The invention relates to a railway business line three-dimensional center line manufacturing method based on a point cloud and image fusion technology, and the method comprises the following steps: S1, field control measurement; S2, acquiring aerial photography data; S3, data preprocessing; S4, registering and fusing the laser point cloud and the image dense point cloud; S5, point cloud cutting; s6, performing real-scene three-dimensional reconstruction on the railway business line; s7, extracting track center feature points; s8, railway line center point feature extraction; and S9, manufacturing a railway three-dimensional center line. According to the method, the laser point cloud and the image dense point cloud are registered and fused, so that the density, integrity and smoothness of the laser radar point cloud are effectively improved; railway business line live-action three-dimensional reconstruction is carried out, and a live-action three-dimensional scene not only contains high-precision geometrical characteristics, but also contains rich texture attributes, so that measurement and discrimination are facilitated. According to the method, the workload of traditional railwaybusiness line surveying and mapping is effectively reduced, the field operation safety is greatly improved, and the method has great practical application value.