The invention relates to the field of 
drilling fluid, and discloses a high-plugging-performance 
drilling fluid composition and a preparation method and application thereof. The high-plugging-performance 
drilling fluid composition contains water, 
bentonite, Na2CO3, a shale inhibitor, a filtrate loss 
reducer, a 
viscosity reducer, an anti-collapse agent, a nanometer plugging agent, a 
lubricant and aweighting agent, wherein the shale inhibitor is modified 
asphalt GLA, the anti-collapse agent is 
calcium carbonate superfine 
powder C80, and the nanometer plugging agent is nanometer 
graphene subjected to 
surface modification by 
polyethylene glycol. According to the high-plugging-performance drilling 
fluid composition, the modified 
asphalt GLA as the shale inhibitor, the 
calcium carbonate superfine 
powder C80 as the anti-collapse agent and the nanometer plugging agent are adopted for effectively plugging micro-nano cracks of the shale stratum of the large-displacement horizontal segment of a deep well, a drilling 
fluid phase is prevented from entering the cracks, the lasting and compact plugging barrier is formed near the well wall, and therefore pore 
pressure transmission is further prevented, the wedge effect of waterpower is further reduced, the block shedding phenomenon is avoided, collapsing of the stratum is effectively prevented, and the stratum is kept stable.