79 results about "Clinical pharmacy" patented technology

The invention discloses a clinical rational drug use risk assessment method based on big data of electronic medical records, which comprises the following steps: S1 extracting rational drug use records and wrong drug use events from electronic medical record data, according to the patient's physiological characteristics, disease diagnosis results, drug combination Based on factors such as drug use, automatically establish a risk assessment model for rational drug use such as drug dosage, drug interactions, and drug contraindications; S2 extracts corresponding patient physiological characteristics, disease diagnosis results, drug combination conditions, etc. from the new electronic medical records Factors, using the risk assessment model for rational drug use, to obtain individual drug risk assessment, to provide decision-making basis for clinical drug affairs management. The clinical rational drug use risk evaluation method of the present invention can automatically evaluate the clinical drug use risk, and the result is accurate and effective, and can provide decision-making basis for the practice of clinical rational drug use.

An online application for approving prior authorization requests for prescription drugs. The application is used by pharmacy benefits providers, physicians, and pharmacies to request prior authorizations for drugs and to receive approvals automatically if a requested drug meets authorization criteria. The online application is accessible through a group pharmacy benefits provider portal on a web site. Requests are processed through a pharmacy benefits manager computer that determines whether prior authorization is required and through a pharmacy benefits provider computer when the pharmacy benefits manager computer determines that prior authorization is required. Requests that meet certain authorization criteria are approved automatically. Requests that cannot be approved automatically are submitted for review by a clinical pharmacy review division that access requests through a drug request transaction computer.

The invention belongs to the technical field of medicine, discloses the application of andrographolide derivative in preparation antineoplastic agents, and relates to 15-benzyl subunit -14-deoxy-11,12-dehydrogenation andrographolide derivative and 3,19 esters thereof. The experience shows that the chemical compounds have the remarkable effects of restraining cancer cell cloning and forming and resisting migration of cancer cell and human vascular endothelial; and the chemical compounds show stronger effects of restraining tumor growth, antimetastasis and antiangiogenic in a mice transplanting tumour animal model. The chemical compounds are used as activity components for preparing antineoplastic agents, have the advantages of high efficient and low toxicity. the invention provides a new drug way for curing and preventing transfer of the tumour, expands selection range of clinical pharmacy, and is significant to taking full advantage of plant resources of the common andrographis herb.

The invention provides a miRNA biomarker for diagnosis of polycystic ovarian syndromes.The miRNA biomarker is miR27a.Research shows that miR27a promotes apoptosis of granular cells, inhibits generation of aromatase, makes female hormones in granular cells disproportionate and leads to ovulation failures to cause polycystic ovarian syndromes.By inducing a mouse polycystic ovarian syndrome model with DHT, it is found that miR27a is highly expressed in the mouse polycystic ovarian syndrome model, and the effect of miR27a and target genes thereof in nosogenesis of polycystic ovarian syndromes is verified.miR27a can serve as a biomarker for polycystic ovarian syndromes, and a theoretical basis is provided for clinical pharmacy.

The invention discloses a portable clinical pharmaceutical medicine dispensing device. The portable clinical pharmaceutical medicine dispensing device comprises a bottom plate and a medicine tube, wherein a medicine containing bowl is placed on the upper surface of the bottom plate; two supports are respectively arranged at the left side and the right side of the bottom plate; shaft holes are formed in the top ends of the supports. According to the portable clinical pharmaceutical medicine dispensing device disclosed by the invention, a pressure sensor which is high in accuracy is adopted for weighing medicine powder and liquid medicine, the accuracy is high, the speed is fast, inconvenience, low efficiency and error caused by a traditional manual weighing mode by medical staff are solved, and the working difficulty of the medical staff is greatly relieved; according to the portable clinical pharmaceutical medicine dispensing device disclosed by the invention, the medicine tube is also erected on the supports, and the medicine tube can rotate around the horizontal axis, so that a powdery agent can be conveniently mixed, the powdery agent can also be quickly dissolved into the liquid medicine, and waste of the liquid medicine caused as a result of an agent bottle is easy to fall off from the hand to be broken into pieces during a process of sucking the liquid medicine by the medical staff can be avoided; meanwhile, the portable clinical pharmaceutical medicine dispensing device is powered by adopting storage batteries, is small and portable and is convenient to use.

The present invention belongs to the field of pharmaceutical technology and clinical pharmacy, relates to a cyclopeptide containing arginine-glycine-aspartic acid (RGD) sequence and its active liposome targeting, its preparation and application. The described cyclopeptide structure meets the requirements as ligand, and is cyclized by amido bond, its spatial conformation is stable, and is not easily degraded, its one end contains active sulphydryl group, and is convenient for modifying artificially-synthetic function peptide, its molecular weight is small, so that it is not easy to result in immune reaction, and can be used as ligand, and can be combined with hepatic stellate cell (HSC) surface integrator acceptor to construct active liposome targeting and implement target therapy for experimental hepatic fibroid cell. Said invention can obtain good therapeutic effect for curing hepatitis fibrosis.

An online application for approving prior authorization requests for prescription drugs. The application is used by pharmacy benefits providers, physicians, and pharmacies to request prior authorizations for drugs and to receive approvals automatically if a requested drug meets authorization criteria. The online application is accessible through a group pharmacy benefits provider portal on a web site. Requests are processed through a pharmacy benefits manager computer that determines whether prior authorization is required and through a pharmacy benefits provider computer when the pharmacy benefits manager computer determines that prior authorization is required. Requests that meet certain authorization criteria are approved automatically. Requests that cannot be approved automatically are submitted for review by a clinical pharmacy review division that access requests through a drug request transaction computer.

The invention provides a cerebral apoplexy pharmacy and genetic correlation detection method. According to the detection method, primers and probes are synthesized through four polymorphic sites of two genes of cytochrome P450CYP2C19*2: rs4244285, CYP2C19*3: rs4986893, CYP2C19*17: rs12248560, and SVIL: rs17834991, real-time fluorescence quantification allele probe detection is implemented, and whether a target belongs to pharmacy susceptible populations or not can be judged. By adopting the method, clinical pharmacy schemes can be instructed and adjusted, bases can be made for clinical individual treatment, and adverse reactions of medicines are prevented. The method is capable of simultaneously detecting four polymorphic sites and has the advantages of being simple and convenient, accurate, rapid, high in flux and the like.

The invention provides a medicine composition containing erlotinib hydrochloride. The medicine composition has the advantages of being good in digestion performance, high in stability, low in clinical pharmacy risk and the like. In the production and preparation process, raw materials and auxiliary materials do not need to be specially treated, and the production process is simple.

The invention discloses a multifunctional clinic pharmacy infusion automatic dosage device. The device structurally comprises a base, a placement box, a stand column, an input pipe, a valve, a pump body, an output pipe and a well shaking device. The stand column is perpendicularly connected to the middle of the base. The left and right sides of the stand column are provided with the placement boxand the well shaking device respectively, a medicine bottle is placed on the placement box, a dosage bottle is arranged on the well shaking device, a pump body is installed at the top of the stand column, the left side of the pump body is communicated with the input pipe, the valve is installed on the input pipe, the tail of the input pipe is connected with the medicine bottle, the output pipe isarranged at the right side of the pump body, the bottom of the input pipe is connected with the dosage bottle, and the well shaking device comprises a motor, a rotating shaft, an oscillation device and a clamping piece. The clamping piece is installed on the oscillation device. The device has the advantages that an oscillation plate can be pressed down through a retainer, the oscillation plate canoscillate up and down while rotating through cooperation of a fluctuation ring and a cooperation rod, liquid medicine vibrates up and down and left and right constantly, the well shaking effect is better, and the using safety is improved.

The invention discloses a portable dosing device based on clinical pharmacy. The device comprises a dosing case body, wherein a dosing tabletop is embedded in one side of the top end of the dosing case body; and a control switch is embedded in one end of the dosing case body, and a push grip is connected with the other end of the dosing case body. The portable dosing device is scientific and reasonable in structure and safe and convenient to use, transfusion bottles to be mixed are put in a second dosing seat with heads upward, a rotary board is rotated to a fixed board, the rotary board and the fixed board are fixedly connected through a fastener, the transfusion bottles to be mixed are fixed, multiple medicinal liquid can be dosed at the same time, a first mixing stop plate and a secondmixing stop plate can be driven to rotate, one end of the second mixing stop plate is hoisted by combining contact of a mixing lug and a mixing top block, transfusion bottles placed in the first mixing stop plate are driven to move up and down, and the transfusion bottles which are dosed can be quickly mixed.

The invention relates to the technical field of a medicine management system, and particularly to a pharmacy medicine dispensing in-advance number calling system and a method. The system comprises a medicine basket; an information label which is used for recording patient identity information, prescription information and medicine information; a medicine dispensing terminal which is used for buffering and dispensing the to-be-dispensed medicine basket; a conveying mechanism which is used for conveying the medicine basket from a medicine preparation part to the medicine dispensing terminal, wherein the conveying mechanism comprises label identification equipment which is used for reading the information label on the medicine basket for obtaining patient information; and a reminding module which is used for transmitting medicine taking reminding information to the patient. According to the system and the method, through arranging the label identification equipment at the front end of the conveying mechanism, the patient information which corresponds with the medicine basket is obtained; in-advance number calling is performed on the patient whose medicine basket is to arrive at the medicine taking terminal, thereby reducing time of the patient from fee paying to medicine taking, improving medicine dispensing efficiency of a hospital clinical pharmacy, reducing the number of persons who wait in a queue in a clinic pharmacy hall, and further reducing buffering pressure of hospital clinic pharmacy foreground buffering equipment.

Belonging to the fields of pharmacy and clinical pharmacy, the invention relates to a folic acid modified and vincristine encapsulated active targeting liposome drug delivery system, a preparation method and application in multidrug resistant tumor targeted drug delivery. The invention discloses a preparation method of a folic acid modified and vincristine encapsulated liposome. Cell specific uptaking and living animal imaging tests show that the drug delivery system has good in vitro and in vivo tumor cell targeting. 3-(4, 5-dimethylthiazole)-3, 5-diphenyltetrazolium bromide (MTT) analysis indicates that the drug delivery system has a good effect for inhibiting the in vitro growth of tumor cells. Pharmacodynamic results show that the drug delivery system has a good effect for inhibiting the in vivo growth of multidrug resistant tumors. The drug delivery system can enter the whole body blood circulation through intravenous injection dosing, then can be targeted to multidrug resistant tumor sites through tumor EPR effect and folic acid mediation and enter the tumor cells.

The invention discloses a portable medicine dispensing device based on clinical pharmacy. The device includes a first shell, and first fixing mechanisms are symmetrically installed on the left side and the right side of the first shell. Straps are arranged at the top end of the first fixing mechanism; one end of a base is inserted into the top end of the first shell, and the other end of the baseextends into an inner cavity of the first shell, second springs are installed at the bottom end of the base from left to right, the bottom ends of the second springs are fixedly connected to the bottom end of the inner cavity of the first shell, sliding grooves are symmetrically formed in the left side and the right side of the base, and limiting blocks are embedded in inner cavities of the sliding grooves. According to the device, a traditional mode of manually shaking a medicament for dispensing is abandoned, the working efficiency and quality of dispensing are greatly improved, and the device is simple and reasonable in overall design, convenient to move and carry by medical staff, flexible to use, high in practicability and capable of meeting the use requirements on the existing market.

A clinical pharmaceutical medicament dispensing device comprises a shell, wherein a motor is fixedly connected to a center of the bottom at the outer surface of the right end of the shell; a transmission device driven by the motor is arranged at the right side of the interior of the shell; a screening device reciprocating back and forth along with the working of the transmission device is arrangedat the top of the transmission device; the screening device comprises a moving plate; and a screening plate vibrating along with the back-and-forth movement of the moving plate is arranged inside themoving plate. According to the clinical pharmaceutical medicament dispensing device, the screening device is arranged, so that the work intensity of medical workers is reduced, impurities in Chineseherb medicine are removed, and medicine properties of medicament are improved; an intermittent mechanism linked with the transmission mechanism is arranged, so that the screening of two kinds of Chinese herb medicine is achieved, and the practicability of the clinical pharmaceutical medicament dispensing device is improved; the goal of adjusting capacity of two measuring cups is achieved through alifting device, so that the primary measurement of the Chinese herb medicine needing to be screened is achieved; and a weighing device is arranged, so that accurate measurement of the Chinese herb medicine is achieved, and the functionality and safety of the clinical pharmaceutical medicament dispensing device are improved.

The invention discloses a convenient medicine dispensing device based on clinical pharmacy, and relates to the technical field of medicine dispensing technologies. The convenient medicine dispensing device based on clinical pharmacy comprises a support seat, a medicine dispensing mechanism, a stirring mechanism and a quantitative medicine taking mechanism. According to the convenient medicine dispensing device based on the clinical pharmacy, through the arrangement of the medicine dispensing mechanism, the convenient medicine dispensing device based on the clinical pharmacy has the effect of conveniently and automatically proportioning medicines, automatic medicine dispensing is achieved by changing the transmission ratio of a driving gear to a driven gear according to the medicine dispensing proportion of various liquid medicines in the using process, liquid medicine is extracted through a sealing piston, and solid medicine is discontinuously put while the liquid medicine is proportioned, so that the effect of conveniently and automatically proportioning the medicine is achieved, and the purpose of improving the working efficiency is achieved.

The invention discloses a clinical pharmaceutical information interactive control method. The method comprises the steps that clinical pharmaceutical information provided by a pharmaceutist account is acquired, and a corresponding notification message is generated based on the clinical pharmaceutical information; a plurality of doctor accounts associated with the clinical pharmaceutical information are determined, and the notification message is pushed to the doctor accounts; response data correspondingly fed back by the doctor accounts responding to the notification message is acquired, and data mining is performed on the response data to form mining result information pushed to the pharmaceutist account; and mark information of the doctor accounts providing the response data is updated to quantitatively reflect participation contributions of the doctor accounts. Through the clinical pharmaceutical information interactive control method and equipment, fast popularization of the clinical pharmaceutical information is realized, resource cost is saved, doctors are promoted to better use medicine, medication problems can be discovered in time, a potential safety hazard occurring to a patient is avoided, and a huge social benefit can be generated.

The invention belongs to the technical field of biomedical detection and relates to a lung cancer diagnosis marker and application thereof. The invention discloses the lung cancer diagnosis marker; the lung cancer diagnosis marker is a UHRF1 gene. The biological marker has very high application value; a detection method is simple and the operation is simple and convenient; a new direction is provided for researches of a lung cancer diagnosis reagent and a theoretical foundation is provided for clinical pharmacy.

The invention discloses a multifunctional clinical pharmacy transfusion automatic dispensing device which comprises a device box, wherein an electric control box is fixedly arranged on the box body onthe left side surface of the device box, a connecting rod is fixedly connected with the middle part of the box body on the right side surface of the device box, an operation control screen is fixedlyarranged on the right end of the connecting rod, the operation control screen is electrically connected with the electric control box, a medicine distribution box is arranged in the middle part of the device box, and a shaft sleeve is fixedly connected with the inner wall of the box body on the left side of the medicine distribution box. One side, far away from the inner wall of the box body on the left side of the medicine dispensing box, of the shaft sleeve is rotatably connected with a medicine dispensing rod, the other end of the medicine dispensing rod passes through the box body on theright side of the medicine dispensing box and is connected with the medicine dispensing box through a bearing, and the right end of the medicine dispensing rod is fixedly provided with a rotating motor. The multifunctional clinical pharmacy transfusion automatic dispensing device has better dispensing effect, realizes automatic dispensing, avoids the disadvantages of manual dispensing, saves timeand labor, has more accurate control on liquid medicine metering and higher safety, can also be used for preparing other liquids, and has wide application and strong practicability.

The invention provides a multifunctional automatic dispensing device for clinical pharmaceutical infusion. The multifunctional automatic dispensing device comprises an operation table, an infusion bottle groove, a powder bottle containing groove, an ampoule bottle containing groove and two sets of dispensing frames. A square through groove is formed in one end of the operation table, and the infusion bottle groove is erected in the square through groove through an oscillation device and oscillated through the oscillation device. The two groups of dispensing frames are erected on two sides of the rear part of the infusion bottle groove respectively. A main shaft is rotationally arranged at the top of the operation table and driven by a rotating device to rotate. A bottom plate is erected below a fixed plate through a vertical moving device and is driven by the vertical moving device to move up and down. A long-strip-shaped through groove is formed in the top of the bottom plate in the length direction, and a U-shaped moving block is erected at the top of the bottom plate through a horizontal moving device and driven by the horizontal moving device to move. Movable plates are erectedon the two sides in a groove of the U-shaped moving block through springs. An n-shaped plate is erected above the U-shaped moving block through a first air cylinder and is fixedly provided with a limiting plate through a fixing shaft. The device can automatically dispense medicines.

The invention belongs to the technical field of clinical pharmacy, and particularly relates to a clinical pharmacy monitoring management system. The system comprises the components of a registering module which records allergy medicines of a patient before hospitalization and basic information of the patient; a medicine registering module which performs arrangement and recording on the medicine tanking amount and medicine taking kinds of the patient in a hospitalization period; a medicine taking monitoring module which performs real-time monitoring on medicine taking of the patient and performs period-differentiated clinical amount medicine taking according to condition of the patient; a medicine taking education module which pre-stores medicine taking education of various medicines; a medicine taking consulting module which records and arranges medicine taking consulting information of daily medicines and special medicines; and a medicine taking evaluating module which evaluates medicine taking rationality of the patient. The system has advantages of finding out latent or actual existing medicine taking problems in time, performing period-differentiated medicine taking in time andpreventing chaos in medicine taking.

The invention discloses a solid reagent dissolving device for clinical pharmacy, and belongs to the technical field of pharmaceutical solid reagent dissolving devices.The solid reagent dissolving device comprises a driving mechanism, a dissolving mechanism and a liquid medicine collecting mechanism, one side of the dissolving mechanism is connected with the driving mechanism, and the other side of the dissolving mechanism is connected with the liquid medicine collecting mechanism; the driving mechanism comprises a fixed rod, a rotating rod, a transmission rod and a driving block; one end of the fixed rod is connected with the inner wall of the driving mechanism; the dissolving mechanism comprises a twitching rod, a piston, a screw rod and a filtering layer; one end of the twitching rod penetrates through the driving block, and the penetrating part is rotationally connected with the transmission rod; the liquid medicine collecting mechanism comprises a liquid medicine box and a collecting tank, the side wall of the liquid medicine box is connected with a filtering layer, and the collecting tank is arranged below the liquid medicine box. According to the device, a solid reagent is subjected to reciprocating rotation movement crushing at the same time, impact force is generated through reciprocating movement between a solution and the solid reagent, a cutting effect is generated in the reciprocating movement process, reagent dissolution is accelerated, and a filtering layer is prevented from being blocked.

An online application for approving prior authorization requests for prescription drugs. The application is used by pharmacy benefits providers, physicians, and pharmacies to request prior authorizations for drugs and to receive approvals automatically if a requested drug meets authorization criteria. The online application is accessible through a group pharmacy benefits provider portal on a web site. Requests are processed through a pharmacy benefits manager computer that determines whether prior authorization is required and through a pharmacy benefits provider computer when the pharmacy benefits manager computer determines that prior authorization is required. Requests that meet certain authorization criteria are approved automatically. Requests that cannot be approved automatically are submitted for review by a clinical pharmacy review division that access requests through a drug request transaction computer.

The invention relates to a medicament preparation device, in particular to a clinical pharmaceutical medicament preparation device. The invention aims to provide a clinical pharmaceutical medicament preparation device convenient for fixing a container. The clinical pharmaceutical medicament preparation device comprises table legs, a bottom plate, a first fixing rod, a sliding rail, a rotating disc, a shifting plate, a mixing tank, a jacking mechanism and the like, the three table legs are connected to the bottom of the bottom plate at intervals, the first fixing rod is connected to the left side of the top of the bottom plate, the sliding rail is connected to the top of the first fixing rod, and the rotating disc is rotationally connected into the sliding rail; shifting plates are connected to the top of the rotating disc at intervals, a jacking mechanism used for jacking is arranged on the bottom plate, and a mixing tank used for storing medicaments is placed on the jacking mechanism. By controlling extension of the telescopic rod of the air cylinder, the mixing tank and the connecting ring can be driven to move upwards and reset, so that the mixing tank is in contact with the lantern ring, the connecting ring is clamped by the clamping plate, and then the mixing tank is fixed.

The invention discloses a portable medicine dispensing device based on clinical pharmacy. The device comprises a machine body, and further comprises a plurality of heat dissipation holes which are respectively and fixedly formed in the rear end of the machine body, a handheld handle obliquely mounted on the rear side of the middle part of the bottom end of the machine body, a driving mechanism arranged in the inner cavity of the machine body, a lower cabin body fixedly mounted at the bottom end of the front side of the machine body, and an upper cabin body arranged at the top end of the lowercabin body in an openable and closable manner through a hinge. According to the portable medicine dispensing device based on clinical pharmacy, the labor intensity of workers is further reduced, a user can hold the device more conveniently, and the device is easy to operate; the requirement on the professional skill level is reduced; meanwhile, the portability is obviously improved; the needle head is prevented from being in contact with an external object, and meanwhile the situation that the medicine bottle falls off or the hand is scratched due to improper force exertion is avoided.

Systems and methods of a cipher-based system for tracking a patient within a clinical pharmacy workflow, the system includes providing a meshed network having smart devices that communicate patient data with aggregators. The smart devices and aggregators located within the space form a meshed network, the aggregators communicate data to a computer in communication with a cloud-based network. A smart device with a mobile application wirelessly communicates with an internet system in communication with the cloud-based network. Receiving by the computer, information about the user smart device entering the meshed network by wireless tags positioned within the space. Information is obtained by the smart devices during a recognition process by wirelessly transmitting messages between the wireless tags to aggregators, and then wirelessly transmitting information from the aggregators to the computer, the computer communicates with the cloud-based network, the cloud-based network communicates with healthcare administrator systems via jointly defined API interface.

The invention belongs to the technical field of vitiligo, and discloses a medicine for treating leucoderma and an application. The medicine for treating vitiligo comprises an miR-223-3p inhibiting factor and a pharmaceutically acceptable carrier. The medicine has the advantages that by inhibiting the combination of the miR-223-3p and a target gene thereof, the proliferation of human epidermal melanocytes is promoted, depigmentation at the skin lesion caused by vitiligo is reduced, and the effect of inhibiting the occurrence and development of vitiligo is achieved. Besides, the invention also provides an application of the miR-223-3p, reveals a signal path of the miR-223-3p for treating vitiligo, and also provides a new idea for clinical pharmacy.

The invention relates to the technical field of medical instruments, in particular to a portable dispensing device for clinical pharmacy. The device comprises a base plate, wherein a first partition plate and a second partition plate with the same length value as the width value of the base plate are evenly arranged at the top of the base plate in a left-right direction; an operation table and aninstallation base are arranged at the front end and the rear end of the part, on the right side of the first partition plate, of the top of the base plate respectively; an oscillation device is arranged at the part, between the first partition plate and the second partition plate, of the top of the base plate; and the part, located at the left end of the second partition plate, of the top of the base plate comprises a transverse plate fixedly arranged on the base plate, a fixing assembly arranged at the rear end of the transverse plate and an injection assembly arranged at the front end of thetransverse plate. The portable dispensing device of the invention can effectively overcome the problems that when a nurse prepares instillation liquid medicine, all the steps cannot be well distinguished in sequence, efficiency is low when the prepared liquid medicine is evenly mixed and bottle plug particles are likely to exist in an infusion bottle in the prior art.

The invention discloses a multifunctional clinical pharmacy infusion automatic dispensing device which comprises a storage box, a medicine bottle placer and a medicine taking device. The medicine bottle placer and the medicine taking device are arranged on the storage box, a set of medicine bottle placer is arranged on the front portion of the top face of the storage box, and the medicine bottle placer comprises a mounting box, a placement box, a moving frame, a limiting frame, a third motor, a transmission disc and a transmission frame. A controller is arranged on the upper surface of the right side of the containing box, a medicine taking device is arranged on the upper surface of the portion, on the rear side of the medicine bottle containing device, of the storage box, and the medicine taking device is composed of a horizontal moving mounting frame, a horizontal lead screw, a first motor, a moving block, a vertical moving mounting frame, a vertical lead screw, a second motor and a lifting medicine taking assembly. According to the automatic medicine dispensing device, efficient mixing is achieved while the automatic medicine dispensing function is achieved, powder medicine is fully utilized, prepared medicine bottles are temporarily stored in a bacterium breeding prevention mode, the functions are complete, and it is guaranteed that the medicine dispensing process is automatic, safe and efficient.

The invention provides a portable medicine dispensing device based on clinical pharmacy, and effectively solves the problems that an existing grinding roller can only grind traditional Chinese medicinal materials with the surfaces in contact with the traditional Chinese medicinal materials; the problems that medicinal materials which are not in contact with the grinding roller cannot be effectively ground, the fan-shaped plate cannot be thoroughly cleaned by manually holding a corresponding tool traditionally, and multi-stage crushing cannot be achieved are solved; a supporting assembly is fixedly connected into the upper box body, a fixing ring is fixedly connected to the upper end of the middle of the supporting assembly, a synchronous ring is rotatably connected to the upper end of the middle of the fixing ring, and a reversing gear ring located on the outer side of the fixing ring is fixedly connected to the upper end of the supporting assembly. The upper end of the fixing ring is evenly and slidably connected with a plurality of driving moving discs fixedly connected with the synchronous rings correspondingly, through cooperative use of rolling claws, sliding-in holes, torsional spring rods and grinding rollers, medicinal materials on the supporting assembly can be rolled up and down, the medicinal materials are ground to be finer, blocky particles are avoided, and therefore the medicinal materials can be more effectively ground. And the medicinal materials are ground more thoroughly.