An electric field enhancement guidance system based on the natural cavity of the human body and its application

Abstract

The present invention discloses an electric field enhancement guidance system based on the human body's natural cavities, comprising: an electric field guidance component for guiding the electric field of an external electrode deep into the human body; the electric field guidance component comprising a field-guiding electrode partially positioned within the human body's natural cavities and a field-guiding body, the field-guiding electrode being located at one end of the field-guiding body proximal to the human body's natural cavities; the field-guiding electrode comprising a field-guiding electrode body and a connecting electrode located at an end of the field-guiding body opposite the field-guiding electrode and proximal to the outer end of the human body's natural cavities; one or more second auxiliary electrodes positioned on the surface of human skin; the connecting electrode and the second auxiliary electrodes cooperating to form an electric field system. Also disclosed is the application of the electric field enhancement guidance system based on the human body's natural cavities in a tumor electric field therapy device. By utilizing the human body's natural cavities, the electric field is guided to a desired location within the body, resulting in a non-invasive treatment with improved therapeutic effects. The system is also larger in size, lacks a noticeable tip, and provides a larger heat distribution surface, preventing localized overheating and improving patient tolerance.

Description

Technical Field

[0001] The present invention relates to the technical field of tumor electric field therapy, and in particular to an electric field enhancement guidance system based on natural cavities of the human body and its application in tumor electric field therapy equipment. Background Art

[0002] During the use of electric fields to treat tumors, the field strength is greatest near the electrode edge and rapidly decreases as it penetrates deeper into the body. This results in the field strength at the tumor site being much weaker than near the electrode, significantly reducing the therapeutic effect.

[0003] Existing electric field guiding devices are implemented by placing electrodes on the skin surface around the head or implanting field guiding components into the human body.

[0004] For example Figure 1 Shown is a schematic diagram of the brain's electric field in a commonly used treatment mode, in which the electrodes are located on the surface of the skin around the head, so the electric field strength reaching the tumor site is relatively small.

[0005] Attachment Figure 2 Shown is a schematic diagram of the brain electric field in an implantable field-guiding mode, in which the electrodes are located on the surface of the skin around the head. When the electric field-guiding component is implanted in the brain, part of the electric field is guided into the brain tissue, thereby increasing the electric field strength reaching the tumor site.

[0006] However, the existing electric field guiding device has the following technical defects:

[0007] 1. As brain implants, electric field guidance devices are relatively small due to the limitations of human rejection and the lack of impact on brain function.

[0008] 2. In addition, in order to achieve the effect of guiding the therapeutic electric field from the body surface into the human body, the field guiding member needs to have a certain length. Therefore, the shape of the electric field guiding device is usually preferably a small and slender type, which leads to the following problems:

[0009] (1) The limited materials of the electric field guiding device implant cannot select materials with better field conducting properties;

[0010] (2) The electric field is mostly concentrated at the smaller tip of the electric field guidance device implant, where the field intensity is the highest, resulting in significant local heating at the tip. In addition, the nerves inside the brain tissue where the electric field guidance device implant is located are sensitive and have poor heat resistance.

[0011] (3) Brain implants are risky and traumatic, leading to poor patient acceptance;

[0012] (4) The implant cannot directly contact the external electrode, and the field guidance effect is reduced. Summary of the Invention

[0013] The purpose of the present invention is to provide an electric field enhancement guidance system based on the natural cavity of the human body and its application in tumor electric field treatment equipment. By utilizing the natural cavity of the human body, the electric field is guided to the desired position inside the body to improve the treatment effect.

[0014] The first aspect of the present invention is to provide an electric field enhancement guidance system based on the natural cavity of the human body, comprising:

[0015] An electric field guiding member is used to guide the electric field of the external electrode deep into the human body; the electric field guiding member includes a field conducting electrode partially placed in the natural cavity of the human body;

[0016] The field conducting electrode comprises a field conducting electrode body and a connecting electrode provided at one end of the field conducting electrode body and close to the outer end of a natural cavity of a human body;

[0017] One or more second auxiliary electrodes, placed on the surface of human skin;

[0018] The connecting electrode and the second auxiliary electrode cooperate to form an electric field system.

[0019] Preferably, the electric field guiding component is divided into three sections corresponding to three layers of human tissue, and different substances can be selected to test different modes in each section.

[0020] Preferably, the electric field guiding member is in the form of a spoon or a lollipop.

[0021] Preferably, the plurality of second auxiliary electrodes are used to form one or more electric fields perpendicular to the distribution plane of the electrodes in the single-direction treatment mode.

[0022] Preferably, the electric field guiding member is made of a material with a relative dielectric constant of 10,000 or more.

[0023] Preferably, the top of the electric field guiding member contacts the inner wall of the human body, and the edge of the electric field guiding member is at a certain distance from the inner wall of the human body, so as to obtain the best electric field guiding effect.

[0024] Preferably, the field conductor body is made of a material with a relative dielectric constant of more than 10,000, and comprises a top and a rear portion, wherein the rear portion is wrapped in an insulating ring.

[0025] Preferably, the connecting electrode is located at the bottom of the electric field guiding component and close to the outer end of the natural cavity of the human body; the bottom is directly connected to the treatment electrode for use.

[0026] Preferably, the insulating ring is used to isolate the rear half of the field conductor electrode from contact with human tissue, and is made of a low relative dielectric constant insulating material close to air with a certain thickness. The low relative dielectric constant insulating material close to air includes FR4 or PTFE polytetrafluoroethylene material.

[0027] The second aspect of the present invention is to provide an application of an electric field enhancement guidance system based on natural cavities of the human body in a tumor electric field treatment device.

[0028] The system device and its application provided by the present invention have the following beneficial technical effects:

[0029] (1) By utilizing the natural cavities of the human body, the electric field guiding component can enter the human body without obstacles, and the electric field concentrated on the electrode part on the surface of the human body can be introduced into the human body. Without additional trauma, the electric field intensity reaching the tumor location and area inside the human body can be increased. The adjustment of the contact method is more acceptable to patients, which is conducive to further improving and enhancing the treatment effect;

[0030] (2) Compared with implants, direct contact with external electrodes has better electric field guidance effect, is larger in size, has no obvious tip, has a larger heat distribution surface, will not cause local overheating, and the nerves in the natural cavity are less sensitive, so patients have better tolerance. The heat resistance of the human body's natural cavity is better than that of implants, and treatment can last longer;

[0031] (3) The position of the electrode patch not connected to the field conduction electrode is adjustable, which facilitates adjustment of the treatment position;

[0032] (4) The field conductive electrodes are made of conventional materials and are more versatile;

[0033] (5) An insulating ring is provided around the field conductor electrode to better guide the electric field to the tumor location;

[0034] (6) The field guide is easy to replace, which helps to select materials with better guiding effects. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] In order to more clearly illustrate the specific embodiments of the present invention or the technical solutions in related technologies, the following briefly introduces the drawings required for use in the specific embodiments or related technical descriptions. Obviously, the drawings described below are some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0036] Figure 1 A schematic diagram of brain electric fields according to a commonly used treatment mode in the prior art;

[0037] Figure 2 Schematic diagram of the brain electric field of an implantable field-guided mode according to the prior art;

[0038] FIG3( a ) is a schematic diagram illustrating the placement of an oral cavity field guide using the oral cavity in a natural cavity of the human body as an example according to the first embodiment of the present invention;

[0039] FIG3( b ) is a schematic diagram of the brain electric field in the oral field conduction mode provided by the first embodiment of the present invention;

[0040] Figure 4 A schematic diagram and principle diagram of the placement of an oral cavity guide provided in the second embodiment of the present invention, taking another oral cavity in the human body as an example;

[0041] Figure 5 A three-dimensional diagram of the overall structure of the simulation model provided by an embodiment of the present invention;

[0042] Figure 6 A schematic cross-sectional view of the overall structure of a simulation model provided by an embodiment of the present invention;

[0043] FIG7(a) is a schematic diagram of the electric field distribution when the relative permittivity is 1 according to an embodiment of the present invention; FIG7(b) is a schematic diagram of the electric field distribution when the relative permittivity is 10 according to an embodiment of the present invention; FIG7(c) is a schematic diagram of the electric field distribution when the relative permittivity is 100 according to an embodiment of the present invention; FIG7(d) is a schematic diagram of the electric field distribution when the relative permittivity is 1000 according to an embodiment of the present invention; FIG7(e) is a schematic diagram of the electric field distribution when the relative permittivity is 10000 according to an embodiment of the present invention;

[0044] Figure 8 This is a field strength table of test points for field conduction of materials with different relative dielectric constants provided by an embodiment of the present invention.

[0045] FIG9(a) is a schematic diagram of the electric field distribution when the field guide provided by an embodiment of the present invention fully occupies the interior of the cavity; FIG9(b) is a schematic diagram of the electric field distribution when a 9mm field guide provided by an embodiment of the present invention is placed in the oral cavity and touches the bottom with air remaining at the edge; FIG9(c) is a schematic diagram of the electric field distribution when an 8mm field guide provided by an embodiment of the present invention is placed in the oral cavity and touches the bottom with air remaining at the edge; FIG9(d) is a schematic diagram of the electric field distribution when a 5mm field guide provided by an embodiment of the present invention is placed in the oral cavity and touches the bottom with air remaining at the edge; FIG9(e) is a schematic diagram of the electric field distribution when a 3mm field guide provided by an embodiment of the present invention is placed in the oral cavity and touches the bottom with air remaining at the edge; FIG9(f) is a schematic diagram of the electric field distribution when the top of the field guide provided by an embodiment of the present invention does not contact the human body;

[0046] Figure 10 This is a field strength table of the field strength test points when the top of the field guide provided by the embodiment of the present invention is in contact with the edge at different distances from the inner wall of the oral cavity.

[0047] Figure 11 A field strength table showing the field strength test points when the top of the field guide provided in an embodiment of the present invention contacts the inner wall of the oral cavity.

[0048] FIG12(a) is a schematic diagram of the electric field distribution when the head is intact according to an embodiment of the present invention; FIG12(b) is a schematic diagram of the electric field distribution when the field guide is partially implanted in brain tissue according to an embodiment of the present invention;

[0049] Figure 13 Schematic diagram of field strength at test points in different field conduction modes provided by an embodiment of the present invention.

[0050] Figure 14 A schematic structural diagram of an electric field guiding component provided in an embodiment of the present invention. DETAILED DESCRIPTION

[0051] The technical solution of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the embodiments described are only some embodiments of the present invention, not all embodiments. All other embodiments obtained by ordinary technicians in this field based on the embodiments of the present invention without making any creative efforts shall fall within the scope of protection of the present invention.

[0052] In the description of the present invention, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings and are intended solely to facilitate and simplify the description of the present invention. They are not intended to indicate or imply that the devices or components referred to must have, be constructed, or operate in a specific orientation, and therefore should not be construed as limitations on the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0053] In the description of the present invention, it should be noted that, unless otherwise expressly specified or limited, the terms "mounted," "connected," and "connected" should be understood in a broad sense. For example, they may refer to fixed, detachable, or integral connections; mechanical or electrical connections; direct or indirect connections through an intermediate medium; and internal communication between two components. Those skilled in the art will understand the specific meanings of the above terms in the present invention based on the specific circumstances.

[0054] As shown in Figure 3(a) and Figure 3(b) and Figure 4 As shown, this embodiment provides an electric field enhancement guidance system based on the natural cavity of the human body, including:

[0055] An electric field guiding member is used to guide the electric field of the external electrode deep into the human body; the electric field guiding member includes a field guiding electrode partially placed in the natural cavity of the human body; the field guiding electrode includes a field guiding electrode body and a connecting electrode arranged at one end of the field guiding electrode body and close to the outer end of the natural cavity of the human body;

[0056] In this embodiment, the electric field guiding component is divided into three sections corresponding to three layers of human tissue, and different substances can be selected to test different modes in each section.

[0057] In this embodiment, the electric field guiding member is in the shape of a spoon or a lollipop. Of course, those skilled in the art should know that other appropriate guiding member forms may also be used.

[0058] The field conducting electrode comprises a field conducting electrode body and a connecting electrode (electrode 2 shown in FIG3 , or electrode 2 shown in FIG3 ) arranged at one end of the field conducting electrode body and close to the outer end of the natural cavity of the human body. Figure 4 Electrode 3 shown);

[0059] One or more second auxiliary electrodes (electrode 1 shown in FIG3 , or Figure 4 The electrodes 1 and 2 shown are placed on the surface of human skin;

[0060] The connecting electrode and the second auxiliary electrode cooperate to form an electric field system.

[0061] As a preferred embodiment, Figure 4 As shown, the plurality of second auxiliary electrodes are used to form one or more electric fields perpendicular to the distribution plane of the electrodes in the single-direction treatment mode.

[0062] FIG3 (a) takes the oral cavity in the human body as an example, showing a schematic diagram of the placement of the oral cavity field guide. The field guide component is placed in the cavity, and the connecting electrode and the second auxiliary electrode are respectively located on the outer end of the field guide near the oral cavity and the skin surface of the top of the head (usually on the skin surface of the skull, FIG3 shows that they are located on either side of the skull skin). Figure 4 The figure shows the skull skin on opposite sides centered on the tumor), guiding the electric field into the body (i.e., the head tissue). By setting field strength test points at the tumor location, it can be determined that the electric field strength at the tumor site can be enhanced to improve the treatment effect.

[0063] Figure 3(b) shows the implantable field guide mode. Without increasing the number of electrodes, an electric field guide component is placed in the oral cavity. The electrodes are located on the skin surface of the top of the head and the field guide is close to the outer end of the oral cavity. This is a schematic diagram of the brain electric field. Most of the electric field is guided into the brain tissue, and the electric field intensity reaching the tumor site is greater.

[0064] like Figure 4 The figure shows that without affecting the distribution of electrodes in the commonly used treatment mode, electric field guiding components and electrodes are placed in the oral cavity. While enhancing the electric field strength reaching the tumor site, the electric field perpendicular to the distribution plane of electrodes in the commonly used treatment mode is increased, so that more electric field directions reach the tumor location, further enhancing the treatment effect.

[0065] In this embodiment, the field-guiding effect of the electric field-enhanced guidance system based on the natural human cavity was determined by simulating the human head structure. Using the simulation software Comsol, a simulation model was established. The electric field intensity at the tumor site was tested under different field-guiding conditions at the cavity site, with the same voltage applied to the ceramic electrodes at both ends (+40V and -40V, respectively). The effectiveness of the field-guiding effect was compared.

[0066] 1. Establishing a simulation model

[0067] like Figure 5 Shown is a three-dimensional diagram of the overall structure of the simulation model; Figure 6 The figure shows a cross-section of the overall structure of the simulation model.

[0068] In this embodiment, Figure 6 The simulation model simulates the overall structure of the human head model, including: skin layer, skull layer, head tissue layer, oral cavity, field guide placed inside the oral cavity, recurrent glioblastoma on the head, and two electrodes (electrode 1 and electrode 2). Among them:

[0069] 1. Electrode 1: Ceramic electrode in contact with the top of the human head, with a radius of 8mm and a thickness of 3mm;

[0070] 2. Electrode 2: The contact field is conducted against the ceramic electrode at the outer end of the oral cavity, with a radius of 8 mm and a thickness of 3 mm;

[0071] 3. Skin layer: simulates the skin on the surface of the human head, with a radius of 106mm, a thickness of 3mm, and a gap at the mouth position. Different modes are tested according to the filling material;

[0072] 4. Skull layer: simulates the human head skeleton, with a radius of 103mm, a thickness of 3mm, and a gap at the mouth position. Different modes are tested according to the filling material;

[0073] 5. Head tissue layer: simulates the internal tissue of the human head, with a radius of 100mm and a gap at the oral position. Different modes are tested according to the filling material.

[0074] 6. Tumor: simulates the location of tumor in the human brain;

[0075] 7. Oral cavity: simulates the natural cavity of the human head oral cavity, with a radius of 10mm and a depth of 8.6mm;

[0076] 8. Field guide: The electric field guide component in the natural cavity guides the external electrode electric field deep into the human body. It is divided into three sections corresponding to the three layers of human tissue. Different substances can be selected to test different modes in each section.

[0077] 9. Field strength test point: Take a point on the tumor surface to test the electric field strength at that point. When the voltage of the electrodes at both ends of the surface is fixed, the electric field strength at this test point can reflect the effect of the field guide in guiding the electric field to the tumor site.

[0078] 2. Material selection of electric field guiding components

[0079] 1. Figure 7(a) is a schematic diagram of the electric field distribution when the field guide has a relative dielectric constant of 1. In Figure 7(a), when the field guide is made of a material with a relative dielectric constant of 1, the electric field distribution in the brain is shown. The white part has a high electric field, and the black part has a low electric field. The air in the mouth is displayed on both sides of the field guide in white.

[0080] The top of the 8mm field guide in the oral part contacts the human body and a 2mm thick air space is left at the edge. The materials of the three sections of the oral position from the outside to the inside are: field guide, field guide, and field guide;

[0081] A voltage was applied across the electrodes, and the field strength test point in the tumor area detected a field strength of 2.4124 V / m.

[0082] 2. Figure 7(b) is a schematic diagram of the electric field distribution when the field guide has a relative dielectric constant of 10. In Figure 7(b), when the field guide is made of a material with a relative dielectric constant of 10, the electric field distribution in the brain is shown. The white part has a high electric field, and the black part has a low electric field. The air in the mouth is displayed in white on both sides of the field guide.

[0083] The top of the 8mm field guide in the oral part contacts the human body and a 2mm thick air space is left at the edge. The materials of the three sections of the oral position from the outside to the inside are: field guide, field guide, and field guide;

[0084] A voltage was applied across the electrodes, and the field strength test point in the tumor area detected a field strength of 3.4699 V / m.

[0085] 3. Figure 7(c) is a schematic diagram of the electric field distribution when the field guide has a relative dielectric constant of 100. In Figure 7(c), when the field guide is made of a material with a relative dielectric constant of 100, the electric field distribution in the brain is shown. The white part has a high electric field, and the black part has a low electric field. The air in the mouth is displayed on both sides of the field guide, which is white.

[0086] The top of the 8mm field guide in the oral part contacts the human body and a 2mm thick air space is left at the edge. The materials of the three sections of the oral position from the outside to the inside are: field guide, field guide, and field guide;

[0087] A voltage was applied across the electrodes, and the field strength test point in the tumor area detected a field strength of 6.3582 V / m.

[0088] 4. Figure 7(d) is a schematic diagram of the electric field distribution when the field guide has a relative dielectric constant of 1000. In Figure 7(d), when the field guide is made of a material with a relative dielectric constant of 1000, the electric field distribution in the brain is shown. The white part has a high electric field, and the black part has a low electric field. The air in the mouth is displayed on both sides of the field guide in white.

[0089] The top of the 8mm field guide in the oral part contacts the human body and a 2mm thick air space is left at the edge. The materials of the three sections of the oral position from the outside to the inside are: field guide, field guide, and field guide;

[0090] A voltage was applied across the electrodes, and the field strength test point in the tumor area detected a field strength of 16.624 V / m.

[0091] 5. Figure 7(e) is a schematic diagram of the electric field distribution when the field guide has a relative dielectric constant of 10,000. In Figure 7(e), when the field guide is made of a material with a relative dielectric constant of 10,000, the electric field distribution in the brain is shown. The white part has a high electric field, and the black part has a low electric field. The air in the mouth is displayed in white on both sides of the field guide.

[0092] The top of the 8mm field guide in the oral part contacts the human body and a 2mm thick air space is left at the edge. The materials of the three sections of the oral position from the outside to the inside are: field guide, field guide, and field guide;

[0093] A voltage was applied across the electrodes, and the field strength test point in the tumor area detected a field strength of 21.56 V / m.

[0094] according to Figure 7(a)-Figure 7(e) draw Figure 8 Table of field strength at test points when conducting electric field using materials with different relative dielectric constants. A comparison shows that field conducting materials with higher relative dielectric constants are more effective at guiding electric fields. The relative dielectric constant of ceramic materials used in ceramic electrodes can reach over 10,000.

[0095] Therefore, as a preferred embodiment, the electric field guide member is made of a material having a relative dielectric constant of 10,000 or more.

[0096] As a preferred embodiment, the connecting electrode and the one or more second auxiliary electrodes are ceramic electrodes, and the relative dielectric constant of the ceramic material used is greater than 10,000.

[0097] 3. Selection of contact method for electric field guiding components

[0098] 1. Figure 9(a) shows the electric field distribution when the field guide fills the cavity. As shown in Figure 9(a), the oral cavity is full, and the materials of the three field guide positions from the outside to the inside are field guide, field guide, and field guide respectively;

[0099] A voltage was applied across the electrodes, and the field strength test point in the tumor area detected a field strength of 7.2665 V / m.

[0100] 2. Figure 9(b) shows the electric field distribution when a 9mm field guide is placed in the mouth, touching the bottom and leaving air around the edges. As shown in Figure 9(b), the top of the 9mm field guide in the mouth is in contact with the human body, with 1mm of air around the edges. The materials of the three sections of the field guide from the outside to the inside are field guide, field guide, and field guide, respectively.

[0101] A voltage was applied across the electrodes, and the field strength test point in the tumor area detected a field strength of 15.079 V / m.

[0102] 3. Figure 9(c) shows the electric field distribution when an 8mm field guide is placed in the mouth and touches the bottom, with air remaining at the edges. As shown in Figure 9(c), the top of the 8mm field guide in the mouth touches the human body, with 2mm of air remaining at the edges. The materials of the three sections of the field guide from the outside to the inside are field guide, field guide, and field guide, respectively.

[0103] A voltage was applied across the electrodes, and the field strength test point in the tumor area detected a field strength of 16.624 V / m.

[0104] 4. Figure 9(d) shows the electric field distribution when a 5mm field guide is placed in the mouth and touches the bottom, with air remaining at the edges. As shown in Figure 9(d), the top of the 5mm field guide in the mouth touches the human body, with 5mm of air remaining at the edges. The materials of the three sections of the field guide from the outside to the inside are field guide, field guide, and field guide, respectively.

[0105] A voltage was applied across the electrodes, and the field strength test point in the tumor area detected a field strength of 14.783 V / m.

[0106] 5. Figure 9(e) shows the electric field distribution when a 3mm field guide is placed in the mouth and touches the bottom, with air remaining at the edges. As shown in Figure 9(e), the top of the 3mm field guide in the mouth touches the human body, with 7mm of air remaining at the edges. The materials of the three sections of the field guide from the outside to the inside are field guide, field guide, and field guide, respectively.

[0107] A voltage was applied across the electrodes, and the field strength test point in the tumor area detected a field strength of 7.9764 V / m.

[0108] 6. Figure 9(f) shows the electric field distribution when the top of the field guide is not in contact with the human body. As shown in Figure 9(f), the top of the 8mm field guide in the oral cavity is 2mm away from the human body, with a 2mm thickness of air left at the edge. The materials of the three sections of the field guide from the outside to the inside are field guide, field guide, and field guide respectively.

[0109] A voltage was applied across the electrodes, and the field strength test point in the tumor area detected a field strength of 7.9558 V / m.

[0110] according to Figure 9(a)-Figure 9(e) get Figure 10 The figure shows the field strength at each test point when the field guide tip is in contact with the inner wall of the mouth at various distances. Comparison shows that the electric field guidance effect is best when the field guide edge is at a certain distance from the inner wall of the mouth. The effect deteriorates when the distance is too far or too close.

[0111] According to Figure 9(c) and Figure 9(f), we can get Figure 11 The table shows the field strength at the test points when the field guide tip is in contact with the inner wall of the mouth. The comparison shows that the electric field guidance effect is significantly better when the field guide tip is in contact with the inner wall of the mouth.

[0112] Therefore, as a preferred embodiment, the top of the electric field guiding member contacts the inner wall of the human body, and the edge of the electric field guiding member is a certain distance away from the inner wall of the human body, so as to obtain the best electric field guiding effect.

[0113] 4. Comparison of the effects of different field guidance modes of electric field guidance components

[0114] 1. Figure 12(a) shows the electric field distribution diagram when the head is intact. As shown in Figure 12(a), the oral cavity is full, and the materials of the three field guide positions from the outside to the inside are skin, skull, and brain tissue respectively;

[0115] That is, the field conductor material at each layer is consistent with the tissue material of that layer, forming a complete head tissue. When voltage is applied to both ends of the electrode, the field strength test point in the tumor area detects a field strength of 5.8025V / m.

[0116] 2. Figure 12(b) shows the electric field distribution when the field guide is partially implanted in the brain tissue. As shown in Figure 12(b), the oral cavity is fully occupied, and the materials of the three sections of field guide from the outside to the inside are skin, skull, and field guide respectively; that is, it is equivalent to the human head skin and skull being intact, and the field guide is implanted inside the brain tissue.

[0117] A voltage was applied across the electrodes, and the field strength test point in the tumor area detected a field strength of 7.1859 V / m.

[0118] according to Figure 12(a) 、 12(b) , Figure 9(a) and Figure 9(c) Figure 13 The following table shows the field strength at different test points under different field conduction modes. Figure 13 As shown in the figure, under the condition that the field guide is in full contact with the head tissue, the electric field guidance effect of the orally placed field guide is better than that of the implanted field guide, that is, the orally placed field guide is still better than the implanted field guide when it is not placed in the optimal way. When the orally placed field guide is placed in the optimal way, the electric field guidance effect is significantly improved.

[0119] Therefore, inserting electric field guiding components into the human body cavity helps to introduce the therapeutic electric field into the human body, increase the electric field strength in the tumor area, and enhance the treatment effect. The enhancement amplitude is better than implanting electric field guiding components in human tissue, which is more convenient and more effective.

[0120] 5. Electric field guiding components

[0121] like Figure 14 The figure shows the structure of an electric field guiding component, which can guide the surface electric field into the human body. Using a high dielectric constant allows for more efficient electric field guidance. The field guiding electrode comprises a field guiding electrode body 1 and a connecting electrode 2 located at one end of the field guiding electrode body, near the outer end of a natural human cavity.

[0122] 1. Field conductor body 1: This embodiment is an electrode made of a high relative dielectric constant material, such as a high dielectric constant ceramic material, which can achieve a relative dielectric constant of over 10,000. It includes a top portion and a rear portion, the rear portion of which is enclosed in an insulating ring 3.

[0123] 2. Connecting electrode 2, located at the bottom of the electric field guiding member and close to the outer end of the natural cavity of the human body;

[0124] The bottom can be directly connected to the original treatment electrode without changing the original equipment, which increases versatility.

[0125] 3. Insulating Ring 3: This ring isolates the rear half of the field conductor from human tissue, allowing the electric field to be more concentrated and directed to the top of the field conductor, enhancing the guiding effect. In this embodiment, insulating ring 3 is made of a low relative dielectric constant insulating material with a near-air-like dielectric constant, such as FR4 or PTFE (polytetrafluoroethylene). FR4 has a relative dielectric constant of 4.4, and PTFE has a relative dielectric constant of 2.55. The lower the relative dielectric constant, the better the insulation effect. A certain thickness ensures sufficient insulation while leaving more space for the field conductor, optimizing the electric field guiding effect.

[0126] Those skilled in the art should know that the same approach can also be used for other natural cavities of the human body, such as ears, noses, etc.

[0127] This embodiment also provides an application of an electric field enhancement guidance system based on natural human cavities in a tumor electric field treatment device.

[0128] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the above embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the above embodiments, or replace some or all of the technical features therein with equivalents. However, these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. An electric field enhancement guidance system based on the natural cavity of the human body, characterized in that: include: An electric field guiding member, used to guide the electric field of the external electrode deep into the human body; The electric field guiding member includes a field conducting electrode partially placed in a natural cavity of the human body; The field conducting electrode comprises a field conducting electrode body and a connecting electrode provided at one end of the field conducting electrode body and close to the outer end of a natural cavity of a human body; One or more second auxiliary electrodes, placed on the surface of human skin; The connecting electrode and the second auxiliary electrode cooperate to form an electric field system; The electric field guiding component is divided into three sections corresponding to three layers of human tissue, and different substances can be selected to test different modes in each section.

2. The electric field enhancement guidance system based on the natural cavity of the human body according to claim 1, characterized in that: The electric field guiding member is in the form of a spoon or a lollipop.

3. The electric field enhancement guidance system based on the natural cavity of the human body according to claim 2, characterized in that: The plurality of second auxiliary electrodes are used to form one or more electric fields perpendicular to the distribution plane of the electrodes in the single-direction treatment mode.

4. The electric field enhancement guidance system based on the natural cavity of the human body according to claim 3, characterized in that: The electric field guide member is made of a material having a relative dielectric constant of 10,000 or more.

5. The electric field enhancement guidance system based on the natural cavity of the human body according to claim 4, characterized in that: The top of the electric field guiding member contacts the inner wall of the human body, and the edge of the electric field guiding member is at a certain distance from the inner wall of the human body, thereby obtaining the best electric field guiding effect.

6. The electric field enhancement guidance system based on the natural cavity of the human body according to claim 5, characterized in that: The field conductor body is made of a material with a relative dielectric constant of more than 10,000, and comprises a top and a rear portion, wherein the rear portion is wrapped in an insulating ring.

7. The electric field enhancement guidance system based on the natural cavity of the human body according to claim 6, characterized in that: The connecting electrode is located at the bottom of the electric field guiding component and close to the outer end of the natural cavity of the human body; the bottom is directly connected to the treatment electrode for use.

8. The electric field enhancement guidance system based on the natural cavity of the human body according to claim 7, characterized in that: The insulating ring is used to isolate the rear half of the field conductor electrode from contact with human tissue. The insulating ring is made of a low relative dielectric constant insulating material close to air with a certain thickness. The low relative dielectric constant insulating material close to air includes FR4 or PTFE polytetrafluoroethylene material.

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