118 results about "Bone mass" patented technology

The invention discloses bifidobacterium longum subsp.infantis capable of promoting bone growth and a metagen thereof, and belongs to the technical field of biology. The bifidobacterium longum subsp. Infantis CCFM1445 provided by the invention can promote the increase of bone volume fraction, femoral bone trabecula thickness and far-end growth plate thickness of mammals in a growth period, reduce the levels of serum bone resorption markers I-type collagen amino-terminal peptide and tartrate-resistant acid phosphatase, improve the levels of serum bone alkaline phosphatase and parathyroid hormone, and improve the clinical application value of the bifidobacterium longum subsp. Infantis CCFM1445. And the relative abundance of the other bacteria in the intestinal flora and the levels of creatine and indole-3-lactic acid are increased. The thermally inactivated bifidobacterium longum subsp. Infantis CCFM1445 can promote the increase of the volume fraction of femoral bones and the number of bone trabecula of malnourished mice and improve the N-terminal propeptide level of serum I-type procollagen. Therefore, the medicine or health care product prepared from the bifidobacterium longum subsp. Infantis CCFM1445 can be used for assisting in regulating bone metabolism and bone mass, and has a wide market prospect.

Systems and methods for real-time navigation of reaming of an acetabulum are disclosed. A first tracking element is interfaced to a reamer. A second tracking element is interfaced at or near the acetabulum. The first tracking element can be interfaced to an outer casing surrounding a portion of the shaft of the reamer. A depth and a tilt angle of the reamer with respect to the acetabulum are determined, based on a location of the first and second tracking elements. Based on a surgical plan, the depth and the tilt angle, the volume of removed bone from the acetabulum can also be determined.

The invention relates to the technical field of medical information, in particular to an osteoporosis risk intelligent early warning method and system based on a big database. The method comprises the following steps: extracting user bone health data in a multi-source health database; evaluating a bone mass state based on the user bone health data; screening osteoporosis risk users in the user bone health data according to the bone mass state; inquiring a medical image of the osteoporosis risk user; extracting a bone mineral density value by using the medical image, and determining a bone mineral density change trend according to the bone mineral density value; detecting the degeneration degree of the bone microstructure by using a medical image; constructing an osteoporosis risk early warning model according to the bone mineral density change trend and the bone microstructure degeneration degree; and inputting the user bone health data into the osteoporosis risk early warning model to generate a risk early warning score. According to the invention, accurate identification and dynamic monitoring of the osteoporosis risk user are realized based on the medical information technology, and the accuracy and response rate of osteoporosis risk early warning are improved.

The invention provides an application of narirutin in preparation of a medicine for preventing and / or treating osteoclast of inflammatory arthritis, relates to the technical field of biomedicine, and adopts a collagen-induced mouse arthritis model to observe the treatment effect of the narirutin on the osteoclast of the inflammatory arthritis. The arthritis activity degree of the mouse is analyzed through general claw photographing, thickness measurement, near-infrared temperature measurement and a claw imprinting experiment, three-dimensional reconstruction and bone trabecula analysis are carried out on local joints and the whole body bone mass of the mouse through micro-CT scanning, and Hamp is applied; e, dyeing and Famp; through histological staining analysis such as O staining and TRAP staining, in combination with immunohistochemical staining and the like, the narirutin is proved to play a role in treating inflammatory arthritis, inhibit macrophage pro-inflammatory M1 type polarization, relieve the inflammation level, improve the bone mass of local joints and the whole body, and further improve bone destruction in inflammatory arthritis diseases. The narirutin provides a new way for medicine prevention and treatment of inflammatory arthritis.

The invention belongs to the field of biomedical engineering, and relates to a nutritional composition for delaying muscle attenuation and bone mass reduction based on muscle-bone axis interaction and a preparation method of the nutritional composition. In particular to a nutritional composition which comprises or consists of beta-hydroxy-beta-methylbutyric acid or salt thereof and milk-derived basic protein; wherein the mass ratio of the beta-hydroxy-beta-methylbutyric acid or the salt thereof to the milk-derived basic protein is (120: 1)-(5: 1). According to the nutritional composition disclosed by the invention, through the synergistic effect of the beta-hydroxy-beta-methylbutyric acid or the salt thereof and the milk-derived basic protein, the muscle-bone axis is jointly regulated and controlled, and the comprehensive improvement effect of muscle-bone health which cannot be achieved by a single component is achieved.

The invention relates to the field of biological medicine, and discloses application of ergothioneine in preparation of a medicine for preventing and / or treating osteoporosis. The invention discloses a new mechanism of the ergothioneine for improving the osteoporosis by regulating and controlling the NF-kB / NFATc1 signal channel and reducing oxidative stress and inflammatory response for the first time, and provides a brand new thought for developing safe and effective anti-osteoporosis medicines. The discovery that the ergothioneine improves bone mass loss related to estrogen decline provides a new solution for lack of osteoporosis treatment means at present, and opens up a new way for application of natural products in bone metabolic diseases.

The application provides an application of Lipofermata in preparation of a product for preventing and treating osteoporosis. The pharmacological experiment of the application shows that Lipofermata can significantly prevent and treat and improve the reduction of bone mass caused by estrogen reduction, and shows that Lipofermata has the effect of preventing and treating osteoporosis, and therefore can be used for preventing and treating osteoporosis. The application not only provides a new therapeutic use of Lipofermata, but also provides a new drug for preventing and treating osteoporosis.

The invention is suitable for the technical field of data recognition, and provides a big data-based body state detection method and device, and the method comprises the steps: collecting high-frequency impedance, low-frequency impedance and a current phase difference through a foot electrode; calculating body composition according to the high-frequency impedance and the low-frequency impedance; wherein the body components comprise body fat percentage, muscle mass, total body moisture, basal metabolic rate and bone mass; calculating the body age according to the body composition; generating body change information according to the body composition and the current phase difference; wherein the body state information comprises body change information and body age. According to the technical scheme, comprehensive measurement of the high-frequency impedance, the low-frequency impedance and the current phase difference is introduced, and analysis and calculation based on big data are carried out, so that comprehensive, accurate and personalized detection of the body state is realized. And the accuracy and the reliability of a measurement result are improved.

The utility model discloses an oral implant which comprises a bone surface supporting structure, the appearance of the bone surface supporting structure is attached to an upper jaw alveolar bone surface or a lower jaw alveolar bone surface, and a net-shaped through hole is formed in the bone surface supporting structure and corresponds to the alveolar bone surface; a plurality of base tables protruding out of the surface are arranged on the surface of one side of the bone surface supporting structure, and the base tables are used for fixedly connecting the oral implant with a prosthesis; one end, connected to the bone surface supporting structure, of the abutment is provided with an intraosseous implant implanted into the jaw bone. According to the utility model, the traditional subperiosteal implant is improved, the subperiosteal implant is designed in the area with insufficient bone mass of the jaw bone, and the novel stent-shaped implant is formed by combining the subperiosteal implant with the intraosseous implant in the area with sufficient bone mass of the jaw bone, so that independent bone increment operation is not needed, and the implant can be implanted only by one operation; and the clinical problem that a patient with serious atrophy of the alveolar ridge is difficult to implant and repair is effectively solved.

The application discloses application of mesenchymal stem cell spheroids in preparation of a preparation for treating osteoarthritis, and relates to the technical field of cell therapy and osteoarthritis treatment, and specifically comprises mesenchymal stem cell spheroids with an average diameter of 120-180 mu m and a solution containing 0.5%-10% human serum albumin. The cells are prepared into 120-180 mu m cell spheroids, and the solution containing specific concentration human serum albumin is used as a carrier, so that the cell survival rate is stabilized at more than 90%, and high-activity delivery is realized; the optimized size ensures smooth injection and long-term retention in the joint cavity, and overcomes the shortcoming that single cells are easily removed; after joint cavity injection, the preparation can synergistically promote bone reconstruction and cartilage repair, and produces clear curative effects such as bone mass increase of more than 30%, cartilage degeneration score reduction of more than 50%, and the like, which are quantifiable and verifiable, so that a stable, long-acting and curative drug preparation and application scheme are provided for osteoarthritis treatment.

The invention provides an individualized tibia defect repairing type knee joint prosthesis, and belongs to the technical field of orthopedic implants. The device is formed by assembling a femoral condyle, a femoral bone marrow needle, a plateau pad, a tibia plateau, a restoration body and a tibia bone marrow needle. Wherein the tibia platform and the restoration body are matched through metal-metal threads and are assisted by bone cement to achieve anti-rotation locking, the restoration body adopts a 3D printing individualized bone trabecula structure and is compounded with an HA coating to promote bone ingrowth, the tibia bone marrow needle and the platform are connected through a standard taper connector, inventory and individualization compatibility is achieved, and the bone marrow needle and the platform are connected through a standard taper connector. The defects that an existing prosthesis is large in bone mass loss, unattractive in reconstruction, free of bone ingrowth function, high in processing cost and the like are overcome, and the postoperative function of a tibia defect patient and the long-term stability of the prosthesis can be remarkably improved.

The utility model relates to medical equipment technical field, concretely is a kind of positioning drill for dental implant surgery. Including driving rod, the one end of driving rod is connected with annular drill bit, the end of annular drill bit is equipped with tooth edge, the inside of annular drill bit is provided with the positioning member extending outward, the middle part of driving rod is provided with fixed ring, driving rod and located the side activity sleeve of annular drill bit is equipped with sleeve, driving rod and located between sleeve and fixed ring is equipped with spring, the side of sleeve and annular drill bit is open structure. Through different specifications sleeve, the safety distance required around implant can be guaranteed;Annular drill bit marks edge, the remaining bone mass around implant after implantation and the distance with adjacent tooth can be intuitively displayed;In the process of continuing to prepare hole, if deviation is generated due to bone density uneven, it can be easily observed and adjusted;Reduce the additional cost generated by the production of guide plate and navigation, reduce the burden of patient.

The invention discloses a 2, 3, 4, 9-tetrahydro-1H-pyridine [3, 4-b] indole compound as well as a preparation method and application of the 2, 3, 4, 9-tetrahydro-1H-pyridine [3, 4-b] indole compound. According to the preparation method, 3-hydroxy-4-methoxybenzaldehyde and 1-(chloromethyl)-2, 6-difluorobenzene are taken as initial raw materials, and 1-(3-((2, 6-difluorophenyl) oxo)-4-methoxyphenyl)-2, 3, 4, 9-tetrahydro-1H-pyridine [3, 4-b] indole is prepared through a two-step reaction. The 1-(3-((2, 6-difluorophenyl) oxo)-4-methoxyphenyl)-2, 3, 4, 9-tetrahydro-1H-pyridine [3, 4-b] indole provided by the invention has a remarkable inhibition effect on osteoclast differentiation induced by RANKL, has no obvious cytotoxicity, can be used as a candidate drug which is novel in structure and is used for inhibiting osteoclast differentiation, and has a broad application prospect. The method is used for targeting osteoclast to treat bone mass loss related diseases.

This invention relates to a method of treating a joint and / or bone disease, slowing progression of a reduction in bone mass, increasing osteoblast formation, decreasing osteoclast formation, and / or reducing osteocyte death, slowing progression of a reduction in joint mobility and / or function, slowing progression of a reduction in cartilage, and / or reducing chondrocyte senescence and / or death by administering a therapeutically effective amount of a SIRT6 activator, optionally with nicotinamide adenine dinucleotide (NAD+) and / or an NAD+ precursor.

The present application provides methods of use, specifically methods of treatment of a disease, disorder, or condition (e.g, a low bone mass condition such as osteoporosis) in a human individual, comprising administration of novel bispecific antibodies that bind to both sclerostin and DKK-1 (e.g, anti-Sclerostin x anti-DKK-1 bispecific antibodies). The present application also provides methods of increasing bone mineral density in a human individual comprising administration of novel anti-Scl erostin x anti-DKK-1 bispecific antibodies. The present application further provides methods of reducing risk of bone fracture (e.g., osteoporotic fracture) in a human individual comprising administration of novel anti-Sclerostin x anti-DKK-1 bispecific antibodies.

The present invention provides a cervical vertebrae prosthesis, which includes: a solid layer, the solid layer including an anterior plate and a posterior plate that are interconnected, the anterior plate and the posterior plate together forming a receiving cavity, the anterior plate being an arc-shaped structure, the axis of the anterior plate extending in the vertical direction; a porous layer, the porous layer filling the receiving cavity; wherein the cervical vertebrae prosthesis has a first bone grafting hole that extends in the vertical direction and passes through the upper and lower end surfaces of the porous layer, and the cervical vertebrae prosthesis also has a second bone grafting hole that passes through the anterior plate and extends into the porous layer. The technical solution provided by this application can solve the problem in the related art that the cervical vertebrae prosthesis cannot increase the amount of bone grafting while meeting the structural strength.

The application discloses a bone mass recognition method and system based on a three-dimensional convolutional neural network and a CT image, and comprises the following steps: acquiring an original CT image comprising a lumbar vertebra; obtaining a probability image and a lumbar vertebra part mask image according to the original CT image and a trained three-dimensional rough segmentation network model of the lumbar vertebra part; obtaining a lumbar vertebra part CT image according to the lumbar vertebra part mask image and the original CT image; obtaining a lumbar vertebra body mask image according to the probability image, the lumbar vertebra part CT image and a trained three-dimensional fine segmentation network model of the lumbar vertebra; obtaining a three-dimensional CT image of the lumbar vertebra body according to the lumbar vertebra body mask image and the original CT image; and obtaining a bone mass recognition result according to the three-dimensional CT image of the lumbar vertebra body and a trained classification network model. The application realizes accurate recognition of bone mass.

The invention relates to a device for bone formation, bone reshaping or healing of bone in dental, oral and maxillofacial applications, specifically in connection with installation of dental implants. The device comprises a sheet structure made of an inert material, wherein the sheet structure has an inner surface intended to be directed towards the bone and an outer surface intended to be directed away from the bone. The geometrical features of the cavity formed between the inner surface of the device and the initial bone surface when the device is installed at the intended location is further used to improve and plan the treatment. The device is customized by means of digital planning based on the initial and the optimal bone volume for the intended treatment. Modifications of the device can be introduced to facilitate a combined installation of dental implants with the device.

The invention provides a composition. The composition is prepared from vitamin A, vitamin D, vitamin E, vitamin K and health-care food or food-acceptable auxiliary materials according to specific proportions and doses. The anti-osteoporosis health-care food has the advantages that the vitamin components have a synergistic effect in the aspect of anti-osteoporosis, and the anti-osteoporosis health-care food can increase bone mineral density and maintain bone mass. In addition, the composition disclosed by the invention can also be used for precise nutritional supplement of specific crowds.

The invention provides a bone evaluation method based on neural network enhancement and finite element analysis. The bone evaluation method comprises the following steps: acquiring an ultrahigh-resolution CT image of a living vertebra; performing domain conversion processing on the CT image by adopting a generative neural network; carrying out resampling and segmentation on the enhanced CT image; constructing a bone trabecula microstructure model in the cancellous bone mask area; assembling the RVE unit and the cortical bone model into a complete vertebral finite element model, and applying a multi-working-condition load to the RVE unit to calculate anisotropic material parameters; and carrying out axial compression finite element analysis on the complete centrum model, and judging the bone health state. According to the method, information of two dimensions of bone mass and bone, especially contribution of a bone trabecula microstructure to bone strength, is comprehensively considered, bone degeneration and fracture high-risk patients can be recognized earlier, and a scientific basis is provided for clinical early intervention.

The present invention discloses a method for verifying osteotomy accuracy during knee replacement surgery, comprising: S1, obtaining a preoperative point cloud of a patient and marking anatomical bony landmarks therein; S2, determining whether it is a non-imaging surgical plan; if so, obtaining a planned osteotomy plane and a planned osteotomy amount, and simultaneously registering the patient's preoperative point cloud with the intraoperative point cloud; otherwise, obtaining a planned osteotomy plane and a planned osteotomy amount; S3, obtaining a postoperative point cloud of the patient after osteotomy, identifying the actual osteotomy plane therein, and then calculating the actual osteotomy amount, while removing points on the identified actual osteotomy plane; S4, registering the patient's preoperative point cloud with the postoperative point cloud after removing the points on the actual osteotomy plane; S5, based on the registration in S4, transforming the actual osteotomy plane obtained in S3 and the planned osteotomy plane obtained in S2 to the same reference, and calculating the osteotomy plane error and the osteotomy amount error accordingly. The present invention can verify osteotomy accuracy under optical navigation.

The invention discloses a metal organic framework material targeting bone marrow fat cells as well as a preparation method and application of the metal organic framework material, and belongs to the technical field of biomedical materials and tissue engineering. The material comprises: (1) a ZIF-8 core structure used for loading nucleic acid / small molecule drugs; (2) surface modification of lipid droplet targeting peptide: the lipid droplet targeting peptide is combined with a PEDF receptor to realize precise targeting; and (3) anti-miR-188 is loaded inside and is used for inhibiting adipogenic differentiation. The method at least has the following advantages: (1) a bone marrow adipocyte specific targeting MOF material is proposed for the first time, and bone metabolism intervention is converted from a mode of targeting osteoblast or macrophage to targeting adipocyte; (2) the MOF core can quickly respond to a marrow weak acid environment to realize accurate release; (3) the AdipoPep targeting peptide can obviously prolong the residence time of the bone marrow; and (4) adipogenic differentiation is significantly inhibited, osteogenesis microenvironment reconstruction is promoted, and an excellent bone mass recovery effect is shown in an osteoporosis model.

The invention discloses an application of a branched ketonic acid dehydrogenase kinase (BCKDK) inhibitor in preparation of a medicine for preventing and treating osteoporosis. The invention finds that BCKDK can inhibit osteoblast differentiation and reduce the expression of endogenous BCKDK in osteogenic precursor cells so as to promote osteoblast differentiation; a small molecule compound inhibitor BT2 (3, 6-dichloro-2-benzothiophene carboxylic acid) of BCKDK promotes osteoblast differentiation of ovariectomized mice, inhibits osteoclast differentiation, reduces ovariectomized mouse bone loss and increases bone mass. According to the invention, the BCKDK inhibitor is proposed for the first time to be capable of promoting osteoblast differentiation, inhibiting osteoclast differentiation and increasing body bone mass by reducing BCKDK expression or inhibiting BCKDK protein biological functions, and has the effect of preventing and treating osteoporosis.

The application provides a strontium-doped beta-tricalcium phosphate / hydroxyapatite biphasic calcined bone, and provides the strontium-doped beta-tricalcium phosphate / hydroxyapatite biphasic calcined bone, which has high porosity, a large average value of pore size, high biocompatibility, and a fast degradation rate, is used for filling and repairing of periodontal bone and maxillofacial surgical bone defects or bone insufficiency, and has a good repairing effect.

A bone part is repaired by a process. A first implant is attached to a first bone part. The first implant corresponds to an intraoperatively defined or an intraoperatively selected cutting path. A preoperatively defined second implant is attached to the first implant. The first implant and the second implant together augment the first bone part.

The invention relates to application of 2, 2 ': 5', 2 ''-trithiophene-5-formaldehyde in preparation of medicines for treating osteoporosis, and belongs to the technical field of biological medicines. The application of 2, 2 ': 5', 2 ''-trithiophene-5-formaldehyde in preparation of the medicine for treating osteoporosis is found for the first time, and especially the excellent application of 2, 2 ': 5', 2 ''-trithiophene-5-formaldehyde in preparation of the medicine for treating osteoporosis of postmenopausal women is found. In the cell level, the 2, 2 ': 5', 2 ''-trithiophene-5-formaldehyde shows obvious osteogenesis promotion and adipogenesis inhibition activity. On the animal level, the 2, 2 ': 5', 2 ''-trithiophene-5-formaldehyde can significantly improve bone mass loss of mice with osteoporosis caused by OVX, and promotes bone formation while inhibiting bone resorption. The result shows that the 2, 2 ': 5', 2 ''-trithiophene-5-formaldehyde has a good osteoporosis treatment effect, provides a novel anti-osteoporosis medicine for clinic, and has a wide application prospect and a relatively high application value.

The utility model discloses a lateral fixed implant, which relates to the technical field of implants and comprises an implant main body, a fixed cavity is arranged at the top of the implant main body, a fixed needle is arranged in the fixed cavity, and the fixed cavity comprises a cone, an anti-rotation structure, a threaded hole, a first hole, a second hole and a third hole which are sequentially communicated with one another from top to bottom. A first thread is arranged on the outer surface of the implant main body, a fourth hole is formed in the outer surface wall, located on the first thread, of the implant main body, the fourth hole is communicated with the third hole, and the fixing needle comprises a cap head, a rod part, an anti-withdrawing thorn and a tip which are fixedly arranged in sequence from top to bottom. Through double fixation of the lateral fixing needle, the stability of the implant is effectively enhanced, the defects of insufficient retention of the implant and complicated methods such as wing plate and cheekbone implantation are overcome, and the lateral fixing implant can be applied to the situation of insufficient bone mass of maxillary alveolar bones.

The invention discloses a computational mechanical analysis system for evaluating bone growth induced by a bone healing scaffold, and relates to the technical field of bone healing evaluation, and the computational mechanical analysis system is specifically characterized in that under unified external load and time gating, quantitative indexes such as a regional average osteogenesis rate curve, an accumulated bone mass, time for reaching a preset healing threshold value, a cross section bridging rate and the like are used for evaluating bone growth induced by a bone healing scaffold; the induction osteogenesis effects of different stent structures are fairly compared, shape scoring and subjective weight are avoided, reproducibility and calibration are emphasized, the method can be used for preoperative structure screening and parameter sensitivity analysis and can also be in butt joint with follow-up images and experimental data, online calibration and treatment course optimization of individualized digital twinning are further supported, and the method is suitable for popularization and application. According to the method, the period boundary, the time-varying supply gating and the multi-physics field coupling of the RVE can be unified into the same calculation framework, and the defects of the prior art in microscopic geometric maintenance, time rhythm expression and biomechanical closed loop are effectively overcome.

The application discloses a kind of acetabulum patch and acetabulum patch system, the acetabulum patch includes main body and adjusting piece, main body includes first distraction and second distraction, one end of first distraction is rotatably connected with the end of second distraction, the side surface of first distraction away from second distraction is fitted with acetabular cup, the side surface of second distraction away from first distraction is fitted with acetabular bone, adjusting piece is arranged on main body, and adjusting piece can adjust the relative distraction angle of first distraction and second distraction and keep first distraction and second distraction at distraction angle.The acetabulum patch of the application can be flexibly equipped with various bone defect values, has high universality, does not need to grind acetabular bone mass, reduces the difficulty of operation, and also does not need to reconstruct patch according to bone defect value, saves cost.

The present invention provides an application of animal Bifidobacterium lactis subspecies CP-9 in the preparation of a product that promotes bone growth and development or improves bone health. After long-term research and a large number of experiments, the present invention found that animal Bifidobacterium lactis subspecies CP-9 can improve the body's bone volume fraction, trabecular thickness, bone density and bone mass, and can also effectively increase the level of growth hormone and insulin-like growth factor 1, thereby promoting bone growth and development. At the same time, animal Bifidobacterium lactis subspecies CP-9 can effectively increase the level of type I procollagen N-terminal propeptide, osteocalcin level, bone morphogenetic protein level, and osteoprotegerin level in the body, and significantly reduce the level of type I collagen amino-terminal peptide and nuclear factor κB receptor activator ligand level, thereby promoting osteoblast differentiation, inhibiting osteoclast differentiation, and then promoting bone formation, inhibiting bone resorption, improving bone metabolism, and ultimately achieving the effect of improving bone health.