151 results about "Increased bone mineral density" patented technology

Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.

The invention is directed to a method of inhibiting bone resorption. The method comprises administering to a human an amount of sclerostin inhibitor that reduces a bone resorption marker level for at least 2 weeks. The invention also provides a method of monitoring anti-sclerostin therapy comprising measuring one or more bone resorption marker levels, administering a sclerostin binding agent, then measuring the bone resorption marker levels. Also provided is a method of increasing bone mineral density; a method of ameliorating the effects of an osteoclast-related disorder; a method of treating a bone-related disorder by maintaining bone density; and a method of treating a bone-related disorder in a human suffering from or at risk of hypocalcemia or hypercalcemia, a human in which treatment with a parathyroid hormone or analog thereof is contraindicated, or a human in which treatment with a bisphosphonate is contraindicated.

A novel class or family of TGF-β binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules. In particular, compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.

Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.

The invention relates to health food for enhancing human immunity and increasing bone mineral density and a preparation method thereof; the health food of the invention comprises the following components: hyaluronic acid, glucosamine, collagen, kudzu root extracts, chondroitin sulfate, vitamins, calcium, etc; because of the embedding processing of hyaluronic acid, the defect of property change of hyaluronic acid due to moisture absorption and influence of environmental factors is overcome; the health food prepared by the organic combination of the embedded hyaluronic acid with glucosamine, collagen, plant extracts, vitamins, mineral matter and the like has functions and effects which can supplement each other, has the effects of lubricating joints, increasing bone mineral density, and enhancing bone strength during long-term administration, and also has the functions of delaying aging, removing freckles and beautifying faces, and the like; the health food of the invention can be prepared into powder, granules, tablets, capsules, is convenient for carrying and taking, has stable and lasting efficacy, has no side effects, and is an ideal health food of patients with hypoimmunity and osteoporosis.

The invention discloses a multicomponent traditional Chinese medicine containing composition for increasing bone mineral density and a preparation method thereof. The composition comprises the traditional Chinese medicine raw materials in parts by weight: 400-500 parts of herba epimedii, 400-500 parts of Rhizoma Drynariae, 300-400 parts of achyranthes root and also comprises the following nutritional substances in parts by weight: 75-95 parts of calcium carbonate, 40-60 parts of fish collagen powder, 20-38 parts of chondroitin sulfate, 5-6.2 parts of glucosamine hydrochloride, 10-13 parts of vitamin C and 0.0003-0.0004 parts of vitamin D. According to conventional process, an oral solid preparation is prepared by extracting herba epimedii, Rhizoma Drynariae and achyranthes root by ethanol and mixing the ethanol extract and the nutritional substances and appropriate amount of auxiliary materials. The medical composition provided by the invention has the function of increasing bone mineral density and can be used for prevention and assistant treatment of osteoporosis.

The invention relates to a composition for increasing bone mineral density, a preparation agent containing the composition, and the preparation method of same. The composition comprises the following raw materials according to the weight portions: 0.5 to 35 portions of calcium carbonate, 0.5 to 30 portions of sulfuric acid dextrosamine, 0.05 to 2 portions of sulfuric acid chondroitin, 0.1 to 10 portions of collagen, and 0.08 to 5 portions of turmeric yellow extractive. In the composition, except a calsium supplement and a calcium absorbing promoting agent, the composition further comprises nutrients and anti-inflammatory mitigative, and can be used for preventing and treating osteoporotic symptom from multiply angles and ways.

The present invention relates to the design and composition of a depot implant for optimal delivery of growth factors to treat osteoporotic bone, in that such depot implant is constructed to be in a cylinder (rod) or sphere shape and have a natural or synthetic polymer scaffold with or without impregnated calcium phosphate particles. The density of the depot is higher than a typical BMP sponge carrier to facilitate it's implantation and slower release of the growth factor. The scaffold is such that it has adequate porosity and pore size to facilitate growth factor seeding and diffusion throughout the whole of the bone structure resulting in increased bone mineral density in the osteoporotic bone. In addition, the shape of the depot implant allows for delivery through a cannula or large bore needle.

The invention relates to a composition for increasing the bone mineral density and preparation and a preparation method thereof. The composition is mainly prepared from, by weight of parts, calcium carbonate, D-glucosamine hydrochloride, chondroitin sulfate, collagen protein, a casein phosphopepetides, a davallia mariesii extract and a vitamin K2. On the specific matched condition, the effect of remarkable synergistic interaction for treating osteoporosis is achieved, and the effects of blocking calcium loss and reinforcing calcium absorption are achieved; after traditional Chinese medicines of shaddock peels, chicken shells, purple bergenia herb and schisandra chinensis are added, the effect of increasing the bone density is further enhanced, and meanwhile the effects of treating the joint inflammation, tonifying the spleen and the kidney, strengthening tendons and bones, improving immunity and the like are achieved.

The invention belongs to the field of health care food, and especially relates to a composition used for improving skeletal system health, and applications thereof. The composition comprises skimmed milk powder, fructo-oligosaccharide, yak bone, orange fruit powder, D-glucosamine hydrochloride, bone collagen, chondroitin sulfate, herba epimedii extract, rhizoma drynariae extract, mushroom powder, magnesium carbonate, casein phosphopeptide, and vitamin K2. The composition possesses excellent prevention effects on patients with osteoporosis and skeletal system disorders such as ankylosis, arthritis, osteoproliferation, arthralgia, and myospasm, and is capable of increasing bone mineral density, and improving skeletal system health. The composition can be used for preparing health care food capable of improving skeletal system health; application range is wide; and economic benefit and social benefit are both high.

The invention provides a health care food used for increasing bone mineral density, preventing osteoarthrosis and enhancing immunity. The health care food is prepared from the following materials in parts by mass: 1500-2500 parts of marine fish bone collagen oligopeptide, 1500-2500 parts of fish bone powder, 200-400 parts of eucommia bark extract and 0.005-0.01 part of vitamin D and a proper amount of pharmaceutic adjuvants such as xylitol, dry skim milk, vegetable fat powder, essences, trichlorosucrose and the like. The health care food is prepared into a granular preparation by the following process steps of: premixing, granulating, total mixing and the like. The invention has the beneficial effects that the raw materials, i.e., marine fish bone collagen oligopeptide and fish bone whichcontain a large quantity of peptide, bone collagen and calcium, work together with eucommia bark extract and vitamin D in the health care food so that a human body can absorb effective ingredients better to increase bone mineral density, slow down bone marrow aging, enhance toughness of bones, and prevent and treat osteoporosis; in addition, peptide also has the functions of adjusting immunity and resisting bacteria and oxidation, thereby improving the immunity of the human body.

The invention relates to a medicinal preparation capable of increasing bone mineral density and improving osteoporosis. The preparation contains specific amounts of the active components consisting of D-glucosamine hydrochloride, chondroitin sulfate, calcium carbonate, vitamin D3 and the like. The preparation provided by the invention can substantially promote healing of fracture, which may be related to the fact that the preparation promotes activity of osteoblasts and increases expression of bone morphogenetic protein in fracture healing in an early stage. Both a medicine and a health product can be prepared from the preparation. Based on modern research, the preparation supplements calcium and vitamin D to exert the definite functions of bone mineral density increasing and osteoporosis improving; and the preparation exerts certain effects on improving ostalgia, arthralgia, osteoarthritis, hyperosteogeny, periarthritis of shoulder, sciatica, numbness of limbs and the like through supplementing D-glucosamine hydrochloride and chondroitin sulfate. The medicinal preparation provided by the invention has the advantages of definite therapeutic effects, safety, nontoxicity and no irritation to gastrointestinal tracts.

The invention discloses a Chinese medicine composition with a function of treating osteoporosis, which is composed of fructus psoraleae, herba epimedii, rhizoma polygonati, drynaria rhizome, fructus lycii, achyranthes root and the like. The Chinese medicine composition with the function of treating osteoporosis is good in curative effect and low in side effect and has the function of remarkably increasing bone mineral density.

The invention provides a composition for increasing the bone mineral density. The composition mainly comprises the following raw materials in parts by weight: 180-540 percent of calcium carbonate, 23-69 percent of D-glucosamine hydrochloride and 15-45 percent of collagen. The invention also provides a preparation method of the composition. The raw materials adopted by the composition for increasing the bone mineral density have no toxic and side effects, health and safety, has the effects of promoting calcium absorption and relieving osteoporosis and can safely and effectively supplement calcium of the human body and ensure that the calcium level is improved so as to prevent fractures and bone loss and has improvement effect on bone formation. Moreover, the invention adopts scientific andreasonable production process and better retains active constituents in various raw materials.

A composition for improving osteoporosis and increasing bone mineral density, a preparation method of the same and an application of the same in preparation of a health-caring product. The composition comprises an active ingredient and auxiliary materials and is characterized in that the active ingredient includes following components, by weight, 65-85 parts of a raw medicine in an extract of epimedium, 5-15 parts of glucosamine, 5-15 parts of chondroitin sulfate, 1.5-3.5 parts of collagen and a proper amount of vitamin D3; and the auxiliary materials include following components, by weight, 1.5-4.5 parts of an excipient and 0.2-1.5 parts of a lubricant. The composition is designed especially for middle-aged and elderly people and is strong in targeted performance. In the invention, the composition is prepared through integration of Chinese and western medicines, not only is traditional Chinese medicine guide theory inherited but also modern medicinal treatment methods are referenced. An experimental result proves that epimedium in the formula can increases the bone mineral density and the chondroitin sulfate, the glucosamine, the collagen and the vitamin D3 have an effect of improving the osteoporosis. The composition has excellent effects of increasing the bone mineral density and promoting absorption of calcium.

The invention provides a method for extracting artemisinin. The artemisinin is prepared through the method of supercritical fluid extraction and the method of microwave-assisted extraction, and the content of the artemisinin is greatly improved. The invention further provides the application of the artemisinin in preparing medicines for inhibiting proliferation of rat adrenal gland pheochromocytoma cell PC-12 and the application of the artemisnin in preparing medicines for increasing bone mineral density.

The invention provides an extraction method of piperine, which is obtained by supercritical extraction and microwave extraction. Thus, the content is greatly improved. The invention also provides application of piperine in preparation of drugs suppressing proliferation of human cervical carcinoma cell HELA cells and in preparation of drugs increasing bone mineral density.

The invention relates to composition with effects of increasing bone mineral density, preventing inflammation and easing pain and a preparation method thereof. The composition with the effects of increasing bone mineral density, preventing inflammation and easing pain is prepared from the following bulk pharmaceutical chemicals ingredients of chondroitin sulfate, glucosamine hydrochloride, calcium carbonate, sodium hyaluronate, dimethyl sulfone and radix puerariae extract. The invention further relates to a film-coated tablet prepared from the composition and a preparation method of the film-coated tablet. The composition has a better curing effect of increasing bone mineral density, and all ingredients have a synergistic effect, can easily improve calcium absorption and can well increase bone mineral density; animal function experiments prove that the composition can obviously improve the thighbone weight, the bone calcium content, the thighbone middle point density and the thighbone telecentric end bone mineral density of a rat.

A method of treating a mammal for a purpose selected from the group consisting of (a) increasing bone mineral density (BMD), (b) treating low BMD, (c) preventing and treatment of low impact fractures, (d)treatment of high impact fractures; (e) treating osteoporosis; (f) modulating a growth factor that influences bone metabolism; and (g) improving bone micro-architecture or connectivity of bone; the method comprising administering to the mammal an effective amount of a N-acylated-2-glucosamine derivative of the general formula (I):- wherein R is an alkyl radical of the general formula CnH2n+1 and n is selected from 2-12; or pharmaceutically-acceptable salts, esters and glucosides thereof; or pharmaceutically-acceptable compositions thereof.

The invention provides a composition capable of improving bone mineral density, which relates to a bone mineral density composition. The objective of the invention is to overcome the problems of great toxic and side effects, high cost, etc. of conventional medicines used for increasing bone mineral density. The composition capable of improving bone mineral density comprises, by mass, 40 to 180 parts of hydrolyzed yolk powder, 250 to 1050 parts of eucommia bark, 400 to 1800 parts of kudzu vine root and 150 to 750 parts of fortune's drynaria rhizome. The hydrolyzed yolk powder used in the invention is a functional substance extracted from egg yolk and is cheap, easily available and suitable for industrial production. The three compatible traditional Chinese medicines are materials applicable to health food or both edible and medicinal materials; the traditional Chinese medicines and new resource food are reasonably compounded and exert a synergistic effect, so the effect of improvement of bone mineral density is achieved. The composition has the advantages of simple and practicable preparation, controllable quality and suitability for industrial production. The composition provided by the invention is applicable to the field of health products.

The invention provides a health food composition for promoting the health of bones and bone joints, which is a preparation made from the materials containing traditional Chinese medicine oyster and hydrolyzed collagen. Wherein, the weight ratio of the oyster and hydrolyzed collagen is: oyster 500-2000 parts and the hydrolyzed collagen 100-2000 parts. The preparation is used for preventing and treating osteoporosis, hyperosteogeny and osteoarthritis with simultaneous effect to principal and subordinate symptoms The animal tests show that: the composition of the invention has a substantial action to the model of rat osteoporosis caused by ovary resection; it also has the substantial inhibition actions to the foot swelling and adjuvant type arthritis of rat caused by carrageenan. The composition has cooperation synergism, achieves positive functions in reducing bone and joint ache, reducing brittleness and increasing bone mineral density, and is suitable for wide application.

The invention discloses a health-care food composition for increasing bone mineral density and a preparation method. The composition consists of the following components by weight percent: 40%-50% of calcium carbonate, 27%-37% of D-glucosamine hydrochloride, 13%-23% of chondroitin sulfate, 0.1%-1% of herba epimedii extract and 0.1%-1% of drynaria fortunei extract. The health-care food composition is contributed to absorption and can be used for effectively increasing the bone mineral density.

The invention is directed to a method of inhibiting bone resorption. The method comprises administering to a human an amount of sclerostin inhibitor that reduces a bone resorption marker level for at least 2 weeks. The invention also provides a method of monitoring anti-sclerostin therapy comprising measuring one or more bone resorption marker levels, administering a sclerostin binding agent, then measuring the bone resorption marker levels. Also provided is a method of increasing bone mineral density; a method of ameliorating the effects of an osteoclast-related disorder; a method of treating a bone-related disorder by maintaining bone density; and a method of treating a bone-related disorder in a human suffering from or at risk of hypocalcemia or hypercalcemia, a human in which treatment with a parathyroid hormone or analog thereof is contraindicated, or a human in which treatment with a bisphosphonate is contraindicated.

The invention provides a pharmaceutical composition with a bone mineral density increasing function and a preparation method thereof. The bulk drugs include: 15-40 parts by weight of epimedium, 15-40 parts by weight of Radix Rehmanniae Preparata, 10-30 parts by weight of Salvia Miltiorrhiza, 10-30 parts by weight of achyranthes bidentata, 1-10 parts by weight of biological calcium carbonate and 1-5 parts by weight of casein phosphopeptide. Preparations prepared from the pharmaceutical composition have the function of increasing bone mineral density. With significant effects in prevention and treatment of osteoporosis, the pharmaceutical composition can be used for preparing drugs or health food and food.

The invention discloses a composition for increasing bone mineral density and a preparation method of the composition. Chinese dwarf cherry, a Chinese herbal medicine extract refined by a modern extraction technology and other raw materials with the function of increasing the bone mineral density are scientifically compounded, are scientifically combined in an omnibearing manner, and work together, so as to achieve the effects of effectively promoting absorption of calcium from a plurality of aspects, restoring and rebuilding cartilago articularis, creating synovial fluid, and promoting collagen synthesis in the cartilago articularis, preventing cartilage from further degenerating, indirectly reducing osteoclast action, inhibiting re-absorption of bones, increasing bone calcium content and improving the mechanical property of the bone, so that the product has a good effect of increasing the bone mineral density. The integrating property and the biological stability of the composition can be further improved by a microwave drying technology in the preparation method. Due to the oxidation resistance of a grape pip extract in the raw materials, high adsorption and embedding effects of modified dietary fiber, and antifungal properties of the Chinese herbal medicine extract, the efficient, safe, nutrient and stable composition with the function of increasing the bone mineral density is finally prepared.

The invention discloses a health product for improving physical performance and increasing bone mineral density. The product is prepared from the following raw materials and auxiliary materials in parts by weight: 20-40 parts of calcium source, 20-40 parts of glucosamine hydrochloride, 10-30 parts of chondroitin sulfate, 10-30 parts of oligopeptide, 5-20 parts of microcrystalline cellulose, 1-10 parts of carboxymethyl starch sodium, 300.2-0.4 part of povidone K, 0.1-0.5 part of hydroxypropyl methylcellulose, 0.8-1.2 part of magnesium stearate, and 0 or 1-10 parts of other auxiliary materials. The health product disclosed by the invention has the following advantages: (1) the product has fast effect after being taken, and the physical performance can be quickly recovered after intense exercise, the body pain and fatigue feeling can be reduced; (2) the oligopeptide can quickly repair the injury, enhance the muscle strength, relieve and prevent the inconvenience caused by insufficient muscle strength; (3) the product can increase the bone mineral density of the body after being taken, the combination of the bone-strengthening and the muscle-strengthening elements can improve the physical performance of the middle aged and elderly people from the root, the middle aged and elderly people can move freely and is full of energy.

The invention discloses a composition for increasing bone mineral density. The composition comprises the following ingredients in parts by weight: 20-26 parts of calcium agent, 55-65 parts of DHA (docosahexaenoic acid) algae oil and 5-11 parts of inulin. According to the composition disclosed by the invention, a synergistic effect is generated through appropriate proportioning. According to the composition, the calcium absorption ratio is obviously increased compared with that of like products, so that the composition is applicable to people of all ages and is particularly applicable to middle-aged and elderly people; and production process conditions are stable, so that the composition is suitable for being produced in a large-scale and industrial manner.

The invention relates to the field of fruit processing and in particular relates to a beverage and a preparation method thereof. The preparation method comprises the following steps: adding collagen to coconut meat extracts and homogenizing to obtain the beverage which is advantageous in good stability, high protein content and complete nutrition. The beverage made by the method provided by the invention can improve health through diet and can achieve comprehensive effects of increasing bone mineral density, preventing and treating osteoporosis and rickets, improving yellowish and loose skin,and reducing wrinkles through diet.