The invention provides a voice noise reduction method for a conference terminal based on the neural network model. The method comprises steps that S1, an audio file is collected by the conference terminal device to generate a digital audio signal in the time domain; S2, the digital audio signal is framed, and short-time Fourier transform is performed; S3, the amplitude spectrum of the frequency domain is mapped into a frequency band, and a Mel-frequency cepstral coefficient is further solved; S4, first-order and second-order differential coefficients are calculated through utilizing the Mel-frequency cepstral coefficient, a pitch correlation coefficient is calculated on each frequency band, and pitch period features and VAD features are further extracted; S5, input characteristic parameters of an audio are used as the input of the neural network model, the neural network is trained offline, the frequency band gain generating the noise reduction speech is learned, and the trained weightis solidified; S6, the neural network model is utilized to learn, the frequency band gain is generated, the outputted frequency band gain is mapped to the spectrum, the phase information is added, and a noise reduction speech signal is reduced through inverse Fourier transform. The method is advantaged in that real-time noise reduction can be achieved.