The invention discloses a latent semantic image retrieval method of region-oriented multi-feature integration and multi-level feedback. It uses result list returned by the initial keyword search, extracting a variety of region-oriented images characteristics, constructing attribute-image matrix, using latent semantic indexing algorithm to get the semantic space of image sets and semantic features of each image, and then using similar images by users feedback to construct or update image query vector, searching again the semantic space, calculating image semantics features and images inquiries vector similarity, getting outcome sets by descending order, and repeatable retrieval. The invention takes full advantage of image content information, making up for the deficiencies of the keyword search, and through the region-oriented multi-feature integration, enhances image content information from the bottom physical layer to the object layer, then further enhances to the semantic layer by HCI feedback, thereby reducing the gap between the image bottom features and high-level semantic, and allowing Web image retrieval to get higher retrieval accuracy.