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46 results about "Glucose management" patented technology

Diabetes and early-stage patient self-management system based on AI and CGM

The invention relates to the technical field of medical care informatization, in particular to a diabetes and early-stage patient self-management system based on AI and CGM, which comprises the following steps: carrying out delayed alignment on CGM blood glucose flow and multi-modal physiological signals through a signal acquisition and synchronization module; an intelligent event triggering module is used for dynamically adjusting a triggering threshold value for different disease course stages so as to identify suspected events; a mixed consistency verification engine is combined with a medical prior rule and an ensemble classification model to carry out joint discrimination, and a consistency probability is output; and the individual parameters are optimized in cooperation with a hierarchical decision-making mechanism of the interaction module and online incremental learning of the adaptive learning module. Therefore, frequent false alarms caused by physical limitations such as inherent physiological delay and signal drifting of a CGM sensor and alarm fatigue and decline of compliance of a patient caused by the frequent false alarms are solved, and more stable and personalized dynamic blood glucose management support is provided for active people in the early stage of diabetes mellitus and the like.
Owner:AFFILIATED HOSPITAL OF CHENGDU UNIV (CHENGDU INST OF TRAUMATOLOGY & ORTHOPEDICS)

Critical patient blood glucose monitoring and risk intervention system based on artificial intelligence

The invention relates to the technical field of intelligent medical monitoring, and discloses a critical patient blood glucose monitoring and risk intervention system based on artificial intelligence. The system comprises a multi-source physiological data integration module, a risk map construction module, an intervention decision generation module and an intervention execution control module. The system integrates and standardizes physiological data from the continuous blood glucose monitor and the multi-parameter monitoring equipment; the physiological parameters are mapped into pathological nodes based on the medical knowledge map, and the activation probability of the pathological nodes is calculated to construct an individualized risk map, so that systematic risk assessment is realized. Further, in combination with individual information of the patient, performing multi-objective optimization on the intervention strategy by applying a simulated annealing algorithm to generate an optimal decision; and analyzing the decision into a control instruction to drive the insulin pump to execute precise intervention. According to the invention, the crossing from passive alarm to active risk prediction and personalized intervention is realized, and the safety and accuracy of blood glucose management of critical patients are improved.
Owner:THE FIRST AFFILIATED HOSPITAL OF XIAMEN UNIV

Glucose control using digital twin metabolic models

PCT designated stageWO2025165924A9Medical simulationPhysical therapies and activitiesLow glucosePhysiology
A diabetes management system optimizes glucoregulatory hormone delivery using a connected glucoregulatory hormone delivery system and a computing device with a processor and non-transitory memory. The system receives glucose management data (glucose, insulin delivery, heart rate, or carbohydrate consumption data) from sensors. A digital twin metabolic model is selected and initialized based on the received data. The system simulates diabetes treatment interventions to predict glucose dynamics and determines an optimized glucoregulatory hormone parameter (e.g., insulin dose or increment that minimizes hyperglycemia and hypoglycemia risk). The determined glucoregulatory hormone parameter is transmitted to the connected glucoregulatory hormone delivery system, which may include an automated insulin delivery (AID) system or a connected insulin pen system, for implementation. By integrating real-time physiological data with predictive metabolic modeling, the system enhances glucoregulatory hormone therapy, providing personalized adjustments to improve glucose control.
Owner:OREGON HEALTH & SCI UNIV

Closed-loop non-invasive insulin detection and precise infusion system

The invention relates to the technical field of intelligent diabetes treatment instruments, in particular to a closed-loop non-invasive insulin detection and precise infusion system which is characterized by comprising a blood glucose monitoring regulator, a non-invasive injector and a closed-loop control mechanism. The closed-loop control mechanism comprises a real-time blood glucose detection module, a temperature detection module, a blood glucose data processing module, a dose decision module, an injection pressure adjusting module, an injection channel control module, an insulin injection module and a closed-loop feedback module; noninvasive and high-sensitivity real-time blood glucose monitoring is achieved, the accuracy and timeliness of insulin administration are improved through trend prediction and individualized dose decision, meanwhile, multi-nozzle array piezoelectric needleless injection is combined with temperature compensation pressure regulation and a closed loop feedback correction mechanism, local tissue burden is effectively reduced, and the insulin administration efficiency is improved. And through multiple safety protection and wireless data transmission, remote monitoring and intelligent management are realized, so that the convenience, accuracy and reliability of blood glucose management of diabetic patients are greatly improved.
Owner:WUHAN UNIV

Blood glucose management system used in hospital

The invention discloses a blood glucose management system used in a hospital, which comprises at least one blood glucose monitoring device comprising a sensor and an emitter, the sensor is used for monitoring blood glucose data of a patient in real time, and the emitter is used for at least emitting blood glucose data information; a plurality of receivers, wherein any one of the plurality of receivers can be used for receiving and transferring the information transmitted by the transmitter; the central server comprises a memory and a communication interface and is used for communicating with external equipment and storing information from the external equipment; and the medical personnel use end equipment is used for communicating with the central server and displaying or checking the blood glucose data information. Due to the fact that any one of the receivers can receive the blood glucose data monitored by the blood glucose monitoring device and upload the blood glucose data to the central server, the activity range of a patient in a hospital is not limited any more, and meanwhile medical staff can conveniently know the blood glucose level of the patient in time and in real time.
Owner:MEDTRUM TECH

Blood glucose management system using continuous blood glucose monitoring device and extended reality glasses and blood glucose management method using the same

PCT designated stageWO2026049295A1Physical therapies and activitiesMedical data miningBlood glucose monitoring equipmentGlycemic management
A blood glucose management system is disclosed, comprising a user terminal configured to capture an image of food, a processor, and an information providing device configured to provide the processor with blood glucose time-series information of a user prior to ingestion of the food. The processor is configured to execute a step of generating blood glucose trend prediction information of the user after ingestion of the food, based on data related to the food captured by the user terminal and the blood glucose time-series information. The user terminal is configured to display the blood glucose trend prediction information.
Owner:SD BIOSENSOR INC

A method for preparing a starch-unsaturated fatty acid complex

PendingCN122375770ABiotechnologyGlycaemic index
The application discloses a preparation method of starch-unsaturated fatty acid compound. The method comprises the following steps: starch is pretreated by a debranching enzyme to obtain a debranched starch solution, the debranched starch solution is mixed with unsaturated fatty acid, an ethanol-water solution is added as a ball milling medium, a multi-stage ball milling parameter dynamic regulation process is adopted, and low-temperature protection, medium-temperature complexing and cooling solidification stage ball milling reactions are sequentially carried out, and finally, drying, crushing and sieving are performed to obtain the starch-unsaturated fatty acid compound. Through the synergistic effect of debranching enzyme pretreatment and multi-stage ball milling, the starch and the unsaturated fatty acid are efficiently compounded under mild conditions. The obtained compound has high compounding rate, high resistant starch content and excellent antioxidant stability. The compound can be used as a low-glycemic index functional food raw material and is used for preparing blood glucose management, weight control or antioxidant functional food. The method is mild, controllable and reproducible, does not need high temperature and high pressure, and meets the clean label consumption trend.
Owner:ZHEJIANG UNIV OF TECH

A glucose management and insulin dose adjustment assist dial for critically ill patients

PendingCN122376381AObstetricsCritically ill
This invention relates to the field of clinical medical and nursing device technology, specifically to an auxiliary turntable for blood glucose management and insulin dose adjustment in critically ill patients. It includes a base and a recommendation component. A support column is fixedly connected to the top of the base. The recommendation component includes a recommendation disc fitted outside the support column. A judgment component, including a judgment disc fitted outside the support column, is fitted outside the support column and is located on top of the recommendation cover. An identification component, including an identification disc fitted outside the support column, is fitted outside the support column. A base component, including a base disc fitted outside the support column, is located on top of the identification cover. Through the base, support column, and four sets of adjustment components, standardized and visual matching of multiple blood glucose indicators and insulin adjustment recommendations is achieved. Combined with three-color risk label strips, it quickly identifies abnormal blood glucose levels and fluctuation risks, enabling early detection and intervention, and reducing dose adjustment errors due to experience.
Owner:TONGJI HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI TECH

A method and apparatus for personalized insulin dose recommendation for diabetes patients

The application relates to the field of medical health data processing, and specifically provides a personalized insulin dose recommendation method and device for a diabetes patient, which has the following steps: S1, multi-source data preprocessing: collecting real-time dynamic data and static personalized parameters of the patient, performing outlier elimination, missing value completion, timestamp alignment and feature standardization processing on the data, and generating a time sequence matrix for input of an adaptive model; S2, constructing and training an LSTM-GRU blood glucose prediction model; S3, constructing and training a reinforcement learning dose decision model; and S4, closed-loop optimization and dose recommendation. Compared with the prior art, the application can significantly improve the accuracy and personalization degree of insulin dose recommendation, and provides reliable technical support for precise blood glucose management of the diabetes patient.
Owner:INSPUR ENTERPRISE CLOUD TECHNOLOGY (SHANDONG) CO LTD

Fluid delivery device and blood glucose management system

PendingCN121944296APromote the second movementrealization drivenPressure infusionFlow monitorsRatchetMedicine
The fluid conveying equipment comprises a medicine storage device, a rotating sleeve, a ratchet wheel, a ratchet wheel transmission part and a power assembly, and a piston rod of the medicine storage device is sleeved with the rotating sleeve in a threaded connection mode; the ratchet wheel is mounted on the rotating sleeve in a circumferential limiting manner; the ratchet wheel transmission part is elastically clamped on the tooth surface of the ratchet wheel; the power assembly is in transmission connection with the ratchet transmission part; wherein the power assembly has a first working mode and a second working mode for continuous operation, and in the first working mode, the power assembly drives the ratchet wheel transmission part to perform first movement and is in linkage with the ratchet wheel to rotate by a first angle in the preset direction; in the second working mode, the power assembly drives the ratchet wheel transmission part to conduct second movement and is in linkage with the ratchet wheel to rotate by a second angle in the preset direction. In this way, the structure of the fluid conveying equipment can be simplified, the size is reduced, and the control precision and reliability of the fluid conveying equipment during working are improved.
Owner:WUHAN UNITED IMAGING HEALTHCARE SURGICAL TECH CO LTD

Intelligent blood glucose management system for early warning and intervention of gestational diabetes mellitus

This invention relates to healthcare information processing technology and discloses an intelligent blood glucose management system for early warning and intervention of gestational diabetes mellitus. The system includes a data acquisition unit, a parameter mapping unit, and a state prediction unit. The data acquisition unit acquires gene polymorphism characteristic parameters and a continuous real-time blood glucose monitoring signal stream. The parameter mapping unit maps the characteristic parameters to the initial state transition matrix of the blood glucose prediction model and determines the process noise covariance matrix. The state prediction unit generates a blood glucose prediction trajectory, calculates the sliding variance of the residual sequence, and triggers covariance adaptive adjustment logic when the sliding variance continuously exceeds a preset threshold. By increasing the diagonal elements of the noise covariance matrix, the blood glucose prediction trajectory is corrected. This invention utilizes a statistically driven adaptive adjustment mechanism to effectively map the nonlinear evolution of the mother's physiological state, eliminate the mismatch between genetic priors and real-time monitoring data, and suppress false positive alarms.
Owner:FUZHOU KANGWEI NETWORK TECH CO LTD

Diabetes child glucose management system graphical user interface for electronic device

ActiveCN309819160SGraphical user interfaceDiabetes management
1.The name of the design product: graphical user interface of a diabetes child blood glucose management system of an electronic device. 2.The use of the design product: the design product is an electronic device. 3.The design points of the design product: the interface content of the graphical user interface in the screen. 4.The picture or photo that best indicates the design points: interface change state diagram 1. 5.The electronic device is a conventional design, and the rear view, left view, right view, top view, and bottom view are omitted. 6.The use of the graphical user interface: the design product is used to provide child diabetes management services for users. 7.The human-computer interaction mode of the graphical user interface: after entering the mobile phone number, password, and verification code in the main view, clicking the “login” button, displaying interface change state diagram 1; clicking the “custom AI recipe” button in interface change state diagram 1, displaying interface change state diagram 2; clicking the corresponding recipe picture in interface change state diagram 2, displaying interface change state diagram 3.
Owner:DALIAN NEUSOFT UNIV OF INFORMATION

Cooking control method, cooking control apparatus, and automatic cooking apparatus

PendingCN122110781AAdapt to blood sugar conditionsMeet blood sugar management needsProgramme control in sequence/logic controllersMedicineContinuous glucose monitoring
The application relates to a cooking control method, a cooking control device and an automatic cooking equipment, and belongs to the technical field of cooking control. The method is applied to the automatic cooking equipment and comprises the following steps: acquiring real-time blood glucose data collected by a continuous blood glucose monitoring device; based on the real-time blood glucose data, adjusting a cooking parameter of the automatic cooking equipment from a preset cooking parameter to a first cooking parameter; determining a predicted blood glucose change rate and an actual blood glucose change rate of the real-time blood glucose data; in response to an error between the actual blood glucose change rate and the predicted blood glucose change rate corresponding to the same time period exceeding a preset threshold, adjusting the cooking parameter of the automatic cooking equipment from the first cooking parameter to a second cooking parameter based on the error. The above method can automatically adjust the cooking parameter according to the real-time blood glucose data of a user and the blood glucose change rate of the real-time blood glucose data, accurately control the glycemic index of cooked food, adapt to the blood glucose condition of the user, and meet the blood glucose management demand of the user.
Owner:NINGBO FOTILE KITCHEN WARE CO LTD

Blood glucose management system for establishing wireless communication connection on basis of signal strength

PCT designated stageWO2026107791A1Connection managementGlycemic managementGlucose management
Disclosed in the present invention is a blood glucose management system for establishing a wireless communication connection on the basis of signal strength. A signal strength threshold is preset in a monitoring module and / or an infusion module; during a period when the monitoring module and / or the infusion module is powered on and sends a broadcast signal to the outside, a program module searches for a nearby broadcast signal and identifies the signal strength of the broadcast signal and the preset signal strength threshold carried therein; when the signal strength of the broadcast signal is not less than the preset signal strength threshold, the program module can establish a wireless communication connection with the monitoring module and / or the infusion module that sends the broadcast signal, without requiring the input of a device identifier of the monitoring module and / or the infusion module. Thus, the reliability of establishing a wireless communication connection between the program module and the patient's own monitoring module and / or infusion module is ensured.
Owner:MEDTRUM TECH

Methods and systems for promoting glucose management

Methods and systems for encouraging interactions with a glucose monitoring system include incrementing a score and / or providing a reward based on a variety of different interactions with the glucose monitoring system. The interactions which improve the score may include initiating or changing displays, downloading data, setting operational parameters and other interactions that are independent of a user's glucose measurements. Encouraging these interactions can enhance success in maintaining healthy glucose concentrations.
Owner:DEXCOM INC

Blood glucose management system for establishing wireless communication connection on basis of signal strength

PCT designated stageWO2026107790A1Medical devicesConnection managementComputer hardwareGlycemic management
Disclosed in the present invention is a blood glucose management system for establishing a wireless communication connection on the basis of signal strength. A signal strength threshold is preset in the blood glucose management system. During a period when a monitoring module and / or an infusion module is powered on and sends a broadcast signal, a program module searches for a nearby broadcast signal and identifies the signal strength of the broadcast signal. When the signal strength of the broadcast signal is not less than the preset signal strength threshold, the program module can establish a wireless communication connection with the monitoring module and / or the infusion module that sends the broadcast signal, without the need to input a device identifier of the monitoring module and / or the infusion module. Moreover, since the broadcast signal identified by the program module is sufficiently strong, it means that the program module is in proximity to the monitoring module and / or the infusion module that sends the broadcast signal, thereby ensuring the reliability of the program module establishing a wireless communication connection with a patient's own monitoring module and / or infusion module.
Owner:MEDTRUM TECH

A postprandial blood glucose suppressing composition containing inactivated AKK and its use

PendingCN122320228AGlycemic managementBULK ACTIVE INGREDIENT
This invention belongs to the technical field of functional foods for blood glucose management, specifically relating to a postprandial blood glucose-suppressing composition containing inactivated Akkermansia myxophilus. Existing blood glucose control products have limited effectiveness or significant side effects. The composition of this invention contains inactivated Akkermansia myxophilus and blood glucose-lowering active ingredients such as mulberry leaf extract and chromium yeast. This invention achieves the effects of reducing postprandial blood glucose peaks and improving glucose metabolism through a dual mechanism of slowing carbohydrate absorption and improving insulin sensitivity. The composition of this invention is stable at room temperature and can be formulated into tablets or capsules.
Owner:HAINAN XUNLONG INTERNET TECHNOLOGY CO LTD

A post-exercise recovery class sports nutrition food composition for glycemic management and a preparation method thereof

PendingCN122271531ABiotechnologyPhysiology
This invention discloses a sports nutrition food for post-exercise recovery and blood glucose management. Each 40g portion contains Astragalus membranaceus extract, Dioscorea opposita extract, white kidney bean extract, mulberry leaf extract, L-arabinose, cinnamon extract, whey protein peptides, and a mineral-vitamin-probiotic premix. This invention utilizes a six-fold blood glucose control pathway through a four-mineral glucose control matrix, triple carbohydrate blocking, probiotics, and dual tonification of Qi and Yin with traditional Chinese medicine. Animal experiments showed that the fasting blood glucose level in the full-formula group decreased to 6.3 mmol / L, significantly better than the control group (*p*<0.05). All ingredients comply with national standards for sports nutrition foods and are safe and compliant.
Owner:文有华

Triple GIP / GLP-1 / glucagon peptide conjugates and methods of use

Provided herein are peptides and peptide conjugates having activity as triple agonists of the glucose-dependent insulinotropic polypeptide (GIP) receptor, the glucagon-like peptide 1 (GLP-1) receptor, and the glucagon (GCG) receptor. The peptide conjugates provided herein are cross-linked via a half-life extending staple. The peptides and peptide conjugates may be used for blood glucose management and treating conditions such as diabetes mellitus, obesity, dyslipidemia, metabolic syndrome, and metabolic dysfunction-associated steatohepatitis (MASH).
Owner:THE SCRIPPS RES INST

Compositions and uses for increasing biometabolism

PCT designated stageWO2026019959A1Organic active ingredientsMetabolism disorderNormal blood glucosePhysiology
Disclosed herein are compositions and uses for healthy weight management by providing a consumable composition comprising N-trans-caffeoyltyramine and N-transferuloyltyramine. Some embodiments provide for glucose management in a subject. Some embodiments provided include, for example, the consumable composition capable of supporting abdominal fat loss, visceral fat loss, maintaining lean body mass, and supporting normal blood glucose regulation.
Owner:BRIGHTSEED INC

Diabetes and pre-diabetes self-management system based on ai and cgm

ActiveCN121641459BHigh biological confidenceAmple room for dynamic adjustmentMedical data miningEnsemble learningDiseaseAdaptive learning
The application relates to the technical field of healthcare informatization, in particular to a diabetes and pre-diabetes patient self-management system based on AI and CGM, which comprises the following steps: delaying and aligning CGM blood glucose flow and multi-modal physiological signals through a signal acquisition and synchronization module; dynamically adjusting a trigger threshold for different disease courses to identify suspected events by using an intelligent event trigger module; combining medical prior rules and an integrated classification model to perform joint discrimination by a hybrid consistency verification engine, and outputting a consistency probability; and cooperating with a hierarchical decision mechanism of an interaction module and online incremental learning of an adaptive learning module to optimize individual parameters. Therefore, the diabetes and pre-diabetes patient self-management system solves frequent false alarms caused by the inherent physiological delay, signal drift and other physical limitations of the CGM sensor, and the resulting patient alarm fatigue and decreased compliance, and provides more stable and personalized dynamic blood glucose management support for active people such as pre-diabetes patients.
Owner:AFFILIATED HOSPITAL OF CHENGDU UNIV (CHENGDU INST OF TRAUMATOLOGY & ORTHOPEDICS)

Blood glucose management method and related electronic device

This application discloses a blood glucose management method and a related electronic device. In the method, meal time of a diet event of a user can be determined based on a blood glucose value of the user, and when a blood glucose curve drawn based on blood glucose values of the user is displayed, the meal time and / or a blood glucose value related to the meal time are / is displayed on the blood glucose curve. In this way, the diet event of the user can be associated with blood glucose of the user, and a blood glucose change of the user before and after a meal can be highlighted. This helps the user more intuitively learn of impact of a diet on the blood glucose, and helps the user manage and control the blood glucose starting from the diet.
Owner:HUAWEI TECH CO LTD

Blood glucose information display method and device, electronic equipment and storage medium

The invention relates to a blood glucose information display method and device, electronic equipment and a storage medium. The blood glucose information display method comprises the steps that a blood glucose curve of continuous glucose monitoring information of a user is displayed on a display interface of a display terminal; configuring a data component of the blood glucose curve and operation information of data display operation of the data component on a display interface; configuring an event part of the blood glucose curve and operation information of event display operation of the event part on a display interface; responding to the data display operation through the data component, acquiring blood glucose data corresponding to the data display operation, and displaying the acquired blood glucose data; and responding to the event display operation through the event component, obtaining event information associated with the event display operation, and displaying the associated event information. According to the method, the blood glucose data and the related event information of the user can be displayed on the blood glucose display page in an associated mode, the user and related parties are helped to efficiently trace the blood glucose change track, fluctuation causes are accurately positioned, and convenience and accuracy of blood glucose management are remarkably improved.
Owner:MICRO TECH MEDICAL HANGZHOU CO LTD

Blood glucose management system using non-invasive blood glucose measurement

Disclosed is a blood glucose management system using non-invasive blood glucose measurement. A blood glucose management system using non-invasive blood glucose measurement according to an embodiment of the present invention comprises: a non-invasive blood glucose diagnosis device which detects an electrical signal by means of contact with a finger of a user and calculates a blood glucose value by applying a preset blood glucose calculation process to the detected electrical signal; and a user terminal device which receives the calculated blood glucose value from the non-invasive blood glucose diagnosis device and generates customized blood glucose information for the user on the basis of the blood glucose value. The customized blood glucose information includes blood glucose management information, diet therapy information, and exercise therapy information corresponding to a preset management period.
Owner:KIM YOUNG JOON

Blood glucose management system providing data intercommunication

PendingCN121620806ADrug and medicationsBiological testingOut of hospitalGlycemic management
The invention discloses a blood glucose management system providing data intercommunication, which comprises a blood glucose management system used in a hospital and a blood glucose management system used outside the hospital, and establishes communication connection between a central server of the blood glucose management system in the hospital and a central server of the blood glucose management system outside the hospital. According to the method, missing blood sugar historical data can be complemented mutually, when the patient is in hospital and after the patient is discharged from hospital, a medical worker, the patient, a guardian or a doctor who sees a doctor outside the hospital can obtain a complete blood sugar historical record, and a rapid and effective treatment and rehabilitation scheme can be formulated conveniently.
Owner:MEDTRUM TECH

Low-glycemic five-black Chinese wolfberry fruit sesame ball and production process thereof

PendingCN121845239AAddressing health burdensLowered glycemic index of foodsLipidic food ingredientsFood ingredient functionsBiotechnologyPumpkin seed
The invention relates to the technical field of food, in particular to a low-glycemic five-black-wolfberry-sesame ball and a production process thereof.The low-glycemic five-black-wolfberry-sesame ball is characterized in that the low-glycemic five-black-wolfberry-sesame ball is prepared from, by weight, 27%-45% of black sesame, 20%-30% of wolfberry, 9%-15% of mulberries, 8%-12% of peeled walnut kernels, 8%-12% of pumpkin seeds, 4%-8% of red date particles, functional adhesives and flavor auxiliary materials; the maltitol liquid and the liquid polydextrose are adopted to construct a composite sugar substitute bonding system, the food blood glucose generation index (GI value) of the product is successfully reduced to 32, compared with a traditional sesame ball with honey or granulated sugar as an adhesive, the sesame ball keeps high protein and high dietary fiber, greatly slows down fluctuation of postprandial blood glucose, and has the advantages of being good in stability and good in stability. A healthy food which not only can nourish bodies but also has a blood glucose management function can be provided for diabetic patients, hyperglycemia crowds and blood-glucose-controlling and fat-reducing crowds, and the health burden caused by too high sugar content of a traditional tonic is solved.
Owner:JIN JIA ZHUANG HUIZHOU HEALTHY FOOD +1

Insulin soluble microneedle patch and preparation method thereof

The invention relates to the technical field of biological medicine and drug delivery devices, in particular to an insulin-soluble microneedle patch and a preparation method thereof.The microneedle patch is made of a composite matrix material of carboxymethylated hyaluronic acid and chitosan and is of a core-shell type partition structure; the microneedle comprises a quick-release shell layer containing free insulin and a slow-release inner core layer containing an insulin microcarrier, and a cross-linking density gradient belt is arranged at the interface of the quick-release shell layer and the slow-release inner core layer. The cross-linking degree in the gradient zone is monotonically decreased from the inner core to the outer shell, and the gradient zone is formed in situ by utilizing chemical potential difference to induce a cross-linking agent to diffuse through a step-by-step centrifugal casting process. Water permeation is limited step by step by utilizing the gradient structure, a double-phase drug delivery mode of'fast release per meal + basic slow release 'is successfully realized, interlayer separation and drug burst release risks of a traditional multi-layer micro-needle are effectively eliminated, and the multi-layer micro-needle is high in mechanical strength and suitable for all-weather blood glucose management of diabetic patients.
Owner:ARTIFACT R&D (SUZHOU) CO LTD