80results about How to "Good taste masking effect" patented technology

The invention relates to a manufacture process of toad venom, which adopts latex of mammalian to soak and treat the solubility component extracted from the toad venom. The invention can improve lasting hemp tongue feeling of a patient's mouth effectively and achieve the degree that patients are willing to accept. The toad venom processed by the process of the invention is applied into Chinese patent drug which comprises the toad venom, thereby further improving the taste of the Chinese patent drug and enhancing compliance and endurance of patients to the invention.

The invention relates to a cefuroxime axetil odor-masking pellet and a preparation method thereof. The cefuroxime axetil odor-masking pellet consists of an uncoated pellet containing the cefuroxime axetil and an odor-masking layer coating outside the uncoated pellet. The cefuroxime axetil odor-masking pellet overcomes the defect of bitter taste of the prior cefuroxime axetil tablets, and provides a novel cefuroxime axetil preparation which masks bitter taste, releases medicament rapidly and has stable quality.

The invention provides a novel azithromycin preparation and particularly provides an azithromycin dry-suspended granule with odor masked. The dry-suspended granule is composed of a coated micro-pellet and a taste-corrective auxiliary material composition. The coated micro-pellet is composed of a drug-carrier pellet, an isolation layer and an odor-masking layer, wherein the odor-masking layer is mainly prepared from Eudragit L30D-55. The taste-corrective auxiliary material composition is mainly composed of sorbitol and isomaltitol. Through the special method, bitter taste and odor of the azithromycin medicine are masked, so that compliance is improved, and meanwhile, with the special coating layer, the preparation is improved in stability without influence on release degree of the azithromycin.

The present invention relates to the field of pharmaceutical preparations, and specifically discloses a water-free-swallowing taste-masking preparation and a preparation method thereof, wherein the water-free-swallowing taste-masking preparation is suitable for patients suffering from dysphagia, especially children, and does not have bitter taste. According to the present invention, the drug active component of the water-free-swallowing taste-masking preparation is coated with at least three layers of coats, wherein the three layers of the coats respectively are a separation layer, a taste masking layer and a smooth layer; through the multi-layer coating technology, the drug active component is subjected to taste masking, the taking taste is improved, and the drug active component is endowed with the good stability, such that the drug can be rapidly released while the good taste is provided, the taste masking effect is good, and the stability of the drug is ensured; and the medicationcompliance is effectively improved, the application population is expanded, and especially the administration to children is easily achieved.

The invention discloses an L-Se-methylselenocysteine inclusion compound and a preparation method thereof. The L-Se-methylselenocysteine inclusion compound is prepared from the main raw materials of L-Se-methylselenocysteine, mono- and diglycerides of fatty acids and sucrose fatty acid ester as well as auxiliary materials of microcrystalline cellulose, beta-cyclodextrine and maltodextrin through certain processes. The L-Se-methylselenocysteine inclusion compound has the advantages of good inclusion effect, high uniformity, good taste-masking effect, no objectional odor after being dissolved and no influence on mouth feeling, is simple and safe in process, does not need water or organic solvent or a drying course, is time-saving and labor-saving, consumes few equipment, is simple in operation method, good in repeatability, low in equipment requirement, suitable for large-scale production and industrialization and wide in applicability, can be uniformly dispersed in milk beverage, and is not liable to moisture absorption.

The invention discloses a grosvenor momordica sweetener and a preparation method thereof. The preparation method comprises the steps of treating raw materials, carrying out high-pressure treatment and supercritical CO2 fluid extraction on the treated raw materials, collecting the extract obtained after the extraction, uniformly mixing the extract and erythritol, and spray drying the mixture to obtain the grosvenor momordica sweetener. The grosvenor momordica sweetener has the advantages of good taste, suitability for production and the like.

The invention discloses a method for reducing the astringency of a traditional Chinese medicine oral preparation containing polyphenol, belonging to the field of traditional Chinese medicine pharmacy.According to the method, an extract of a traditional Chinese medicine containing polyphenol is acquired, the pH value of the extract is adjusted to 4-4.5, and then a traditional Chinese medicine extract with reduced astringency is obtained. The invention further provides a polyphenol-containing traditional Chinese medicine oral preparation with reduced astringency. The polyphenol-containing traditional Chinese medicine oral preparation is prepared by the steps of fetching the traditional Chinese medicine extract with reduced astringency prepared by virtue of the method, and adding pharmaceutically acceptable auxiliaries, so as to obtain the traditional Chinese medicine oral preparation. According to the method, the pH value of the extract of a pharmaceutical composition containing polyphenol is adjusted to 4-4.5, so that the component stability is guaranteed, the original astringency of drugs is unexpectedly and substantially reduced, the taking compliance of patient is improved, theadding of a large number of corrigents is avoided, the use amount of a sweetening agent in a formula is reduced, and the production cost is lowered; and the taste masking effect is obvious, the drug dose of the patient is not increased, and the traditional Chinese medicine oral preparation is simple, convenient and practical.

The invention discloses a preparation method of slow-release tilmicosin microcapsule powder. The preparation method comprises the following steps that firstly, acrylic acid is dissolved in water, thepH value of a solution is adjusted to be neutral, then starch and hydroxypropyl methylcellulose are added, heating, stirring and dissolving are carried out, then tilmicosin raw material and calcium chloride are added, and stirring and mixing are carried out to obtain first mixed solution; then polyethylene glycol and sodium polyacrylate are added into the first mixed solution, and after stirring and dissolving, the mixture is homogenized under high pressure by a homogenizer to obtain a homogenized solution; under the condition of stirring, a sodium alginate aqueous solution is dropped into thehomogenized solution and is continuously stirred for 40-50 minutes to obtain a mixed solution; and finally, the mixed solution is dried to obtain the slow-release tilmicosin microcapsule powder. Themicrocapsule powder obtained by the method has good taste masking effect and long-term slow-release effect, can maintain high blood drug concentration in stomach and intestine environment for a long time, and improves curative effect.

The invention discloses a flunixin meglumine taste masking orally-disintegrating preparation and a preparing method thereof, and belongs to the technical field of veterinary drugs. The preparing method of the preparation includes the steps that raw-material flunixin meglumine and taste masking agents are mixed in the weight ratio of 1:(2-4) to be subjected to taste masking treatment, taste-masking solid dispersion is made, then the taste-masking solid dispersion and auxiliary materials including water solubility fillers, disintegrating agents, flavoring agents, lubricants and the like are evenly mixed, and the preparation is obtained. Compared with the prior art, the taste masking effect of the flunixin meglumine taste masking orally-disintegrating preparation is achieved with the hot melt extrusion technology, and medicine is rapidly released in a buffer solution with the pH of 4.5 and still achieves medicine action; due to the adding of the auxiliary materials, the preparation has the advantages that disintegrating is rapid, mouthfeel is good, dissolution is rapid, swallowing is easy, irritation to the mouth mucosa is avoided, and the compliance of animal medicine taking is improved. In addition, the technology is advanced, easy to operate, safe, free of pollution and suitable for industrial large-scale production.

The invention discloses a preparation method of an orally disintegrating tablet containing sertraline hydrochloride. The orally disintegrating tablet contains a sertraline hydrochloride-polacrilin potassium compound and other pharmaceutically acceptable auxiliary materials. An ion exchange technology is adopted to mask taste, and the orally disintegrating tablet is prepared by wet granulation and tabletting and can be disintegrated in the oral cavity without needing water, thereby effectively masking the bitter, pungent and spicy taste of the main active ingredient, namely sertraline hydrochloride. The preparation method is simple and convenient in process and suitable for industrial production.

The invention discloses a taste-masking coated composition. The composition contains high molecular polymer, plasticizing agent, antisticking agent and coloring agent, wherein the high molecular polymer comprises methacrylic resin and amino-acrylic resin; and the weight ratio of methacrylic resin to amino-acrylic resin is between 1:9 and 9:1. The invention also discloses coated liquid prepared during preparing the taste-masking coated composition and a formulation adopting the composition. The taste-masking coated composition has the advantages that the composition cannot be dissolved quickly under nonacid oral environment (pH 5.0 to 7.0) but can be dissolved quickly under acidic stomach environment (pH 1.0 to 3.0), thereby obtaining excellent taste-masking effect; moreover, the composition has stable preparation property and takes effect quickly after being taken orally without changing the bioavailability of medicament obviously.

The present invention belongs to the field of oral solid preparations, and particularly relates to a taste-masking coating preparation and a preparation method thereof, wherein the taste-masking coating preparation is suitable for patients suffering from dysphagia, and does not have bitter taste. According to the present invention, the drug core is directly subjected to taste masking through a coating technology; the drug active component of the preparation is coated with at least three layers of coats, wherein the three layers of the coats respectively are an acid protection layer, a separation layer and a taste masking layer, such that the drug can be rapidly released while the good taste is provided, the taste masking effect is good, and the taste cannot be released into the oral cavityduring the taking so as not to produce bitterness and other bad tastes; after the preparation enters the stomach environment, the coat membrane is rapidly dissolved, such that the drug is released into the stomach acid environment so as to be absorbed by the body and provide the treatment effect.

The invention discloses a grosvener siraitia beverage with a low blood sugar index. The grosvener siraitia beverage consists of the following components in percentage by weight: 0.5-1.0 percent of grosvener siraitia extracting solution, 0.3-0.5 percent of supplementary element, 0.2-0.3 percent of erythritol and the balance of pure water, wherein the grosvener siraitia extracting solution is prepared by raw material treatment, high-pressure treatment, super-critical CO2 fluid extraction and collection extraction. The grosvener siraitia beverage is obtained by weighing and uniformly mixing the components, then filtering, filling and carrying out high-pressure sterilization.

The invention relates to the technical field of medicine and discloses an orally disintegrating tablet with functions of oral cavity paralysis and taste masking and a preparation method of the orally disintegrating tablet. The orally disintegrating tablet with the functions of oral cavity paralysis and taste masking comprises the following raw materials in percentage by weight: 40-80 percent of a medicine core, 10-50 percent of an auxiliary material absorbed with a taste masking agent, 5-30 percent of a disintegrating agent, 0-2 percent of a lubricating agent and 0-0.5 percent of an essence, wherein the taste masking agent is a water decoction formed by one or a combination of more of chili, black pepper and Sichuan pepper. The orally disintegrating tablet tastes good, has a spicy fragrance, and has a good taste masking effect; the taste masking effect on roxithromycin, norfloxacin and amoxicillin is extremely good by virtue of verification at present; by adding sesame oil and the essence, the stink of the amoxicillin can be well masked.

The invention relates to a bitter taste masking method for a cefuroxime axetil medicine. The bitter taste masking method comprises the following steps: preparing bitter taste masking microspheres fromcefuroxime axetil, heating and melting the cefuroxime axetil with auxiliary materials, and carrying out freeze spraying. Compared with granules made through common wet-method pelletizing or hot-melting extrusion pelletizing, the obtained microspheres are smaller in particle size. Because of the small particle size, the obtained microspheres are small in dissolution amount in water within a shorttime, good in bitter taste masking effect, small in particle size, smooth in particle, free of gravel feeling when being orally taken, convenient to swallow and easily acceptable by patients. The production process is also relatively simple and convenient to produce.

The invention belongs to the field of pet medicines, and relates to a metronidazole tablet for pets and a preparation method of the metronidazole tablet. The metronidazole tablet is coated by adding adisintegrating agent, a diluent and an adhesive when metronidazole coated pellets are prepared, and auxiliary material particles added with a phagostimulant, the disintegrating agent, the diluent andthe adhesive are prepared. The metronidazole coated pellets and the auxiliary material particles are mixed to prepare the metronidazole tablet, so that the bitter taste of metronidazole is masked, the purpose of inducing pets to take the metronidazole tablet actively is achieved, the compliance of pets is improved, and the convenience of clinical medication is also improved.

The invention provides a preparation method of a mequindox taste-masking nanometer prodrug, an amino functionalized MCM-41 type mesoporous nanomaterial MSN-NH2 is taken as a carrier, the mequindox isimmobilized in a porous channel of the mesoporous nanomaterial through an acid-sensitive Schiff base covalent bond to prepare the mequindox nanometer prodrug MEQ@MSN-NH2, and the purpose of masking the taste is fulfilled. The mequindox is successfully loaded in a pore of mesoporous silica, and forms a dispersion spherical particle, and the average diameter of the dispersion spherical particle is about 100 nm. The result of the external release experiment shows that the release rate of the nanometer prodrug in simulated saliva in five minutes is only 8.7%, and the taste masking performance is excellent; the nanometer prodrug is rapidly released in the artificial gastric juice, 67% of the total drug loading capacity of the nanometer prodrug is released within 30 minutes, the nanometer prodrug is basically completely released within 24 hours, and the result proves the excellent drug delivery and sustained-release properties.

The invention discloses a method for preparing taste-masking orally disintegrating tablets containing sertraline hydrochloride. The orally disintegrating tablets contain sertraline hydrochloride and other pharmaceutically acceptable excipients. The taste can be masked by adopting a granule coating technology, the prepared orally disintegrating tablets can be disintegrated in oral cavity without using water, bitterness and spicy and pungent flavor of sertraline hydrochloride, the main active ingredient of the orally disintegrating tablets, can be effectively masked, and the preparation method is simple and convenient in process and suitable for industrial production.

The invention provides a traditional Chinese medicine granule composition for treating infantile common cold. The traditional Chinese medicine granule composition comprises a traditional Chinese medicine volatile oil clathrate compound, an adhesive, a filling agent and a traditional Chinese medicine extract, wherein the adhesive is selected from at least one of hydroxypropyl methylcellulose and sodium carboxymethyl cellulose. The invention also provides a preparation method of the traditional Chinese medicine granule composition, a preparation and a preparation method of the preparation. The specific adhesive is added into a prescription, so that the particle size distribution can be improved, and the taste masking effect is enhanced.

The invention provides a preparation method and application of a four-arm polyethylene glycol succinic acid florfenicol compound. The compound is generated by reacting four-arm PEG succinic acid with florfenicol under the action of a catalyst and a dehydrating agent. The compound is used for preparing four-arm polyethylene glycol succinic acid florfenicol particles, and the preparation method comprises the following steps: (1) sieving sucrose, and uniformly mixing the sieved sucrose with the four-arm polyethylene glycol succinic acid florfenicol compound to obtain powder; (2) uniformly mixing 95v% medicinal ethanol, povidone and Tween 80 to prepare a wetting agent; and (3) uniformly mixing the wetting agent and the powder, and conducting granulating, drying and sieving. The four-arm polyethylene glycol succinic acid florfenicol granular preparation is good in taste masking effect, slow in release, safe and efficient. The granular preparation has the unique advantages that the solubility is increased, and the treatment effect is remarkably improved.

The invention belongs to the technical field of veterinary drug preparations, in particular to a traditional Chinese medicine sustained-release drug preparation capable of substituting antibiotics to have a prevention and sterilization effect, and particularly relates to sophorae flavescentis seed flavone sustained-release pellets for veterinary use and having a by-pass rumen protection for ruminants and a preparation process of the sophorae flavescentis seed flavone sustained-release pallet. The pellets are prepared from the following raw materials: 40 to 45 percent of main herbs, 15 to 30 percent of wax materials, 15 to 20 percent of Carbomer, 10 to 20 percent of ethyecellulose and 1 to 5 percent of anti plastering agent and flavoring agent. By utilizing the characteristic of pH sensitivity of the Carbomer, the swelling of the Carbomer is controlled by virtue of the variation of a pH environment of rumen and abomasum so as to achieve drug sustained-release and positioned release purposes, so that a coating process is omitted, the preparation process is simple and fast, and the repeatability is good. The invention also provides a method for preparing the sustained-release pellets by virtue of a melt high-speed stirring technology. The preparation method has the advantages of high production efficiency, good pellet stability, and time and labor conservation.