The invention relates to a traditional Chinese medicinal composition for preventing and treating swine eperythrozoonosis and a preparation method of the traditional Chinese medicinal composition. The traditional Chinese medicinal composition for preventing and treating the swine eperythrozoonosis is prepared by carrying out scientific compatibility on eleven traditional Chinese medicines, namely sweet wormwood herb, antifebrile dichroa, houttuynia cordata, sophora flavescens, astragalus, ligusticum wallichii, radix paeoniae rubra, liquorice, mirabilite, burdock and cyrtomium rhizome, grinding the traditional Chinese medicines by virtue of an ultrafine grinder and uniformly mixing. The traditional Chinese medicinal composition for preventing and treating the swine eperythrozoonosis is obvious in curative effect, has dual function in prevention and treatment and has a good application practice in the aspect of preventing and treating the swine eperythrozoonosis; meanwhile, the technology is simple, the application is convenient, the cost is low, no toxic or side effect such as teratogenesis and mutagenesis is produced, safety in application is guaranteed, and no residue is produced.