The invention discloses a highly effective feed mixing preparation device special for aquaculture. The device includes a base plate, a stirring drum, T-shaped supporting rods, an electric motor, a first rotating shaft, a first belt pulley, a belt, a second belt pulley, a second rotating shaft, stirring rods, a third gear, an outer gear ring, a cam, a discharging board, a solid feed drum and a liquid feed drum. According to the invention, the electric motor, the first rotating shaft, the third gear, the outer gear ring, the first belt pulley, the belt, the second belt pulley and the second rotating shaft are arranged to work together to drive the stirring rods and the stirring drum rotating reversely so as to improve stirring and mixing efficiency. With the arrangement of a first gear, a second gear, a third rotating shaft and helical blades, feed at the bottom of the stirring drum is brought upward and moves to the bottom of the stirring drum under the effect of gravity; and after continuous cycles, the stirring and mixing efficiency is further improved. The arrangement of the cam and the discharging board realizes intermittent discharging and avoids the problems of incomplete and uneven stirring and mixing caused by discharging feed too fast and too much under the condition of continuous discharging.