The present invention discloses a short-term operation optimization method for a power system including large-scale wind power, comprising modeling the randomness of wind power output, modeling the randomness of the load of electric power system and modeling net load of electric power system. Net load refers that for probability distribution of net load that is too discretized, probability distribution curve of net load is divided into N intervals, the probabilities for each interval are obtained and probability distribution curve of net load is obtained through calculating and weighing each interval. Through calculating randomness of power wind output and standard deviation of load prediction error of the electric power system, net load prediction error of the electric power system is obtained and reasonable coordination is made on the electric power system according to prediction error and prediction amount to better regulate the correlations between randomness, volatility, regionalism, double-circuit peak shaving and load of wind power generation, so as to realize optimization operation of the electric power system.