4 results about "Increased bone mineral density" patented technology

The invention relates to an application of plant lactobacillus Hi188 in promotion of bone health. The invention provides the application of the plant lactobacillus Hi188 or the afterbiogen thereof or the composition thereof in increasing the bone mineral density, increasing the bone mineral density, promoting the skeletal development, increasing the bone mineral content and / or promoting the tibia growth. Or preparing food for increasing bone mineral density, increasing bone mineral density, promoting skeletal development, increasing bone mineral content and / or promoting tibia growth; wherein the composition comprises: (A) Phytobacterium plantarum Hi188 or a postbiotic thereof, and (B) Bifidobacterium lactis Ca360 or a postbiotic thereof.

The present application provides methods of use, specifically methods of treatment of a disease, disorder, or condition (e.g, a low bone mass condition such as osteoporosis) in a human individual, comprising administration of novel bispecific antibodies that bind to both sclerostin and DKK-1 (e.g, anti-Sclerostin x anti-DKK-1 bispecific antibodies). The present application also provides methods of increasing bone mineral density in a human individual comprising administration of novel anti-Scl erostin x anti-DKK-1 bispecific antibodies. The present application further provides methods of reducing risk of bone fracture (e.g., osteoporotic fracture) in a human individual comprising administration of novel anti-Sclerostin x anti-DKK-1 bispecific antibodies.

This invention discloses a composition with bone-health-promoting functions and its applications, belonging to the field of microbial engineering. The composition comprises milk calcium, colostrum basic protein, and Bifidobacterium breve i1088 powder. The composition provided by this invention, which has a synergistic effect between milk calcium, colostrum basic protein, and Bifidobacterium breve i1088 powder, enhances the conversion rate of calcium from the blood to bone through the action of probiotics, thereby improving the actual utilization rate of calcium and effectively promoting bone health. Experimental data show that this composition significantly increases bone mineral density, bone volume fraction, and trabecular thickness in a female rat osteoporosis model, and significantly reduces trabecular spacing in the same model. The composition provided by this invention is suitable for promoting bone health and preventing and / or improving osteoporosis.

This invention discloses the application of Morkotin A (quercetin-3-O-rutin-7-O-glucoside) in the preparation of pharmaceuticals, health foods, or functional foods, belonging to the field of biomedical technology. Animal experiments have demonstrated that Morkotin A can significantly increase bone mineral density in ovariectomized osteoporotic mice, improve bone microstructure, and regulate calcium and phosphorus metabolism and bone turnover marker levels. Simultaneously, in vitro cell experiments have confirmed that Morkotin A can significantly promote osteoblast differentiation and inhibit osteoclast formation. The Morkotin A used in this invention is derived from the medicinal and edible herb, Lycium barbarum leaf, and has high safety. Both in vitro and in vivo experiments have confirmed that Morkotin A promotes bone formation and inhibits bone resorption, making it suitable for development as a drug for the prevention and treatment of osteoporosis, or as a health food or functional food that helps improve bone mineral density.