19 results about "Patient tolerance" patented technology

The invention discloses a rapid scar-free healing device for limb and face sutured wounds. The rapid scar-free healing device comprises a supporting plate, a threaded bushing, a sliding column, an adjusting rod, a pressure bolt, a pan head pull rod, a push plate, a pressing plate, a breathable plate, a limiting pin, a tension spring, a hanging rod and a fastening belt. Through the retraction force of the tension spring, the push plate extrudes tissues on the two sides of a sutured wound to bulge towards the middle, and tissue tension is changed into tissue tightening force; the pressing plate and the breathable plate are pushed to move downwards through the pressure bolt, the protruding portion of the wound is wedged and flattened, tissues on the two sides of the wound are tightly attached in an airtight level, the butt joint and anastomosis speed of the tissues is increased, microorganisms can be effectively prevented from invading the wound, and infection is prevented. By flattening and suturing the convex part of the wound, the forced tissue hyperplasia can only be carried out subcutaneously, the body surface is always kept in a flat, smooth and non-hyperplasia state, and the sutured wound can be quickly healed without scars; the vertical pressure of the pressing plate and the transverse pushing force of the pushing plate can be steplessly adjusted through the pressure bolt and the adjusting rod so as to adapt to the tolerance of a patient.

This invention discloses a combined anoscope for irrigation, drainage, suturing, and compression hemostasis, comprising a hollow cylindrical tube. A piston head is fixedly fitted inside the tube near its smooth, curved end. A hollow tube is formed within the piston head along the axial direction of the tube, creating a cavity between the piston head and the hollow tube. A drainage tube extending to the outside of the tube is connected to the bottom of the cavity. A connecting rod is slidably mounted inside the hollow tube. An arc-shaped plate, which covers the piston head and forms a hemispherical structure with it, is fixedly connected to the top of the connecting rod. The arc-shaped plate can move axially along the hollow tube towards the smooth, curved end of the tube to open the piston head and connect the rectum to the cavity of the piston head. This invention enables simultaneous insertion of the anoscope tube and drainage tube, flexible hemostasis of the wound, prevention of drainage tube dislodgement, and convenient disassembly. It solves the problems of traditional anoscopes having limited functionality and the risk of wound damage from repeated instrument insertion and removal, reducing the risk of anorectal tissue damage and improving diagnostic and treatment efficiency and patient tolerance.

The application provides a traditional Chinese medicine external application method for reducing the risk of fistula fibrosis in dialysis patients, relates to the technical field of clinical application of traditional Chinese medicine, is suitable for the prevention of autologous arteriovenous fistula fibrosis of maintenance hemodialysis patients, can effectively reduce the incidence of complications such as fistula peripheral tissue fibrosis and vascular stenosis, and prolongs the service life of the fistula. The drug stability and skin permeability are improved through optimization of adjuvants, and based on the grouping intervention of maintenance hemodialysis patients, the fistula blood flow and fibrosis improvement are evaluated in combination with color Doppler ultrasound. The application takes the principles of promoting blood circulation to remove blood stasis, dredging collaterals and resolving knots, and detoxification and swelling reduction as the therapeutic principles, prepares a fistula protection ointment by screening and optimizing a traditional Chinese medicine formula, realizes the effects of improving local microcirculation of the fistula, inhibiting fibrous tissue proliferation and reducing inflammatory reactions through external application intervention, thereby reducing the incidence of fistula fibrosis and related complications, prolonging the fistula patency time, simultaneously reducing the treatment cost, and improving the patient tolerance and life quality.

The invention discloses a brain-computer interface swallowing nerve and muscle electrical stimulation system and method, the system comprises an electroencephalogram collection device, an electrical stimulation device and an interaction terminal, the electroencephalogram collection device is used for collection, processing, staging identification and the like of electroencephalogram signals; the electrical stimulation device is used for receiving an intention recognition result of the electroencephalogram acquisition system and outputting personalized electrical stimulation, time sequence calibration and the like; the interaction terminal is used for man-machine interaction and data management. At least quadruple improvement of treatment pertinence, rehabilitation efficiency, patient tolerance and safety is achieved through staging feature recognition, double-impedance compensation, multi-mode feedback, time sequence calibration, personalized waveform and safety three-level early warning protection and conversion from passive stimulation to active cooperative training.

The invention relates to the technical field of medical treatment, in particular to an intragastric weight loss method based on a volume-adjustable balloon, which comprises the following steps: detecting indexes such as body weight index and stomach volume of a target patient before an operation, and screening adapters; implanting a weight reduction balloon through a gastroscope, filling according to a preset initial volume, and monitoring the filling pressure in real time; the weight change, diet tolerance and the like of the patient are dynamically monitored after the operation, and the balloon volume is adjusted based on data; when the body weight is reduced and the diet tolerance reaches the standard, a degradation medium is injected to realize step-by-step volume reduction; and after the balloon is lowered to the lowest adaptive value and the body weight reaches the standard and is stable, taking out the balloon through a gastroscope and establishing a long-term follow-up mechanism. According to the method, personalized adaptation is achieved through multi-parameter threshold regulation and control, the volume is dynamically adjustable, volume reduction is accurate and controllable, minimally invasive operation is achieved in the whole process, safety is high, the tolerance of a patient and the stability of the weight reduction effect are effectively improved, and the clinical personalized weight reduction requirement is met.

The utility model discloses a flexible enemator convenient to fix, and relates to the technical field of enemator. The flexible enemator convenient to fix comprises a stoma base plate, an extension tube is communicated with the middle of the stoma base plate, two sets of air bags are arranged on the extension tube in a limiting mode, a blocking piece installed in the extension tube is arranged between the two air bags, the whole blocking piece is conical, and the conical end of the blocking piece is located at the end, inserted into an intestinal stoma, of the extension tube. An expansion air bag is filled in the blocking piece in a limiting manner. By expanding and blocking the air bag, the expanding air bag and the blocking piece, sealing of the intestinal stoma and the intestinal stoma or further blocking of the intestinal tract or the intestinal stoma of a patient are completed, the phenomena of overflowing while irrigating and pollution of enema liquid and excrement liquid are avoided, the material of the extension tube is changed, the pain of the patient and the intestinal perforation condition are relieved, and the use safety of the patient is improved. And the intubation compliance and the patient tolerance are improved.

The invention relates to a control method for a cavity fluid infusion device, a flow limiting system and a medium, and belongs to the technical field of medical engineering and medical instruments. The method comprises the following steps: acquiring a physiological tolerance feature set of a target orifice and a physical attribute set of fluid to be infused; converting the feature set into control boundary parameters of the infusion device based on a preset mapping model, wherein the control boundary parameters comprise the maximum allowable volume flow rate; the actual output volumetric flow rate is physically limited not to exceed the maximum value in response to the parameter by a controller or a flow limiting mechanism. According to the method, through a feedforward control mode, the maximum output volume flow rate is locked based on preset physiological and physical parameters, dynamic adjustment is carried out without depending on real-time intracavity sensor signals, personalized fluid infusion of natural cavities such as rectum, vagina and bladder can still be safely and comfortably completed under the condition of no real-time feedback; the drug retention effect and the target object tolerance are effectively improved.

The application provides an application of 3-(methylsulfonyl) propionitrile in preparation of a medicine for treating peripheral nerve adhesion diseases, relates to the field of biomedical technology, and is verified through a sciatic nerve adhesion mouse model that 3-(methylsulfonyl) propionitrile can effectively reduce the adhesion degree of nerves and peripheral tissues, and can significantly improve muscle atrophy symptoms; compared with the traumatic and high recurrence rate of surgical treatment, the drug is a non-invasive or minimally invasive treatment, has good patient tolerance, can effectively reduce treatment risks and rehabilitation costs, and has wider clinical applicability. Secondly, the drug plays a treatment effect through a double action mechanism: on the one hand, adhesion formation is inhibited, and nerve compression is released; on the other hand, nerve myelin sheath regeneration can be promoted, myelin sheath structure integrity is improved, nerve conduction velocity is improved, and the synergistic effect of 'adhesion release + nerve repair' is realized. Animal experiments prove that the drug can significantly improve the motion balance ability and gait function of model mice.

The invention relates to the field of medical instruments, and discloses an intragastric balloon which comprises an inner balloon, a middle balloon and an outer balloon which are sequentially arranged from inside to outside, and the inner wall of the inner balloon, the inner wall of the middle balloon and the inner wall of the outer balloon are sequentially provided with a first one-way valve, a second one-way valve and a third one-way valve which are located on the same straight line; the middle-layer bag is made of a breathable but liquid-tight material; a first reactant and at least two slow-release capsules with different slow-release time are arranged outside the inner-layer capsule in the middle-layer capsule, a second reactant is arranged in each slow-release capsule, the first reactant is dissolved in water, and a solution obtained after the first reactant is dissolved in water can be in contact reaction with the second reactant to release gas. The intragastric balloon is small in size when being placed and then swells slowly to the final treatment size, so that the stomach has enough time to adapt to the balloon, adverse reactions such as stomachache and vomiting in the early stage of placement are remarkably reduced, and the tolerance and the treatment success rate of a patient are improved.

This invention relates to the field of medical auxiliary device technology and discloses a pull-out painless gastrointestinal endoscopy elbow arm fixation frame, comprising: an elbow arm fixation assembly including a support frame, two hinged ears fixedly connected to the top of the support frame, a knob with a screw inserted between the two hinged ears, a circular lug with a double-toothed structure rotatably connected to the outer surface of the screw of the knob, and a damping rotating shaft fixedly connected to the outer circumferential surface of the circular lug. This invention, through a multi-dimensional adjustable structural design, can flexibly adapt to the needs of patients with different body types, arm lengths, and lateral decubitus positions, precisely adjusting the fixation position, tilt angle, and circumferential angle to ensure that the elbow arm is placed in accordance with the physiological contour; it can prevent displacement caused by unconscious agitation of the patient under sedation, while ensuring smooth peripheral venous access, providing reliable protection for anesthetic drug infusion and vital sign monitoring, and significantly improving the safety and patient tolerance of painless gastrointestinal endoscopy.

This application discloses the fusion polypeptide AJ007 and its use, and belongs to the art of ophthalmic drugs. This fusion polypeptide AJ007 is formed by linking a TAT membrane-permeable peptide to the tip of a polypeptide HM-1 molecule that inhibits neovascularization. The fusion polypeptide AJ007 was used in the preparation of polypeptide eye drops, and by selecting the formulation of this application, the fusion polypeptide AJ007 was prepared as an eye drop. In the prevention or treatment of wet age-related macular degeneration, the method of administering eye drops effectively avoids various serious side effects and low patient tolerance problems associated with intravitreal injection in clinical practice, and has the advantage of non-invasive treatment. Furthermore, in a laser-induced mouse wAMD model, it showed extremely good efficacy in improving abnormal hyperplasia of choroidal neovascularization, and possesses high clinical therapeutic potential.

The application discloses a kind of external use traditional Chinese medicine compound compositions for reducing sensitivity of glans penis and penis and prolonging intravaginal ejaculation latency, and the pharmaceutical composition includes the following weight fractions of components: 30-70 parts of gallnut, 0.2-3 parts of toad venom, 9-35 parts of pomegranate peel, 6-14 parts of cnidium, 9-35 parts of dandelion, 6-14 parts of sophora, 2-10 parts of mint, 0.5-4 parts of pepper.The traditional Chinese medicine compound composition provided by the application uses scientific proportioning, mutually coordinates and mutually promotes between components, and plays the role of synergistic effect.The external use traditional Chinese medicine compound of the application can significantly reduce the sensitivity of glans penis and penis, prolong intravaginal ejaculation latency, has definite clinical curative effect, is convenient to use, has good patient tolerance and compliance, is safe and has no side effect, long-term use is not found adverse reaction, and after being made into standard preparation, can promote the standardization treatment of external treatment of traditional Chinese medicine.

The combined anoscope comprises a hollow cylindrical lens barrel, a piston head is fixedly embedded in the position, close to the smooth arc-shaped end, of the interior of the lens barrel, a hollow pipe is formed in the piston head in the axial direction of the lens barrel, and a cavity is formed between the piston head and the hollow pipe; the bottom of the cavity is communicated with a liquid discharge pipe extending to the outside of the lens cone; a connecting rod is slidably mounted in the hollow pipe, an arc-shaped plate which covers the piston head and is matched with the piston head to form a hemispheroid structure is fixedly connected to the top end of the connecting rod, and the arc-shaped plate can move towards one side of the smooth arc-shaped end of the lens cone in the axial direction of the hollow pipe so as to open the piston head and enable the interior of the rectum to be communicated with a cavity of the piston head. Synchronous insertion of the lens cone and the drainage tube, flexible hemostasis of a wound surface, falling prevention of the drainage tube and convenient disassembly can be achieved, the problems that a traditional anoscope is single in function, and the wound surface is prone to being damaged by multiple times of instrument insertion and extraction are solved, the anorectal tissue damage risk is reduced, and the diagnosis and treatment efficiency and patient tolerance are improved.

The invention belongs to the technical field of ultrasonic contrast agents, and discloses a tsamba gastrointestinal ultrasonic contrast agent as well as a preparation method and application thereof. The contrast agent takes Tibet Plateau pure natural tsamba powder as a core matrix, is subjected to superfine grinding and sterilization, is matched with a natural suspension stabilizer, a food-grade defoaming agent and a flavoring agent, and is blended with warm water according to a specific proportion to form a suspension; the preparation process comprises three steps of raw material pretreatment, dry mixing and suspension preparation, and is simple and convenient to operate. By regulating and controlling parameters such as granularity (more than 90% of particles are 10-50 microns) and concentration (8-12g / 100mL warm water) of zanba powder, acoustic characteristics can be adjusted, in-vitro detection shows that the contrast agent is medium-fine in echo, stable in suspension within 30 minutes and free of rear sound attenuation, and a gastrointestinal wall structure can be clearly drawn. The invention has the advantages of high biocompatibility, low side effect, good patient tolerance, nutrition support effect, convenience in storage and transportation and low preparation cost, and is suitable for gastrointestinal ultrasound examination of various crowds.

The invention relates to the technical field of tissue repair and regeneration and regenerative medicine, and discloses a stem cell active factor capsule for tissue repair and regeneration, which comprises a capsule body, and the capsule body has a core-shell-targeting composite structure, and sequentially comprises a load core body, an exosome containing a mesenchymal stem cell source, an exosome containing a mesenchymal stem cell source, and an auxiliary body from inside to outside, at least one recombinant growth factor is loaded on the surface of the exosome; the stem cell exosome is used for carrying growth factors, a human body self-repairing mechanism is synergistically activated, the limitation that only symptoms are relieved traditionally is broken through, and tissue functional regeneration is achieved. Intelligent shell layer targeted delivery is achieved, immunological rejection and systemic side effects are remarkably reduced, and donor shortage is solved. Multi-way administration such as oral administration and intravenous injection is supported, the patient tolerance is good, the utilization degree is improved through enzyme sensitive protection, and the defects that traditional delivery targeting is poor, and absorption is insufficient are effectively overcome.

This invention discloses a urinary stone-dissolving instrument based on the fusion of electrotherapy and mechanical vibration technology. This invention relates to the field of lithotripsy technology and includes a control box. The control box contains a stone-dissolving component and a storage component. The stone-dissolving component includes electrodes, a vibrating rod, a limiting rod, and a plug. The side of the electrode is connected to one end of the plug, and the inner wall of the vibrating rod is threadedly connected to the outer periphery of the plug. Both the electrode and the vibrating rod are electrically connected to the control box via the plug. The advantages of this invention are: the complementary combination of electrotherapy and vibration technologies improves the efficiency of urinary stone dissolving. During treatment, electrotherapy continuously exerts analgesia and vasodilatory effects, while vibration focuses on promoting dissolving. When vibration causes spasmodic pain due to stone movement, electrotherapy can relieve pain and improve patient tolerance. Simultaneously, continuous blood circulation provides sufficient nutrition to the ureter, reducing traction damage to tissues caused by vibration, ultimately achieving simultaneous improvement in stone dissolving efficiency and symptom relief.

The invention discloses a system for sequential delivery and synthesis of allicin and application thereof, and belongs to the field of drug targeted delivery, the system comprises two units of GISA-A and GISA-B. The GISA-A comprises alliinase, and the GISA-B comprises alliin; wherein the system is configured such that, after administration, the alliinase is administered at a first point in time, the alliin is administered at a second point in time, and the second point in time is later than the first point in time. According to the system, allicin can be synthesized at the targeted part of the intestinal tract to realize precise, efficient and stable antibiosis, and meanwhile, safety and patient tolerance can be taken into account.

The invention discloses a rapid scar-free healing device for a body suture wound. The rapid scar-free healing device comprises a support, a threaded bushing, a pan head bolt, a left push plate, a limiting pin, a pressing plate, a breathable plate, a right push plate, a hanging pin, an adjusting belt, a buckle, a fastening belt, a gear shaft and a fixing rod. The left and right push plates are pushed by pan head bolts to oppositely move towards the two sides of a wound, tissues on the two sides are extruded to protrude towards the middle, and tissue tension is changed into tissue tightening force; a pan head bolt pushes a pressing plate and a breathable plate to move downwards, a wound bulge is wedged and flattened, tissues on the two sides of a wound are in airtight-level fit, tissue hyperplasia can only be forcibly carried out subcutaneously, the tissue butting and anastomosis speed is increased, the body surface is always kept in a flat, smooth and non-hyperplasia state, microorganisms can be effectively prevented from invading the wound, and the wound healing effect is improved. Infection is prevented, so that rapid scar-free healing of sutured wounds is realized. Transverse thrust, vertical pressure and body binding force can be finely adjusted in a stepless mode through the buckles so as to adapt to the tolerance of a patient.

The application discloses a replaceable guide head for a medical instrument and relates to the technical field of medical instruments, which comprises a guide head, one end of the guide head is fixedly connected with an elastic piece, one end of the elastic piece is fixedly connected with a first connecting block, one end of the first connecting block is threadedly connected with a guide wire main body, an inner groove is arranged on the inner side of the guide head, and one end of the guide head is provided with a smooth conical surface. The lubricating solution supply mechanism is arranged, the lubricating solution is sprayed out from the first circular hole of the guide head through the through channel, a continuous liquid lubricating film is formed, solid friction is converted into smooth liquid friction, the resistance during the advancement of the guide wire is significantly reduced, direct contact between the guide wire and dry mucosa is avoided, irritation and abrasion caused by the direct contact are avoided, and the safety and patient tolerance of the operation are further improved.