjects into an MCI group and an NC group through cognitive evaluation; the potential risk factors comprise demographic characteristics and clinical characteristics; screening target factors from the potential risk factors according to the related data of the potential risk factors and the cognitive assessment result; and constructing a column diagram about the target factor, and predicting the quantitative risk of the cognitive impairment according to the column diagram. According to the method, the risk can be quickly quantified through the column diagram, and the risk can be systematically evaluated by integrating a plurality of target factors, so that the cognitive dysfunction risk of the type 2 diabetes mellitus crowd can be conveniently and accurately predicted.

The application discloses a diabetes patient biological age calculation method based on glycosylation markers and a multi-task deep learning framework, and belongs to the technical field of bioinformatics and medical data processing technology, and the method comprises the following steps: obtaining glycomics feature data and clinical examination data of diabetes patients; preprocessing the data; obtaining a feature set by adopting a multi-method screening and fusion strategy; constructing a deep learning model comprising a multi-modal feature fusion module and a multi-task learning module for training, wherein the multi-task learning module comprises a main task of aging clock regression and at least one auxiliary task; and outputting biological age prediction values and age acceleration evaluation results of individuals by using the trained model. The method realizes deep fusion of multi-modal biological data and exclusive modeling for the diabetes population, can accurately quantify the biological aging process and the deviation degree relative to the calendar age, and provides an objective quantitative tool for clinical evaluation.

The invention discloses pea noodles and a preparation process thereof, and the preparation process comprises the following steps: a pea seedling cultivation step: taking pre-screened peas as seed beans, soaking the seeds in a pre-prepared seed soaking solution for 12-18 hours, and sowing the seeds in a seedling raising tray until the pea seedlings grow out; a pea pulp preparation step: crushing and pulping fresh pea seedlings to obtain pea pulp for later use; pea meal preparation: peas are peeled and finely ground to obtain pea meal; preparing mixed flour: uniformly stirring and mixing pea flour, oat flour, wheat flour, coarse rice flour and buckwheat flour to obtain the mixed flour for later use; a dough preparation step: taking mixed flour, pea pulp, vital gluten, egg white, edible salt, beta-cyclodextrine and edible sodium carbonate, uniformly mixing and stirring, and preparing uniform and consistent dough in vacuum dough kneading equipment; and preparing the noodles. The nutritional structure of the noodles is optimized, so that the noodles can be suitable for more people to use, and are suitable for diabetics to eat.

The invention provides a type II diabetes intelligent detection method based on an improved logistic regression integrated model, and belongs to diabetes intelligent detection, and the method comprises the steps: designing a voice vowel data collection scheme of a diabetic patient and a normal person, and constructing a data set: extracting voice audio features in the data set through the Praat voice analysis, and carrying out the standardization processing; feature selection is carried out based on Lasso regression and recursive feature elimination, and a training set, a verification set and a test set are divided; constructing a tree-shaped logistic regression model based on the attention mechanism, performing training by using the training set, performing verification by using the verification set, and dynamically determining an optimal prediction threshold value to obtain a trained tree-shaped logistic regression model based on the attention mechanism; and taking the test set as input, testing the trained tree logic regression model based on the attention mechanism, and obtaining a detection result. According to the method, the detection accuracy is improved under the condition of not depending on demographic characteristics.

The invention relates to the field of food manufacturing, and particularly discloses a high-resistance flour-based soda biscuit capable of stabilizing blood sugar and a preparation method of the high-resistance flour-based soda biscuit. The method comprises the following steps: sequentially performing premixing, steam treatment, gradient cooling, freezing aging and resistant starch extraction on wheat flour and polydextrose to obtain high-resistance flour; then the high-resistance flour is mixed with yeast, baking soda, salt, corn oil, milk and water to prepare dough, and the dough is fermented, shaped and baked to obtain the soda biscuits capable of stabilizing the blood sugar. By adding polydextrose into wheat starch, the content of resistant starch in the prepared flour is remarkably increased, and the prepared high-resistance flour is matched with microwave-assisted fermentation to prepare the soda biscuit, so that the preparation energy consumption of the soda biscuit prepared by the application is reduced, and a large amount of resistant starch is contained; the food can effectively maintain the stability of human blood sugar and reduce postprandial blood sugar and insulin response, and is extremely suitable for diabetics to eat.

The invention relates to the technical field of probiotics, in particular to an anti-sugar probiotic particle and a preparation method thereof, in order to improve the life quality of diabetics, when the probiotic particle is prepared, the content of the probiotic particle is strictly limited, and inonotuso bliquus polysaccharide, pediococcus pentosaceus, chromium yeast and soybean peptide are introduced into the probiotic particle; by utilizing the synergistic effect of different components and probiotics, the insulin utilization level of a human body is jointly enhanced, and the improvement of the blood sugar level is inhibited; on the basis, in order to avoid the phenomena that the activity of the granules is reduced and the probiotics are inactivated under the action of gastric acid after the granules are taken, the effective components in the granules are subjected to embedding treatment, and substances such as the probiotics added in the granules are prevented from being digested and inactivated by gastric juice through a multiple embedding technology; but can be released in intestinal tracts, so that an excellent anti-sugar effect is achieved.

The invention provides an insulin aspart 50 injection and a preparation method thereof, and belongs to the field of pharmaceutical preparations, the insulin aspart 50 injection comprises the following components: insulin aspart: protamine sulfate: glycerol: m-cresol: phenol: sodium chloride: disodium hydrogen phosphate = 100,000 IU: (0.21-0.42 g): (16-20 g): (1.5-2 g): (1-2 g): (0.8-1 g): (1-1.5 g), and the pH value is 7.0-7.8. The preparation method is simple in preparation process, scientific and reasonable, and the preparation method is suitable for industrial production. The preparation method is simple and easy to operate, the prepared insulin aspart 50 injection has the advantages of high stability and good drug effect, the insulin aspart in the injection exists in two forms, one form is in a solution and plays a quick-acting role, and the other form is in a solution. One of the two insulin preparations is combined with protamine sulfate to form a precipitate, and has the time phase characteristic of medium-efficiency insulin, so that the insulin preparation has the action characteristics of two insulin preparations, great convenience is brought to diabetics, and the injection frequency and the pain and inconvenience caused by the injection frequency are reduced.

The invention provides a sugar control composition with a targeted inhibition function and application of the sugar control composition in health care products, special meals or nutritional meals, and belongs to the technical field of functional foods or health care products. The invention provides a sugar control composition. Comprising chia seeds, polydextrose, isomaltooligosacharide, konjac powder, oat beta glucan, xylooligosaccharide, inulin, green coffee powder, a white kidney bean extract, fermented soybean powder, mulberry leaf and bitter gourd powder, citric acid, sodium citrate, stevioside, white peach concentrated juice, lemon concentrated juice, lime concentrated juice, passion flower concentrated juice, apple concentrated juice and potassium sorbate. The invention also provides a preparation method of the sugar-controlling composition and application of the sugar-controlling composition in preparation of medicines, health-care products, special meals or nutritional meals, and provides a special meal suitable for diabetics to eat. The sugar control composition and the special meal prepared from the sugar control composition can inhibit the biological activity of DPP-IV (peptidase IV) in a targeted mode, and the remarkable sugar control effect is achieved.

1. The name of the product under this design: Diabetes treatment device. 2. Purpose of this design product: as a medical device to treat diabetics. 3. The design key point of this appearance design product lies in the shape. 4. The picture or photo that best illustrates the design points: Stereoscopic diagram 1.

The invention relates to a pharmaceutical composition kit for controlling blood sugar. The pharmaceutical composition kit comprises an oral insulin enteric capsule and a ketoester oral liquid or a ketoester capsule. The insulin enteric capsule is orally taken before sleep, so that fasting blood-glucose at night and in the morning can be well controlled. The ketoester oral liquid is taken before meals in daytime, so that a human body enters a ketogenic state, the blood sugar is reduced, and the postprandial blood sugar peak can be avoided. The combination of the two medicines can realize better control of human blood sugar. Furthermore, ketone ester can enhance insulin sensitivity and enhance the heart function of the diabetic patient. The kit is low in cost and good in sugar control effect, and is an ideal sugar control scheme for diabetics at present.

Insulin therapy revolutionized the care of patients with diabetes, yet insulin-induced hypoglycemia remains a serious life-threatening complication of insulin therapy. Glucagon is a highly effective treatment for hypoglycemia; however, current dosage forms remain under- utilized due to poor patient compliance. High-density, readily soluble, and thermostable solid glucagon formulations applied with painless, application-specific microneedle-patches can treat hypoglycemia in type 1 diabetes patients who are awake or asleep. On-demand patches can prevent or treat mild hypoglycemia during the day, and enzyme-driven hypoglycemia-responsive patches can release glucagon autonomously during the night. These patches have excellent in vitro glucagon stability, loading, and release kinetics and can treat hypoglycemia in diabetic humans and animals. These delivery systems enable new modes of glucagon therapy, thereby expanding the clinical role of glucagon beyond the emergency setting.

The invention discloses corn composite powder as well as a preparation method and application thereof, and relates to the technical field of health food preparation. The invention aims to provide a food which can meet the taste requirement and does not cause blood sugar rise for diabetics. The feed specifically comprises corn kernels, corncobs and corn stigmas, and the corn kernels, the corncobs and the corn stigmas account for 75%-98.5% of the corn kernels, 1%-20% of the corncobs and 0.5%-5% of the corn stigmas in percentage by mass. According to the present invention, the diabetes mellitus patient digestion burden can be alleviated, the blood sugar can be reduced, the metabolic balance of the diabetes mellitus patient body can be easily maintained, the corn kernel powder, the corn cob powder and the corn stigma powder are mixed so as to provide rich and fine taste, and the consumer's pursuit of delicious food can be met; the corn cob and the corn stigma can be effectively utilized, the grain utilization rate is increased, and the economic benefit and the medicinal value of corn planting are improved.

The invention provides a nutrition dynamic optimization method and system based on multi-model fusion, and relates to the technical field of nutrition health and artificial intelligence, and the method comprises the steps: carrying out the blood glucose prediction based on the comprehensive data of a user, generating a blood glucose prediction sequence, carrying out the key metabolic path node recognition based on the comprehensive data, and obtaining a node activation distribution vector. Calculating a metabolic elasticity index based on the comprehensive data and the node activation distribution vector, optimizing a dietary fiber threshold value of the user based on the metabolic elasticity index and the comprehensive data, generating various nutrition schemes based on the metabolic elasticity index, the blood glucose prediction sequence, the node activation distribution vector and the comprehensive data, and calculating the dietary fiber content of the nutrition schemes. Calculating the difference value between the dietary fiber threshold value and the dietary fiber threshold value, arranging the difference value in an ascending order, and outputting the first nutrition scheme. Through multi-omics linkage and dynamic optimization of the metabolic elasticity index, accurate matching of nutrition intervention and real-time physiological status and flora characteristics of the user is realized, and a personalized scheme is provided for diabetic people.