79 results about "Gestational period" patented technology

The present invention provides methods and compositions related to biomarker profiles for each trimester of pregnancy. The present invention also provides methods for identifying patients at risk of developing a complication of pregnancy, such as preeclampsia. In further embodiments, the present invention relates to methods for the diagnosis of patients with preeclampsia.

The present invention provides methods and compositions related to biomarker profiles for each trimester of pregnancy. The present invention also provides methods for identifying patients at risk of developing a complication of pregnancy, such as preeclampsia. In further embodiments, the present invention relates to methods for the diagnosis of patients with preeclampsia.

The invention provides α-amino esters of a hydroxypropylthiazolidine carboxamide derivative, (2S)-3-([1,1′-biphenyl]-4-ylsulfonyl)-N-[(1S)-3-hydroxy-1-phenylpropyl]-1,3-thiazolidine-2-carboxamide, as well as salts and crystal polymorphs thereof, that can be used to inhibit prostaglandin F receptor. The invention further encompasses methods of treating disorders such as pre-term labor at the early gestational stage by the administration of these substances to a patient in need of treatment.

Disclosed is a maternity biodata measurement system, wherein a sum of a pre-pregnancy energy expenditure and a pregnancy extra energy amount of a subject is determined as an energy amount necessary for the subject in a pregnancy period. In particular, the pregnancy extra energy amount is determined based on pre-pregnancy body-mass index data and elapsed pregnancy-period data about the subject, so as to allow the necessary energy amount to be determined as a value appropriate for the subject. The maternity biodata measurement system of the present invention makes it possible to measure a necessary energy amount for a pregnant woman on an individual basis.

A Chinese traditional medicine used for curing cough in the gestational period belongs to the Chinese traditional medicine for curing miscellaneous diseases. The ingredients of the medicine are 15g of tendril-leaved fritillary bulb, 15g of aster, 12g of stemona roots, 10g of balloon flower roots, 10g of herb of fineleaf schizonepeta, 10g of white swallowwort rhizome, 10g of Indian trumpet flowers, 6g of dried orange peel and 5g of liquorice; the auxiliary ingredients are 15g of rehmannia roots, 15g of wolfberry bark, 20g of winter wheat and 12g of figwort roots under the situation of dry cough without sputum and night sweat caused by damp heat; 9g of schisandra fruit, 10g of pulp of dogwood fruit and 15g of Chinese yam rhizome under the situation of urine incontinence caused by unstopping cough; 10g of angelica roots, 6g of magnolia flowers and 10g of chrysoidine under the situation of headache, watery nasal discharge and angina caused by external factors. The composition of the Chinese herbal medicines is simple and the medicines used in the prescription are totally natural herbal medicines; people can conveniently fetch and use the medicines and the manufacture method is simple; the medicine effect is excellent and the price is low; in this way, the Chinese traditional medicine is especially fit for people living in remote villages far away from counties and towns; the expense for curing the disease of cough in the gestational period is low and the problem that the household income is low and the life is poor and the local medical conditions are deficient is solved.

The invention discloses nutrient milk powder for pregnant women and a preparation method thereof, particularly milk powder which is helpful to give good birth and good care and has an auxiliary protection effect on pregnant women and fetuses, belonging to the technical field of processing of milk products. The nutrient milk powder is characterized in that every 1kg of a finished product of the nutrient milk powder for the pregnant women comprises the following components: 2000mg-8000mg of yolk globulin IgY, 300mg-1000mg of lactoferrin, 1mg-3mg of a trivalent chromium element and 1x1010cfu to 9x1011cfu of complex probiotics. The nutrient milk powder disclosed by the invention has the advantages of fully playing roles of nutrient complementation and synergistic interaction, making up the market vacancy, remarkably preventing and improving discomfort symptoms of the pregnant women in the gestation period, also enhancing the immunity and keeping full health of the pregnant women and fetuses, causing no adverse effects in aspects such as color, taste and stability, being convenient to eat and carry, and causing no harms, toxic effects or side effects to human body after being eaten normally.

The invention discloses a sow feeding mode for improving the sow breeding performance and a matched sow feed. According to the feeding mode, after multiparous sows are bred, feed is restricted strictly within 0-5 d, the feeding amount of matched feed at the pregnancy earlier stage is 2-2.2 kg, and at 6-50 d of the gestation period, the feeding amount is increased to 2.5-2.7 kg; within 51-85 d of the sow gestation period, the matched feed of the pregnancy earlier stage is fed, 2.3-2.5 kg of the feed is fed to each sow, a back fat instrument is adopted for monitoring the thickness of sow back fat to be 16-18 mm; the feeding amount is corresponding decreased or increased by 0.2-0.3 kg every time the thickness of the back fat is 1 mm lower than or large than 16-18 mm. Compared with the sow feed matched with the sow feeding mode, the feed includes the pregnancy earlier stage feed, the pregnancy later stage feed and the milking sow feed. The propagation characteristics of the stages of the sows are combined, feeding programs and feed nutrients meeting the sow breeding requirements are applied, and the sow breeding performance and health degree thereof can be effectively improved.

The invention discloses a feed for sows in the gestation period. The feed is prepared from the following components: cottonseed cake, flax cake, bone meal, salt, broken rice, wheat bran, shell powder, mountain flour, lysine, methionine, cystine, pea, corn, rice, sugar beet pulp, sweet potato vine, salt, coarse protein, compound vitamin and compound polymineral. The invention also discloses a preparation method of the feed for the sows in the gestation period. The feed for the sows in the gestation period is capable of providing basic nutrient substances to the sows in the gestation period, is capable of ensuring normal nutritional requirement of the sows and embryos due to the addition of the lysine, the methionine, the cystine, the salt, the coarse protein, the compound vitamin, the compound polymineral and the like, and is also capable of maximally developing the fertility of the sows, increasing the survival rate of the embryos and ensuring the normal development of the embryos.

A Chinese traditional medicine for curing combined urinary tract infection in gestational period belongs to a Chinese traditional medicine for curing miscellaneous diseases in gestational period. The ingredients of the medicine are 30g of honeysuckle, 20g of forsythia, 20g of dandelion, 20g of Tokyo violet herb, 20g of polygonum aviculare.L, 15g of shearer pyrrosia leaves, 15g of cock tree bark, 15g of Tuckahoe, 15g of plantain seeds, 18g of largehead atractylode rhizome, 18g of yam, 18g of raw gardenia, 10g of lalang grass rhiome and 6g of liquorice tips; the auxiliary ingredients are 15g of eucommia and 15g of himalayan teasel roots under the situation of lumbago; 20g of ramie roots and 20g of herb of yerbadetajo under the situation of hematuria; 10g of chingma abutilon seeds under the situation of dry excretion; 10g of bupleur and 10g of scutellaria roots under the situation of fever; 20g of pinellia tuber and 20g of bamboo shavings under the situation of vomiting. The composition of the Chinese herbal medicine is simple and the medicines used in the prescription are all natural ones and the fetching and use are convenient; the manufacture method is simple and the effect is excellent; the price is low; in this way, the herbal medicine is especially fit for people living in remote villages far away from counties and towns; the curing expense for patients of pregnant women with the disease of combined urinary tract infection in gestational period is low which solves the problem that the household income is low and the life is poor and the medical conditions is deficient locally.

The invention provides microencapsulated peony seed oil, compound composition and a preparation method of the microencapsulated peony seed oil. The microencapsulated peony seed oil is prepared from a peony seed oil core material and a Maillard product wall material and has good antioxidant effect. The microencapsulated peony seed oil is taken as a raw material and compounded with folic acid and xylooligosaccharide for further preparation of a product which has better antioxidant property, is high in storage stability and meets special physiological needs of pregnant women in the gestation period. The compound product has the better antioxidant property, is high in storage stability, meets physiological characteristics of the pregnant women in the gestation period and needs of growth and development of fetuses, can promote fetal brain development, guarantee normal development of fetal organs, relieve constipation of the pregnant women in the gestation period, improve organism immunity of the pregnant women and reduce blood pressure, blood fat and blood sugar, and reduces incidence rate of diseases such as hypertension, diabetes mellitus and the like in the gestation period.

The invention discloses a method for establishing a model for early prediction of gestational diabetes mellitus, comprising the following steps: 1, clinically retrospectively collecting a plurality ofpregnant women with normal blood glucose during pregnancy and gestational diabetes mellitus, taking the pregnant women as total collection cases, and collecting information data of each case; 2, randomly extracting a plurality of cases from the total collection cases in the step 1 to serve as a training set; compiling a LightGBM model in the form of 'yes-no' by using a Python language and spyderor jupyter notebook software; setting model parameters, then importing information data of each case of the training set and a result of finally judging whether the patient suffers from gestational diabetes mellitus or not, and constructing a LightGBM prediction model; and 3, inputting the information data of the pregnant woman to be predicted into the lightBGM prediction model constructed in thestep 2 to obtain a prediction risk value of the gestational diabetes mellitus risk in the future, and determining whether the pregnant woman will be sick or not according to the prediction risk value.The method has the advantages of simple and convenient implementation, high result accuracy and the like.

The invention relates to prenatal nursing exercise equipment for a pregnant woman in the obstetrical department. Exercise of the pregnant woman is completed through cooperation of a bottom plate, a mounting plate, a lifting device and a protection device. The prenatal nursing exercise equipment for the pregnant woman in the obstetrics department can solve the problems that when the pregnant woman climbs stairs for exercise in practice, due to the fact that a single-layer stair of an existing stair is high, the pregnant woman in the later stage of pregnancy is difficult to climb, the exercise effect is difficult to achieve, and when the pregnant woman climbs the stairs for exercise in practice, an existing stair handrail is difficult to adapt to the pregnant women with different heights, the pregnant woman usually sits down by the existing nursing exercise equipment and then exercises local organs by using the equipment, so that the pregnant woman is difficult to do sufficient activity exercise in a protection state, and the exercise amplitude cannot be adjusted by the existing exercise equipment, therefore, the pregnant women in different gestation periods are difficult to fully protect.

A Chinese traditional medicine for curing acne belongs to a Chinese traditional medicine for curing miscellaneous diseases in gestational period. The ingredients of the medicine are 10g of loquat leaves, 10g of mulberry bark, 10g of gardenia, 10g of wild chrysanthemum flowers, 10g of red peony roots, 12g of scutellaria roots, 6g of coptis and 30g of lalang grass rhizome; the auxiliary ingredients are 10g of coix seeds, 10g of fresh largehead atractylode rhizome and 10g of fresh orange fruit under the situation of I-grade and II-grade acnes and much spilt sebum; 15g of dandelion, 15g of Tokyo violet herb and 15g of glabrous greenbrier rhizome under the situation of III-grade and IV-grade acnes with inflammation and cyst as the main syndrome; 10g of selfheal, 10g of caladium and 10g of Chinese honeylocust spine under the situation of the main syndrome of cyst and tubercle. The composition of the Chinese herbal medicine is simple and the medicines used in the prescription are all natural ones and the fetching and use are convenient; the manufacture method is simple and the effect is excellent; the price is low; in this way, the herbal medicine is especially fit for people living in remote villages far away from counties and towns; the curing expense for patients of pregnant women with the disease of acne is low which solves the problem that the household income is low and the life is poor and the medical conditions is deficient locally.

The present invention relates to the application of refined OMEGA3 sea dog oil in preparation of medicine for preventing and curing menopausal syndrome and dysmenorrhea and health-care of woman in gestational period. Its compositino comprises (wt%) octadecadienoic acid 1.7%, calendic acid 2.0%, EPA 8.5%, DPA 4.9%, DHA 11.2%, squalene 2.5%, vitamin E 0.5%, unsaturated fatty acid 59.53% and saturated fatty acid 9.47%. Said refined OMEGA3 sea dog oil richly contains the OMEGA3 type multicarbon unsaturated fatty acid which is necessary for human body and can not be self-synthesized in human body.It can supplement nutrients for woman in gestational period, promote normal development of fetal brain.

The present disclosure is directed to a nutritional powder, a translucent reconstitutable beverage formed therefrom, and methods relating thereto. The nutritional powder and beverage are adapted to include the proper balance of proteins, lipids, carbohydrates, vitamins and minerals appropriate for a pregnant woman. The nutritional compositions further stem the glycemic response and improve glycemia and insulinemia during gestational and lactating periods for preventing or reduce the incidence of glucose intolerance later in life.

The invention discloses a method and device for classifying pregnancy state of a user, electronic equipment and a medium. In the application, the method includes: calling a sample data set of a gestational user from an antenatal examination data center, wherein the sample data comprises a gestational week value of the gestational user; continuously optimizing and training the decision tree model through a random forest algorithm to obtain a target prediction model; and acquiring physiological feature data of a to-be-detected user in the gestation period, and inputting the physiological feature data of the to-be-detected user in the gestation period into the target prediction model to obtain a gestation state classification result of the to-be-detected user in the gestation period. By applying the technical scheme of the invention, the Bagging type random forest integration algorithm can be obtained by combining and optimizing the decision tree model, so that the target prediction model capable of determining the pregnancy state classification can be generated for the user in the pregnancy period; therefore, the purpose of automatically judging the pregnancy state of the user in the gestation period according to the physiological feature data of the user in the gestation period can be achieved, and then corresponding processing can be conducted on the user in a targeted mode.

The invention belongs to the technical field of medical appliances, and discloses a kit which comprises primary antibody digoxin antibody, secondary antibody rat anti-goat IgG, 3H labeled divaricoside, polyethyleneglycol 6000, phosphate buffer solution (PBS) with the pH value of 7.4, 3H scintillation solution, and tris(hydroxymethyl)metyl aminomethan buffer solution (Tris buffer solution) with the pH value of 7.4, and / or divaricoside. The kit provided by the invention is simple and convenient to operate, has the advantages of high sensitivity, high specificity and the like, and can perform stable and reliable early diagnosis on gestational period eclamptism, thereby providing favorable support for subsequent treatment.

The invention provides a Chinese medicinal preparation made from Jasminum lanceolarium for treating gynecological diseases particularly acute and chronic pelvic inflammatory disease, pelvic inflammatory mass, acute and chronic mastitis, hyperplasia of mammary glands, cervicitis and ovarian cyst, and a preparation method thereof. The preparation method comprises the following steps of: cleaning Jasminum lanceolarium, sun drying, slicing to slices of thickness 1-2 cm, extracting with 1,500 mL water for 2 hrs at 100 DEG C under pressure less than or equal to 0.1 MPa, filtering, extracting with 1,000 mL water for 1.5 h at 100 DEG C under pressure less than or equal to 0.1 MPa, filtering, mixing filtrates, vacuum concentrating under vacuum degree of -0.05-0.08 Mpa, temperature of less than and equal to 110 DEG C, and vapor pressure of 0.1 MPa to obtain 1,000 mL filtrate, adding 5% methyl p-hydroxybenzoate alcoholic solution 100 mL, stirring, and bottling. The preparation has the advantages of short treatment course, good therapeutic effect, no toxicity, no adverse side effects, convenience for carrying, and good taste. In addition, the women in lactation period and gestational period can also use the preparation.

The invention discloses a safety device for symptoms of gestational eclampsia, which comprises a database, an information collection module, a classification module, a diagnosis module and a safety module, and is characterized in that the database records data information of patients with various gestational eclampsia symptoms, the information collection module collects the data information of thecurrent patient, the data information of the current patient comprises age, other medical history, blood pressure, urine protein proportion and pulse rate, the information collection module sends theage and other medical history of the patient to the classification module, and the classification module adopts a clustering algorithm to extract data information belonging to the same category as the data information of the patient from the database, and sends the blood pressure, urine protein proportion and pulse rate data in the same category of data information to the diagnosis module. According to the invention, the identification and attack period of the eclampsia can be effectively processed, so that safety protection is performed according to the specific situation of the eclampsia, and meanwhile, an intelligent identification mode is adopted in the identification process, so that the identification efficiency can be greatly improved.

A Chinese traditional medicine for curing cystitis in gestational period belongs to a Chinese traditional medicine for curing miscellaneous diseases in gestational period. The ingredients of the medicine are 10g of angelica, 12g of tendril-leaved frillary bulb and 10g of lightyellow sophora roots; the auxiliary ingredients are 10g of rehmannia root, 10g of medlar, 10g of plantain seeds and 10g of clematis under the situation of yin deficiency; 12g of cock tree bark, 12g of henom bamboo leaf and 12g of mongloian snakegourd under the situation of excessive heat; 8g of fresh gardenia and 8g of scutellaria roots under the situation of heat overabundance; 10g of winter wheat and 10g of radix adenophorae under the situation of severe thirsty; 15g of scutellaria root, 15g of codonopsis pilosula and 15g of dipsacus roots under the situation of qi deficiency. The medicines used in the prescription are all natural herbs and the Chinese traditional medicine is processed with traditional method; the fetching of material is convenient and the prescription and manufacture method are simple; the expense for manufacturing the medicine is low. The composition of the Chinese herbal medicine is simple and the medicines used in the prescription are all natural ones and the fetching and use are convenient; the manufacture method is simple and the effect is excellent; the price is low; in this way, the herbal medicine is especially fit for people living in remote villages far away from counties and towns; the curing expense for patients of pregnant women with the disease of cystitis in gestational period is low which solves the problem that the household income is low and the life is poor and the medical conditions is deficient locally.

The disclosure relates to nutritional supplements to be administered to, or to be taken by, women desiring to become pregnant, and pregnant and nursing women, so that a woman (and any fetus) will be nutritionally supplemented before, during and after the gestation period. The nutritional supplements have a blend of folic acid, lycopene and co-enzyme QIO, optionally docosahexaenoic acid, and other vitamins and minerals, and a nutritionally acceptable carrier therefor, but are free or substantially free of other materials in nutritionally effective amounts. Specific nutritional supplements are described.

The invention discloses an early prediction method for gestational diabetes mellitus. The prediction method comprises the following steps: S1, obtaining clinical index test results of a research object in 11-18 weeks of pregnancy; s2, the indexes obtained through detection in the step S1 are preprocessed; s3, indexes related to gestational diabetes mellitus are selected, Fisher values are used for evaluating all the indexes, and sorting is carried out according to the Fisher values of all the indexes from large to small; s4, the first 11 indexes are selected to be input into the machine learning model, the machine learning model is trained according to the selected input indexes, and the predictive ability of the indexes for gestational diabetes mellitus is verified; s5, obtaining a prediction model of the gestational diabetes mellitus according to a result of the step S4; s6, substituting another group of new clinical index test results into the prediction model for verification so as to evaluate the accuracy of the prediction model; and S7, predicting whether the pregnant woman is sick or not through the prediction model.

The invention discloses a pregnant woman nutrition bag suitable for gestational diabetes mellitus and a preparation method thereof. The pregnant woman nutrition bag comprises the following raw materials: maltodextrin, resistant starch, whey protein concentrate and the like. The preparation method comprises the following steps: proportioning, homogenizing and packaging. The specific full-nutrition formula special medical food designed for gestational diabetes mellitus patients can effectively improve the malnutrition state of pregnant women, reduce the blood sugar level and reduce the incidence rate of gestation complications and adverse outcomes.

The invention relates to selenium-rich food applicable to pregnant women and a preparation method of the selenium-rich food. The selenium-rich food can supplement selenium, takes special physiological needs of the pregnant women into consideration, can be eaten for a long time and can meet the special nutrition requirements of the pregnant women. Every 100 g of the selenium-rich food contains 15 mu g or more of selenium, the requirement of the pregnant women for selenium can be safely and effectively met, functions of enhancing the body immunity of the pregnant women and controlling the blood glucose level of gestational diabetes mellitus are achieved, and effects of promoting brain intelligence development of fetuses and nourishing qi and blood are realized.

A Chinese traditional medicine for curing syndrome of incoordination between liver and stomach in early gestational period belongs to the Chinese traditional medicine for curing hyperemesis gravidarum. The ingredients of the medicine are that 15g of perilla leaves, 15g of bamboo shavings, 10g of coptis, 10g of dried orange peel, 10g of pinellia tuber and 10g of ebony; the auxiliary ingredients are 15g of radix adenophorae and 15g of dendrobium under the situation of impairment of fluid caused by serious vomiting; 20g of fried date seeds and 15g of multiflower knotweed under the situation of insomnia. The medicines used in the prescription are all natural herbs and the Chinese traditional medicine is processed with traditional method; the fetching of material is convenient and the prescription and manufacture method are simple; the expense for manufacturing the medicine is low. The composition of the Chinese herbal medicine is simple and the medicines used in the prescription are all natural ones and the fetching and use are convenient; the manufacture method is simple and the effect is excellent; the price is low; in this way, the herbal medicine is especially fit for people living in remote villages far away from counties and towns; the curing expense for patients with the disease of incoordination between liver and stomach in early gestational period is low which solves the problem that the household income is low and the life is poor and the medical conditions is deficient locally.

The invention discloses an accurate feeding method for pregnant pigs in a large pigsty. The method comprises the following steps: 1, conducting management in a gestation period; 2, blending feed in the gestation period; 3, feeding with feed in the gestation period; 4, separating fat and thin pigs in different pigsties; 5, preparing feed in the perinatal period; and 6, feeding feed in the perinatal period. Compared with an existing pregnant pig feeding method, a one-time feeding method is adopted, individuals with poor body conditions conduct secondary ingestion on residual feed, even if food grabbing occurs, it can be ensured that each pig can be full, adjustment and management of backfat are achieved, meanwhile, the hardware input cost is reduced, according to the method, the pigsty separating management is carried out according to the backfat condition of the pregnant pigs, the daily feeding amount is reasonably planned, so that the pregnant pigs are prevented from being too fat or too thin, feed supply with different contents of nutritional ingredients is implemented according to the pregnancy requirements of the pregnant pigs in different periods, the dystocia rate of sows is reduced, and the newborn vitality of piglets is improved.

A Chinese traditional medicine for curing aphonia in gestational period belongs to a Chinese traditional medicine for curing miscellaneous diseases in pregnancy period. The ingredients of the medicine are 10g of balloon flower roots, 6g of liquorice, 15g of figwort, 15g of winter wheat, 10g of dendrobium and 3g of asarum. The medicines used in the prescription are all natural herbs and the Chinese traditional medicine is processed with traditional method; the fetching of material is convenient and the prescription and manufacture method are simple; the expense for manufacturing the medicine is low. The composition of the Chinese herbal medicine is simple and the medicines used in the prescription are all natural ones and the fetching and use are convenient; the manufacture method is simple and the effect is excellent; the price is low; in this way, the herbal medicine is especially fit for people living in remote villages far away from counties and towns; the curing expense for patients with the disease of aphonia in gestational period is low which solves the problem that the household income is low and the life is poor and the medical conditions is deficient locally. Moreover, patients have no adverse reaction in the curing process with the prescription.

The invention provides a preparation method of a traditional Chinese medicine feed for cattle in a gestational period. The traditional Chinese medicine feed comprises the following raw materials in parts by weight: 13-21 parts of wheat straw, 13-16 parts of corn straw, 7-11 parts of bean meal, 3-6 parts of wheat bran, 9-14 parts of licorice roots, 7-10 parts of astragalus roots, 5-7 parts of angelica, 5-8 parts of glossy privet fruits, 4-7 parts of common yam rhizomes, 3-7 parts of prepared rehmannia roots and 1-2 parts of brown sugar. The preparation method is also relatively simple, nutritional ingredients of the raw materials can be fully kept, and the prepared feed can fully improve the immunity of the cattle in the gestational period so as to improve the effect of preventing miscarriage.

The invention discloses application of sipunculid peptide to preparation of gestational period hypertension treatment or prevention products. The amino acid sequence of the sipunculid peptide is His-Thr-Arg-Asp-Gly. The sipunculid peptide can effectively reduce the blood pressure and the urine protein of a mouse with gestational period hypertension caused by L-nitrous acid L-arginine methyl ester,inhibit the increase of the oxidative stress index of the mouse with gestational period hypertension and can also reduce the up-regulation of inflammatory marker molecules. The sipunculid peptide isa compound capable of effectively intervening the gestational period hypertension diseases generated during the woman gestational period. The sipunculid peptide has high use safety on users-pregnant women with gestational period hypertension diseases, and has the characteristics of no toxicity and low side effect. The sipunculid peptide can be widely used in pharmacy, heath care products and food,and is used for prevention and treatment.

The invention discloses a noninvasive antenatal gene detection sequencing data analysis method and device and a storage medium. The method comprises the following steps: acquiring an original sequencing result of a sample with two or more chromosome aneuploids from NIPT sequencing data, comparing the original sequencing result with a reference genome, and removing mismatched or repeated reads; and calculating Z values of other chromosomes except the Y chromosome and the No.19 chromosome according to an NIFTY algorithm, calculating an average value of the first five absolute values of the Z values, and if the average value is greater than a threshold value, judging that the to-be-detected object is a tumor high-risk population. The average value of the first five absolute values of the Z value of the chromosome of the MCA sample in NIPT detection is used for evaluating the pregnancy tumor condition for the first time, NIPT sequencing data is directly used in the analysis method, the analysis method is simple and convenient, extra cost except NIPT sequencing is avoided, and the use of NIPT in detection of the latent maternal cancer in the pregnancy period is further expanded.