Traditional Chinese medicine granule composition for treating infantile common cold and preparation method of traditional Chinese medicine granule composition

A technology of traditional Chinese medicine granules and children's colds, which can be used in drug combination, drug delivery, pharmaceutical formulations, etc., and can solve problems such as lack of specific treatment plans and physical damage.

Active Publication Date: 2021-07-06
JUMPCAN PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Colds are generally treated with anti-virus, anti-infection, and symptomatic treatment, but there...

Method used

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  • Traditional Chinese medicine granule composition for treating infantile common cold and preparation method of traditional Chinese medicine granule composition
  • Traditional Chinese medicine granule composition for treating infantile common cold and preparation method of traditional Chinese medicine granule composition
  • Traditional Chinese medicine granule composition for treating infantile common cold and preparation method of traditional Chinese medicine granule composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0107] The preparation of embodiment 1 Chinese medicine volatile oil clathrate

[0108]444g forsythia, 222g mint, 222g Nepeta, 222g Bupleurum and 16L water were decocted, and the volatile oil was extracted for 3 hours to obtain 4ml volatile oil. The distilled aqueous solution is collected in another device, and the obtained medicinal residue is used for future use. Next, 32 ml of 60% ethanol / water mixed solvent was added to the volatile oil, and stirred until uniform to obtain an ethanol solution of volatile oil. Afterwards, weigh 40g of β-cyclodextrin, add it into an inclusion pot filled with 240ml of purified water, heat until completely dissolved, and then cool. Finally, under temperature control at 60-66°C, slowly drop the ethanol solution of volatile oil into the aqueous solution of β-cyclodextrin, so that the volatile oil and β-cyclodextrin are fully included, and keep the temperature at 48-52°C after adding Stir for 4 hours, then refrigerate and centrifuge, dry the ob...

Embodiment 2

[0109] The preparation of embodiment 2 Chinese medicine extract

[0110] 10 medicinal materials including 333g light tempeh, 189g gardenia (stir-fried), 189g rhubarb, 333g artemisia annua, 222g red peony root, 167g betel nut, 333g officinalis officinalis officinalis officinalis officinalis officinalis officinalis officinalis officinalis officinalis officinalis officinalis officinalis Magnoliae officinalis 167g, 333g skullcap, 333g pinellia and 189g licorice The obtained dregs are combined and decocted twice with water. The first time, add 8 times the amount of water, and decoct for 1.5 hours; the second time, add 6 times the amount of water, and decoct for 1 hour. Afterwards, the decoction was combined, filtered, and the filtrate was combined with the aqueous solution collected in Example 1 and then concentrated to a clear paste with a relative density of 1.05 to 1.10 (55° C.). Then add 65% ethanol to the clear ointment, stir, stand overnight, filter, and concentrate to obtain...

Embodiment 3～36

[0114] Examples 3-36 spray granulation (comprising binding agent, table 1)

[0115] With 16.2g of Chinese medicine volatile oil clathrate prepared according to the method of Example 1, 20g of steviol glycosides, 10g of citric acid, 3g of sucralose, 40g of orange essence, an appropriate amount of binder, and a surplus of dextrin as the base material, All were placed in a granulator and mixed evenly, and 982 g of the Chinese medicine extract in the form of liquid extract prepared according to the method described in Example 2 was sprayed and granulated to make 1000 g of dry granules, and the granules were sized to obtain final product. According to the total weight of the obtained granules and the consumption of other components, the Chinese medicine extract (dry weight) in the dried Chinese medicine granule composition is calculated to be 370g.

[0116] The relevant parameters are as follows: peristaltic pump speed 20-25r / min, atomization pressure 55-65kPa, air volume 80-140m ...

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Abstract

The invention provides a traditional Chinese medicine granule composition for treating infantile common cold. The traditional Chinese medicine granule composition comprises a traditional Chinese medicine volatile oil clathrate compound, an adhesive, a filling agent and a traditional Chinese medicine extract, wherein the adhesive is selected from at least one of hydroxypropyl methylcellulose and sodium carboxymethyl cellulose. The invention also provides a preparation method of the traditional Chinese medicine granule composition, a preparation and a preparation method of the preparation. The specific adhesive is added into a prescription, so that the particle size distribution can be improved, and the taste masking effect is enhanced.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to a traditional Chinese medicine granule composition and a preparation method for treating infantile colds. Background technique [0002] Cold is an acute upper respiratory tract infection disease, and it is also a common disease in children, especially infants with immature upper respiratory tract anatomical structure, low immunity, and easy to get sick when the environment changes and the climate changes. Influenza is mainly caused by viral infection. It has the characteristics of high incidence rate, high recurrence rate, and migratory course of disease. It is prone to complications such as tonsillitis, bronchitis, and otitis media, causing great troubles to children and parents. Colds are generally treated with anti-virus, anti-infection, and symptomatic treatment, but there is a lack of specific treatment options, and this method is easy to cause certain damage to the body of...

Claims

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Application Information

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IPC IPC(8): A61K36/889A61K9/16A61K9/00A61K47/69A61K47/38A61P11/00
CPCA61K36/534A61K36/634A61K36/538A61K36/233A61K36/48A61K36/744A61K36/708A61K36/282A61K36/71A61K36/65A61K36/889A61K36/575A61K36/539A61K36/8888A61K36/484A61K9/1652A61K9/0053A61P11/00A61K2236/331A61K2236/51A61K2236/53A61K2300/00Y02A50/30
Inventor 李超朱法根赵文艳吴菲陈维可
Owner JUMPCAN PHARMA GRP
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