57 results about "Osteoporotic fracture" patented technology

A mechanical bone tamping device for osteoporotic repair include a pair of arms mounted on a spreading mechanism such as a screw jack. The mechanism is introduced into a small hole in a vertebra through a cannula, and is then operated to spread the arms apart, forming a cavity which may be filled with cement to fortify the vertebra.

The invention provides method, system and device for determining trabecular bone structure and strength by digital topological analysis, and offers, for the first time, a demonstration of superior associations between vertebral deformity and a number of architectural indices measured in the distal radius, thus permitting reliable and noninvasive detection and determination of the pathogenesis of osteoporosis. A preferred embodiment provides imaging in three dimension of a region of trabecular bone, after which the 3D image is converted into a skeletonized surface representation. Digital topological analysis is applied to the converted image, and each image voxel is identified and classified as a curve, a surface, or a junction; and then associated with microarchitectural indices of trabecular bone to quantitatively characterize the trabecular bone network. The invention is applicable in vivo, particularly on human subjects, or ex vivo.

This invention is directed to methods for treating conditions which present with low bone mass in a patient in need thereof using continuous combination therapy with a synergistically effective combination of an EP4 receptor selective agonist or a pharmaceutically acceptable salt thereof, such as 5-(3-{2S-[3R-hydroxy-4-(3-trifluoromethyl-phenyl)-butyl]-5-oxo-pyrrolidin-1-yl}-propyl)-thiophene-2-carboxylic acid or a pharmaceutically acceptable salt thereof; and an estrogen or a pharmaceutically effective salt thereof, The present methods are useful for treating conditions that present with low bone mass including osteoporosis, osteotomy, osteoporotic fracture, childhood idiopathic bone loss, periodontitis and low bone mass and for enhancing bone healing following facial reconstruction, maxillary reconstruction or mandibular reconstruction, inducing vertebral synostosis, enhancing long bone extension, enhancing the healing rate of a bone graft or a long bone fracture or enhancing prosthetic ingrowth in a patient in need thereof.

Cervical fixation devices, systems and methods for repairing odontoid fractures to the C2 vertebral body, including an anchoring feature that crosses the fracture site to be positioned external to the fractured bone fragment and which provides compressive and radial forces externally to the bone to immobilize the bone fragment(s) for fixation to the main bone structure.

The invention provides method, system and device for determining trabecular bone structure and strength by digital topological analysis, and offers, for the first time, a demonstration of superior associations between vertebral deformity and a number of architectural indices measured in the distal radius, thus permitting reliable and noninvasive detection and determination of the pathogenesis of osteoporosis. A preferred embodiment provides imaging in three dimension of a region of trabecular bone, after which the 3D image is converted into a skeletonized surface representation. Digital topological analysis is applied to the converted image, and each image voxel is identified and classified as a curve, a surface, or a junction; and then associated with microarchitectural indices of trabecular bone to quantitatively characterize the trabecular bone network. The invention is applicable in vivo, particularly on human subjects, or ex vivo.

This invention is directed to methods of treating conditions which present with low bone mass, particularly osteoporosis, frailty, an osteoporotic fracture, a bone defect, childhood idiopathic bone loss, alveolar bone loss, mandibular bone loss, bone fracture, osteotomy, bone loss associated with periodontitis, or prosthetic ingrowth comprising administering prostaglandin agonists which are EP4 receptor selective prostaglandin agonists. This invention is especially directed to those methods wherein the EP4 receptor selective agonist is a compound of Formula I: wherein the variables are as defined in the specification.

A vibration motion prevention and treatment instrument of osteoporosis pertains to the field of the prevention and the physical rehabilitation treatment of osteoporosis and is mainly used in the prevention and the rehabilitation treatment of osteoporosis. The invention can attach the reciprocating swing vibration which takes a central point of a platform as a shaft center at the same time of driving the vibration platform to do vertical vibration, so as to allow the platform to be in a slight constant changing flexible unstable state in the horizontal plane. The users can continuously and initiatively adjust the posture at the same time of receiving passive vibration, so as to maintain body balance. The exercise of the nerve-muscle is further strengthened at the same time of obtaining the benefit of the vertical vibration in the process, so the exercise is systemic. The invention mainly solves the problems that the vibration transmissibility after the users receive the vibration and generate the vibration adaptation is lowered, the effective vibration stimulation is weakened, the beneficial effects of the passive receiving of the vibration on the nerve-muscle system are smaller, and the role for reducing osteoporosis and the fracture which are caused by non-violent falling down is limited.

The present invention provides methods for treating physical conditions resulting from postmenopausal estrogen decline in a postmenopausal subject, and in particular methods for reducing the risk of osteoporotic bone fractures in a postmenopausal subject. The present invention also provides a kit useful for carrying out the methods of the present invention.

The invention relates to a food composition containing Maca and saussurea involucrata culture and an application thereof. The composition is prepared by the following raw materials in percentage by weight: 50-90% of maca, 10-50% of saussurea involucrata culture and 0-0.02% of vitamin K2. The food composition is used for preventing and treating rheumatism, arthritis, osteomalacia, osteoporosis and osteoporotic fracture. The food composition has a kidney regulating function and body building and bone benefiting functions, can strengthen the muscle and bone motion capability, and can stimulate the active ingredients of tissue cells. The food composition regulates internal secretion, strengthens an immune function and improves chronic fatigue syndrome, depressive disorder and osteoporotic syndrome.

The invention discloses a traditional Chinese medicine composition used for treating fractures, a preparation method thereof, and an application thereof. The traditional Chinese medicine is prepared from materials of, by weight: 10-20 parts of drynaria, 10-20 parts of radix dipsaci, 10-30 parts of salvia miltiorrhiza, 4-8 parts of safflower, 10-20 parts of ligusticum, and 10-14 parts of common achyranthes. According to the invention, salvia miltiorrhiza, safflower, and ligusticum are processed through ethanol extraction; the medicine residue obtained after ethanol extraction is mixed with drynaria, radix dipsaci and common achyranthes; the mixture is processed through water extraction and alcohol precipitation; the obtained solutions are combined, and the mixture is processed through spray-drying; and the product is prepared into corresponding preparations. The invention provides the application of the traditional Chinese medicine composition in preparing medicines used for treating fractures, and especially osteoporotic fractures.

The invention discloses a new application of statin compound as topical medicine for preventing and curing osteoporotic fracture and enhancing bone plant strength in osteoporotic bone, particularly, discloses a topical statin composite for bone. The topical statin composite can increase bone mass, improve bone density, improve bone tissue microstructure and enhance bone mechanical property, thereby being used for preventing and curing osteoporotic fracture and enhancing the bone plant strength in osteoporotic bone.

This invention is directed to methods of treating conditions which present with low bone mass, particularly osteoporosis, frailty, an osteoporotic fracture, a bone defect, childhood idiopathic bone loss, alveolar bone loss, mandibular bone loss, bone fracture, osteotomy, bone loss associated with periodontitis, or prosthetic ingrowth comprising administering prostaglandin agonists which are EP4 receptor selective prostaglandin agonists. This invention is especially directed to those methods wherein the EP4 receptor selective agonist is a compound of Formula I: wherein the variables are as defined in the specification.

The present invention relates to a preparation method and an application of a GelMA hydrogel for locally slow-releasing Abaloparatide or related polypeptides. Gel methacrylate anhydride monomers are weighed to be dissolved in a PBS solution, and the dissolved methacrylate anhydride gelatin monomers are oscillated and dissolved at 37-50 DEG C in the dark; a lithium phenyl-2,4,6-trimethylbenzoylphosphonate blue light initiator is weighed to be mixed with the prepared GelMA solution at room temperature in the dark, and the solution is filtered into a sterile centrifuge tube with a sterile filter;and the related polypeptides or Abaloparatide is added to the sterile centrifuge tube containing the solution, and then the mixed solution is irradiated with a blue light source and cured into the hydrogel of any shapes. Effective entrapment and release of the Abaloparatide and PTH1-34 drugs are conducted and a cumulative release rate reaches approximately 86% on the 12th day. The hydrogel is also applied in cavity locally filled stent materials or applied for repairing and filling bone defects caused by osteoporotic fractures.

The invention relates to the use of lycopodium clavatum in the preparation of a medicament for treating bone diseases. Lycopodium clavatum or active ingredients thereof can stimulate osteoblasts by activating the transmission path of a bone morphogenetic protein (BMP) signal and therefore specially promotes the formation of new bones. Pharmaceutical and clinic experiments show that the medicament and the active ingredients thereof can be used on various clinic occasions when new bones are needed to be formed. Lycopodium clavatum or active ingredients thereof can be applied on the whole body or partially for preventing and treating osteoporosis, and can be used for treating osteoporotic fracture and other fractures and obviously improving fracture repair rate.

The invention discloses a serum microRNA diagnostic marker for osteoportic fractures in old people and a diagnostic kit thereof to overcome the technical problem of poor sensitivity of conventional serum microRNA diagnostic kits for osteoportic fractures in old people. According to a technical scheme in the invention, the microRNA biomarker is one selected from a group consisting of hsa-miR-497-5p, hsa-miR-1290, hsa-miR-4299, hsa-miR-181c-5p, hsa-miR-320a and hsa-miR-204-3p, or a combination of hsa-miR-181c-5p and hsa-miR-4299, or a combination of hsa-miR-497-5p and hsa-miR-1290. The marker and primers thereof can be applied to the diagnostic kit; and the diagnostic kit has high sensitivity when applied to diagnosis of osteoportic fractures in old people.

The invention discloses a traditional Chinese medicine compound preparation for treating osteoporotic fractures. The compound preparation is prepared from traditional Chinese medicine for strengthening the spleen and reinforcing the kidney and pharmaceutical excipients, wherein the traditional Chinese medicine for strengthening the spleen and reinforcing the kidney is prepared, by weight, 6-30 parts of codonopsis pilosula, 6-30 parts of acanthopanax senticosus, 6-30 parts of drynaria rhizome, 6-30 parts of epimedium, 6-15 parts of salvia miltiorrhiza and 3-12 parts of angelica pubescens. According to the traditional Chinese medicine compound preparation for the treating osteoporotic fractures, a formula for strengthening the spleen and reinforcing the kidney is based on a spleen-kidney-related theory that the kidney is a congenital origin and the spleen is an acquired foundation, through animal experiments, it is found that the formula for strengthening the spleen and reinforcing the kidney can significantly promote healing of bone calluses in different periods of ovariectomized mice suffering from the osteoporotic fractures, the bone mass and biomechanical strength of the bone calluses are improved, the expression of beta-catenin in fractured bone end muscles and bone calluses is promoted, the number of muscle-derived stem cells in the fractured bone end muscles is increased, the proliferative activity is promoted, the muscle-derived stem cells are promoted to migrate to the bone calluses, and therefore osteogenic differentiation is simulated, and healing of the osteoporotic fractures is accelerated. The invention further discloses a preparation method and medicinal application of the traditional Chinese medicine compound preparation.

The invention provides a constructing method and application for an osteoportic fracture disease animal model. According to the provided technical scheme, based on a constructed osteoporosis animal model, thighbone small lateral incision fracture molding of a model animal is conducted, then a femur fractured end bilateral inverse intramedullary nail inserting internal fixation is conducted, and the osteoportic fracture disease animal model is constructed. The method avoids influences of uncontrollable factors on an experimental result, ensures the uniformity of modeling, shortens the molding time, and accelerates the experiment process. The method is applied to the preparation of the osteoportic fracture disease animal model and is beneficial for meeting related requirements of the osteoportic fracture disease animal model, and the osteoportic fracture disease animal model is taken as a study object to study the pathogenesis, prevention and treatment of basic and clinical osteoportic fractures.

The invention relates to a food composition containing Maca and saussurea involucrata culture and an application thereof. The composition is prepared by the following raw materials in percentage by weight: 50-90% of maca, 10-50% of saussurea involucrata culture and 0-0.02% of vitamin K2. The food composition is used for preventing and treating rheumatism, arthritis, osteomalacia, osteoporosis and osteoporotic fracture. The food composition has a kidney regulating function and body building and bone benefiting functions, can strengthen the muscle and bone motion capability, and can stimulate the active ingredients of tissue cells. The food composition regulates internal secretion, strengthens an immune function and improves chronic fatigue syndrome, depressive disorder and osteoporotic syndrome.

This invention is directed to pharmaceutical combination compositions and methods comprising (-)-cis-6-phenyl-5-(4-(2-pyrrolidin-1-yl-ethoxy)-phenyl)-5,6,7,8-tetrahydronaphthalene-2-ol or a pharmaceutically acceptable salt thereof and parathyroid hormone or a biologically active fragment thereof, methods of using such compositions and kits containing such compositions. The compositions are useful for treating musculoskeletal frailty, including osteoporosis, osteoporotic fracture, low bone mass and frailty.

The invention discloses a square-pole screw, comprising a screw body and a fixing pin; the screw body is axially provided with an inner hole; the tail of the screw body is axially provided with an oblique hole that is communicated with the inner hole; the fixing pin matched with the inner hole is arranged in the same. The square-pole screw has the advantages that the fixing pin is mounted in the screw body, screw retreating prevention can be achieved by direct screwing with no need for cap fixation; alternatively, double fixing pins are mounted in the screw body, a cap is tightened, and accordingly dual-fixing screw treating prevention can be achieved; the square-pole screw prevents the risk of screw retreating after fixation for a patient with osteoporotic fracture, and bone healing rateis increased for the patient with osteoporotic fracture.

The invention discloses self-developing polymethacrylate used for bone cement and a preparation method for the self-developing bone cement. The powder body of the bone cement consists of self-developing polymethyl iodine alcohol acrylate and benzoperoxide, wherein the self-developing polymethyl iodine alcohol acrylate is polymerized by methacrylic acid and non-ionic contrast agent, namely an iodine alcohol compound after esterification; a liquid consists of a methyl acrylate monomer, N,N-dimethyl-p-toluidine and hydroquinone; the polymethacrylate is endowed with the developing property by utilizing iodine, and meanwhile, the defect that the nonionic contrast agent cannot develop for a long time in vivo is improved. The bone cement can be used for plastic surgery, osteoporosis fracture fixation and bone defect filling, and can also be used as a denture base material.

The invention discloses a protein biomarker for diagnosis of osteoporosis and an application thereof, which belongs to the technical field of biological detection. The invention uses Abl Interactor 1protein as a biomarker for the diagnosis of osteoporosis. The protein biomarker provided by the invention can be used for preparing a diagnostic kit, which has excellent diagnostic value when appliedto blood samples for diagnosis of osteoporosis. By using the protein of the present invention alone, the value of AUC diagnosis can reach 0.76. With a cut-off point of 0.376 ng / ml, the sensitivity andspecificity are 73.3% and 64.3%. By combining CTX and P1NP, the AUC diagnosis can reach 0.78. The protein can be used as a biomarker for the diagnosis of human osteoporosis blood samples, which is helpful for the diagnosis of osteoporosis, the identification and the prevention and treatment of high-risk groups of osteoporotic fractures.

The invention discloses a Chinese medicinal composition for promoting osteoporotic fracture healing, and relates to the technical field of Chinese medicinal compositions. The Chinese medicinal composition is prepared from the following Chinese medicinal materials in part by weight: 15 to 20 parts of Chinese angelica, 15 to 20 parts of twotooth achyranthes root, 20 to 25 parts of peach seed, 12 to18 parts of tangerine peel, 20 to 25 parts of safflower, 8 to 12 parts of notoginseng root, 10 to 15 parts of beautiful sweetgum fruit, 15 to 20 parts of suberect spatholobus stem, 10 to 15 parts of liquoric root and 30 to 40 parts of honey. The Chinese medicinal composition can prevent osteopenia of patients who suffer from osteoporotic fractures, so that bone mass is close to normal femoral density, and has obvious effects in aspects of maintaining bone forms and improving the speed of bone formation.

The invention discloses a traditional Chinese medicine preparation for sclerotin healing of an osteoporotic fracture. The traditional Chinese medicine preparation is prepared from, by weight, 1-4 parts of radix codonopsis, 2-5 parts of milkvetch roots, 1-4 parts of cortex eucommiae, 1-4 parts of radix dipsaci, 1-4 parts of glossy privet fruit, 1-4 parts of mulberries, 1-4 parts of fructus corni, 2-6 parts of barbary wolfberry fruit, 2-6 parts of prepared radix rehmanniae, 1-4 parts of raspberries, 2-5 parts of Chinese magnoliavine fruit, 1-4 parts of flatstem milkvetch seeds, 2-5 parts of semen cuscutae, 1-4 parts of herba cistanche, 1-4 parts of herba cynomorii, 1-4 parts of herba epimedii, 1-4 parts of bone fossils of big mammals, 3-8 parts of concha ostreae and 1-4 parts of tortoise plastrons. All the medicinal materials jointly achieve the effects of benefiting qi for activating blood circulation, tonifying the kidney and strengthening the bone, relieving swelling and pain, promoting tissue blood circulation, increasing the blood flow volume, improving bone tissue metabolism, increasing the bone mineral density and achieving sclerotin healing.

Belonging to the technical field of research on the dose-effect of natural drug prescription compatibility and use, the invention discloses a natural drug composition for treatment of osteoporotic fracture and / or osteoarthritis and application thereof. The natural drug composition comprises, by mass percentage, 73.3%-98.3% of sea buckthorn fruit oil and 1.7%-26.7% of panax notoginseng saponins. The natural drug composition can transform and generate a signal molecule of eicosatrienoic acid, and the signal molecule can activate protein and cyclic nucleotide, calcium ion and other multi-path molecular signal pathways to generate the effect of synergistic amplification of signal molecule; the composition can improve the hematopoietic microenvironment, regulate endocrine, adjust the metabolic balance of osteoclast and osteoblast, reduce alkaline phosphatase, improve serum osteoprotegerin, osteocalcin and other bone metabolism marker indexes, increase the femur, tibia and vertebral bone density, significantly improves the bone remodeled bone shape and bone biomechanical symbolic indexes, and can effectively prevent and treat osteoporotic fracture, osteoarthritis and ostealgia diseases.

The invention discloses an internal fixing device aiming at osteoporotic fracture treatment and a preparation method thereof. The internal fixing device comprises an internal implant matrix, wherein the cross section of the internal implant matrix is in a round shape or a quasi-circular shape, the internal implant matrix comprises a tip portion, and a zoledronic acid coating layer and a calcium phosphate coating layer are sequentially arranged on the internal implant matrix from inside to outside. The internal fixing device provided by the invention utilizes magnesium alloy with an elasticitymodulus which is perfectly matched with bone of an osteoporosis patient as the internal implant matrix, zoledronic acid is loaded by the surface of the matrix, fracture reduction fixation is achieved,fracture healing time is shortened at the same time, and fracture healing quality is improved; the zoledronic acid coating layer is further covered by the calcium phosphate coating layer, so that notonly is a corrosion rate of the magnesium alloy matrix material effectively reduced, but also a slow release effect of loading medicine (the zoledronic acid) is further achieved; furthermore, the internal fixing device need not be taken out after operation, so that pain of the patient is reduced, and the application prospect is good.

The present invention discloses a topical drug combination for promotion of fracture healing and application, the topical drug combination comprises an active component and a medicinal supplementary material, and the active component is prepared from root of wallich swallowwort and alangium platanifolium as Chinese herbal medicine raw materials. The topical drug combination can promote the fracture healing, and improve the biomechanical characteristics of compression resistance and fracture resistance of bones of elderly osteoporotic patients through increase of femoral maximum load and elastic ratio of osteoportic fracture patients.

The invention discloses self-developing polymethacrylate used for bone cement and a preparation method for the self-developing bone cement. The powder body of the bone cement consists of self-developing polymethyl iodine alcohol acrylate and benzoperoxide, wherein the self-developing polymethyl iodine alcohol acrylate is polymerized by methacrylic acid and non-ionic contrast agent, namely an iodine alcohol compound after esterification; a liquid consists of a methyl acrylate monomer, N,N-dimethyl-p-toluidine and hydroquinone; the polymethacrylate is endowed with the developing property by utilizing iodine, and meanwhile, the defect that the nonionic contrast agent cannot develop for a long time in vivo is improved. The bone cement can be used for plastic surgery, osteoporosis fracture fixation and bone defect filling, and can also be used as a denture base material.