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80results about How to "Good taste masking effect" patented technology
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Orally disintegrating dosage forms
InactiveUS20070292508A1Good taste masking effectStable formBiocideBacteria material medical ingredientsLipid formationActive agent
The present invention is directed to orally disintegrating dosage forms comprising lipid coated substrates and silicified excipients. The use of silicified excipients in the orally disintegrating dosage form along with lipid coating of active agents, allows for improvements in the ability to prepare these dosage forms. Further, the dosage form can prevent unpleasant taste or aftertaste and provide better chemical and mechanical stability of the coated active substrate. This present invention also provides the possibility of harder more durable tablets, along with targeted immediate or modified release profiles for the active agent.
Owner:BALCHEM CORP
Preparing method for improving toad venom taste
InactiveCN101167749AImprove securityGreat tasteAmphibian material medical ingredientsPowder deliveryMedicinal herbsToad Venom
The invention relates to a manufacture process of toad venom, which adopts latex of mammalian to soak and treat the solubility component extracted from the toad venom. The invention can improve lasting hemp tongue feeling of a patient's mouth effectively and achieve the degree that patients are willing to accept. The toad venom processed by the process of the invention is applied into Chinese patent drug which comprises the toad venom, thereby further improving the taste of the Chinese patent drug and enhancing compliance and endurance of patients to the invention.
Owner:CHONGQING PHARMA RES INST
Cefuroxime axetil odor-masking pellet and preparation method
InactiveCN101590021ADisintegrates quicklyImprove solubilityAntibacterial agentsOrganic active ingredientsMedicineBitter taste
The invention relates to a cefuroxime axetil odor-masking pellet and a preparation method thereof. The cefuroxime axetil odor-masking pellet consists of an uncoated pellet containing the cefuroxime axetil and an odor-masking layer coating outside the uncoated pellet. The cefuroxime axetil odor-masking pellet overcomes the defect of bitter taste of the prior cefuroxime axetil tablets, and provides a novel cefuroxime axetil preparation which masks bitter taste, releases medicament rapidly and has stable quality.
Owner:湖南中南科伦药业有限公司 +1
Tilmicosin smell masking preparation and preparing method thereof
InactiveCN104958764AMaintain the efficacy of the drugReduce exposureAntibacterial agentsPowder deliverySolubilityGastric fluid
The invention discloses a tilmicosin smell masking preparation and a preparing method thereof, and belongs to the field of antibiotic preparations for livestock. According to the smell masking preparation, tilmicosin and gastric solubility high polymer materials serve as raw materials; and the smell masking preparation is prepared through the steps of fusion through an extruding machine, shearing and conveying. Compared with the prior art, digestion of the tilmicosin smell masking preparation in artificial saliva is slow, so that the effect of stopping releasing of the medicine in the oral cavity is achieved; contact between the medicine and the taste bud of the tongue is less, so that the bitter and hemp tastes can be obviously reduced, and the masking effect is achieved; and the medicine is rapidly released in a 0.01 mol / L hydrochloric acid solution (simulated gastric fluid), and the medicine keeps to play the medicine effect. In addition, the tilmicosin smell masking preparation is prepared with the hot melting extrusion technology, the technology is advanced, the process is simple, organic solvents are not used, and therefore the tilmicosin smell masking preparation is safe and free of pollution; mixing is carried out without a dead corner, the dispersion effect is good, and the medicine losses are fewer; and operation of multiple units is integrated together, so that space is saved, the cost is reduced, and the tilmicosin smell masking preparation is suitable for industrial large-scale production.
Owner:GUANGXI UNIV
Azithromycin dry-suspended granule with odor masked and preparation method thereof
InactiveCN105982858AMask bitternessCover up the smellAntibacterial agentsOrganic active ingredientsAzithromycinIsolation layer
The invention provides a novel azithromycin preparation and particularly provides an azithromycin dry-suspended granule with odor masked. The dry-suspended granule is composed of a coated micro-pellet and a taste-corrective auxiliary material composition. The coated micro-pellet is composed of a drug-carrier pellet, an isolation layer and an odor-masking layer, wherein the odor-masking layer is mainly prepared from Eudragit L30D-55. The taste-corrective auxiliary material composition is mainly composed of sorbitol and isomaltitol. Through the special method, bitter taste and odor of the azithromycin medicine are masked, so that compliance is improved, and meanwhile, with the special coating layer, the preparation is improved in stability without influence on release degree of the azithromycin.
Owner:COSCI MED TECH CO LTD
Fructus momordicae aspartame and preparation method thereof
ActiveCN104137979APromote dissolutionHigh yieldFood preparationFood extractionHigh pressureErythritol
The invention discloses fructus momordicae aspartame and a preparation method of the fructus momordicae aspartame. The preparation method of the fructus momordicae aspartame comprises the following steps of raw material processing, high-pressure micro jet superfine smashing processing and supercritical CO2 fluid extraction, an extract solution obtained after extraction is collected, the extract solution and erythritol are mixed evenly and are dried in an atomizing mode, and the fructus momordicae aspartame is finally obtained. The fructus momordicae aspartame has the advantages of being good in taste, suitable for production and the like.
Owner:GUILIN SHILI SCI & TECH COMPANY
Florfenicol taste masking preparation and preparation method for same
ActiveCN102526007AGood taste masking effectDissolution slowAntibacterial agentsOrganic active ingredientsMedicineAqueous solution
The invention discloses a florfenicol taste masking preparation, which comprises the following components in percentage by weight: 5 to 75 percent of florfenicol, 5 to 40 percent of gastric-soluble high polymer material, 20 to 90 percent of filler, 0 to 10 percent of hydrophilic adhesive material and 0 to 5 percent of insoluble material. The invention also discloses a preparation method for the florfenicol taste masking preparation. The method is simple, convenient, and reliable; a coating and special equipment are not required; and the gastric-soluble high polymer material and the other minor ingredients are used together, so that the florfenicol achieves the dual effects of taste masking and fast action, and prepared taste masking particles or pellets have the characteristics of slow dissolution in an aqueous solution or saliva and quick dissolution in gastric juice.
Owner:SHANDONG LUKANG SHELILE PHARMA
Water-free-swallowing taste-masking preparation and preparation method thereof
InactiveCN107625742AGreat tasteImprove stabilityPharmaceutical non-active ingredientsMicrocapsulesActive componentBitter taste
The present invention relates to the field of pharmaceutical preparations, and specifically discloses a water-free-swallowing taste-masking preparation and a preparation method thereof, wherein the water-free-swallowing taste-masking preparation is suitable for patients suffering from dysphagia, especially children, and does not have bitter taste. According to the present invention, the drug active component of the water-free-swallowing taste-masking preparation is coated with at least three layers of coats, wherein the three layers of the coats respectively are a separation layer, a taste masking layer and a smooth layer; through the multi-layer coating technology, the drug active component is subjected to taste masking, the taking taste is improved, and the drug active component is endowed with the good stability, such that the drug can be rapidly released while the good taste is provided, the taste masking effect is good, and the stability of the drug is ensured; and the medicationcompliance is effectively improved, the application population is expanded, and especially the administration to children is easily achieved.
Owner:COSCI MED TECH CO LTD
Azithromycin taste masking pellet preparation and preparation method thereof
InactiveCN107789336ASmall particle sizeSmall portionAntibacterial agentsOrganic active ingredientsOld patientsAzithromycin
The invention relates to an azithromycin taste masking pellet preparation. The azithromycin taste masking pellet preparation comprises an azithromycin taste masking pellet and a coating layer, whereinthe average particle size of the azithromycin pellets is 160 mu m-200 mu m, the azithromycin pellet contains micro-powder azithromycin, and the average thickness of coating layers is 15 mu m-120 mu m. Compared with common pellets, the azithromycin taste masking pellet well masks the bitter and foreign taste of the medicine, uses no corrigent, reduces packaging quantity of the medicine, improves compliance of children and old patients, is easy to take, and improves bioavailability. Further, the preparation method is advanced, improves product stability and quality, and is suitable for industrial mass production.
Owner:武汉九州钰民医药科技有限公司
L-Se-methylselenocysteine inclusion compound and preparation method thereof
ActiveCN102846586AGood embedding effectGood taste masking effectOrganic active ingredientsMetabolism disorderOrganic solventL-Se-Methylselenocysteine
The invention discloses an L-Se-methylselenocysteine inclusion compound and a preparation method thereof. The L-Se-methylselenocysteine inclusion compound is prepared from the main raw materials of L-Se-methylselenocysteine, mono- and diglycerides of fatty acids and sucrose fatty acid ester as well as auxiliary materials of microcrystalline cellulose, beta-cyclodextrine and maltodextrin through certain processes. The L-Se-methylselenocysteine inclusion compound has the advantages of good inclusion effect, high uniformity, good taste-masking effect, no objectional odor after being dissolved and no influence on mouth feeling, is simple and safe in process, does not need water or organic solvent or a drying course, is time-saving and labor-saving, consumes few equipment, is simple in operation method, good in repeatability, low in equipment requirement, suitable for large-scale production and industrialization and wide in applicability, can be uniformly dispersed in milk beverage, and is not liable to moisture absorption.
Owner:江西川奇药业有限公司
Grosvenor momordica sweetener and preparation method thereof
The invention discloses a grosvenor momordica sweetener and a preparation method thereof. The preparation method comprises the steps of treating raw materials, carrying out high-pressure treatment and supercritical CO2 fluid extraction on the treated raw materials, collecting the extract obtained after the extraction, uniformly mixing the extract and erythritol, and spray drying the mixture to obtain the grosvenor momordica sweetener. The grosvenor momordica sweetener has the advantages of good taste, suitability for production and the like.
Owner:GUILIN SHILI SCI & TECH COMPANY
Method for reducing astringency of traditional Chinese medicine oral preparation containing polyphenol
ActiveCN108113962AReduce astringencyReduce dosageInorganic non-active ingredientsPharmaceutical delivery mechanismPharmacyMedical prescription
The invention discloses a method for reducing the astringency of a traditional Chinese medicine oral preparation containing polyphenol, belonging to the field of traditional Chinese medicine pharmacy.According to the method, an extract of a traditional Chinese medicine containing polyphenol is acquired, the pH value of the extract is adjusted to 4-4.5, and then a traditional Chinese medicine extract with reduced astringency is obtained. The invention further provides a polyphenol-containing traditional Chinese medicine oral preparation with reduced astringency. The polyphenol-containing traditional Chinese medicine oral preparation is prepared by the steps of fetching the traditional Chinese medicine extract with reduced astringency prepared by virtue of the method, and adding pharmaceutically acceptable auxiliaries, so as to obtain the traditional Chinese medicine oral preparation. According to the method, the pH value of the extract of a pharmaceutical composition containing polyphenol is adjusted to 4-4.5, so that the component stability is guaranteed, the original astringency of drugs is unexpectedly and substantially reduced, the taking compliance of patient is improved, theadding of a large number of corrigents is avoided, the use amount of a sweetening agent in a formula is reduced, and the production cost is lowered; and the taste masking effect is obvious, the drug dose of the patient is not increased, and the traditional Chinese medicine oral preparation is simple, convenient and practical.
Owner:CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
Preparation method of slow-release tilmicosin microcapsule powder
ActiveCN108653243AGood dispersionStable blood concentrationAntibacterial agentsOrganic active ingredientsPolyethylene glycolBlood drug concentration
The invention discloses a preparation method of slow-release tilmicosin microcapsule powder. The preparation method comprises the following steps that firstly, acrylic acid is dissolved in water, thepH value of a solution is adjusted to be neutral, then starch and hydroxypropyl methylcellulose are added, heating, stirring and dissolving are carried out, then tilmicosin raw material and calcium chloride are added, and stirring and mixing are carried out to obtain first mixed solution; then polyethylene glycol and sodium polyacrylate are added into the first mixed solution, and after stirring and dissolving, the mixture is homogenized under high pressure by a homogenizer to obtain a homogenized solution; under the condition of stirring, a sodium alginate aqueous solution is dropped into thehomogenized solution and is continuously stirred for 40-50 minutes to obtain a mixed solution; and finally, the mixed solution is dried to obtain the slow-release tilmicosin microcapsule powder. Themicrocapsule powder obtained by the method has good taste masking effect and long-term slow-release effect, can maintain high blood drug concentration in stomach and intestine environment for a long time, and improves curative effect.
Owner:JIANGSU NANNONG GAOKE ANIMAL PHARMA CO LTD
Flunixin meglumine taste masking orally-disintegrating preparation and preparing method thereof
ActiveCN105232486AGood taste masking effectMaintain the efficacy of the drugAntipyreticAnalgesicsSolubilityFLUNIXIN MEGLUMINE
Owner:GUANGXI UNIV
Orally disintegrating tablet containing sertraline hydrochloride and preparation method thereof
InactiveCN105616367ASimple processGood taste masking effectOrganic active ingredientsNervous disorderOrally disintegrating tabletPOLACRILIN POTASSIUM
The invention discloses a preparation method of an orally disintegrating tablet containing sertraline hydrochloride. The orally disintegrating tablet contains a sertraline hydrochloride-polacrilin potassium compound and other pharmaceutically acceptable auxiliary materials. An ion exchange technology is adopted to mask taste, and the orally disintegrating tablet is prepared by wet granulation and tabletting and can be disintegrated in the oral cavity without needing water, thereby effectively masking the bitter, pungent and spicy taste of the main active ingredient, namely sertraline hydrochloride. The preparation method is simple and convenient in process and suitable for industrial production.
Owner:AVENTIS PHARMA HAINAN
Taste-masking coated composition, coated liquid and formulation
InactiveCN101579524AOvercoming the characteristics of easy dissolutionStable in natureAntibacterial agentsOrganic active ingredientsAcrylic resinBioavailability
The invention discloses a taste-masking coated composition. The composition contains high molecular polymer, plasticizing agent, antisticking agent and coloring agent, wherein the high molecular polymer comprises methacrylic resin and amino-acrylic resin; and the weight ratio of methacrylic resin to amino-acrylic resin is between 1:9 and 9:1. The invention also discloses coated liquid prepared during preparing the taste-masking coated composition and a formulation adopting the composition. The taste-masking coated composition has the advantages that the composition cannot be dissolved quickly under nonacid oral environment (pH 5.0 to 7.0) but can be dissolved quickly under acidic stomach environment (pH 1.0 to 3.0), thereby obtaining excellent taste-masking effect; moreover, the composition has stable preparation property and takes effect quickly after being taken orally without changing the bioavailability of medicament obviously.
Owner:SUN YAT SEN UNIV
Taste-masking coating preparation and preparation method thereof
PendingCN107625741AGood taste masking effectEnhanced taste masking effectOrganic active ingredientsInorganic non-active ingredientsActive componentTherapeutic effect
The present invention belongs to the field of oral solid preparations, and particularly relates to a taste-masking coating preparation and a preparation method thereof, wherein the taste-masking coating preparation is suitable for patients suffering from dysphagia, and does not have bitter taste. According to the present invention, the drug core is directly subjected to taste masking through a coating technology; the drug active component of the preparation is coated with at least three layers of coats, wherein the three layers of the coats respectively are an acid protection layer, a separation layer and a taste masking layer, such that the drug can be rapidly released while the good taste is provided, the taste masking effect is good, and the taste cannot be released into the oral cavityduring the taking so as not to produce bitterness and other bad tastes; after the preparation enters the stomach environment, the coat membrane is rapidly dissolved, such that the drug is released into the stomach acid environment so as to be absorbed by the body and provide the treatment effect.
Owner:北京科信聚润医药科技有限公司
Grosvener siraitia beverage with low blood sugar index
The invention discloses a grosvener siraitia beverage with a low blood sugar index. The grosvener siraitia beverage consists of the following components in percentage by weight: 0.5-1.0 percent of grosvener siraitia extracting solution, 0.3-0.5 percent of supplementary element, 0.2-0.3 percent of erythritol and the balance of pure water, wherein the grosvener siraitia extracting solution is prepared by raw material treatment, high-pressure treatment, super-critical CO2 fluid extraction and collection extraction. The grosvener siraitia beverage is obtained by weighing and uniformly mixing the components, then filtering, filling and carrying out high-pressure sterilization.
Owner:GUILIN SHILI SCI & TECH COMPANY
Orally disintegrating tablet with functions of oral cavity paralysis and taste masking and preparation method of orally disintegrating tablet
ActiveCN104382869AGreat tasteGood taste masking effectPill deliveryPharmaceutical non-active ingredientsRoxithromycinOrally disintegrating tablet
The invention relates to the technical field of medicine and discloses an orally disintegrating tablet with functions of oral cavity paralysis and taste masking and a preparation method of the orally disintegrating tablet. The orally disintegrating tablet with the functions of oral cavity paralysis and taste masking comprises the following raw materials in percentage by weight: 40-80 percent of a medicine core, 10-50 percent of an auxiliary material absorbed with a taste masking agent, 5-30 percent of a disintegrating agent, 0-2 percent of a lubricating agent and 0-0.5 percent of an essence, wherein the taste masking agent is a water decoction formed by one or a combination of more of chili, black pepper and Sichuan pepper. The orally disintegrating tablet tastes good, has a spicy fragrance, and has a good taste masking effect; the taste masking effect on roxithromycin, norfloxacin and amoxicillin is extremely good by virtue of verification at present; by adding sesame oil and the essence, the stink of the amoxicillin can be well masked.
Owner:安徽万春日化有限公司
Bitter taste masking method for cefuroxime axetil medicine
InactiveCN109432014ASmall particle sizeReduce dissolutionAntibacterial agentsOrganic active ingredientsMicrosphereHot melt
The invention relates to a bitter taste masking method for a cefuroxime axetil medicine. The bitter taste masking method comprises the following steps: preparing bitter taste masking microspheres fromcefuroxime axetil, heating and melting the cefuroxime axetil with auxiliary materials, and carrying out freeze spraying. Compared with granules made through common wet-method pelletizing or hot-melting extrusion pelletizing, the obtained microspheres are smaller in particle size. Because of the small particle size, the obtained microspheres are small in dissolution amount in water within a shorttime, good in bitter taste masking effect, small in particle size, smooth in particle, free of gravel feeling when being orally taken, convenient to swallow and easily acceptable by patients. The production process is also relatively simple and convenient to produce.
Owner:HAINAN MEDICAL COLLEGE
Florfenicol taste masking preparation and preparation method for same
ActiveCN102526007BGood taste masking effectDissolution slowAntibacterial agentsOrganic active ingredientsMedicineAqueous solution
Owner:SHANDONG LUKANG SHELILE PHARMA
Metronidazole tablet for pets and preparation method thereof
PendingCN112076164AGood taste masking effectUniform contentAntibacterial agentsOrganic active ingredientsBitter tastePharmaceutical Aids
The invention belongs to the field of pet medicines, and relates to a metronidazole tablet for pets and a preparation method of the metronidazole tablet. The metronidazole tablet is coated by adding adisintegrating agent, a diluent and an adhesive when metronidazole coated pellets are prepared, and auxiliary material particles added with a phagostimulant, the disintegrating agent, the diluent andthe adhesive are prepared. The metronidazole coated pellets and the auxiliary material particles are mixed to prepare the metronidazole tablet, so that the bitter taste of metronidazole is masked, the purpose of inducing pets to take the metronidazole tablet actively is achieved, the compliance of pets is improved, and the convenience of clinical medication is also improved.
Owner:河北远征药业有限公司 +1
Preparation method of mequindox taste-masking nanometer prodrug
InactiveCN108159430AAvoid the disadvantage of poor water solubilityOvercome the disadvantage of insoluble in waterAntibacterial agentsOrganic active ingredientsMesoporous silicaPorous channel
The invention provides a preparation method of a mequindox taste-masking nanometer prodrug, an amino functionalized MCM-41 type mesoporous nanomaterial MSN-NH2 is taken as a carrier, the mequindox isimmobilized in a porous channel of the mesoporous nanomaterial through an acid-sensitive Schiff base covalent bond to prepare the mequindox nanometer prodrug MEQ@MSN-NH2, and the purpose of masking the taste is fulfilled. The mequindox is successfully loaded in a pore of mesoporous silica, and forms a dispersion spherical particle, and the average diameter of the dispersion spherical particle is about 100 nm. The result of the external release experiment shows that the release rate of the nanometer prodrug in simulated saliva in five minutes is only 8.7%, and the taste masking performance is excellent; the nanometer prodrug is rapidly released in the artificial gastric juice, 67% of the total drug loading capacity of the nanometer prodrug is released within 30 minutes, the nanometer prodrug is basically completely released within 24 hours, and the result proves the excellent drug delivery and sustained-release properties.
Owner:JIANGXI AGRICULTURAL UNIVERSITY
Taste masking preparation
ActiveCN101912613BImprove the lubrication effectHelp swallowingAntibacterial agentsOrganic active ingredientsContact timeMedicine
The invention relates to an oral taste masking preparation and a preparation method thereof. The invention is characterized in that an auxiliary material which expands with water is added in the preparation process, owning to the hydro-expansiveness of the auxiliary material, a film is formed in the outer layer of a medicine, thus enabling the medicine to form a shape similar to an frog egg, delaying the contact time between the medicine and body liquid and masking the taste; and an preparation formula and an preparation process of the original product do not need to be changed, and a production spot and a device do not need to be reformed. The preparation method is simple and convenient, and industrialization can be easily achieved.
Owner:HANGZHOU ZHONGMEI HUADONG PHARMA
Taste-masking orally disintegrating tablets containing sertraline hydrochloride and preparation method thereof
InactiveCN106109432ASimple processGood taste masking effectOrganic active ingredientsNervous disorderFlavorOrally disintegrating tablet
The invention discloses a method for preparing taste-masking orally disintegrating tablets containing sertraline hydrochloride. The orally disintegrating tablets contain sertraline hydrochloride and other pharmaceutically acceptable excipients. The taste can be masked by adopting a granule coating technology, the prepared orally disintegrating tablets can be disintegrated in oral cavity without using water, bitterness and spicy and pungent flavor of sertraline hydrochloride, the main active ingredient of the orally disintegrating tablets, can be effectively masked, and the preparation method is simple and convenient in process and suitable for industrial production.
Owner:BEIJING VENTUREPHARM BIOTECH
Traditional Chinese medicine granule composition for treating infantile common cold and preparation method of traditional Chinese medicine granule composition
ActiveCN113069496AGreat tasteImprove compliancePharmaceutical non-active ingredientsGranular deliveryCelluloseCarboxymethyl cellulose
The invention provides a traditional Chinese medicine granule composition for treating infantile common cold. The traditional Chinese medicine granule composition comprises a traditional Chinese medicine volatile oil clathrate compound, an adhesive, a filling agent and a traditional Chinese medicine extract, wherein the adhesive is selected from at least one of hydroxypropyl methylcellulose and sodium carboxymethyl cellulose. The invention also provides a preparation method of the traditional Chinese medicine granule composition, a preparation and a preparation method of the preparation. The specific adhesive is added into a prescription, so that the particle size distribution can be improved, and the taste masking effect is enhanced.
Owner:JUMPCAN PHARMA GRP
Lappaconitine hydrobromide orally disintegrating tablets and preparation method thereof
InactiveCN102178658BHigh yieldGreat tasteOrganic active ingredientsNervous disorderOrally disintegrating tabletAcrylic resin
The invention discloses lappaconitine hydrobromide orally disintegrating tablets. The lappaconitine hydrobromide orally disintegrating tablets consist of the following ingredients in part by weight: 5 to 10 parts of lappaconitine hydrobromide, 3 to 10 parts of disintegrating agent, 30 to 100 parts of filling agent, 2 to 10 parts of flavoring agent, 0 to 60 parts of adhesive, 0 to 3 parts of lubricating agent and 0 to 50 parts of stomach-soluble acrylic resin. The lappaconitine hydrobromide orally disintegrating tablets which do not comprise the stomach-soluble acrylic resin in the formula canbe prepared by a wet pelleting tabletting method, a dry pelleting tabletting method or a direct tabletting method; and the lappaconitine hydrobromide orally disintegrating tablets which comprise the stomach-soluble acrylic resin in the formula are prepared by the steps of preparing the lappaconitine hydrobromide into smell concealing particles by using the stomach-soluble acrylic resin and then preparing the orally disintegrating tablets by the wet pelleting tabletting method, the dry pelleting tabletting method or the direct tabletting method. The lappaconitine hydrobromide orally disintegrating tablets have good mouthfeel, do not influence medicament release, have a simple preparation process, high yield and low cost, and are suitable for industrialized production.
Owner:THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV
Preparation method and application of four-arm polyethylene glycol succinic acid florfenicol compound
ActiveCN113416304AGood taste masking effectImprove solubilityAntibacterial agentsOrganic active ingredientsSucrosePtru catalyst
The invention provides a preparation method and application of a four-arm polyethylene glycol succinic acid florfenicol compound. The compound is generated by reacting four-arm PEG succinic acid with florfenicol under the action of a catalyst and a dehydrating agent. The compound is used for preparing four-arm polyethylene glycol succinic acid florfenicol particles, and the preparation method comprises the following steps: (1) sieving sucrose, and uniformly mixing the sieved sucrose with the four-arm polyethylene glycol succinic acid florfenicol compound to obtain powder; (2) uniformly mixing 95v% medicinal ethanol, povidone and Tween 80 to prepare a wetting agent; and (3) uniformly mixing the wetting agent and the powder, and conducting granulating, drying and sieving. The four-arm polyethylene glycol succinic acid florfenicol granular preparation is good in taste masking effect, slow in release, safe and efficient. The granular preparation has the unique advantages that the solubility is increased, and the treatment effect is remarkably improved.
Owner:四川永诺生物科技有限公司
Taste-masked enrofloxacin soluble powder and preparation method thereof
ActiveCN107412189BSolve the problem of limited clinical use of bitter tasteWork around limited usageAntibacterial agentsOrganic active ingredientsEconomic benefitsNational standard
The invention discloses taste-masking enrofloxacin soluble powder and a preparation method thereof. The taste-masking enrofloxacin soluble powder comprises, by mass, 10-15 parts of enrofloxacin, 75.5-84.5 parts of inclusion agent, 3-5 parts of cosolvent, 0.5-1.5 parts of corrigent and 2-3 parts of film-forming release control agent. The enrofloxacin soluble powder has the advantages that the molecule inclusion and spray slow release double taste-masking technology is used to achieve a good masking effect on the bitter taste of the enrofloxacin, the enrofloxacin soluble powder can be dissolved in water through stirring, and content can be detected completely according to national-standard requirements; the problem that feed, stirred by a cultivation terminal, for feeding animals is poor in palatability, is solved, the drinking water problem of poultry is solved, drug bioavailability is increased, and evident social and economic benefits are achieved.
Owner:ZHEJIANG WANFANG BIO TECH CO LTD
Sophorae flavescentis seed flavone sustained-release pellets for veterinary use and preparation
InactiveCN106880659AImprove roundnessImprove stabilityAntibacterial agentsPharmaceutical non-active ingredientsSustained release pelletsVeterinary Drugs
The invention belongs to the technical field of veterinary drug preparations, in particular to a traditional Chinese medicine sustained-release drug preparation capable of substituting antibiotics to have a prevention and sterilization effect, and particularly relates to sophorae flavescentis seed flavone sustained-release pellets for veterinary use and having a by-pass rumen protection for ruminants and a preparation process of the sophorae flavescentis seed flavone sustained-release pallet. The pellets are prepared from the following raw materials: 40 to 45 percent of main herbs, 15 to 30 percent of wax materials, 15 to 20 percent of Carbomer, 10 to 20 percent of ethyecellulose and 1 to 5 percent of anti plastering agent and flavoring agent. By utilizing the characteristic of pH sensitivity of the Carbomer, the swelling of the Carbomer is controlled by virtue of the variation of a pH environment of rumen and abomasum so as to achieve drug sustained-release and positioned release purposes, so that a coating process is omitted, the preparation process is simple and fast, and the repeatability is good. The invention also provides a method for preparing the sustained-release pellets by virtue of a melt high-speed stirring technology. The preparation method has the advantages of high production efficiency, good pellet stability, and time and labor conservation.
Owner:QINGDAO UNIV OF SCI & TECH
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