71 results about "Bone mass" patented technology

The invention relates to the technical field of medical information, in particular to an osteoporosis risk intelligent early warning method and system based on a big database. The method comprises the following steps: extracting user bone health data in a multi-source health database; evaluating a bone mass state based on the user bone health data; screening osteoporosis risk users in the user bone health data according to the bone mass state; inquiring a medical image of the osteoporosis risk user; extracting a bone mineral density value by using the medical image, and determining a bone mineral density change trend according to the bone mineral density value; detecting the degeneration degree of the bone microstructure by using a medical image; constructing an osteoporosis risk early warning model according to the bone mineral density change trend and the bone microstructure degeneration degree; and inputting the user bone health data into the osteoporosis risk early warning model to generate a risk early warning score. According to the invention, accurate identification and dynamic monitoring of the osteoporosis risk user are realized based on the medical information technology, and the accuracy and response rate of osteoporosis risk early warning are improved.

The invention belongs to the field of biomedical engineering, and relates to a nutritional composition for delaying muscle attenuation and bone mass reduction based on muscle-bone axis interaction and a preparation method of the nutritional composition. In particular to a nutritional composition which comprises or consists of beta-hydroxy-beta-methylbutyric acid or salt thereof and milk-derived basic protein; wherein the mass ratio of the beta-hydroxy-beta-methylbutyric acid or the salt thereof to the milk-derived basic protein is (120: 1)-(5: 1). According to the nutritional composition disclosed by the invention, through the synergistic effect of the beta-hydroxy-beta-methylbutyric acid or the salt thereof and the milk-derived basic protein, the muscle-bone axis is jointly regulated and controlled, and the comprehensive improvement effect of muscle-bone health which cannot be achieved by a single component is achieved.

The utility model discloses an oral implant which comprises a bone surface supporting structure, the appearance of the bone surface supporting structure is attached to an upper jaw alveolar bone surface or a lower jaw alveolar bone surface, and a net-shaped through hole is formed in the bone surface supporting structure and corresponds to the alveolar bone surface; a plurality of base tables protruding out of the surface are arranged on the surface of one side of the bone surface supporting structure, and the base tables are used for fixedly connecting the oral implant with a prosthesis; one end, connected to the bone surface supporting structure, of the abutment is provided with an intraosseous implant implanted into the jaw bone. According to the utility model, the traditional subperiosteal implant is improved, the subperiosteal implant is designed in the area with insufficient bone mass of the jaw bone, and the novel stent-shaped implant is formed by combining the subperiosteal implant with the intraosseous implant in the area with sufficient bone mass of the jaw bone, so that independent bone increment operation is not needed, and the implant can be implanted only by one operation; and the clinical problem that a patient with serious atrophy of the alveolar ridge is difficult to implant and repair is effectively solved.

The application discloses application of mesenchymal stem cell spheroids in preparation of a preparation for treating osteoarthritis, and relates to the technical field of cell therapy and osteoarthritis treatment, and specifically comprises mesenchymal stem cell spheroids with an average diameter of 120-180 mu m and a solution containing 0.5%-10% human serum albumin. The cells are prepared into 120-180 mu m cell spheroids, and the solution containing specific concentration human serum albumin is used as a carrier, so that the cell survival rate is stabilized at more than 90%, and high-activity delivery is realized; the optimized size ensures smooth injection and long-term retention in the joint cavity, and overcomes the shortcoming that single cells are easily removed; after joint cavity injection, the preparation can synergistically promote bone reconstruction and cartilage repair, and produces clear curative effects such as bone mass increase of more than 30%, cartilage degeneration score reduction of more than 50%, and the like, which are quantifiable and verifiable, so that a stable, long-acting and curative drug preparation and application scheme are provided for osteoarthritis treatment.

The invention provides an individualized tibia defect repairing type knee joint prosthesis, and belongs to the technical field of orthopedic implants. The device is formed by assembling a femoral condyle, a femoral bone marrow needle, a plateau pad, a tibia plateau, a restoration body and a tibia bone marrow needle. Wherein the tibia platform and the restoration body are matched through metal-metal threads and are assisted by bone cement to achieve anti-rotation locking, the restoration body adopts a 3D printing individualized bone trabecula structure and is compounded with an HA coating to promote bone ingrowth, the tibia bone marrow needle and the platform are connected through a standard taper connector, inventory and individualization compatibility is achieved, and the bone marrow needle and the platform are connected through a standard taper connector. The defects that an existing prosthesis is large in bone mass loss, unattractive in reconstruction, free of bone ingrowth function, high in processing cost and the like are overcome, and the postoperative function of a tibia defect patient and the long-term stability of the prosthesis can be remarkably improved.

The utility model relates to medical equipment technical field, concretely is a kind of positioning drill for dental implant surgery. Including driving rod, the one end of driving rod is connected with annular drill bit, the end of annular drill bit is equipped with tooth edge, the inside of annular drill bit is provided with the positioning member extending outward, the middle part of driving rod is provided with fixed ring, driving rod and located the side activity sleeve of annular drill bit is equipped with sleeve, driving rod and located between sleeve and fixed ring is equipped with spring, the side of sleeve and annular drill bit is open structure. Through different specifications sleeve, the safety distance required around implant can be guaranteed;Annular drill bit marks edge, the remaining bone mass around implant after implantation and the distance with adjacent tooth can be intuitively displayed;In the process of continuing to prepare hole, if deviation is generated due to bone density uneven, it can be easily observed and adjusted;Reduce the additional cost generated by the production of guide plate and navigation, reduce the burden of patient.

The present application provides methods of use, specifically methods of treatment of a disease, disorder, or condition (e.g, a low bone mass condition such as osteoporosis) in a human individual, comprising administration of novel bispecific antibodies that bind to both sclerostin and DKK-1 (e.g, anti-Sclerostin x anti-DKK-1 bispecific antibodies). The present application also provides methods of increasing bone mineral density in a human individual comprising administration of novel anti-Scl erostin x anti-DKK-1 bispecific antibodies. The present application further provides methods of reducing risk of bone fracture (e.g., osteoporotic fracture) in a human individual comprising administration of novel anti-Sclerostin x anti-DKK-1 bispecific antibodies.

The application discloses a bone mass recognition method and system based on a three-dimensional convolutional neural network and a CT image, and comprises the following steps: acquiring an original CT image comprising a lumbar vertebra; obtaining a probability image and a lumbar vertebra part mask image according to the original CT image and a trained three-dimensional rough segmentation network model of the lumbar vertebra part; obtaining a lumbar vertebra part CT image according to the lumbar vertebra part mask image and the original CT image; obtaining a lumbar vertebra body mask image according to the probability image, the lumbar vertebra part CT image and a trained three-dimensional fine segmentation network model of the lumbar vertebra; obtaining a three-dimensional CT image of the lumbar vertebra body according to the lumbar vertebra body mask image and the original CT image; and obtaining a bone mass recognition result according to the three-dimensional CT image of the lumbar vertebra body and a trained classification network model. The application realizes accurate recognition of bone mass.

The invention relates to a device for bone formation, bone reshaping or healing of bone in dental, oral and maxillofacial applications, specifically in connection with installation of dental implants. The device comprises a sheet structure made of an inert material, wherein the sheet structure has an inner surface intended to be directed towards the bone and an outer surface intended to be directed away from the bone. The geometrical features of the cavity formed between the inner surface of the device and the initial bone surface when the device is installed at the intended location is further used to improve and plan the treatment. The device is customized by means of digital planning based on the initial and the optimal bone volume for the intended treatment. Modifications of the device can be introduced to facilitate a combined installation of dental implants with the device.

The invention provides a bone evaluation method based on neural network enhancement and finite element analysis. The bone evaluation method comprises the following steps: acquiring an ultrahigh-resolution CT image of a living vertebra; performing domain conversion processing on the CT image by adopting a generative neural network; carrying out resampling and segmentation on the enhanced CT image; constructing a bone trabecula microstructure model in the cancellous bone mask area; assembling the RVE unit and the cortical bone model into a complete vertebral finite element model, and applying a multi-working-condition load to the RVE unit to calculate anisotropic material parameters; and carrying out axial compression finite element analysis on the complete centrum model, and judging the bone health state. According to the method, information of two dimensions of bone mass and bone, especially contribution of a bone trabecula microstructure to bone strength, is comprehensively considered, bone degeneration and fracture high-risk patients can be recognized earlier, and a scientific basis is provided for clinical early intervention.

The invention discloses a metal organic framework material targeting bone marrow fat cells as well as a preparation method and application of the metal organic framework material, and belongs to the technical field of biomedical materials and tissue engineering. The material comprises: (1) a ZIF-8 core structure used for loading nucleic acid / small molecule drugs; (2) surface modification of lipid droplet targeting peptide: the lipid droplet targeting peptide is combined with a PEDF receptor to realize precise targeting; and (3) anti-miR-188 is loaded inside and is used for inhibiting adipogenic differentiation. The method at least has the following advantages: (1) a bone marrow adipocyte specific targeting MOF material is proposed for the first time, and bone metabolism intervention is converted from a mode of targeting osteoblast or macrophage to targeting adipocyte; (2) the MOF core can quickly respond to a marrow weak acid environment to realize accurate release; (3) the AdipoPep targeting peptide can obviously prolong the residence time of the bone marrow; and (4) adipogenic differentiation is significantly inhibited, osteogenesis microenvironment reconstruction is promoted, and an excellent bone mass recovery effect is shown in an osteoporosis model.

The invention discloses an application of a branched ketonic acid dehydrogenase kinase (BCKDK) inhibitor in preparation of a medicine for preventing and treating osteoporosis. The invention finds that BCKDK can inhibit osteoblast differentiation and reduce the expression of endogenous BCKDK in osteogenic precursor cells so as to promote osteoblast differentiation; a small molecule compound inhibitor BT2 (3, 6-dichloro-2-benzothiophene carboxylic acid) of BCKDK promotes osteoblast differentiation of ovariectomized mice, inhibits osteoclast differentiation, reduces ovariectomized mouse bone loss and increases bone mass. According to the invention, the BCKDK inhibitor is proposed for the first time to be capable of promoting osteoblast differentiation, inhibiting osteoclast differentiation and increasing body bone mass by reducing BCKDK expression or inhibiting BCKDK protein biological functions, and has the effect of preventing and treating osteoporosis.

A bone part is repaired by a process. A first implant is attached to a first bone part. The first implant corresponds to an intraoperatively defined or an intraoperatively selected cutting path. A preoperatively defined second implant is attached to the first implant. The first implant and the second implant together augment the first bone part.

The utility model discloses a lateral fixed implant, which relates to the technical field of implants and comprises an implant main body, a fixed cavity is arranged at the top of the implant main body, a fixed needle is arranged in the fixed cavity, and the fixed cavity comprises a cone, an anti-rotation structure, a threaded hole, a first hole, a second hole and a third hole which are sequentially communicated with one another from top to bottom. A first thread is arranged on the outer surface of the implant main body, a fourth hole is formed in the outer surface wall, located on the first thread, of the implant main body, the fourth hole is communicated with the third hole, and the fixing needle comprises a cap head, a rod part, an anti-withdrawing thorn and a tip which are fixedly arranged in sequence from top to bottom. Through double fixation of the lateral fixing needle, the stability of the implant is effectively enhanced, the defects of insufficient retention of the implant and complicated methods such as wing plate and cheekbone implantation are overcome, and the lateral fixing implant can be applied to the situation of insufficient bone mass of maxillary alveolar bones.

The invention discloses a computational mechanical analysis system for evaluating bone growth induced by a bone healing scaffold, and relates to the technical field of bone healing evaluation, and the computational mechanical analysis system is specifically characterized in that under unified external load and time gating, quantitative indexes such as a regional average osteogenesis rate curve, an accumulated bone mass, time for reaching a preset healing threshold value, a cross section bridging rate and the like are used for evaluating bone growth induced by a bone healing scaffold; the induction osteogenesis effects of different stent structures are fairly compared, shape scoring and subjective weight are avoided, reproducibility and calibration are emphasized, the method can be used for preoperative structure screening and parameter sensitivity analysis and can also be in butt joint with follow-up images and experimental data, online calibration and treatment course optimization of individualized digital twinning are further supported, and the method is suitable for popularization and application. According to the method, the period boundary, the time-varying supply gating and the multi-physics field coupling of the RVE can be unified into the same calculation framework, and the defects of the prior art in microscopic geometric maintenance, time rhythm expression and biomechanical closed loop are effectively overcome.

The application discloses a kind of acetabulum patch and acetabulum patch system, the acetabulum patch includes main body and adjusting piece, main body includes first distraction and second distraction, one end of first distraction is rotatably connected with the end of second distraction, the side surface of first distraction away from second distraction is fitted with acetabular cup, the side surface of second distraction away from first distraction is fitted with acetabular bone, adjusting piece is arranged on main body, and adjusting piece can adjust the relative distraction angle of first distraction and second distraction and keep first distraction and second distraction at distraction angle.The acetabulum patch of the application can be flexibly equipped with various bone defect values, has high universality, does not need to grind acetabular bone mass, reduces the difficulty of operation, and also does not need to reconstruct patch according to bone defect value, saves cost.

This invention belongs to the field of cell engineering technology, specifically relating to an engineered mitochondrial nanoshield, its preparation method, and its applications. The engineered mitochondrial nanoshield can resist damage from high concentrations of calcium ions in the extracellular environment, and also possesses BMMSCs targeting ability and ROS-responsive characteristics. After intravenous injection, the engineered mitochondrial nanoshield can selectively target BMMSCs to alleviate cellular senescence and increase bone mass in aged mice.

The application belongs to the technical field of biological medicine, and particularly relates to a use of an IP6K2 inhibitor in preparation of a drug for treating osteoporosis. The application finds that IP6K2 regulates osteoclast activity through a series of experiments, and targeting IP6K2 can be used as a treatment method for treating OP. The application mainly finds that IP6K2 is a key target point for regulating osteoclast activity, and inhibiting IP6K2 in osteoclasts (in mature osteoclasts and osteoclast precursors) or the whole body can significantly improve bone mass.

The invention provides a vertebral bone quality detection and evaluation method for osteoporotic fracture, which comprises the following steps: automatically extracting a vertebral bone region through an advanced deep segmentation network, analyzing the main direction of a bone trabecula based on a Hessian matrix, constructing an anisotropic guide map and forming a physical constraint convolution kernel to simulate biomechanical response; performing low-dimensional coding on the strain energy density field by using a variational auto-encoder, and realizing dynamic fusion of images and biomechanical features through a dual-channel gating fusion network in combination with image features extracted by a convolutional network; and finally, linear regression is adopted to predict the equivalent bone mineral density, and the performance is improved through end-to-end optimization, so that the centrum bone structure and mechanical characteristics can be accurately reflected, and the generalization ability and clinical practicability of bone mineral density prediction are improved.

The application discloses a pea peptide mixture with calcium binding and osteogenesis promoting effects and application thereof, wherein the pea peptide mixture is derived from protein components in a by-product of pea starch extraction, is obtained through alkaline protease and papain enzymolysis and separation and purification, and is rich in aspartic acid and glutamic acid residues. The pea peptide mixture can effectively bind with calcium ions, the pea peptide mixture can promote calcium ion delivery in osteoblasts, improve alkaline phosphatase activity, and promote osteoblast differentiation, the osteogenesis promoting effect of the pea peptide mixture is related to epidermal growth factor receptor EGFR and downstream PI3K-Akt signal pathway regulation. The pea peptide mixture can improve glucocorticoid-induced zebrafish bone mass reduction, and up-regulate mRNA expression levels of ALP, EGFR, PI3K and Akt and other genes related to osteogenesis. The pea peptide mixture has both functions and nutrition, can be used for preparing products for promoting osteogenesis, improving bone mass, improving bone mass reduction and assisting in improving osteoporosis, and has a wide application prospect in the field of bone health.

The aqueous pharmaceutical formulation with improved stability comprises denosumab and a poloxamer, and preferably a histidine buffer and / or a sugar or sugar alcohol. The formulation is for use in the treatment or prevention of skeletal-related events associated with osteoporosis, reduced bone mass, multiple myeloma, solid tumor bone metastasis, giant cell tumor of bone, or hypercalcemia.

To provide a heel stimulation device that can effectively suppress bone loss and increase bone mass. [Solution] The heel stimulation device comprises a base member 10, a pair of left and right pedals 20 for placing the foot on and pressing down, a pedal support mechanism 30 for supporting each pedal 20 on the upper side of the base member 10 in a state where it can be raised and lowered, and a pair of left and right heel stimulation protrusions 40 that are inserted through holes 21 provided in the heel portion of the pedals 20. When the pedals 20 are pressed down, the upper ends of the heel stimulation protrusions 40 protrude from inside the through holes 21 to the upper surface of the pedals 20, stimulating the heel of the foot placed on the pedals 20. When the pedals 20 are raised, the upper ends of the heel stimulation protrusions 40 retract into the through holes 21, resulting in a state where the heel of the foot is not stimulated.

The invention relates to a dental short implant, and belongs to the technical field of medical instruments. The implant comprises a main body, the lower part of the main body is a fixing part, the upper part of the main body is a connecting part, the upper side of the fixing part is provided with a composite thread consisting of a sawtooth-shaped counterfort thread and a sawtooth-shaped reverse counterfort thread, a pressure surface is formed between the sawtooth-shaped counterfort thread and the sawtooth-shaped reverse counterfort thread, the lower side of the fixing part is a V-shaped thread, and the bottom of the fixing part is a circular truncated cone; and the fixing part and the connecting part are integrally formed and manufactured. The invention aims to be applied to cases of bone mass insufficiency in maxillary sinus areas or near mandibular nerve tube parts, prevent a central screw from being broken and loosened, and overcome the problem of inflammation caused by a micro gap between an abutment and an implant.

This invention belongs to the technical field of Mongolian medicine composition, and discloses a Mongolian medicine composition for treating osteoporosis, its preparation and application. The composition, by weight, consists of 5-15 parts of ginseng, 10-20 parts of dragon bone, 8-18 parts of gypsum, 6-16 parts of pomegranate, 3-9 parts of cardamom, 4-12 parts of safflower, 2-8 parts of cinnamon, and 2-8 parts of long pepper. This Mongolian medicine composition integrates characteristic Mongolian medicines such as ginseng and gypsum, following the Mongolian medicine theory of "harmonizing cold and heat, and combining tonification and purgation." It can simultaneously act on three key pathological links: "inhibiting osteoclast activity," "promoting osteogenic differentiation," and "regulating the inflammatory microenvironment of bone tissue," achieving multi-target synergistic treatment. It not only effectively improves low bone mass but also significantly relieves bone pain, fundamentally intervening in bone metabolic imbalance and achieving a comprehensive therapeutic effect that addresses both the symptoms and the root cause.

A toilet seat with an integrated body fat scale capable of measuring body fat percentage, muscle mass, water content, and bone mass.

In a dental implant surgery, bone grafting is needed due to insufficient bone mass, and periosteum tension reduction is needed during bone grafting, so that the minimally invasive periosteum tension reduction device is an instrument for periosteum minimally invasive tension reduction during dental implant, and aims to reduce the pain of a patient during periosteum tension reduction during implant and improve the operation convenience of a doctor. In the current oral implant surgery, the existing implant periosteum distension reduction instrument is only provided with a surgical blade clinically at present, and a doctor needs to add a vertical incision in the periosteum distension reduction process, so that the pain of a patient is greatly increased, the operation time of the doctor is greatly prolonged, and the operation difficulty of the doctor is also increased. According to the minimally invasive periosteum tension reducing instrument for oral implantation, vertical incisions of an implantation area are reduced, the direction and the movement track of a traditional scalpel are changed, the minimally invasive purpose is achieved, and the consequences that the vertical incisions of gingival mucosa are increased by the traditional scalpel and the soft tissue of a patient is excessively injured due to too deep cutting of the traditional scalpel are not brought to a doctor; compared with the prior art, the device has the advantages of being minimally invasive, reducing the pain of a patient, shortening the operation time, facilitating operation of a doctor, improving the operation efficiency, removing a vertical incision during periosteum tension reduction, reducing postoperative suture wound cracking, preventing the risk of infection caused by bone meal exposure, providing an effective solution for complex oral implant cases, and having a wide application prospect. And the treatment experience and satisfaction degree of the patient are improved.

To support planning of a surgical treatment suitable for an affected bone of a subject. An information processing system includes a first estimator and an outputter. The first estimator inputs input information including a first image showing an affected area including a target bone of a subject in which an implant is placed into a trained first learning model, and estimates first estimation information regarding at least any of a bone density, a bone mass, and a bone quality of the target bone. The outputter outputs the first estimation information.

The invention discloses a biomarker related to bone fragility and / or fracture of a diabetic patient and a kit of the biomarker. The biomarker related to the bone fragility and / or fracture of the diabetic patient is maltol. Along with the increase of the content of maltol in the body of a diabetic patient, the possibility of fracture is also increased. When a diabetic patient is treated, the content of maltol in the body can be used as a basis for judging whether treatment is effective or not and / or whether bone quality is improved or not.

This invention provides the application of Neoruscogenin in the preparation of anti-osteoporosis drugs, belonging to the field of pharmaceutical biotechnology. It was found that Neoruscogenin can significantly increase bone volume fraction, bone surface area to tissue volume ratio, bone mineral density, trabecular bone number, and trabecular bone thickness in osteoporotic mice, while significantly reducing trabecular bone separation; that is, Neoruscogenin can alleviate low bone mass in postmenopausal osteoporotic mice. Furthermore, Neoruscogenin treatment for 8 weeks did not significantly affect the major organs of mice, suggesting the biocompatibility of Neoruscogenin.

The application discloses a prosthesis capable of fixing a proximal femur in hip joint revision surgery and relates to the technical field of medical devices.The prosthesis comprises a femoral stem body and a dynamic auxiliary structure.The dynamic auxiliary structure comprises a side groove, a counterweight and a limiting seat.The side groove is provided through the wide side of the femoral stem body.The two side ports of the side groove are provided with elastic plates, and the side groove is provided with a guide rod.The counterweight is movably sleeved on the guide rod.A traction spring is arranged between the top of the counterweight and the end of the side groove.The two sides of the counterweight are embedded with protrusions.The limiting seat is arranged on the inner wall of the side groove and located on the two sides of the counterweight.A guide column is slidably arranged through the limiting seat, and the end of the guide column close to the counterweight is provided with a transmission seat corresponding to the protrusions.The prosthesis can reduce the micromotion of the prosthesis and the femoral medullary cavity, promote bone ingrowth, reduce the incidence of long-term loosening, activate osteoblast activity, inhibit osteoclast proliferation, maintain the bone mass around the prosthesis, and prolong the service life of the prosthesis.