The invention relates to a feedback fuzzy inference-based unmanned plane real-time route planning method. The method comprises the following steps of: 1, updating a mode of the unmanned plane route; 2, establishing a fuzzy rule base; 3, acquiring a fuzzy antecedent; 4, designing a feedback fuzzy inference method; 5, defuzzifying; 6, determining other parameters; 7, determining the next position of the unmanned plane; and 8, completing the design. Compared with the conventional unmanned plane real-time route planning method, the method ensures that the unmanned plane has primary independent studying capability by applying the feedback fuzzy inference method so as to improve the route planning effect. The real-time route planning method designed according to the method has the advantages of short route, smooth path, global astringency and easy implementation, and is a more practical and reliable unmanned plane real-time route planning method for engineering application.