The invention belongs to the field of research of related medicines for Alzheimer's disease, and particularly discloses sclerostin and application thereof in preparation of related products for treating or preventing Alzheimer's disease. The sclerostin is a protein secreted by bone cells and used for regulating and controlling bone mass, and the amino acid sequence of the sclerostin is shown as SEQ NO.1. Through synthesis of sclerostin recombinant protein and a corresponding neutralizing antibody, it is verified throughcell and zoology experiments that the sclerostin recombinant protein can accelerate generation of A beta protein outside brain tissue and accelerate cognitive function decline; after the neutralizing antibody is added, the BACE1 protein expression is obviously inhibited, so that the production of A beta protein is inhibited, and the effect of relieving Alzheimer's disease is achieved. The neutralizing antibody prepared on the basis of the sclerostin has a treatment and/or prevention effect, and can be used for preparing a medicine or a health care product for treating and/or preventing the Alzheimer's disease, so that a brand new choice and thought are provided for treating and/or preventing the Alzheimer's disease, and the selection field for treating the Alzheimer's disease is widened.