170 results about "Bone mass" patented technology

The invention provides an application of bifidobacterium animalis subsp. Lactis CP-9 in preparation of a product for promoting bone growth and development or improving bone health. Long-term research and a large number of experiments show that the bifidobacterium animalis subsp. Lactis CP-9 can improve the bone volume fraction, the bone trabecula thickness, the bone density and the bone volume of an organism, and can also effectively improve the growth hormone level and the insulin-like growth factor 1 level, so that bone growth and development are promoted. Meanwhile, the bifidobacterium animalis subsp. Lactis CP-9 can effectively improve the N-terminal propeptide level, osteocalcin level, bone morphogenetic protein level and osteoprotectin level of I-type procollagen in a body, and remarkably reduce the amino-terminal peptide level of the I-type collagen and the ligand level of nuclear factor kappa B receptor activating factor, so that osteoblast differentiation is promoted, osteoclast differentiation is inhibited, and osteoclast differentiation is inhibited. Furthermore, bone formation is promoted, bone resorption is inhibited, bone metabolism is improved, and finally the effect of improving bone health is achieved.

The invention relates to the technical field of medical informatics, in particular to a construction method of an osteoporotic fracture risk prediction model. The method comprises the following steps: acquiring an included angle between a foot and the ground, a step speed and a CT image of a target person in a monitoring process; dividing pixel points in the CT image into a plurality of bone tissue areas; according to the shape distribution characteristics of the edge lines in the bone tissue area, bone characteristic values of the bone structure are obtained; obtaining a posture control factor of each gait according to the included angles between the left and right feet of the target person in each gait and the ground; determining an abnormal posture index of each gait in combination with the posture control factor and the corresponding step speed; obtaining a control disorder coefficient of each time period according to the numerical distribution characteristics and the change characteristics of all the posture control factors in each time period; and determining an osteoporosis evaluation value by integrating the bone characteristic value and the disorder control coefficient of the skeleton structure. The accuracy of the bone comprehensive evaluation result of the target person is improved.

The invention discloses an edentulous jaw dental implant positioning method combined with depth variation reasoning. The method comprises the following steps: S1, generating optimized medical image data; s2, generating a jaw bone three-dimensional reconstruction model of the edentulous jaw patient; s3, generating anatomical feature data; s4, generating a preliminary implant positioning scheme; s5, generating a local bone reconstruction simulation result; s6, performing dynamic interaction on a local bone reconstruction simulation result and the preliminary implant positioning scheme, optimizing the preliminary implant positioning scheme through a depth variation inference model, and generating an implant optimized positioning scheme including mechanical stability and biomechanical performance evaluation; and S7, based on the implant optimization positioning scheme, generating implant guide plate design data and surgical navigation data in combination with the jaw bone three-dimensional reconstruction model of the patient. According to the method, the final implant positioning point obtains a globally optimal solution in the aspects of long-term stability and biological adaptability.

The invention discloses bifidobacterium longum subsp.infantis capable of promoting bone growth and a metagen thereof, and belongs to the technical field of biology. The bifidobacterium longum subsp. Infantis CCFM1445 provided by the invention can promote the increase of bone volume fraction, femoral bone trabecula thickness and far-end growth plate thickness of mammals in a growth period, reduce the levels of serum bone resorption markers I-type collagen amino-terminal peptide and tartrate-resistant acid phosphatase, improve the levels of serum bone alkaline phosphatase and parathyroid hormone, and improve the clinical application value of the bifidobacterium longum subsp. Infantis CCFM1445. And the relative abundance of the other bacteria in the intestinal flora and the levels of creatine and indole-3-lactic acid are increased. The thermally inactivated bifidobacterium longum subsp. Infantis CCFM1445 can promote the increase of the volume fraction of femoral bones and the number of bone trabecula of malnourished mice and improve the N-terminal propeptide level of serum I-type procollagen. Therefore, the medicine or health care product prepared from the bifidobacterium longum subsp. Infantis CCFM1445 can be used for assisting in regulating bone metabolism and bone mass, and has a wide market prospect.

Systems and methods for real-time navigation of reaming of an acetabulum are disclosed. A first tracking element is interfaced to a reamer. A second tracking element is interfaced at or near the acetabulum. The first tracking element can be interfaced to an outer casing surrounding a portion of the shaft of the reamer. A depth and a tilt angle of the reamer with respect to the acetabulum are determined, based on a location of the first and second tracking elements. Based on a surgical plan, the depth and the tilt angle, the volume of removed bone from the acetabulum can also be determined.

The invention relates to the technical field of medical information, in particular to an osteoporosis risk intelligent early warning method and system based on a big database. The method comprises the following steps: extracting user bone health data in a multi-source health database; evaluating a bone mass state based on the user bone health data; screening osteoporosis risk users in the user bone health data according to the bone mass state; inquiring a medical image of the osteoporosis risk user; extracting a bone mineral density value by using the medical image, and determining a bone mineral density change trend according to the bone mineral density value; detecting the degeneration degree of the bone microstructure by using a medical image; constructing an osteoporosis risk early warning model according to the bone mineral density change trend and the bone microstructure degeneration degree; and inputting the user bone health data into the osteoporosis risk early warning model to generate a risk early warning score. According to the invention, accurate identification and dynamic monitoring of the osteoporosis risk user are realized based on the medical information technology, and the accuracy and response rate of osteoporosis risk early warning are improved.

The invention provides an application of narirutin in preparation of a medicine for preventing and / or treating osteoclast of inflammatory arthritis, relates to the technical field of biomedicine, and adopts a collagen-induced mouse arthritis model to observe the treatment effect of the narirutin on the osteoclast of the inflammatory arthritis. The arthritis activity degree of the mouse is analyzed through general claw photographing, thickness measurement, near-infrared temperature measurement and a claw imprinting experiment, three-dimensional reconstruction and bone trabecula analysis are carried out on local joints and the whole body bone mass of the mouse through micro-CT scanning, and Hamp is applied; e, dyeing and Famp; through histological staining analysis such as O staining and TRAP staining, in combination with immunohistochemical staining and the like, the narirutin is proved to play a role in treating inflammatory arthritis, inhibit macrophage pro-inflammatory M1 type polarization, relieve the inflammation level, improve the bone mass of local joints and the whole body, and further improve bone destruction in inflammatory arthritis diseases. The narirutin provides a new way for medicine prevention and treatment of inflammatory arthritis.

A method of improving and / or enhancing at least one of bone mineralization, bone strength, bone mass, and bone mineral density in an individual in need thereof, the method comprising administering to the individual a composition comprising one or more anabolic amino acids, and the composition further comprising one or more autophagy-inducing compounds. In one embodiment, the one or more autophagy-inducing compounds are selected from the group consisting of thymol, carvacrol, spermidine, urolithin (e.g., Urolithin A, B or D), rapamycin, Torin1, valproic acid, polyphenols (e.g., resveratrol), caffeine, metformin, 5′ AMP-activated protein kinase (AMPK) activators, L-type calcium channel inhibitors, ketones (e.g. beta-hydroxybutyrate, ketone salts, or ketone ester derivatives), 4,4′-dimethoxychalcone and mixtures thereof.

The invention belongs to the field of biomedical engineering, and relates to a nutritional composition for delaying muscle attenuation and bone mass reduction based on muscle-bone axis interaction and a preparation method of the nutritional composition. In particular to a nutritional composition which comprises or consists of beta-hydroxy-beta-methylbutyric acid or salt thereof and milk-derived basic protein; wherein the mass ratio of the beta-hydroxy-beta-methylbutyric acid or the salt thereof to the milk-derived basic protein is (120: 1)-(5: 1). According to the nutritional composition disclosed by the invention, through the synergistic effect of the beta-hydroxy-beta-methylbutyric acid or the salt thereof and the milk-derived basic protein, the muscle-bone axis is jointly regulated and controlled, and the comprehensive improvement effect of muscle-bone health which cannot be achieved by a single component is achieved.

The invention relates to the field of food, in particular to colostrum basic protein as well as a preparation method and application thereof. The colostrum basic protein of the present invention can increase bone mass, increase bone density, promote skeletal development, promote skeletal regeneration or repair, promote calcium absorption, promote bone collagen production, and / or prevent and / or treat bone related diseases (such as osteoporosis, osteoporosis, rickets, osteoarthrosis).

The invention relates to the field of biological medicine, and discloses application of ergothioneine in preparation of a medicine for preventing and / or treating osteoporosis. The invention discloses a new mechanism of the ergothioneine for improving the osteoporosis by regulating and controlling the NF-kB / NFATc1 signal channel and reducing oxidative stress and inflammatory response for the first time, and provides a brand new thought for developing safe and effective anti-osteoporosis medicines. The discovery that the ergothioneine improves bone mass loss related to estrogen decline provides a new solution for lack of osteoporosis treatment means at present, and opens up a new way for application of natural products in bone metabolic diseases.

The application provides an application of Lipofermata in preparation of a product for preventing and treating osteoporosis. The pharmacological experiment of the application shows that Lipofermata can significantly prevent and treat and improve the reduction of bone mass caused by estrogen reduction, and shows that Lipofermata has the effect of preventing and treating osteoporosis, and therefore can be used for preventing and treating osteoporosis. The application not only provides a new therapeutic use of Lipofermata, but also provides a new drug for preventing and treating osteoporosis.

The invention is suitable for the technical field of data recognition, and provides a big data-based body state detection method and device, and the method comprises the steps: collecting high-frequency impedance, low-frequency impedance and a current phase difference through a foot electrode; calculating body composition according to the high-frequency impedance and the low-frequency impedance; wherein the body components comprise body fat percentage, muscle mass, total body moisture, basal metabolic rate and bone mass; calculating the body age according to the body composition; generating body change information according to the body composition and the current phase difference; wherein the body state information comprises body change information and body age. According to the technical scheme, comprehensive measurement of the high-frequency impedance, the low-frequency impedance and the current phase difference is introduced, and analysis and calculation based on big data are carried out, so that comprehensive, accurate and personalized detection of the body state is realized. And the accuracy and the reliability of a measurement result are improved.

The utility model discloses an oral implant which comprises a bone surface supporting structure, the appearance of the bone surface supporting structure is attached to an upper jaw alveolar bone surface or a lower jaw alveolar bone surface, and a net-shaped through hole is formed in the bone surface supporting structure and corresponds to the alveolar bone surface; a plurality of base tables protruding out of the surface are arranged on the surface of one side of the bone surface supporting structure, and the base tables are used for fixedly connecting the oral implant with a prosthesis; one end, connected to the bone surface supporting structure, of the abutment is provided with an intraosseous implant implanted into the jaw bone. According to the utility model, the traditional subperiosteal implant is improved, the subperiosteal implant is designed in the area with insufficient bone mass of the jaw bone, and the novel stent-shaped implant is formed by combining the subperiosteal implant with the intraosseous implant in the area with sufficient bone mass of the jaw bone, so that independent bone increment operation is not needed, and the implant can be implanted only by one operation; and the clinical problem that a patient with serious atrophy of the alveolar ridge is difficult to implant and repair is effectively solved.

The application discloses application of mesenchymal stem cell spheroids in preparation of a preparation for treating osteoarthritis, and relates to the technical field of cell therapy and osteoarthritis treatment, and specifically comprises mesenchymal stem cell spheroids with an average diameter of 120-180 mu m and a solution containing 0.5%-10% human serum albumin. The cells are prepared into 120-180 mu m cell spheroids, and the solution containing specific concentration human serum albumin is used as a carrier, so that the cell survival rate is stabilized at more than 90%, and high-activity delivery is realized; the optimized size ensures smooth injection and long-term retention in the joint cavity, and overcomes the shortcoming that single cells are easily removed; after joint cavity injection, the preparation can synergistically promote bone reconstruction and cartilage repair, and produces clear curative effects such as bone mass increase of more than 30%, cartilage degeneration score reduction of more than 50%, and the like, which are quantifiable and verifiable, so that a stable, long-acting and curative drug preparation and application scheme are provided for osteoarthritis treatment.

The invention provides an individualized tibia defect repairing type knee joint prosthesis, and belongs to the technical field of orthopedic implants. The device is formed by assembling a femoral condyle, a femoral bone marrow needle, a plateau pad, a tibia plateau, a restoration body and a tibia bone marrow needle. Wherein the tibia platform and the restoration body are matched through metal-metal threads and are assisted by bone cement to achieve anti-rotation locking, the restoration body adopts a 3D printing individualized bone trabecula structure and is compounded with an HA coating to promote bone ingrowth, the tibia bone marrow needle and the platform are connected through a standard taper connector, inventory and individualization compatibility is achieved, and the bone marrow needle and the platform are connected through a standard taper connector. The defects that an existing prosthesis is large in bone mass loss, unattractive in reconstruction, free of bone ingrowth function, high in processing cost and the like are overcome, and the postoperative function of a tibia defect patient and the long-term stability of the prosthesis can be remarkably improved.

The utility model relates to medical equipment technical field, concretely is a kind of positioning drill for dental implant surgery. Including driving rod, the one end of driving rod is connected with annular drill bit, the end of annular drill bit is equipped with tooth edge, the inside of annular drill bit is provided with the positioning member extending outward, the middle part of driving rod is provided with fixed ring, driving rod and located the side activity sleeve of annular drill bit is equipped with sleeve, driving rod and located between sleeve and fixed ring is equipped with spring, the side of sleeve and annular drill bit is open structure. Through different specifications sleeve, the safety distance required around implant can be guaranteed;Annular drill bit marks edge, the remaining bone mass around implant after implantation and the distance with adjacent tooth can be intuitively displayed;In the process of continuing to prepare hole, if deviation is generated due to bone density uneven, it can be easily observed and adjusted;Reduce the additional cost generated by the production of guide plate and navigation, reduce the burden of patient.

The invention discloses a 2, 3, 4, 9-tetrahydro-1H-pyridine [3, 4-b] indole compound as well as a preparation method and application of the 2, 3, 4, 9-tetrahydro-1H-pyridine [3, 4-b] indole compound. According to the preparation method, 3-hydroxy-4-methoxybenzaldehyde and 1-(chloromethyl)-2, 6-difluorobenzene are taken as initial raw materials, and 1-(3-((2, 6-difluorophenyl) oxo)-4-methoxyphenyl)-2, 3, 4, 9-tetrahydro-1H-pyridine [3, 4-b] indole is prepared through a two-step reaction. The 1-(3-((2, 6-difluorophenyl) oxo)-4-methoxyphenyl)-2, 3, 4, 9-tetrahydro-1H-pyridine [3, 4-b] indole provided by the invention has a remarkable inhibition effect on osteoclast differentiation induced by RANKL, has no obvious cytotoxicity, can be used as a candidate drug which is novel in structure and is used for inhibiting osteoclast differentiation, and has a broad application prospect. The method is used for targeting osteoclast to treat bone mass loss related diseases.

This invention relates to a method of treating a joint and / or bone disease, slowing progression of a reduction in bone mass, increasing osteoblast formation, decreasing osteoclast formation, and / or reducing osteocyte death, slowing progression of a reduction in joint mobility and / or function, slowing progression of a reduction in cartilage, and / or reducing chondrocyte senescence and / or death by administering a therapeutically effective amount of a SIRT6 activator, optionally with nicotinamide adenine dinucleotide (NAD+) and / or an NAD+ precursor.

The present application provides methods of use, specifically methods of treatment of a disease, disorder, or condition (e.g, a low bone mass condition such as osteoporosis) in a human individual, comprising administration of novel bispecific antibodies that bind to both sclerostin and DKK-1 (e.g, anti-Sclerostin x anti-DKK-1 bispecific antibodies). The present application also provides methods of increasing bone mineral density in a human individual comprising administration of novel anti-Scl erostin x anti-DKK-1 bispecific antibodies. The present application further provides methods of reducing risk of bone fracture (e.g., osteoporotic fracture) in a human individual comprising administration of novel anti-Sclerostin x anti-DKK-1 bispecific antibodies.

The present invention provides a cervical vertebrae prosthesis, which includes: a solid layer, the solid layer including an anterior plate and a posterior plate that are interconnected, the anterior plate and the posterior plate together forming a receiving cavity, the anterior plate being an arc-shaped structure, the axis of the anterior plate extending in the vertical direction; a porous layer, the porous layer filling the receiving cavity; wherein the cervical vertebrae prosthesis has a first bone grafting hole that extends in the vertical direction and passes through the upper and lower end surfaces of the porous layer, and the cervical vertebrae prosthesis also has a second bone grafting hole that passes through the anterior plate and extends into the porous layer. The technical solution provided by this application can solve the problem in the related art that the cervical vertebrae prosthesis cannot increase the amount of bone grafting while meeting the structural strength.

Blood plasma samples are obtained from type 2 diabetes (T2D) patients and a concentration of F2-isoprostanes (F2I) in the sample is quantified. Plasma F2I levels assess oxidative stress levels in the patient and indicate elevated risk of T2D-associated complications including incident clinical fracture, cardiovascular complications, renal disease, etc. in the T2D cohort, independently of other risk factors. Fracture risk in the T2D population is heightened for a given bone mineral density (BMD) and is underestimated by evaluation tools such as Fracture Risk Assessment Tool (FRAX). The patient's BMD T-score can be adjusted based on F2I concentrations, capturing reductions in bone quality as well as quantity that lead to the elevated fracture risk in T2D patients. These diagnostic procedures can be effectively deployed in a patient's course of treatment merely by supplementing an existing blood panel, rather than with a separate blood draw.

The application discloses a bone mass recognition method and system based on a three-dimensional convolutional neural network and a CT image, and comprises the following steps: acquiring an original CT image comprising a lumbar vertebra; obtaining a probability image and a lumbar vertebra part mask image according to the original CT image and a trained three-dimensional rough segmentation network model of the lumbar vertebra part; obtaining a lumbar vertebra part CT image according to the lumbar vertebra part mask image and the original CT image; obtaining a lumbar vertebra body mask image according to the probability image, the lumbar vertebra part CT image and a trained three-dimensional fine segmentation network model of the lumbar vertebra; obtaining a three-dimensional CT image of the lumbar vertebra body according to the lumbar vertebra body mask image and the original CT image; and obtaining a bone mass recognition result according to the three-dimensional CT image of the lumbar vertebra body and a trained classification network model. The application realizes accurate recognition of bone mass.

The invention relates to a device for bone formation, bone reshaping or healing of bone in dental, oral and maxillofacial applications, specifically in connection with installation of dental implants. The device comprises a sheet structure made of an inert material, wherein the sheet structure has an inner surface intended to be directed towards the bone and an outer surface intended to be directed away from the bone. The geometrical features of the cavity formed between the inner surface of the device and the initial bone surface when the device is installed at the intended location is further used to improve and plan the treatment. The device is customized by means of digital planning based on the initial and the optimal bone volume for the intended treatment. Modifications of the device can be introduced to facilitate a combined installation of dental implants with the device.

The invention provides a composition. The composition is prepared from vitamin A, vitamin D, vitamin E, vitamin K and health-care food or food-acceptable auxiliary materials according to specific proportions and doses. The anti-osteoporosis health-care food has the advantages that the vitamin components have a synergistic effect in the aspect of anti-osteoporosis, and the anti-osteoporosis health-care food can increase bone mineral density and maintain bone mass. In addition, the composition disclosed by the invention can also be used for precise nutritional supplement of specific crowds.

The invention provides a bone evaluation method based on neural network enhancement and finite element analysis. The bone evaluation method comprises the following steps: acquiring an ultrahigh-resolution CT image of a living vertebra; performing domain conversion processing on the CT image by adopting a generative neural network; carrying out resampling and segmentation on the enhanced CT image; constructing a bone trabecula microstructure model in the cancellous bone mask area; assembling the RVE unit and the cortical bone model into a complete vertebral finite element model, and applying a multi-working-condition load to the RVE unit to calculate anisotropic material parameters; and carrying out axial compression finite element analysis on the complete centrum model, and judging the bone health state. According to the method, information of two dimensions of bone mass and bone, especially contribution of a bone trabecula microstructure to bone strength, is comprehensively considered, bone degeneration and fracture high-risk patients can be recognized earlier, and a scientific basis is provided for clinical early intervention.

The present invention discloses a method for verifying osteotomy accuracy during knee replacement surgery, comprising: S1, obtaining a preoperative point cloud of a patient and marking anatomical bony landmarks therein; S2, determining whether it is a non-imaging surgical plan; if so, obtaining a planned osteotomy plane and a planned osteotomy amount, and simultaneously registering the patient's preoperative point cloud with the intraoperative point cloud; otherwise, obtaining a planned osteotomy plane and a planned osteotomy amount; S3, obtaining a postoperative point cloud of the patient after osteotomy, identifying the actual osteotomy plane therein, and then calculating the actual osteotomy amount, while removing points on the identified actual osteotomy plane; S4, registering the patient's preoperative point cloud with the postoperative point cloud after removing the points on the actual osteotomy plane; S5, based on the registration in S4, transforming the actual osteotomy plane obtained in S3 and the planned osteotomy plane obtained in S2 to the same reference, and calculating the osteotomy plane error and the osteotomy amount error accordingly. The present invention can verify osteotomy accuracy under optical navigation.

1. The name of the product of this design: mandibular prosthesis (PEEK polyetheretherketone). 2. Purpose of the product of this design: to repair mandibular bone defect and mandibular bone surface dysplasia. 3. The design key point of this appearance design product lies in the shape. 4. The picture or photo that best illustrates the design key points: 3D image of component 1.

The invention discloses a metal organic framework material targeting bone marrow fat cells as well as a preparation method and application of the metal organic framework material, and belongs to the technical field of biomedical materials and tissue engineering. The material comprises: (1) a ZIF-8 core structure used for loading nucleic acid / small molecule drugs; (2) surface modification of lipid droplet targeting peptide: the lipid droplet targeting peptide is combined with a PEDF receptor to realize precise targeting; and (3) anti-miR-188 is loaded inside and is used for inhibiting adipogenic differentiation. The method at least has the following advantages: (1) a bone marrow adipocyte specific targeting MOF material is proposed for the first time, and bone metabolism intervention is converted from a mode of targeting osteoblast or macrophage to targeting adipocyte; (2) the MOF core can quickly respond to a marrow weak acid environment to realize accurate release; (3) the AdipoPep targeting peptide can obviously prolong the residence time of the bone marrow; and (4) adipogenic differentiation is significantly inhibited, osteogenesis microenvironment reconstruction is promoted, and an excellent bone mass recovery effect is shown in an osteoporosis model.

The invention discloses an application of a branched ketonic acid dehydrogenase kinase (BCKDK) inhibitor in preparation of a medicine for preventing and treating osteoporosis. The invention finds that BCKDK can inhibit osteoblast differentiation and reduce the expression of endogenous BCKDK in osteogenic precursor cells so as to promote osteoblast differentiation; a small molecule compound inhibitor BT2 (3, 6-dichloro-2-benzothiophene carboxylic acid) of BCKDK promotes osteoblast differentiation of ovariectomized mice, inhibits osteoclast differentiation, reduces ovariectomized mouse bone loss and increases bone mass. According to the invention, the BCKDK inhibitor is proposed for the first time to be capable of promoting osteoblast differentiation, inhibiting osteoclast differentiation and increasing body bone mass by reducing BCKDK expression or inhibiting BCKDK protein biological functions, and has the effect of preventing and treating osteoporosis.