82 results about "FLUNIXIN MEGLUMINE" patented technology

The present invention relates to a long-acting flunixin meglumine injection for animals and method for preparing same. The invention provided flunixin meglumine injection delays medicine absorption so as to prolong medicine action time by adding proper polyvinylpyrrolidone and poloxamer high molecular compound in the preparation process. Approved by clinical experiments that action time of the invention is longer than common flunixin meglumine injection, the invention reduces labor strength and reduces stress response of animals with more obvious medicine effect, and capable of using with long-acting antibacterials to provide a synergistic effect. The invention provides a animals specific medicine of long-acting, effective antipyretic, antiphlogosis and analgesic for veterinary clinical.

The invention discloses compound florfenicol injection and a preparation method and application thereof. The compound florfenicol injection comprises main medicaments, injection solvent and local anodyne; and the main medicaments are florfenicol and flunixin meglumine. The compound florfenicol injection is safe and convenient to use, controllable in quality, stable in preparation process, suitable for industrialized production and low in cost; and the compound florfenicol enhances the prevention and treatment effects of porcine or bovine respiratory diseases, improves the survival rate of pigs or cattle, and is suitable for popularization and application.

The invention relates to a method for preparing a veterinary oxytetracycline-artemisinin injection and clinical application of the veterinary oxytetracycline-artemisinin injection. Raw materials of the injection mainly comprise oxytetracycline, artemisinin, trimethoprim, flunixin meglumine, magnesium oxide or magnesium chloride, an antioxidant, a pH regulator, a compound organic solvent and water. As a veterinary compound preparation, the veterinary oxytetracycline-artemisinin injection is mainly used for treating infectious diseases and secondary infection which are caused by sensitive gram positive bacteria and negative bacteria, eperythrozoon, rickettsia and mycoplasma. The method for preparing the veterinary compound oxytetracycline-artemisinin injection is simple, the production process is mild, the chelating temperature is low, the stability is high, and the injection is convenient to use and is suitable for industrialized production.

The invention discloses a perfusion medicament for treating milk cow mastitis and a preparation method thereof. The perfusion medicament is prepared from the following raw materials by weight: 0.9-4.3g of cefquinome sulphate, 0.15-0.25g of prednisolone, 0.5-1.3g of flunixin meglumine, 1-1.5g of glycerin monostearate, 3-8g of Vaseline, 0.05g of ethylparaben and 65-70g of whiteruss. The preparationmethod comprises the following specific steps of: (1) putting one tenth of the liquid paraffin into a burdening tank in a certain weight ratio; (2) adding one third of the liquid paraffin into a heating tank; and (3) putting the rest of the liquid paraffin left after the steps (1) and (2) and auxiliary materials in the step (2) into an emulsifying tank, adding 0.9-4.3g of cefquinome sulfate in a certain weight ratio, and stirring till uniform distribution to obtain the perfusion medicament for treating milk cow mastitis. The perfusion medicament has the advantages of no induction of endotoxemia in a milk cow mastitis treating process, remarkable curative effect on mastitis and freeness from medicament tolerance.

The invention belongs to the field of a special pharmaceutical preparation for animals, and relates to an in-situ gel preparation for injecting flunixin meglumine and a preparation method thereof. The in-situ gel preparation is prepared from water as a solvent, flunixin meglumine, in-situ gel matrix known in the field, and other pharmaceutical necessary auxiliary materials. The preparation method is clarified. The preparation disclosed by the invention is liquid which freely flows at room temperature; sold or semi-solid gel is formed after dosing by intramuscular injection or subcutaneous injection; drug release is delayed; the lasting time is long; just one-time dosing in a course of treatment is achieved; and the in-situ gel has the advantages that the in-situ gel is simple to prepare, stable in property, convenient to dose, strong in animal adaption, and the like. The preparation disclosed by the invention has the effects of relieving fever, easing pain, diminishing inflammation and the like, and is used for preventing and treating diseases of animals such as pigs, sheep, dogs, cats, cattle and birds.

The invention provides a method for synthesizing flunixin meglumine. According to the method, reaction is carried out in a manner that 2-chloronicotinic acid and 2-methyl-3-trifluoromethylaniline serve as raw materials, water serves as a solvent and cupric oxide and para-toluenesulfonic acid serve as catalysts. According to the method, on the premise that the condition that para-toluenesulfonic acid serves as a catalyst is reported in the existing literature, cupric oxide is added, so that the catalysis efficiency is increased greatly, the reaction can be carried out efficiently, the reaction time is shortened, and the yield is increased; obtained flunixin and meglumine are salified in an acetonitrile solvent and are recrystallized, so as to obtain flunixin meglumine, and the total yield is about 90%; through synthesizing flunixin meglumine by the method, the operation is convenient and simple, and the requirements for equipment are low, so that the method is applicable to industrial large-scale production.

The invention is a compound ceftiofur sodium freeze-dried power injection used for injection, and the compound ceftiofur sodium freeze-dried power injection provided by the invention is mainly composed of the following effective components in parts by weight: 2-4 parts of ceftiofur sodium, 1 parts of sulbactam sodium and 1 parts of flunixin meglumine; a vacuum freeze drying method is adopted to prepare the effective components into the compound ceftiofur sodium freeze-dried power injection used for injection. The compound ceftiofur sodium freeze-dried power injection has the advantages that the preparation cost can be lowered, and the drug resistance of bacteria on the ceftiofur sodium is relieved; and the broad antimicrobial spectrum is wide, the activity is strong, the drug administration times is less, and low stress and slight side effect are endured; and the negative effect of endotoxin can be effectively blocked.

The invention relates to a veterinary compound sulfadiazine sodium injection and a preparation method thereof. The veterinary compound sulfadiazine sodium injection comprises sulfadiazine sodium, enrofloxacin, flunixin meglumine, trimethoprim, dexamethasone sodium phosphate, an organic solvent and water for injection. The injection serving as a veterinary special compound preparation has a special treating effect on various infectious diseases, mixed infections and systemic infections of the digestive system, the respiratory system, the urinary system and the skin soft tissue caused by sensitive bacteria and mycoplasmas of oxen, swines, poultries, canines, cats and aquatic animals The injection has the advantages of convenient use, short period of treatment, low medicament resistance and the like.

The invention relates to a flunixin meglumine coated granule and a preparation method thereof. The preparation method of the flunixin meglumine coated granule comprises the following steps: dissolving raw materials in a solvent (serving as an adhesive), spraying into auxiliary materials which are uniformly mixed in a fluidized bed to carry out granulation, and finally spraying into a water-soluble coating solution to prepare the flunixin meglumine coated granule. The flunixin meglumine has very strong pungent smell which causes abnormal discomfort to the respiratory tracts and eyes of people in the production, packaging and using processes; according to the flunixin meglumine coated granule, the flunixin meglumine is dissolved in the solvent, sprayed into the auxiliary materials of the fluidized bed and finally coated, so that the operators and farmers are prevented from the pungent smell in the whole production, packaging and using processes; and above all, the coated granule is capable of reducing the sensitivity of the animals and improving the compliance, so that the effect of the coated granule can come into play better.

The synthesis and extraction and refine method for meglumine flunixin comprises: with p-toluenesulfonic monohydrate as catalyst and 20% KOH as extract, selecting 2-methyl-3- (trifluoromethyl) aniline and 2-chloronicotioyl by mole ratio as 2:1 for reaction with end pH value more than 11.5; cooling and crystallizing the residual aniline to separate and recover; using methanol in extraction and purification for flunixin; static cooling and crystallizing, and separating and cleaning the crystal to obtain the refined product; finally, recrystallizing to prepare the flunixin methylglucamine in water. This invention has high yield.

The invention discloses a synthesis method of flunixin meglumine, which comprises the following steps: adding 2-chloronicotinic acid and 2-methyl-3-trifluoromethyl aniline into a sodium hydroxide water solution, stirring, adding toluene and a phase-transfer catalyst, reacting at controlled temperature of 40-45 DEG C for 4-5 hours, regulating the pH value of the solution to 10-11, stirring, standing to stratify, regulating the pH value of the water layer to 5-6, stirring, filtering, washing the filter cake, and drying to obtain flunixin, reacting flunixin and N-methylglucosylamine in isopropanol, heating under reflux for 0.5-1.5 hours, filtering, cooling to 50-60 DEG C, and stirring to crystallize; and when the system temperature drops to 25 DEG C below, continuing stirring for 1 hour, carrying out vacuum filtration on the crystal, and washing with isopropanol to obtain the flunixin meglumine. The method lowers the reaction temperature, saves the energy, shortens the reaction time, and is simple for synthesis operation, low in facility requests and convenient for industrialized operation.

The invention discloses a compound sulphamethoxazole injection and a preparation method thereof. The injection is prepared from 5-20 % of the main drug sulphamethoxazole, 2-10 % of flunixin meglumine, 1-4 % of trimethoprim, 0.2-0.4 % of an accessory anti-oxidant, 40-70 % of an organic solvent, 0.5-2 % of an adjusting reagent and the balance being water for injection. The injection prepared by the invention can provide effective treatment for secondary infections and mixed infections of streptococcus diseases, toxoplasmosis, eperythrozoonosis, E. coli diseases, asthma and other diseases, is obvious in long-term effects, with a drug effect being enhanced by several times to dozens of times, small in application amount, few in drug using times, little in irritation and fast in performance of drug effects, saves production cost, increases added value of products, and reduces toxic and side effects due to drug mismatch during treatment.

The invention discloses a compound florfenicol preparation for treating swine respiratory tract infection diseases and a preparation method thereof. The compound florfenicol preparation comprises florfenicol, flunixin meglumine, a composite organic solvent and an antioxidant agent, and the florfenicol and the flunixin meglumine are used as main drugs. The compound florfenicol preparation has anti-infection, anti-inflammation, antipyresis and analgesia effects, is dosed through subcutaneous injection and has remarkable effects for preventing and treating the swine respiratory tract diseases. The compound florfenicol preparation is exquisite in preparing process, controllable in quality, safe, reliable, convenient to use, low in cost, and suitable for being popularized and applied to cultivation industry.

The invention relates to a tablet containing flunixin meglumine and a preparation method, which belongs to the veterinary drug technical field. The tablet can prolong the action time and reduce the stimulation of drug on gastrointestinal tract, and the pesticide effect is obvious.

The invention relates to a veterinary compound enrofloxacin injection and a preparation method thereof. The veterinary compound enrofloxacin injection mainly comprises enrofloxacin, sulfamethoxazole,trimethoprim, flunixin meglumine, tylosin, organic solvent and water for injection. The veterinary compound enrofloxacin injection is used as a veterinary special compound preparation, used for treating various infectious diseases of a respiratory system, a digestive system and a skin soft tissue caused by livestock and poultry bacterial and mycoplasma infection, particularly has special effects on secondary hemophilus disease of pigs and poultries caused by hemophilus and has the advantages of convenient use, short course, low drug resistance and the like.

The invention discloses a flunixin meglumine monoclonal antibody hybridoma cell strain YY and application thereof and belongs to the field of food safety immunoassay. The flunixin meglumine monoclonal antibody hybridoma cell strain YY disclosed by the invention is preserved in China General Microbiological Culture Collection Center (CGMCC for short) with a preservation number of CGMCC No.13096. The monoclonal antibody secreted by the cell strain has better specificity and detection sensitivity (an IC50 value is 0.24ng/mL) to flunixin meglumine, provides raw materials for immunoassay of flunixin meglumine residues in food and has an actual application value.

The invention discloses a high-concentration compound florfenicol injection, and a preparation method and an application thereof. The method comprises the following steps: dissolving prescription doses of florfenicol and flunixin meglumine in a 75% single solvent, and carrying out heating stirring for dissolving; adding the solvent to a full capacity; adding 0.4% activated carbon, and adsorbing for 30min; and filtering, encapsulating, and carrying out 100DEG C flowing steam sterilization for 30minin order to obtain the high-concentration compound florfenicol injection. The compound florfenicol injection prepared through the preparation method has the advantages of safety, convenience, controllable quality, stable preparation process, suitableness for industrial production, and low cost; and the injection enhances the prevention effect on porcine and bovine infectious diseases caused by pathogenic microorganisms sensitive to florfenicol, improves the survival rate of pigs or cattle, and is suitable for popularization and application.

The invention discloses a compound terramycin injection and a preparation method thereof. The compound terramycin injection comprises, by weight, 20 parts of terramycin, 2 parts of flunixin meglumine, 30-40 parts of propylene glycol, 10-15 parts of dimethyl formamide, 3 parts of polyvinylpyrrolidone, 6-7 parts of magnesium oxide, 0.5 parts of an anti-oxidant, 6.1-6.5 parts of ethanolamine and 28 parts of injection water. The compound terramycin injection can be used for treating therapy-sensitive infectious diseases caused by gram-positive bacteria and gram-negative bacteria, rickettsia and mycoplasma and has good treatment effects. The compound terramycin injection has good stability, does not discolor after being heated or stored for a long time, does not product precipitates, solves the problem that under the acid or alkaline conditions, the existing terramycin injection discolors or precipitates after being heated or stored for a long time so that titer is reduced, and can slowly release drug active components in the human body so that long-acting effects are obtained.

The invention relates to a compound doxycycline hydrochloride injection for animals, and its preparation method. The above compound preparation is composed of doxycycline hydrochloride and fluoronicotinic acid. The method comprises the following steps: dissolving an antioxidant in injection water, adding the above obtained aqueous solution into an organic solvent, adding doxycycline hydrochloride and a complexing agent, adjusting the pH value, adding a metal ion chelating agent and parts of the antioxidant, adding flunixin dissolved in a proper amount of the organic solvent, uniformly mixing, filtering, filling nitrogen, and disinfecting to obtain the compound doxycycline hydrochloride injection for animals. The compound doxycycline hydrochloride injection prepared in the invention has the advantages of good stability, controllable quality, better treatment effect than single doxycycline hydrochloride injection and flunixin meglumine injection, reduction of the administration frequency, reduction of the labor intensity and the animal stress response, improvement of the treatment effect and efficiency, and wide application prospect in the veterinary clinical medicine.

The invention discloses a flunixin meglumine taste masking orally-disintegrating preparation and a preparing method thereof, and belongs to the technical field of veterinary drugs. The preparing method of the preparation includes the steps that raw-material flunixin meglumine and taste masking agents are mixed in the weight ratio of 1:(2-4) to be subjected to taste masking treatment, taste-masking solid dispersion is made, then the taste-masking solid dispersion and auxiliary materials including water solubility fillers, disintegrating agents, flavoring agents, lubricants and the like are evenly mixed, and the preparation is obtained. Compared with the prior art, the taste masking effect of the flunixin meglumine taste masking orally-disintegrating preparation is achieved with the hot melt extrusion technology, and medicine is rapidly released in a buffer solution with the pH of 4.5 and still achieves medicine action; due to the adding of the auxiliary materials, the preparation has the advantages that disintegrating is rapid, mouthfeel is good, dissolution is rapid, swallowing is easy, irritation to the mouth mucosa is avoided, and the compliance of animal medicine taking is improved. In addition, the technology is advanced, easy to operate, safe, free of pollution and suitable for industrial large-scale production.

The invention provides a long-acting compound florfenicol injection and a preparation method thereof, and belongs to the technical field of medicine preparation. Every 100mL of the injection comprises10-40g of florfenicol, 1-7g of flunixin meglumine, 1-10g of polyvinylpyrrolidone K30, 1-20g of poloxamer 407 and 60-85mL of solvents. The long-acting compound florfenicol injection has long-lasting drug effect which can last more than 40 hours or above, and the number of times for drug administration can be reduced effectively.

The invention discloses a long-acting compound tildipirosin injection and a preparation method thereof. The long-acting compound tildipirosin injection comprises the following main components: tildipirosin, flunixin meglumine and sinomenine. The invention provides a long-acting compound injection special for animals for veterinary clinic, wherein the injection not only can be used for treating respiratory system infectious diseases caused by sensitive bacteria, but also can help to treat or reduce the stress of sick animals; and combination of drugs can significantly improve the clinical symptoms, and can enhance the activity of antibacterial drugs, reduce the use amount of drugs, reduce the administration frequency, reduce animal stress, enhance animal compliance and reduce labor intensity, and the injection is convenient to use.

The invention belongs to compound Flunixin meglumine injection and a preparation method thereof. The compound Flunixin meglumine injection comprises, by weight percentage, 8-10% of Flunixin meglumine, 1-5% of honeysuckle extract, 1-5% of baicalin, 3-10% of taurine, 1-10% of cecropin, 10-15% of polyoxyethylene 40 hydrogenated castor oil, 10-21% of propylene glycol, 1-20% of ethanol and 0.5-1% of tween 80. The compound Flunixin meglumine injection has the advantages that the compound Flunixin meglumine injection combines Chinese and western medicine, has antipyretic and analgesic effects and antibacterial and anti-inflammation effects, and is capable of increasing organism immunity and disease resistance and evidently changing clinical symptoms; the compound Flunixin meglumine injection is long in curative effect duration, the cost is lowered, stress reactions, caused by multiple injection, of animals are reduced, bacterium drug resistance cannot be generated easily, and the compound Flunixin meglumine injection is low in toxicity, reliable in curative effect and lasting in effect.

The invention discloses a compound long-acting injection containing enrofloxacin and flunixin. Each 1000mL of the injection is prepared from 50-300g of enrofloxacin or/and a salt thereof, 0-200g of flunixin or flunixin meglumine in a dispersed form, 0-150g of flunixin or flunixin meglumine inclusion compound, 5-20g of a suspending agent, 5-15g of a wetting agent and the balance of dispersion medium, and the flunixin and/or flunixin meglumine in the dispersed form, flunixin and/or flunixin meglumine inclusion compound cannot be zero at the same time. The injection can be used only for one injection, can address both symptoms and root causes, improves the compliance of animals, reduces the stress of the animals, and promotes and improves the outcome and prognosis of diseases. After long-termplacement, drug particles can be evenly dispersed; the injection does not need to be operated under aseptic conditions and can be sterilized only by sterilizing at 115 DEG C for 30 minutes after dispensing, indexes of the injection before and after sterilization are in compliance with the regulations, and the injection is suitable for industrial production.

The invention relates to a medicine formula for eliminating in-vivo enolotoxin. The medicine formula comprises a formula A and a formula B, wherein the formula A comprises raw materials in parts by weight as follows: 1-4 parts of flunixin meglumine and 1-6 parts of vitamin C; the formula B comprises raw materials in parts by weight as follows: 2-8 parts of ceftiofur sodium and 1.5-5 parts of enrofloxacin, wherein flunixin meglumine is an injection with a specification of 0.05g/ml, the vitamin C is an injection with a specification of 0.1g/ml, enrofloxacin is an injection with a specification of 0.05g/ml, and ceftiofur sodium is a freeze-dried powder injection. The medicine formula can effectively eliminate enolotoxin causing diseases to animals, has high sensitivity to pathogenic bacteria such as escherichia coli, infectious actinobacillus pleuropneumoniae, haemophilus parasuis and the like, can be used for effectively treating diseases such as hydropsy, infectious pleuropneumonia, fevering, loss of appetite and the like caused by the pathogenic bacteria and has remarkable curative effects.