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Taste-masking coated composition, coated liquid and formulation

A composition and coating technology, which is applied in the directions of non-active ingredients medical preparations, organic active ingredients, antibacterial drugs, etc. Applicable to problems such as suspensions, to achieve the effect of changing bioavailability, good taste masking effect, and stable preparation properties

Inactive Publication Date: 2009-11-18
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for some drugs with strong bad taste, such as antibiotics with particularly strong bitter taste, the bitter taste cannot be completely covered only by adding flavoring agents, and the taste masking can be achieved by coating, ion exchange resin adsorption, cyclodextrin inclusion and other methods. Effect
Among them, the use of coating is an efficient, convenient and widely applicable method. However, the existing coating prescriptions and methods are mainly suitable for larger solid preparations such as tablets. isolation layer to achieve the effect of isolating saliva and drugs, but this process is not suitable for suspensions with small particle sizes; in addition, orally disintegrating tablets and chewable tablets have a long residence time in the oral cavity Metropolis will dissolve in the non-acidic oral environment (pH5.0~7.0), and the taste masking effect cannot be achieved

Method used

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  • Taste-masking coated composition, coated liquid and formulation
  • Taste-masking coated composition, coated liquid and formulation
  • Taste-masking coated composition, coated liquid and formulation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Preparation of doxycycline hydrochloride microcapsule coating preparation:

[0054] Prepare doxycycline hydrochloride microcapsule coating preparation according to the following steps:

[0055] Step 1, preparing coated particles. Weigh each component material according to the following formula:

[0056] Prescription of Coated Granules

[0057] Blank ball core 600g

[0058] Doxycycline Hydrochloride 600g

[0059] Polyvinylpyrrolidone 150g

[0060] Hydroxypropyl Methyl Cellulose 70g

[0061] water 1500g

[0062]

[0063] Total 2920g

[0064] Doxycycline hydrochloride, polyvinylpyrrolidone, and hydroxypropyl methylcellulose are dissolved in water to prepare a drug solution, and blank ball cores with a particle size of 150-200um are put into a fluidized bed for drug application to obtain a drug solution. Coating particles.

[0065] Step 2, preparing a coating solution. Weigh each component material according to the f...

Embodiment 2

[0086] Preparation of Azithromycin Powder Coating Formulation 2:

[0087] Prepare each component material according to the following formula:

[0088] Azithromycin Powder Coating Formulation

[0089] Azithromycin 450g

[0090] Polyvinylpyrrolidone 50g

[0091] Methacrylic resin 375g

[0092] Aminomethacrylic resin 3375g

[0093] Polyethylene glycol 6000 112.5g

[0094] Glyceryl monostearate 125g

[0095] Tween 80 50g

[0096] Water 3462g

[0097] Prepare the azithromycin powder coating preparation as follows:

[0098] Step 1, methacrylic resin in this prescription: aminomethacrylic resin is 1: 9, wherein two kinds of resins are commercially available coating liquid products, solid content is 30%, two kinds of coating liquids are mixed, add 2100g Water, then add polyethylene glycol 6000 plasticization;

[0099] Step 2, add the prescription amount of glyceryl monostearate and Tween 80 into the remaining 1362g of water and mix evenly; then pour into the mixed solution o...

Embodiment 3

[0111] Preparation of Azithromycin Microcapsule Coating Formulation 3:

[0112] Prepare the azithromycin microcapsule coating formulation as follows:

[0113] Step 1, preparing coated particles. Weigh each component material according to the following formula:

[0114] Prescription of Coated Granules

[0115] Microcrystalline Cellulose 335g

[0116] Azithromycin 150g

[0117] Polyvinylpyrrolidone 15g

[0118] water 300g

[0119]

[0120] Total 800g

[0121] Put the prescribed amount of microcrystalline cellulose into a centrifugal granulation pot, mix evenly with azithromycin and polyvinylpyrrolidone, supply the powder, spray into the prescribed amount of water, and centrifugally granulate to obtain core particles.

[0122] Step 2, preparing a coating solution. Weigh each component material according to the formula of the following coating solution:

[0123] Coating Solution Prescription

[0124] Methacrylic resin 391.5g

[0125] Ami...

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Abstract

The invention discloses a taste-masking coated composition. The composition contains high molecular polymer, plasticizing agent, antisticking agent and coloring agent, wherein the high molecular polymer comprises methacrylic resin and amino-acrylic resin; and the weight ratio of methacrylic resin to amino-acrylic resin is between 1:9 and 9:1. The invention also discloses coated liquid prepared during preparing the taste-masking coated composition and a formulation adopting the composition. The taste-masking coated composition has the advantages that the composition cannot be dissolved quickly under nonacid oral environment (pH 5.0 to 7.0) but can be dissolved quickly under acidic stomach environment (pH 1.0 to 3.0), thereby obtaining excellent taste-masking effect; moreover, the composition has stable preparation property and takes effect quickly after being taken orally without changing the bioavailability of medicament obviously.

Description

technical field [0001] The present invention relates to the field of medicines and health care products, in particular to a taste-masking coating composition; in addition, the present invention also discloses a coating solution prepared during the preparation of the taste-masking coating composition and the use of the taste-masking coating composition. dosage form. Background technique [0002] Nutrient ingredients of many medicines and health care products have bad taste, among which bitter taste is in the majority. For example, most antibiotics have strong bitter taste. patients take. Although, the bitter taste of the drug can be largely avoided by directly swallowing the tablet or capsule for administration. However, ordinary tablets or capsules are not suitable for the elderly, children, or some patients who have difficulty swallowing. For this group of people, the medicine needs to be made into chewable tablets, orally disintegrating tablets, dispersible tablets, or ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/32A61K47/34A61K31/7052A61P31/04A61K47/10
Inventor 吴传斌刘阳
Owner SUN YAT SEN UNIV
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