The invention discloses a medicinal composition for treating chronic cholecystitis. The medicinal composition is prepared from the following raw medicaments: longhairy antenoron herb, officinal magnolia barks, fried gardenia, Szechwan chinaberry fruits, long peppers, roses, endothelium corneum gigeriae galli, bamboo shavings, gentianopsis barbata, oysters, lythrum salicaria, mucuna sempervirens, sanguisorba officinalis, clethra loosestrife herb, pumpkin roots, coix seeds, Philippine violet herb, murraya paniculata, wolfberries, semen cassiae, cowherb seeds, acorus gramineus, rubia cordifolia, cassia twigs, green tangerine peel, hawthorns, licorice, dandelions, hedyotis diffusa, plantain seeds, willow branches, radix polygonum multiflorum preparata and northern divaricate saposhnikovia roots. According to the medicinal composition, the raw medicaments are combined on the basis of the principle of monarch, minister, assistant and guide of traditional Chinese medicine to achieve the effects of clearing liver-gallbladder, soothing the liver, promoting qi circulation, regulating qi activity, clearing away heat and toxic materials, nourishing the heart to tranquilize the mind, invigorating spleen, supplementing qi and promoting bile flow, fulfill the aim of treating chronic cholecystitis and overcome the defects of long treatment course, poor effects and high recurrence rate of modern medicine in treatment of chronic cholecystitis.