The invention relates to a high-strength and high-toughness weather-proof hot-rolled steel plate comprising the chemical components in percentage by weight: (wt,%): 0.05%-0.10% of C, 0.10%-0.50% of Si, 1.00%-1.30% of Mn, less than or equal to 0.015% of P, less than or equal to 0.010% of S, 0.30%-0.70% of Cr, 0.10%-0.40% of Ni, 0.25%-0.50% of Cu, 0.020%-0.050% of Al, 0.010%-0.040% of Nb, 0.010%-0.030% of Ti and the balance Fe and unavoidable impurity elements. Meanwhile, the traditional hot strip rolling process is adopted, and a preparation method specifically comprises the steps: deep desulphurization of molten iron until S is less than or equal to 0.0050%, converter top and bottom combined blowing, alloy fine adjustment, LF secondary refining, slab continuous casting, heating, two-rack rough rolling and seven-rack finish rolling, laminar cooling and reeling. The steel plate disclosed by the invention has the mechanical properties that ReL is 450-500MPa, the Rm is greater than or equal to 550MPa, A is 25.0%-30.0%, the -60 DEG C longitudinal Charpy V-shaped gap impact power is greater than 300J, the high-strength and high-toughness weather-proof hot-rolled steel plate has good matching of strength and toughness, good cold bending forming and welding properties and favorable atmosphere corrosion resistance, and the corrosion resistance of the high-strength and high-toughness weather-proof hot-rolled steel plate is twice as high as that of Q345B steel.