The invention discloses a mixed flow turbocharger with a variable nozzle ring which comprises a compressor impeller, a compressor casing, a bearing body, an actuating mechanism, a bearing, a nozzle ring blade, a turbine casing, a turbine shaft and a turbine impeller, wherein the actuating mechanism comprises an actuator, a rocker arm component, a driving ring and spatial link mechanisms; the actuator is connected with the rocker arm component, the rocker arm component is connected with the spatial link mechanisms, and the spatial link mechanisms are connected with the nozzle ring blade; the spatial link mechanisms are annularly arranged in the spherical shell formed by the bearing body and the turbine casing; the right angle shaped by the central line of the radial section outlet of the turbine casing and the axial direction can be changed into an obtuse angle. According to the invention, the top surface and the bottom surface of the nozzle ring blade are designed to concentric circular arcs, and the opening of the mixed flow turbine nozzle ring blade can be adjusted to rotate by utilizing the spatial link mechanisms, thus realizing the best matching of the mixed low turbocharger with the variable nozzle ring and each changing working condition of the internal combustion engine.