12 results about "Trabecular bone" patented technology

This invention is based on the creation of a polymer scaffold structure as a result of the proportional combination of β-Tricalcium Phosphate (β-TCP) that will increase the 3D and osteoconductive effect allowing / supporting cell infiltration by using extrusion deposition, in other words, added manufacturing process, and with physiological buffered HA solution with the Deep Coating Method and by increasing the transmission rate of growth factors as a result of coating and expanding their areas with the biological tissue implant, which allows its use with titanium mesh plates or contoured structures.

This application relates to the field of medical device technology, and in particular to a modular bio-ring reconstruction integrated device for the acetabulum, comprising a combined reconstruction ring and a bio-reconstruction support. The combined reconstruction ring is embedded in the acetabular fossa and forms a metal trabecular bone to reconstruct a complete acetabular fossa. The bio-reconstruction support is connected to the combined reconstruction ring and is used to connect the combined reconstruction ring to the acetabulum. This application has the effect of improving the inability to provide effective support and stable reconstruction for the acetabulum.

This invention discloses a biomimetic helical chiral porous bone repair and bone augmentation scaffold, comprising: a scaffold body composed of an array of multiple lattice units, each lattice unit being a biomimetic trabecular bone cell; the lattice units follow the natural helical arrangement of human bone trabeculae, forming a continuous and interconnected helical channel network within the scaffold body; the lattice units are distributed in a helical gradient along the radial direction of the scaffold body, and the outer wall of the scaffold body has a protruding structure integrally formed with the lattice units. This invention, through the deep coupling of the biomimetic helical chiral structure and cellular fluid dynamics, overcomes the limitations of traditional scaffolds with "static channels," forming a composite flow field of "high-speed guidance - low-speed vortex," effectively solving the problem of "nutrient islands," and significantly improving the survival rate and quality of osteoblasts in the central region.

This invention discloses the application of PT-129 in the preparation of drugs for treating rheumatoid arthritis (RA), belonging to the field of RA treatment. This invention is the first to demonstrate that the compound PT-129 can target and intervene in the synovial microenvironment, effectively inhibiting the abnormal activation behaviors of RA fibroblast-like synovial cells (FLS) such as proliferation, migration, and invasion, and downregulating the expression of N-cadherin and MMP3 proteins in synovial tissue. This invention provides a combined drug formulation containing PT-129 and RGFP966. This composition exhibits a significant synergistic effect in vivo, effectively relieving joint swelling, increasing bone density and trabecular bone thickness, reducing trabecular bone separation, thereby inhibiting cartilage degradation and bone destruction. This invention provides a novel targeted drug and combination therapy with definite efficacy for the clinical intervention of RA, possessing extremely high clinical application development value.

This invention provides the application of Neoruscogenin in the preparation of anti-osteoporosis drugs, belonging to the field of pharmaceutical biotechnology. It was found that Neoruscogenin can significantly increase bone volume fraction, bone surface area to tissue volume ratio, bone mineral density, trabecular bone number, and trabecular bone thickness in osteoporotic mice, while significantly reducing trabecular bone separation; that is, Neoruscogenin can alleviate low bone mass in postmenopausal osteoporotic mice. Furthermore, Neoruscogenin treatment for 8 weeks did not significantly affect the major organs of mice, suggesting the biocompatibility of Neoruscogenin.

This application discloses an automatic analysis method for CT images of long bones in mice and rats, relating to the field of image processing technology. The method includes: acquiring a CT image sequence of the target long bone, extracting the three-dimensional spatial distribution of bone tissue, and performing pose alignment and three-dimensional cropping to obtain a standardized bone image sequence; then constructing candidate depth intervals based on butterfly-shaped anatomical features and key points of growth plate strip-shaped gaps, respectively, and obtaining a fine search range through intersection operation; subsequently identifying candidate slices of triangular fractures and determining the anatomical zero point; finally, mapping the target analysis region based on the anatomical zero point, completing cortical bone segmentation, medullary cavity segmentation, and trabecular bone extraction under closed mask constraints, and outputting quantitative parameters of bone tissue. This application achieves accurate positioning of the growth plate and unified analysis region mapping in long bone CT images, improving the accuracy of trabecular bone extraction and the consistency of bone tissue quantification results.

This application provides a self-adaptive trabecular bone knee joint prosthesis and its design and fabrication method. The electronic device acquires a bone-cut model of the knee joint and a prosthesis model that adapts to the osteotomy surface of the bone-cut model; assembles the bone-cut model and the current prosthesis model into an assembly; performs mechanical simulation using the assembly to obtain the stress and strain distribution at the contact surface between the prosthesis model and the bone-cut model; if the strain distribution does not meet the ideal strain range requirement, the structure of the contact interface is adjusted according to the strain distribution to obtain a new prosthesis model; this process continues until the strain distribution at the contact interface meets the ideal strain range requirement. Thus, instead of relying on experience or a uniform template, a fitting scheme is dynamically generated based on each patient's actual anatomy and mechanical response, thereby solving the current problem of not being able to adapt to individual patient differences, improving the long-term bonding stability of the prosthesis and bone, and extending the prosthesis's lifespan.

The application discloses an acetabular cup for acetabular surgery, which adopts a multilayer structure, namely a first acetabular cup and a second acetabular cup, and the two are connected through an acetabular cup spacer block, the acetabular cup spacer block can prevent the relative movement between the first acetabular cup and the second acetabular cup, improve the stability and wear resistance of the acetabular cup, prolong the service life of the acetabular cup, the first acetabular cup and the second acetabular cup are both trabecular bone structure and are both hollow hemispheres, and have high porosity, so that the biomechanical adaptability of the acetabular cup can be improved, the growth of bone tissue and the fixation of the acetabular cup can be promoted, the stress concentration and osteolysis of the acetabular cup can be reduced, the biocompatibility and corrosion resistance of the acetabular cup can be improved, and a plurality of groups of internal thread base holes are formed in the first acetabular cup, the second acetabular cup and the acetabular cup spacer block, so that the installation and fixation of the acetabular cup are facilitated, and thus the accurate positioning and close connection of the acetabular cup are realized.

This application relates to the field of medical device technology, and in particular to a method for manufacturing a unicompartmental prosthesis system and the unicompartmental prosthesis system itself. The method for manufacturing the unicompartmental prosthesis system includes using zirconium-niobium alloy powder as raw material to sequentially print a first body and a first trabecular bone structure layer to form a first intermediate product of the femoral condyle prosthesis, and sequentially printing a second body and a second trabecular bone structure layer to form a first intermediate product of the tibial plateau prosthesis; when printing to the first trabecular bone structure layer of the femoral condyle prosthesis and when printing to the second trabecular bone structure layer of the tibial plateau prosthesis, magnesium metal particles are added to the zirconium-niobium alloy powder; heat treatment; machining and shaping; and surface oxidation treatment. According to the manufacturing method and unicompartmental prosthesis system provided in this application, the bone formation rate of elderly patients is effectively improved, and the incidence of aseptic loosening is reduced.

The application discloses an artificial intelligence driven jaw bone defect bionic reconstruction system and method. A three-dimensional segmentation model is used to segment the facial CBCT image of a healthy person to construct a jaw bone dentition database; the segmentation model is used to segment the healthy side and the diseased side of the jaw bone of a patient, and intelligent matching is performed in the database based on the segmented healthy side jaw bone data as a reference to obtain the most similar target jaw bone; then the opposite jaw bone of the target jaw bone is taken as a to-be-applied template, three-dimensional integration is performed with the diseased side defect of the patient to generate a basic virtual jaw bone support; then a planting scheme is generated according to the matched healthy dentition data to obtain a segmented virtual support; trabecular bone structure filling is performed in the segmented virtual support to output a bionic reconstruction customized body; finally, the overhanging structure of the trabecular bone is detected according to the complex topological structure of the trabecular bone, and corresponding printing support is generated. The above can improve the bionic adaptation degree of the reconstructed defect jaw bone, and support entity production such as 3D printing.

This application discloses a method, apparatus, and electronic device for determining the microstructural parameters of trabecular bone, relating to the field of oral medicine technology, and invented to reduce the error in determining the microstructural parameters of trabecular bone. The method includes: acquiring a first three-dimensional image of the trabecular bone; wherein the first three-dimensional image is an image based on cone-beam computed tomography (CBCT); predicting the pixel values ​​of the second three-dimensional image based on the coordinates of a second three-dimensional image to be generated and features of the first three-dimensional image; wherein the resolution of the second three-dimensional image is higher than the resolution of the first three-dimensional image; generating the second three-dimensional image based on the pixel values ​​and coordinates of the second three-dimensional image; and determining the microstructural parameters of the trabecular bone based on the second three-dimensional image. This application is applicable to clinical oral examinations.

The present invention relates to an implant fusion device and a method of manufacturing an implant fusion device. More particularly an orthopedic or spinal implant configured to be implanted between adjacent vertebrae or within a gap in a bone or between bones, the device having a manufactured body structure simulating the physical characteristics of trabecular bone, but with improved osteoinductive features on the exterior surface wherein the device is fabricated using 3D printing. Alternatively, the implant may be made through 3D printing in a manner that results in a relatively or completely solid structure, but with a surface that mimics trabecular bone structure.