150 results about "Troxerutin" patented technology

The invention relates to a method for synthesizing troxerutin with high content. According to the invention, hydroxyethyl reaction is implemented on a phenolic hydroxyl group on a rutin flavone skelecton by using ethylene oxide in alkaline water or a mixed water and ethanol solvent. The reaction is implemented through two steps: in the first step, dihydroxyethylrutin and troxerutin (namely trihydroxyethylrutin) are mainly generated, and in the second step, borax is added and serves as a coordination catalyst to protect C5-OH, so that the generation proportion of tetrahydroxyethylrutin acquired from excessive reaction is effectively reduced and the preparation of 3',4',7-tri-beta-hydroxyethylrutin is implemented, wherein the purity of the 3',4',7-tri-beta-hydroxyethylrutin after being purified can reach 90% or higher and the yield of the 3',4',7-tri-beta-hydroxyethylrutin can reach 70% or higher.

The present invention relates to a preparation method of trihydroxyethyl rutoside. In the method, rutin is firstly prepared into 7-monohydroxyethyl rutoside in a content of greater than or equal to 98% by weight, and then 7-monohydroxyethyl rutoside is hydroxyethylated continuously to obtain troxerutin having the impurity of non hydroxyethylated rutoside derivatives less than 2%. The content of 7,3',4'-trihydroxyethyl rutoside in the troxerutin is above 80% by weight. The product is further refined, and the 7,3',4'-trihydroxyethyl rutoside in a content of greater than or equal to 98% by weight could be obtained.

The invention relates to skin whitening and fleck removing skin-care cosmetic composition. The composition can prevent excessive generation of melanin and realizes effects of skin whitening, fleck removing and skin brightening. Specifically, the skin whitening and fleck removing skin-care cosmetic composition contains troxerutin, sapindoside and papain. The composition realizes the effects of skin whitening, blackspot removal and skin brightening through synergistic effects of troxerutin, sapindoside and papain.

The present invention discloses a medicine composition. Said medicine composition contains troxerutin obtained by making rutin undergo the process of hydroxyethylation, brain extract extracted from brain tissue of mammal except for human being and ganglioside extracted from brain tissue of mammal except for human being. Said invention also provides the concrete mixing ratio of the above-mentioned three components, and provides its preparation process and application.

The invention discloses a method for preparing troxerutin by adopting a self-suction type stirred autoclave. The method comprises the following steps: adding raw materials namely rutin, ethylene oxide, a solvent namely methanol and a catalyst namely natural weakly-alkaline high-molecular compound chitosan into a self-suction type stirred autoclave, starting a digital control instrument, setting a temperature to be 70-90 DEG C, regulating a voltage to be 100V, setting a rotating speed to be 1000r / min, stirring and heating to reach a set temperature, and reacting for 3-6 hours; and stopping stirring after reaction is ended, rapidly cooling by using cold water, shutting down the digital control instrument, opening a reaction kettle, pouring out reaction liquid, adjusting a pH value of the poured reaction liquid to be 5-6 by using hydrochloric acid, performing suction filtration, adding a crystal seed into the reaction liquid subjected to suction filtration, standing for later crystallization, and filtering to obtain a product namely troxerutin. According to the method disclosed by the invention, the reaction raw materials are integrally added into the self-suction type stirred autoclave, so that material feeding steps can be simplified; and the adopted catalyst is natural weakly-alkaline high-molecular compound chitosan, so that the raw material is wide in source, and is natural, non-toxic and weakly-alkaline, and side reactions such as hydrolysis, oxidation and the like caused by strong alkaline catalysis can be avoided.

A granular troxerutin for improving microcirculation and treating venous insufficiency and pile is prepared from troxerutin, sweetening agent, mannitol and polyvinyl pyrrolidone through drying, pulverizing, sieving, proportionally mixing, and granulating. Its advantage is high curative effect.

The invention discloses a composition with blue-ray resistance and repair efficacy and a preparation method and application thereof. The composition with blue-ray resistance and repair efficacy includes the following ingredients (by weight): 1-5 parts of troxerutin, 20-45 parts of a gotu kola extract, and 20-50 parts of a selaginella extract. The invention also provides a stock solution containingthe above composition with blue-ray resistance and repair efficacy. Tests prove that the composition with blue-ray resistance can effectively resist damage of blue rays to skin cells, improve rough skin and repair damaged skin cells so as to achieve the effects of delaying skin aging and reducing skin chromatosis. The three ingredients in the composition have significant blue-ray resistant and repairing synergism, have mild nature and high safety, and will not cause skin irritation.

The invention relates to the field of chemical pharmacy, in particular to a method for synthesizing 3',4',7-troxerutin, and solves the problems that a reaction end point has the characteristics of not easy control, low content, various impurities and the like in a conventional synthesizing method. In the method, rutin reacts with epoxy ethane by taking sodium hydroxide as a catalyst, wherein the weight ratio of the rutin to the epoxy ethane is 1:2 to 1:4; the weight ratio of the rutin to the sodium hydroxide is 100:1-100:1.5; before the pH value of reaction solution reaches 9.5 to 9.6 and when the reaction temperature is between 50 and 80 DEG C, the additive amount of the epoxy ethane per hour is 4 to 5 percent based on the weight the rutin; after the pH value of the reaction solution reaches 9.5 to 9.6 and when the reaction temperature is between 40 and 70 DEG C, the additive amount of the epoxy ethane is 2.5 to 3.5 percent based on the weight of the rutin; and when the pH value of the reaction solution is 9.5 to 9.6, a weak acid salt is added. The content of the troxerutin is stabilized over 78 percent while an obtained product has very few impurities, so that national medicament standards can be reached without refining; and therefore, method improves the yield by 125 to 130 percent, reduces production cost, and is suitable for industrial production.

The present invention relates to a compound veterinary imidocarb dipropionate preparation applied to eperythrozoonosis and a preparation method thereof. The present invention is made from the main materials of the imidocarb dipropionate, astragalus extract, florfenicol and artesunate, which are confected with auxiliary materials, by the regular methods of weighing, stirring, mixing, checking, measuring, packing, etc. The compound preparation can be medicated by stirring, and the components and the weight percentages of the compound preparation are 5 percent to 15 percent of the imidocarb dipropionate, 2 percent to 5 percent of the astragalus extract, 3 percent to 12 percent of the florfenicol, 5 percent to 15 percent of the artesunate, 25 percent to 65 percent of beta-cyclodextrin and 10 percent to 40 percent of troxerutin. The present invention has the characteristics of low cost, stable storage, assured effect, thoroughly removing eperythrozoon, etc., and is a novel effective preparation for remedying animal eperythrozoonosis.