The invention relates to a word sense disambiguation method fusing a sentence local context with document domain information, and belongs to the technical field of natural language processing. The word sense disambiguation method comprises the steps of: 1, carrying out dependency grammar analysis on a sentence where an ambiguous word is positioned, and obtaining sentence local context related words with a direct dependency relationship with the ambiguous word; 2, carrying out dependency grammar analysis on a domain document set, collecting all dependency tuples which the domain document set contains, and constructing a dependency tuple library; 3, carrying out statistic analysis on the dependency tuple library, and finding a group of domain related words with the closest relationship with the ambiguous word; 4, according to a dependency distribution similarity of the domain related words and word sense relevance between the domain related words and the local context, determining disambiguation weights of the domain related words; 5, merging the sentence local context related words with the domain related words, and constructing a related word set; and 6, according to weighted accumulation relevance of each word sense of the ambiguous word and the related word set, judging a correct word sense. According to the method disclosed by the invention, adaptability of a word sense disambiguation system on a specific domain can be improved, and disambiguation accuracy can be improved.