18 results about "Troxerutin" patented technology

The present application relates to a cosmetic composition, and more particularly, to a cosmetic composition comprising an amino acid-amino acid eutectic mixture and Troxerutin as an effective ingredient, thereby providing an effect of inhibiting inflammation and relieving / reducing skin irritation.

This invention relates to ophthalmic compositions comprising troxerutin and a surfactant selected from polyoxyethylene 35 castor oil, polyoxyethylene 40 hydrogenated castor oil, polyoxyethylene (20) sorbitan monooleate, polyoxyethylene (20) sorbitan monolaurate, and mixtures thereof, wherein the weight ratio of troxerutin to the surfactant is from 0.02:1 to 100:1, wherein the surfactant is present in an amount of up to 7% by weight relative to the total weight of the composition, and wherein the composition is in the form of a solution, suspension, or gel. The invention also relates to the compositions for treating dry eye disease.

The invention provides an anti-atherosclerosis lipidosome carrier drug and a preparation method thereof, and belongs to the technical field of biological pharmacy, the lipidosome carrier drug is prepared by taking tussah peptide, premna microphylla leaf flavonoid glycoside, clausena lansium leaf polysaccharide and troxerutin as active ingredients. The antheraea pernyi peptide is a product between 1kDa and 5kDa obtained by extracting protein from antheraea pernyi and sequentially carrying out enzymolysis by bacillus subtilis protease and pepsin. The premna microphylla leaf flavonoid glycoside is prepared by performing enzymolysis and water extraction on premna microphylla leaves and then purifying the premna microphylla leaves through an HPD-600 macroporous adsorption resin column. The clausena lansium leaf polysaccharide is prepared by the following steps: extracting clausena lansium leaves with water, precipitating with ethanol, redissolving, and purifying through a DEAE-52 cellulose column and a Sephadex G-100 gel column in sequence. All the components aim at key pathological links of atherosclerosis respectively, and the core advantages of high efficiency, safety and stability are achieved through multi-component synergistic compatibility and closed-loop optimization of a fine preparation process.

The invention discloses a composition for inhibiting color change of a whitening agent based on troxerutin. The composition is prepared from the following core active components in parts by mass: 0.1 to 0.5 part of syringyl malonic acid diethyl hexyl ester, 0.01 to 0.05 part of pentaerythritol tetra (bis-tert-butyl hydroxy hydrocinnamic acid) ester, 0.5 to 2 parts of troxerutin liposome and 0.05 to 0.5 part of toxostat; the composition does not contain any one or more of sodium pyrosulfite, sodium sulfite and sodium hydrogen sulfite; sulfate components are not used in the whole process, all the components are cosmetic-grade safe raw materials, skin irritation tests prove that the composition has no obvious irritation to people with sensitive skin and is wide in applicable people coverage, and the pain point that a traditional inhibitor is not friendly to sensitive skin is solved.

The invention relates to a soothing composition containing trans-4-tert-butyl cyclohexanol, and belongs to the technical field of cosmetics. The soothing composition comprises a main agent; the main agent is prepared from trans-4-tert-butyl cyclohexanol, nordihydroguaiamic acid and troxerutin; the soothing composition further comprises an auxiliary agent; the auxiliary agent is prepared by the following steps: S1, pretreating white water lily roots to obtain white water lily root powder; s2, pretreating the roots of the buckthorn to obtain powder of the roots of the buckthorn; s3, extracting active substances of the white water lily root powder and the buckthorn root powder in a deionized water environment under the action of cellulase; the soothing composition is high in safety adaptability and easy to accept by skin, sensitivity irritation is reduced, the components have a prominent synergistic effect on the soothing effect, and further application of trans-4-tert-butyl cyclohexanol in the field of cosmetics is promoted.

The application relates to a whitening material liquid capable of softening cutin, a production process and a mask, which comprises the following components and contents: glycerol 1-3%, polyglutamic acid sodium 0.01-0.05%, sodium hyaluronate 0.01-0.20%, arginine 0.01-0.20%, skin probiotic 0.01-0.20%, tranexamic acid 1.00-3.00%, oat extract 0.1-1.0%, troxerutin 0.01-0.20%, anti-allergic agent 0.1-1.0%, antioxidant 0.1-1.0%, whitening agent 1.00-3.00%, stabilizer 0.05-0.20%, butanediol 1.00-3.00%, and the rest is water. The application has the effect of more gently and effectively performing the keratosis care.

The application provides a kind of nano-liposome protective agent with anti-ultraviolet and antioxidant function, preparation method, preparation and application, it is related to cosmetic technical field.The nano-liposome protective agent includes the following components: benzotriazolyl dodecyl p-cresol / benzotriazolyl butylphenol sulfonic acid sodium, tris (tetramethylhydroxy piperidol) citrate, troxerutin / rutin and pentaerythritol tetra (bis-tert-butyl hydroxyl hydrogenated cinnamic acid) ester / tocopheryl acetate.The nano-liposome protective agent has anti-ultraviolet and antioxidant activity at the same time, when it is added to nano-liposome, it can effectively reduce the loss of active ingredient activity and nano-liposome phospholipid membrane material caused by ultraviolet and oxygen during storage and shelf life, achieve the effect of prolonging shelf life, improving curative effect and promoting the percutaneous penetration of nano-liposome.

The invention belongs to the technical field of biological medicines, and particularly relates to application of troxerutin in preparation of medicines for preventing and / or treating skin keratinocyte aging and skin tissue aging. The medicine can delay skin keratinocyte senescence by protecting skin keratinocytes from intracellular active oxygen accumulation, mitochondrial dysfunction and DNA damage caused by ionizing radiation, and the troxerutin can delay skin tissue senescence by protecting skin tissues from skin tissue thinning caused by ionizing radiation. The invention provides a new medicine source for preventing, protecting, delaying and researching the aging of skin keratinocytes and skin tissues. The medicine for controlling the aging of cells and organisms, provided by the invention, is safe, relatively strong in pharmacological action, small in side effect and definite in curative effect.

The present application relates to the technical field of preparation of quercetin, and discloses a method for preparing quercetin by using troxerutin waste liquid powder, which comprises the following steps: step S1, dissolving the troxerutin waste liquid powder in a protonic acid or a Lewis acid, heating and refluxing until the reaction is complete; and step S2, reducing to normal temperature, filtering, washing the filter cake with deionized water until neutral, and drying to obtain quercetin. In the technical solution, the acid is used as a catalyst, the sugar molecules are hydrolyzed while the hydroxyethyl groups are removed, all the rutin substitutes in the waste liquid powder are converted into quercetin, the hydrolysis of two molecules of sugar on the rutin molecules and the removal of the hydroxyethyl groups are completed at the same time in one step, the process time is effectively shortened, the production cost is reduced, and good economic benefits are achieved.

The invention belongs to the technical field of medicines, and particularly relates to a troxerutin suppository and a preparation method thereof. The invention provides a troxerutin suppository. The troxerutin suppository is prepared from the following raw materials in percentage by mass: 20-40% of troxerutin, 25-35% of cocoa butter and 35-45% of mixed fatty glyceride. According to the troxerutin suppository, the cocoa butter and the mixed fatty glyceride are adopted as auxiliary materials of the suppository, meanwhile, the cocoa butter and the mixed fatty glyceride are optimized to be matched with the troxerutin in a proper mass ratio, the obtained troxerutin suppository has good stability, and the release degree meets the standard. Meanwhile, the troxerutin suppository provided by the invention can realize rectal administration, reduces gastrointestinal irritation, is long in acting time, improves bioavailability, is suitable for patients who cannot take orally or are difficult to take orally, and improves drug compliance.

The present application relates to the technical field of cosmetics, in particular to a skin care composition with blue light protection efficacy and application thereof, the skin care composition comprises tetrahydro methyl pyrimidine carboxylic acid, troxerutin, red ginger extract and cocoa seed extract, the composition obtained by compounding the above raw materials can reduce the generation of ROS triggered by light damage, reduce the content of melanin and red pigment in the skin under blue light irradiation, has significant blue light protection efficacy, and is mild and non-irritating.

This invention discloses a method for studying the mechanism of troxerutin targeting EGLN3 / LRPPRC in lung adenocarcinoma, including the following steps: construction and screening of lung adenocarcinoma research models, baseline detection of EGLN3 expression levels and clinical relevance analysis, verification of EGLN3 / LRPPRC protein interaction and analysis of regulatory mechanisms, troxerutin targeting screening and determination of intervention parameters, in vitro verification of troxerutin intervention in the malignant biological behavior of lung adenocarcinoma cells, in vivo verification of troxerutin intervention in lung adenocarcinoma, evaluation of intervention effect and confirmation of mechanism, and formulation of personalized consolidation intervention plan. This invention integrates the links of target verification, drug screening, in vivo and in vitro intervention, effect evaluation, and clinical translation to form a standardized and reproducible lung adenocarcinoma intervention method, filling the technical gap in B[a]P-induced lung adenocarcinoma targeted intervention, and is different from the fragmented research of existing single cell / animal experiments.

The invention belongs to the technical field of daily chemicals, and particularly relates to a scalp care composition for helping rapid growth of hair as well as a preparation method and application of the scalp care composition. The scalp care composition is prepared from the following components in parts by mass: 12 to 25 parts of recombinant XVII type collagen, 20 to 30 parts of glucosyl hesperidin, 25 to 42 parts of caffeine seed extract, 12 to 20 parts of troxerutin and 5 to 12 parts of PEG-5 (Polyethylene Glycol) ethylhexanoate. Through synergism of multiple components, a good effect of helping hair to grow rapidly is achieved through multiple aspects of promoting hair growth, enhancing transdermal absorption of active components, maintaining scalp steady state, resisting inflammation, relieving and providing nutrition for scalp and hair; comprehensively, breakthrough is realized in four aspects of transdermal delivery of active ingredients, hair growth regulation and control, scalp microenvironment repair and use safety.

The invention belongs to the field of medical application, and particularly relates to application of troxerutin in a medicine for preventing and treating ototoxicity induced by cis-platinum. The invention provides an application of troxerutin in a medicine for preventing and treating ototoxicity induced by cis-platinum, research finds that troxerutin can remarkably inhibit ROS accumulation, Fe overload and GPX4 reduction induced by cis-platinum, so that excessive accumulation of active oxygen and ferroptosis in hair cells are blocked, the auditory function is improved, troxerutin remarkably inhibits cell apoptosis induced by cis-platinum, and the troxerutin can be used for preventing and treating ototoxicity induced by cis-platinum. And a new way is provided for transformation application of traditional Chinese medicine micromolecules in ear toxicity prevention and treatment.

The invention provides pet cat food capable of improving immunity and a preparation method of the pet cat food, and relates to the technical field of pet food. The pet cat food capable of improving the immunity is prepared from cat food base food, plant extracts and probiotics, wherein the plant extract is prepared from the following components in percentage by mass: 3 to 10 percent of phlorizin, 5 to 10 percent of troxerutin and the balance of spirulina polysaccharide. By adding phlorizin, troxerutin and spirulina polysaccharide into the pet cat food, the immunity of pet cats is remarkably improved, and the incidence rate of diseases is effectively avoided.

The invention relates to the technical field of cosmetics, in particular to a skin care composition with a blue light protection effect and application thereof.The skin care composition is prepared from tetrahydromethylpyrimidine carboxylic acid, troxerutin, a zingiber zingiberensis extract and a cocoa seed extract.The composition obtained by compounding the raw materials can reduce generation of ROS triggered by light damage, and the skin care effect is good. The content of melanin and haematochrome in the skin under the irradiation of blue light is reduced, and the composition has a remarkable blue light protection effect and is mild and non-irritant.

The invention discloses a troxerutin tablet and a preparation method thereof. The preparation method comprises the following steps: adding troxerutin and an adhesive into a wetting agent, carrying out boiling granulation, adding a lubricant and a disintegrating agent after granulation is finished, and carrying out size stabilization and mixing; after mixing is finished, a specific punching die is used for pressing tablets; and coating the tablet core with sugar. The troxerutin tablet prepared by the method has good dissolution performance and tablet weight difference. The method is particularly suitable for preparing troxerutin, and ensures that the medicine has a stable curative effect and a good dissolution behavior in the storage and taking processes. The method is simple to operate, does not need special reaction conditions and equipment, is more suitable for industrial production, and conforms to the concept of green development.

The invention relates to the technical field of biological medicine, in particular to application of troxerutin in preparation of a medicine for improving dyslipidemia. According to the application disclosed by the invention, in a streptozotocin-induced type 2 diabetes rat model, the intervention of troxerutin for seven weeks generates a remarkable and dose-dependent improvement effect, and the effect of troxerutin reaches a level which can be compared with or even better than that of a reference drug metformin (10 mg / kg / day). And the troxerutin is derived from a natural plant, the water-soluble characteristic of the troxerutin is beneficial to absorption and metabolism, and no obvious adverse reaction is observed in the experimental period of the invention, which indicates that the troxerutin has better safety than many synthetic drugs.