9 results about "Increased bone mineral density" patented technology

The invention relates to an application of plant lactobacillus Hi188 in promotion of bone health. The invention provides the application of the plant lactobacillus Hi188 or the afterbiogen thereof or the composition thereof in increasing the bone mineral density, increasing the bone mineral density, promoting the skeletal development, increasing the bone mineral content and / or promoting the tibia growth. Or preparing food for increasing bone mineral density, increasing bone mineral density, promoting skeletal development, increasing bone mineral content and / or promoting tibia growth; wherein the composition comprises: (A) Phytobacterium plantarum Hi188 or a postbiotic thereof, and (B) Bifidobacterium lactis Ca360 or a postbiotic thereof.

The present application provides methods of use, specifically methods of treatment of a disease, disorder, or condition (e.g, a low bone mass condition such as osteoporosis) in a human individual, comprising administration of novel bispecific antibodies that bind to both sclerostin and DKK-1 (e.g, anti-Sclerostin x anti-DKK-1 bispecific antibodies). The present application also provides methods of increasing bone mineral density in a human individual comprising administration of novel anti-Scl erostin x anti-DKK-1 bispecific antibodies. The present application further provides methods of reducing risk of bone fracture (e.g., osteoporotic fracture) in a human individual comprising administration of novel anti-Sclerostin x anti-DKK-1 bispecific antibodies.

This invention discloses a composition with bone-health-promoting functions and its applications, belonging to the field of microbial engineering. The composition comprises milk calcium, colostrum basic protein, and Bifidobacterium breve i1088 powder. The composition provided by this invention, which has a synergistic effect between milk calcium, colostrum basic protein, and Bifidobacterium breve i1088 powder, enhances the conversion rate of calcium from the blood to bone through the action of probiotics, thereby improving the actual utilization rate of calcium and effectively promoting bone health. Experimental data show that this composition significantly increases bone mineral density, bone volume fraction, and trabecular thickness in a female rat osteoporosis model, and significantly reduces trabecular spacing in the same model. The composition provided by this invention is suitable for promoting bone health and preventing and / or improving osteoporosis.

The invention discloses an application of 6-CEPN in preparation of a product for preventing and improving osteoporosis. According to the invention, ovariectomized mice are fed with two doses of 6-CEPN, which discovers that the 6-CEPN can obviously inhibit abnormal weight increase of the mice caused by estrogen decrease and can also improve bone microstructure of the ovariectomized mice; the bone trabecula network structure is adjusted by increasing the bone trabecula connection density, the bone trabecula number and the bone trabecula thickness and reducing the separation degree of the bone trabecula, meanwhile, 6-CEPN can further increase the bone density and the bone volume fraction of ovariectomized mice, increase the rigidity and deflection of bones and improve the bone strength, the effect of high-dose 6-CEPN is larger than that of low-dose 6-CEPN, and the effect of high-dose 6-CEPN is better than that of low-dose 6-CEPN. Therefore, the composition has a dose-dependent effect.

The invention discloses a bone source factor gel candy for promoting skeletal development of children and a preparation method thereof, and relates to the technical field of food and gel candies, the bone source factor gel candy comprises a gelling agent, a moisturizing and sweetening agent, a protein and peptide additive, a mineral substance and calcium source additive, a functional additive, and a seasoning and appearance additive, vitamin D metabolism-related pathway activity is indirectly improved by increasing the dosage of the hydrolyzed yolk powder, vitamin D3 is not directly added, pumpkin seeds are newly added to serve as a magnesium source, magnesium element is provided, phytosterol and other synergistic components are contained, overall metabolic regulation is facilitated, osteoblast functions are synergistically promoted, bone resorption is inhibited, and the effect of promoting osteogenesis is achieved. The traditional Chinese medicine composition can effectively promote osteocyte proliferation and differentiation, inhibit osteoclast activity, jointly promote osteoblast activity, enhance bone mineralization process, improve bone mineral density and bone strength, effectively support growth and development of children's bones and increase bone mineral density and bone strength, and can effectively promote osteocyte proliferation and differentiation, inhibit osteoclast activity, improve bone mineral density and bone strength.

The invention belongs to the technical field of microorganisms, and particularly relates to application of bifidobacterium longum B188 in products for promoting calcium absorption and skeletal development. The preservation number of the bifidobacterium longum B188 is GDMCC No: 67123, and the bifidobacterium longum B188 can play roles through multiple mechanisms: the intestinal calcium absorption efficiency is improved so as to repair the calcium metabolism steady state and regulate serum related indexes; bone formation is promoted, bone resorption is inhibited, and bone health related markers are regulated and controlled; growth and development disorders caused by low-calcium diet are improved, organ indexes are adjusted, bone trabecula structures are repaired, bone mineral density is improved, and cortical bone thickness is increased. The strain can be used for preparing functional foods, health foods or dietary supplements for promoting calcium absorption and improving skeletal development, and a new scheme is provided for intervention of related problems of calcium metabolism.

The invention belongs to the technical field of dairy products, and particularly relates to formula milk powder for increasing bone mineral density and a preparation method thereof. The fermented milk comprises the following components: raw milk, raw goat milk, beta-galactosidase, light protease and food-grade zymophyte. According to the invention, raw milk and raw goat milk are taken as a base, CPP-ACP nano-clusters are constructed through membrane separation, light enzymolysis and pH circulation, GOS is generated in situ and is complexed with light organic acid, and dual-channel calcium supply is formed; the continuous absorption of soluble calcium and intestinal segments is improved, and the brewing is stable.

This invention discloses the application of Morkotin A (quercetin-3-O-rutin-7-O-glucoside) in the preparation of pharmaceuticals, health foods, or functional foods, belonging to the field of biomedical technology. Animal experiments have demonstrated that Morkotin A can significantly increase bone mineral density in ovariectomized osteoporotic mice, improve bone microstructure, and regulate calcium and phosphorus metabolism and bone turnover marker levels. Simultaneously, in vitro cell experiments have confirmed that Morkotin A can significantly promote osteoblast differentiation and inhibit osteoclast formation. The Morkotin A used in this invention is derived from the medicinal and edible herb, Lycium barbarum leaf, and has high safety. Both in vitro and in vivo experiments have confirmed that Morkotin A promotes bone formation and inhibits bone resorption, making it suitable for development as a drug for the prevention and treatment of osteoporosis, or as a health food or functional food that helps improve bone mineral density.

This invention discloses the application of atormoxetine in the preparation of drugs that increase H-subtype endothelial cells in bone vessels. Specifically, it discloses the application of a combination of atormoxetine and deferoxamine mesylate in the preparation of drugs that increase H-subtype endothelial cells in bone vessels, drugs that increase bone mineral density, or drugs for treating osteoporosis. This invention discovers that the combined use of atormoxetine and deferoxamine mesylate can further promote the generation of H-subtype bone vascular endothelial cells. The generation of H-subtype bone vascular endothelial cells leads to an increase in the bone mineral density coupled with them, thus promoting bone formation. Using this combined medication, the treatment of senile osteoporosis can be achieved.