4 results about "Vascular permeability" patented technology

The application discloses a kind of hardness correlation liver cancer lung premetastatic niche mouse model construction method, it includes the following steps: (1) in vitro enrichment respectively on the low hardness substrate of hardness 6kPa and the high hardness substrate of hardness 16kPa, the condition culture supernatant of mouse liver cancer cell Hepa1-6 that is cultured and grows, respectively named mL-CM and mH-CM;(2) mL-CM and mH-CM are respectively injected into two groups of mice using tail vein injection mode, every 1 day injection 1 time, until the 26th day, during continuous monitoring the recruitment of BMDCs in fresh lung tissue, while with the induction endpoint, i.e. 26th day premetastatic niche mark feature detection includes lung tissue matrix remodeling, immunosuppression, angiogenesis, vascular permeability and inflammation etc..The method has the advantages of short modeling cycle, easy operation, controllable induction condition, can comprehensively and accurately evaluate the common characteristics of liver cancer lung premetastatic niche formation etc..

This invention provides a high-voltage pulse ablation system integrating energy transmission and real-time temperature monitoring. It includes a catheter with several electrodes, each equipped with a temperature sensing unit. A temperature monitoring unit corresponds one-to-one with each temperature sensing unit, and their ends are electrically connected via a first wiring harness and a second wiring harness. The high-voltage pulse signal generated by the main unit's pulse module is transmitted to the corresponding electrode via the first or second wiring harness of the temperature monitoring unit corresponding to that electrode, and is also transmitted back to the pulse module via the first or second wiring harness of the corresponding temperature monitoring unit of any other electrode. The temperature monitoring unit synchronously couples and filters out common-mode interference generated by the high-voltage pulse signal using the first and second wiring harnesses, and performs temperature measurement based on the differential signal obtained from the temperature sensing unit via the first and second wiring harnesses. This invention significantly reduces the catheter's outer diameter and enhances its flexibility and vascular permeability.

This invention discloses a novel magnetic guidewire with a variable stiffness tip and its preparation method, belonging to the field of medical device technology. The magnetic guidewire includes a guidewire body, a magnetically controlled tip, and a spring coil. The guidewire body comprises a core wire and an outer layer. One end of the core wire is connected to the spring coil, and the end of the spring coil furthest from the core wire is connected to the magnetically controlled tip. The core wire and the spring coil are embedded together inside the magnetically controlled tip. The spring coil is a continuous spring with a gradually changing stiffness distribution along the axial direction, consisting of an unstretched section, a transition section, and a stretched section. The preparation method includes guidewire body pretreatment, spring coil treatment and fixation, magnetically controlled tip forming, and post-treatment. This invention solves the problems of uneven stiffness transition, easy slippage of the magnetically controlled tip, and susceptibility to puncture by the core wire in conventional magnetic guidewires. It achieves a natural and smooth stiffness transition, improves vascular permeability and connection stability, has a simple preparation process, good biocompatibility, and is suitable for vascular interventional surgery.

The invention relates to means and methods for the treatment of diseases involving autophagy by cells, which process according to the invention is involved in mechanisms of tissue repair, vascular permeability and immune responses. The invention provides methods and means to target the elastin receptor complex specifically and to provide molecules and compositions comprising a specific targeting agent as well as amino acid compositions that are involved in the pathway of autophagy and the diseases related thereto. The disclosure also relates to peptide-drug development, in particular to (the improvement of) autophagy inhibiting amino acid containing peptides, more in particular glutamine-containing peptides and / or glutamine and other autophagy modulating amino acid containing compositions useful in the treatment of vascular and inflammatory conditions. The invention further relates to the improvement of glutamine peptides useful in the treatment of diabetic, vascular and / or inflammatory conditions. The invention provides a Q- ER peptide, comprising a synthetic peptide or functional analogue thereof provided with at least one PG-domain amino acid motif xGxxPG or functional equivalent thereof, said PG- domain motif allowing targeting of said peptide to the elastin receptor complex (ER), wherein at least one amino acid at position x is selected from the group of amino acids alanine (in one letter code: A), glutamine (Q), glycine (G), valine (V), leucine (L), isoleucine (I), proline (P) and arginine, said peptide provided with at least one glutamine (Q).