Imidocarb dipropionate compound preparations for eperythrozoonosis for animals and preparation

A technology of imidazolium dipropionate and eperythrozoonosis, which is applied in the field of preparations and its preparation, and can solve problems such as inability to purify eperythrozoonosis and inability to completely eliminate eperythrozoonosis

Inactive Publication Date: 2008-07-09
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Found through literature retrieval to prior art, relevant report is very few, and Huang Shuihong etc. published " the medicine curative effect exploration of porcine eperythrozoon disease " on the 2nd period of " contemporary animal husbandry " in 2004, proposed to use to Eperythrozoon Sensitive drugs "Xuechongjing", sulfa-methoxine sodium, oxytetracycline, chlortetracycline, metronidazole and doxycycline in the treatment of Eperythrozoon disease can reduce the infection intensity of Eperythrozoon to a certain extent, However, none of them can purify the Eperythrozoon in the blood, and the existence of Eperythrozoon can still be detected after the treatment of the disease, and neither can completely remove the Eperythrozoon disease in the blood.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The veterinary compound preparation containing imidazolium dipropionate is prepared by the following method:

[0025] (1) Weigh 15g of imidazolium dipropionate, 5g of astragalus extract, 12g of florfenicol, 15g of artesunate, 33g of β-cyclodextrin, and 20g of Fumei powder;

[0026] (2) mix artesunate and β-cyclodextrin;

[0027] (3) add imidazolium dipropionate and florfenicol, and mix;

[0028] (4) mix astragalus extract and Fumei powder;

[0029] (5) Mix the solutions obtained in the above step (3) and step (4), and mix evenly to prepare a compound preparation containing imidazolium dipropionate.

[0030] The compound preparation containing imidazuron dipropionate prepared above is used to treat rats artificially infected with Eperythrozoon. Rats were randomly divided into 5 groups, namely: blank control (1), imidazolium dipropionate (2), Bernier (3), long-acting oxytetracycline (4), compound imidazolium dipropionate (5 ). The experimental results are shown in Ta...

Embodiment 2

[0038] The veterinary compound preparation containing imidazolium dipropionate is prepared by the following method:

[0039] (1) Weigh 5 g of imidazolium dipropionate, 2 g of astragalus extract, 3 g of florfenicol, 5 g of artesunate, 65 g of β-cyclodextrin, and 20 g of Fumei powder;

[0040] (2) mix artesunate and β-cyclodextrin;

[0041] (3) add imidazolium dipropionate and florfenicol, and mix;

[0042] (4) mix astragalus extract and Fumei powder;

[0043] (5) Mix the solutions obtained in the above step (3) and step (4), and mix evenly to prepare a compound preparation containing imidazolium dipropionate.

[0044] The compound preparation containing imidazolium dipropionate prepared above was used for anti-eperythrozoon drug susceptibility test in vitro. The implementation is as follows: aseptically collect anticoagulant blood, add 1:7 nutrient solution RPMI-1640, add the prepared drug mother solution to each well, shake gently, and then place the 96-well plate in a 37°C...

Embodiment 3

[0063] The veterinary compound preparation containing imidazolium dipropionate is prepared by the following method:

[0064](1) Weigh 8 g of imidazolium dipropionate, 4 g of astragalus extract, 6 g of florfenicol, 6 g of artesunate, 50 g of β-cyclodextrin, and 26 g of Fumei powder;

[0065] (2) mix artesunate and β-cyclodextrin;

[0066] (3) add imidazolium dipropionate and florfenicol, and mix;

[0067] (4) mix astragalus extract and Fumei powder;

[0068] (5) Mix the solutions obtained in the above step (3) and step (4), and mix evenly to prepare a compound preparation containing imidazolium dipropionate.

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PUM

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Abstract

The present invention relates to a compound veterinary imidocarb dipropionate preparation applied to eperythrozoonosis and a preparation method thereof. The present invention is made from the main materials of the imidocarb dipropionate, astragalus extract, florfenicol and artesunate, which are confected with auxiliary materials, by the regular methods of weighing, stirring, mixing, checking, measuring, packing, etc. The compound preparation can be medicated by stirring, and the components and the weight percentages of the compound preparation are 5 percent to 15 percent of the imidocarb dipropionate, 2 percent to 5 percent of the astragalus extract, 3 percent to 12 percent of the florfenicol, 5 percent to 15 percent of the artesunate, 25 percent to 65 percent of beta-cyclodextrin and 10 percent to 40 percent of troxerutin. The present invention has the characteristics of low cost, stable storage, assured effect, thoroughly removing eperythrozoon, etc., and is a novel effective preparation for remedying animal eperythrozoonosis.

Description

technical field [0001] The invention relates to a preparation in the field of biotechnology and a preparation method thereof, in particular to a veterinary compound preparation of imidazolium dipropionate for eperythrozoonosis and a preparation method thereof. Background technique [0002] Eperythrozoonosis is a zoonotic disease caused by Eperythrozoon parasitizing on the surface of human and animal red blood cells, plasma and bone marrow. Porcine Eperythrozoonosis mainly causes fever, anemia, jaundice and sow abortion in piglets. The disease is often mixed with other pig diseases. It is difficult to prevent and control, and the harm is very serious, causing huge economic losses to the pig industry. However, there is no safe, efficient and environmentally friendly specific drug for the clinical treatment of the disease at present. Some drugs are commonly used in clinical practice and have better effects, but because they are used alone, drug resistance is prone to occur, su...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A61K47/40A61P33/02A61K31/4178A61K31/165A61K31/357
Inventor 华修国李政萍崔立杨志彪沈权
Owner SHANGHAI JIAO TONG UNIV
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