The invention relates to a water-based drilling fluid of a shale gas horizontal well reinforced well wall and an application thereof. The water-based drilling fluid comprises, by weight, 100 parts of water, 0-5 parts of clay, 0.5-3 parts of micro-nano particle blocking agents, 0.5-3 parts of chemical blocking agents, 0.1-2 parts of tackifier, 1-5 parts offiltrate reducer, 0.05-2 parts of encapsulating inhibiting agents, 0.1-3 parts of polyamine inhibiting agents, 1-5 parts of lubricant, 0.1-1 part of alkalinity regulator, 2-25 parts of inorganic salt, and 0-200 parts of weighting agents. The micro-nano particle blocking agents and the chemical blocking agents in the water-based drilling fluid of the shale gas horizontal well reinforced well wall have the effect of reinforcing the well wall in a cooperative mode, can effectively block micropore seams of shale to hinder pressure transmission, can further obviously improve the membrane efficiency of the shale, and facilitates the balance anti-collapse function of chemical activity.