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Pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, preparation process and quality control method thereof

A technology for cardiovascular and cerebrovascular diseases and compositions, which is applied to cardiovascular system diseases, drug combinations, blood diseases, etc., can solve problems such as unsuitable for long-term use, large fluctuations in curative effect, and low bioavailability, and achieve strong pharmacological effects and overcome Large fluctuations in curative effect, good curative effect

Inactive Publication Date: 2007-05-30
BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Chuanxiong Xinxiang Xingsan, warms the blood vessels, ascends the head, descends into the sea of ​​blood, has the functions of promoting blood circulation and qi, dispelling wind and relieving pain, and is known as the Qi medicine in the blood by the predecessors. Modern research shows that: total lactones of Chuanxiong, total Alkaloids and chuanxiong volatile oil are its main physiologically active components, which have the functions of relieving spasm, reducing vascular resistance and strongly inhibiting platelet aggregation. Myocardial oxygen supply, reducing myocardial oxygen consumption, etc., but at present, medicinal materials are mostly used in medicine, resulting in low bioavailability and large fluctuations in curative effect; Troxerutin can inhibit platelet aggregation and prevent thrombosis, but due to side effects, it is not suitable long-term use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Embodiment 1 of the present invention: troxerutin 30g chuanxiong total lactone 70g

[0058] Take troxerutin and chuanxiong total lactones and add water for injection, stir to dissolve, filter, add 1.0% (W / V) activated carbon after the filtrate is boiled, keep slightly boiling for 30 minutes, filter slightly cold, adjust the pH value of the filtrate to 5.5 ~7.0, boiled, refrigerated (4°C) overnight, coarsely filtered, finely filtered; mannitol plus water for injection was prepared into a 120mg / ml solution (the volume ratio of mannitol solution to medicinal solution was 2:1), mixed with the above filtrate Mix well, filter, add water for injection to the specified amount, subpackage, freeze-dry, pre-freeze at -45°C, and pre-freeze for 10 hours; start vacuuming, and raise the temperature to -40°C, keep for 8 hours; and freeze for 12 to 72 hours Gradually increase the temperature to 10°C with a gradual differential speed, keep for 2 hours, raise the temperature to 20°C, keep...

Embodiment 2

[0059] Embodiment 2 of the present invention: Troxerutin 70g Chuanxiong total alkaloids 30g

[0060] Take troxerutin, add water for injection, stir to dissolve, and set aside the liquid medicine; take the total alkaloids of Ligusticum chuanxiong and add water for injection, stir to dissolve, filter, and set aside the filtrate; combine the above two liquid medicines, and adjust the pH value to 5.5~ 7.0, add 1.0% activated carbon for needles, boil for adsorption, remove carbon, fine filter, add water for injection to the specified amount of filtrate, refrigerate overnight at 4°C, coarse filter, fine filter, pack into ampoules, and sterilize , sub-package, that is, small-volume injection or concentrated solution for injection.

Embodiment 3

[0061] Embodiment 3 of the present invention: troxerutin 1g total alkaloids of Ligusticum chuanxiong 99g

[0062] Take troxerutin and total alkaloids of Ligusticum chuanxiong, add appropriate amount of water for injection to dissolve, filter, add a specified amount of glucose or sodium chloride to the filtrate, mix and dissolve, add 1.0% activated carbon for needles according to volume, boil, keep slightly boiling for 30min, Cold filtration, add water for injection to the filtrate to an appropriate amount, adjust the pH value to 5.5-7.0, boil, refrigerate overnight at 4°C, coarse filter, fine filter, add water for injection to the full amount, subpackage, and sterilize to obtain glucose or chloride Sodium IV infusion.

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Abstract

The invention provides a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, its preparing process and quality control method, wherein Troxerutin and one or two of ligustilides and Ligusticum wallichii alkaloids are employed in combination to obtain various dose forms of injections and oral administration preparations. The composite preparation is mainly used for treating coronary disease, angina pectoris, cerebrovascular disease, pulmonary heart disease, thrombotic phlebitis, capillary vessel hemorrhage and hypertension.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, a preparation method and a quality control method thereof, and belongs to the technical field of medicines. technical background [0002] Among the causes of human death, about 17 million people die from cardiovascular and cerebrovascular diseases in the world every year, accounting for more than 50% of the total death toll, ranking first; among human diseases, the recurrence rate of cardiovascular and cerebrovascular diseases is as high as 87% , ranking first; in human diseases, the disability rate of cardiovascular and cerebrovascular diseases is as high as 50%, ranking first. This grim fact has been highly concerned by all walks of life. There are already a lot of western medicines. Chemical medicines are used to control symptoms and have definite curative effects. , but the bioavailability is low, the curative effect is longer, and the c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/23A61K31/352A61K9/08A61K9/10A61K9/14A61K9/16A61K9/19A61K9/20A61K9/48A61K9/70A61P9/10A61P9/12A61P9/00A61P7/02A61P3/06G01N30/02G01N33/15
Inventor 于文风
Owner BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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