84 results about "Trabecular bone" patented technology

The invention relates to the technical field of medical instruments, and discloses an additive manufacturing bionic bone trabecula full-porous interbody fusion cage which is applied to spinal fusion surgery and is of a bionic bone trabecula full-porous structure made of medical metal through a laser melting or electron beam melting additive manufacturing technology. The interbody fusion cage comprises a front end face, a rear end face, a first side surface, a second side surface, an upper fusion face and a lower fusion face, the upper fusion face and the lower fusion face make direct contact with a vertebral body end plate of a spine, anti-skid teeth are arranged on the surfaces of the upper fusion face and the lower fusion face, and a bone grafting window penetrating through the upper fusion face and the lower fusion face is formed in the center of the interbody fusion cage. The interbody fusion cage has the structure and mechanical property similar to those of cancellous bone and trabecular bone of a human body, can improve the bone combination area and bone ingrowth space, has excellent initial and long-term stability, and can effectively reduce stress shielding so as to improve the bone fusion capability.

The invention relates to the field of medical imaging analysis, and discloses a bone trabecula feature construction method and system, and the method comprises the steps: preferentially extracting a fragile region from an obtained vertebral image sequence, and generating an initial feature set representing the stability of a fine-grained structure; performing coherence comparison on the initial feature set in a cross-slice dimension to obtain a composite feature vector capable of reflecting the vulnerability level of the structure; based on the composite feature vector, a connectivity change curve of the bone trabecula in a loading environment is extracted by adopting a multi-layer progressive clustering mode, and candidate bone trabecula units with potential micro-damage trends are marked; classifying the candidate bone trabecula units according to risk gradients, and reconstructing a bone trabecula local topology network with weight levels; and according to the local topology network, identifying high-risk nodes showing an imbalance tendency in a specific mechanical simulation period, and generating a feature construction path finally used for micro-fracture risk prediction. The method has the advantage of improving the micro-fracture risk prediction sensitivity.

The invention relates to the field of disease animal model construction, and particularly discloses a postmenopausal osteoporosis and knee osteoarthritis co-disease animal model construction method which comprises the following steps: selecting a female animal as an experimental subject; the selected female animals are injected with a GnRH agonist, meanwhile, low-calcium feed feeding and oxidative stress stimulation are conducted, and feeding is conducted for a preset time; detecting bone mineral density and bone trabecula parameters of the fed female animals, and screening qualified female animals meeting set standards; performing meniscus tearing operation on the qualified female animal, and implanting sustained release microspheres loaded with inflammatory factors at the torn part during the operation; carrying out weight-bearing training on the female animal after the operation, and continuing for a set time length; and performing health detection on the female animals at different time points. According to the method, through multi-factor collaborative induction of the PMOP, minimally invasive construction of the KOA and multi-dimensional health detection, accurate simulation of a co-disease pathological process and clinical characteristics is realized, and the authenticity and stability of the model are improved.

The invention provides an application of narirutin in preparation of a medicine for preventing and / or treating osteoclast of inflammatory arthritis, relates to the technical field of biomedicine, and adopts a collagen-induced mouse arthritis model to observe the treatment effect of the narirutin on the osteoclast of the inflammatory arthritis. The arthritis activity degree of the mouse is analyzed through general claw photographing, thickness measurement, near-infrared temperature measurement and a claw imprinting experiment, three-dimensional reconstruction and bone trabecula analysis are carried out on local joints and the whole body bone mass of the mouse through micro-CT scanning, and Hamp is applied; e, dyeing and Famp; through histological staining analysis such as O staining and TRAP staining, in combination with immunohistochemical staining and the like, the narirutin is proved to play a role in treating inflammatory arthritis, inhibit macrophage pro-inflammatory M1 type polarization, relieve the inflammation level, improve the bone mass of local joints and the whole body, and further improve bone destruction in inflammatory arthritis diseases. The narirutin provides a new way for medicine prevention and treatment of inflammatory arthritis.

The invention relates to the technical field of joint prostheses, in particular to an ankle joint prosthesis based on a bionic bone trabecula, the ankle joint prosthesis comprises a tibia prosthesis (10), a talus prosthesis (30) and a liner (20), the tibia prosthesis (10) and the talus prosthesis (30) are both made of metal materials and are integrally formed through 3D printing, the tibia prosthesis (10) comprises a tibia body (101), and the liner (20) is arranged on the tibia body (101). The first bone contact layer (100) is integrally formed on the tibia body (101), and the first bone contact layer (100) is of a porous structure of which the pore diameter is gradually reduced from outside to inside; the talus prosthesis (30) comprises a talus body (301) and a second bone contact layer (300) integrally formed on the talus body (301), and the second bone contact layer (300) is of a porous structure with the aperture gradually reduced from outside to inside.

The invention discloses bifidobacterium longum subsp.longum capable of improving the physiological activity function of vitamin D and maintaining bone health and application of the bifidobacterium longum subsp.longum, and belongs to the technical field of biological medicine. The bifidobacterium longum subsp. Longum CCFM1448 provided by the invention can obviously improve the total bone mineral density, the bone mineral density of distal femur bone trabecula, the thickness of the bone trabecula, the number of the bone trabecula, the connectivity of the bone trabecula and the bone volume fraction of an osteoporosis mouse, and obviously reduce the separation degree of the bone trabecula of the osteoporosis mouse; the content of a vitamin D metabolite 1, 25-dihydroxy vitamin D in serum of a mouse with osteoporosis is remarkably increased, the content of serum calcium and alkaline phosphatase in the serum of the mouse with osteoporosis is reduced, and the level of osteocalcin and I-type procollagen amino-terminal original peptide in the serum is increased. Therefore, the bifidobacterium longum subsp. Longum CCFM1448 has the effects of relieving bone calcium loss, maintaining bone health, repairing bone injury, increasing osteoblasts and reducing osteoporosis degree.

The invention discloses a titanium-magnesium hollow screw system capable of promoting fracture healing and a manufacturing method. The titanium-magnesium hollow screw system comprises a titanium-based supporting structure and a magnesium filling layer. The titanium-based supporting structure comprises a main body part, the surface of the main body part is provided with an imitated bone trabecula part, and a plurality of bone gaps are formed in the imitated bone trabecula part; wherein bone gaps are filled with the magnesium filling layer, and the magnesium filling layer is combined with the titanium-based supporting structure in a physical embedding mode; the titanium-based supporting structure bears and maintains initial fixation and long-term bearing, so that the strength and the stability of the screw are ensured; the surface imitated bone trabecula and the communicated bone gaps increase the surface area and provide a physical channel for vascularization and bone tissue ingrowth, so that synostosis is promoted; the magnesium filling layer releases magnesium ions after being locally controllably degraded, so that osteogenesis and angiogenesis are favorably stimulated, the local biological environment is improved, instant mechanical support after an operation is ensured, bone healing is promoted through local biological activity release and structural orientation, the healing time is favorably shortened, and the healing quality is favorably improved.

The invention relates to the technical field of medical diagnosis, and discloses a fracture risk prediction method based on bone trabecula extraction features, and the method comprises the steps: obtaining two-dimensional image data of a bone of a patient, and carrying out the preprocessing; separating the bone trabecula from the background by using an improved image segmentation algorithm; reconstructing a three-dimensional structure of the bone trabecula, extracting features of the bone trabecula and collecting clinical index data of a patient; screening bone trabecula characteristics and clinical indexes; constructing a fracture risk prediction model, and evaluating and verifying the model; scanning to obtain a normal position spine image of the patient and obtaining a TBS value; and combining the TBS value with a probability value output by the fracture risk prediction model, performing comprehensive evaluation on the patient, and determining a fracture risk level. According to the method, the bone trabecula image features and clinical indexes can be effectively combined, and more accurate and more comprehensive fracture risk prediction is realized through an improved image processing technology and an optimized machine learning model.

CT images from the neck, lung, cardiac, abdominal, pelvis, hip, spine or lower extremity areas are obtained and analyzed by a computer to measure trabecular bone density on each level it is available, in the spine and hip. Any bone tissue associated with vertebrae that is fractured is excluded, along with Schmorl's nodes, large blood vessels, and cortical bone, to accurately average the trabecular bone density on a scan. The density of fat, heart, and muscle tissue of a subject is used to calibrate the results. That data may be input to an absolute fracture risk model (Fracture Risk Algorithm calculator). Information such as bone density, T score, Z score, fracture risk, and identification of vertebral fractures (if present) may be determined and reported.

This application relates to the technical field of medical devices, and particularly to an artificial knee joint prosthesis. An artificial knee joint prosthesis includes: a tibial tray; a liner mounted on the tibial tray; a femoral condyle prosthesis, which includes a femoral condyle metal component and a femoral condyle ceramic component. The femoral condyle ceramic component covers the outer wall of the femoral condyle metal component. The femoral condyle ceramic component is in sliding fit with the liner. The inner wall of the femoral condyle metal component is a 3D printed trabecular bone structure, which can achieve biological fixation and bone ingrowth. This application has the effect of reducing the friction between the liner and the femoral condyle prosthesis, reducing the particles generated by polyethylene wear, thereby reducing the occurrence of inflammation in patients, avoiding bone cement reactions, and reducing the occurrence of postoperative pain and joint instability in patients.

The invention belongs to the technical field of medicines, and particularly relates to application of lycium barbarum glycopeptide in preparation of a medicine for preventing or treating senile ossification. The experimental results show that the wolfberry glycopeptide can improve the posterior limb movement ability and the bone trabecula condition of old mice by increasing the femoral hardness, relieving the bone tissue calcium loss condition, improving the bone formation rate, promoting osteoblasts and inhibiting osteoclasts, so that the effect of treating bone aging is achieved. As a traditional Chinese medicinal material extraction product, the lycium barbarum glycopeptide can be effectively used for preventing and treating senile ossification, has the prospect of being developed into the medicine for preventing and treating senile ossification, provides more treatment choices for clinically preventing or treating senile ossification, and has important social benefits and economic values.

A method and system for analysis of medical images is presented in the field of analysis of medical images. The method and systems is provided to determine one or more parameters of bones in medical images. The method and system may be characterized as an advancement in analysis of medical images to ascertain bone health and discern pathologies in bone. Specifically, a system and method is disclosed for analysing medical images showing at least a portion of a bone to determine one or more bone parameters for the at least one portion of a bone. Steps taken by the system and method include: determining a region of interest of the medical image; identifying a boundary of at least one of an inner edge and an outer edge of cortical bone of the at least one portion of the bone within the region of interest; identifying at least one boundary of trabecular bone of the at least one portion of the bone within the region of interest; utilising the identified boundaries to determine at least one of the following bone parameters: orientation, bone mineral density, length, width of trabecular structure, for the at least one portion of bone within the region of interest.

The invention discloses a bone trabecular bionic implant, and relates to the field of bone trabecular bionic planting, the bone trabecular bionic implant comprises a bone trabecular bionic body, the lower end of the bone trabecular bionic body is fixedly connected with a fixed threaded part, and a reserved filling cavity is formed in the bone trabecular bionic body; an external threaded piece is arranged at the lower end of the bone trabecula bionic body. According to the bone trabecular bionic implant, the whole bone trabecular bionic body is made of a tantalum metal material, the tantalum metal has bone healing force and supporting strength, and the surface of the bone trabecular bionic body is of a porous structure, so that attachment and ingrowth of muscle fulcrums are facilitated, fulcrums are provided for long-term stability of nodules and muscles, exertion of muscle force is facilitated, and the bone trabecular bionic implant has a good application prospect. The bone trabecula bionic body is filled with gel biological factor substances through a reserved filling cavity, the bone trabecula bionic body is mainly applied to implant operation after femoral head necrosis in early and middle stages and drilling decompression, and other drugs can be plugged into micropores in the surface of the bone trabecula bionic body and are slowly released.

Described herein are three-dimensional scaffold compositions and methods for bone repair or regeneration. In some embodiments, the disclosed scaffolds comprise a core portion mimicking a native trabecular bone structure that is surrounded by an exterior portion mimicking a native cortical bone structure. In some embodiments, the scaffolds may be functionalized by mineralization and / or pre-vascularization to promote bone and blood vessel formation.

This invention is based on the creation of a polymer scaffold structure as a result of the proportional combination of β-Tricalcium Phosphate (β-TCP) that will increase the 3D and osteoconductive effect allowing / supporting cell infiltration by using extrusion deposition, in other words, added manufacturing process, and with physiological buffered HA solution with the Deep Coating Method and by increasing the transmission rate of growth factors as a result of coating and expanding their areas with the biological tissue implant, which allows its use with titanium mesh plates or contoured structures.

An implant device configured to be at least partially in contact with bone on implantation has an improved osteoinductive feature to enhance new bone formation. The implant device has one or more bone growth surfaces extending from a structurally solid feature of the implant device. The one or more bone growth surfaces are configured to mimic adult trabecular bone by having trenches, grooves or surface recesses or prominences exhibiting numerous structural elements or walls not perpendicular to the surface that are non-coplanar or arched extending 20 to 500 microns in depth having an increasing inclination from the surface extending inwardly and not parallel to opposing or adjacent walls forming a random or non-random network. The one or more bone growth surfaces configured to mimic trabecular bone have discernable nano features on the structural elements or walls exhibiting nano scale features of less than 200 nano meters within the network.

The present invention discloses a method for generating a trabecular porous structure model based on cancellous bone micro-CT and preparing a trabecular porous structure, and relates to the field of biomedical technology. A specific implementation of the method for generating a trabecular porous structure model based on cancellous bone micro-CT includes: scanning the cancellous bone based on micro-CT to obtain a three-dimensional image of the cancellous bone; determining the position of the cavity of the cancellous bone according to the gray value of each point in the three-dimensional image; and generating a trabecular porous structure model based on the Voronoi algorithm according to the cavity position. This implementation can reproduce the microstructure, density distribution, mass transfer characteristics and biological properties of the bone, and at the same time has good mechanical properties and bone ingrowth properties.

The present application relates to a kind of trabecula-cement composite finite element model construction method, method includes obtaining trabecula microimage data;Reconstruct the three-dimensional structure of trabecula in the region of interest;The trabecula in the three-dimensional structure image of trabecula is polished and smoothed;Convert to entity after being wrapped using fluid domain;Two-dimensional surface mesh subdivision is carried out to fluid domain, and three-dimensional body mesh division is carried out after subdivision to fluid domain;Trabecula is divided into three-dimensional body mesh;With fluid domain as cement, obtain the trabecula-cement composite of preset filling depth, respectively give cement, trabecula grid corresponding material attribute and material parameter, set boundary condition, load and the contact type between cement and trabecula, obtain trabecula-cement composite finite element model.The method of the present application omits the process of traditional construction trabecula-cement composite sample, and the finite element model established is high in accuracy, low in cost and easy to popularize.

The present application relates to a kind of biomimetic reticular nanofiber composite coating and its preparation method and infectious bone defect repair application, belong to biomedical material field.The present application is aimed at solving the technical problem of the poor bone integration of implant in infectious bone defect.The present application provides a kind of biomimetic reticular nanofiber composite coating, which is formed by layer-by-layer self-assembly on the surface of implant by lysozyme amyloid fiber and polyphenols (such as tannin etc.) Form reticular structure, then prepared with bioactive metal ions coordination;The number of coating layers is 4-8 layers.Preparation method includes lysozyme fiberization, alternate deposition and ion loading steps.The composite coating of the present application has broad-spectrum antibacterial, antioxidant stress and promotes osteogenesis function;In animal model, bacterial load is reduced by 80%, bone volume fraction and trabecular bone parameters are significantly improved, and can realize anti-bacterial biofilm infection-antioxidant stress-angiogenesis-promote bone regeneration synergy.

A semi-closed negative pressure restoration for jaw defects comprises a base body and a closed shell, the base body is of a titanium alloy net structure formed through 3D printing, the two ends of the base body can be matched with bone fracture ends in an attached mode, and a negative pressure suction base tube is embedded into the surface of the closed shell inwards. And an outer tube opening of the negative pressure suction base tube is used for being connected with a suction tube of a negative pressure suction device in a sealing manner. Aiming at the situation that the jaw defect degree is that periosteum does not exist, the titanium alloy prosthesis is manufactured through 3D printing, the two ends of the prosthesis are tightly attached to the bone fracture end, the outer surface of the prosthesis is in a closed state, and therefore it is guaranteed that the interior of the prosthesis is in a negative pressure environment and the interior of the prosthesis is of a bone trabecula imitating grid structure under the situation that the periosteum does not exist; a negative pressure suction base tube is arranged at the lower end of the negative pressure suction tube and communicated with a suction tube of a negative pressure suction device, intermittent negative pressure suction (15-30 min / h) is carried out, growth and differentiation of local osteoblasts are promoted, and rapid osteogenic repair in a repair body is promoted.

This application relates to the field of medical device technology, and in particular to a modular bio-ring reconstruction integrated device for the acetabulum, comprising a combined reconstruction ring and a bio-reconstruction support. The combined reconstruction ring is embedded in the acetabular fossa and forms a metal trabecular bone to reconstruct a complete acetabular fossa. The bio-reconstruction support is connected to the combined reconstruction ring and is used to connect the combined reconstruction ring to the acetabulum. This application has the effect of improving the inability to provide effective support and stable reconstruction for the acetabulum.

The present disclosure discloses the hip prosthesis containing zirconium-niobium alloy on oxidation layer and a preparation method thereof, the hip prosthesis comprises a femoral stem, a femoral head, liners and a shell; the shell and femoral stem are prepared by using zirconium-niobium alloy powder as a raw material, and performing Sinter-HIP, cryogenic cooling and surface oxidation; the prepared shell and femoral stem are provided with partitioned trabeculae and formed by 3D printing. The problem of traditional manufacturing methods cannot process complex structures and failure of connection between sleeve and femoral handle is solved by 3D printing technology. Meanwhile, the preparation method can improve the bonding strength between trabecular bone and solid, and improve the service life of prosthesis.

The present invention provides a calculation method for the morphological metrology parameters of trabecular bone in polymer-embedded sectional specimens, which relates to the field of biomedical engineering technology. The aim is to solve the problems in the existing trabecular bone morphology measurement, such as the inability to quickly reflect the true situation in vivo and the repeated sampling, which increases the labor intensity. The adopted technical solution is that at the macro-micro level, the precise morphological metrology parameters of trabecular bone at multiple positions are intelligently identified in a large range, which is of great significance for understanding the biomechanical information of the trabecular bone gradient change in situ bone and further developing biomaterials with better biocompatibility; in programming software, the division of the region of interest of bone sections is realized, and the operator can repeatedly extract the trabecular bone information of the region of interest in a large range and at multiple sites according to his own situation, without the need for manual cutting and grinding of bone tissue, reducing the human error and simplifying the work process.

The invention provides an implicit porous structure modeling method based on Voronoi subdivision, and relates to the technical field of implicit modeling. The method comprises the following steps: firstly, carrying out Voronoi space subdivision on a point set to generate a three-dimensional cell structure; constructing an internally tangent implicit field based on the surface normal and vertex coordinates; constructing a surface-level connected implicit field according to a surface-adjacency relationship, and further fusing to generate a unit-level implicit field; fusing all the unit fields to obtain a global implicit field, and extracting a contour surface to generate a porous structure. By adjusting control parameters, high-precision controllable modeling of the pore structure is achieved, and the method is suitable for bone trabecula structure matching.

This invention discloses a biomimetic helical chiral porous bone repair and bone augmentation scaffold, comprising: a scaffold body composed of an array of multiple lattice units, each lattice unit being a biomimetic trabecular bone cell; the lattice units follow the natural helical arrangement of human bone trabeculae, forming a continuous and interconnected helical channel network within the scaffold body; the lattice units are distributed in a helical gradient along the radial direction of the scaffold body, and the outer wall of the scaffold body has a protruding structure integrally formed with the lattice units. This invention, through the deep coupling of the biomimetic helical chiral structure and cellular fluid dynamics, overcomes the limitations of traditional scaffolds with "static channels," forming a composite flow field of "high-speed guidance - low-speed vortex," effectively solving the problem of "nutrient islands," and significantly improving the survival rate and quality of osteoblasts in the central region.

The invention discloses application of quercidic acid in preparation of a medicine or a medicine composition for preventing or treating diseases or symptoms related to excessive glucocorticoid. According to the application disclosed by the invention, the protective effect of the quercidic acid on the GIONFH is verified through a preclinical model, and evidence that the quercidic acid can be applied to prevention or treatment of the GIONFH is provided. Animal experiments prove that the quercidic acid can inhibit methylprednisolone-induced rat GIONFH, and the action mechanism is related to inhibition of osteoclasts. The medicine or the medicine composition described by the invention can obviously improve the formation of necrotic fossa in femoral head of GIONFH, bone loss of bone trabecula, CTSK positive cell expression, osteoclast formation, bone resorption protein expression and osteoclast overactivity at a lower dosage, and provides a potential prevention and treatment scheme for treatment of GIONFH.

The present disclosure discloses an osteoporosis treatment system, apparatus, and method. According to the present disclosure, the osteoporosis treatment system includes: a solid gel pad that has a groove formed to be inclined in consideration of a main direction of trabeculae for an osteoporosis treatment area of a patient obtained using an imaging device; and a fixing part that fixes the solid gel pad to skins near treatment areas of each patient, wherein a probe of low-intensity pulsed ultrasound is inserted into the groove of the solid gel pad so that pulsed ultrasound applied by the low-intensity pulsed ultrasound amplifies movement of fluid inside a trabecular bone to maximize a response of osteoblasts distributed on a surface of the trabeculae.

The invention relates to application of ergothioneine in preparation of a preparation for improving an ovarian reserve function. The invention creatively discovers that the ergothioneine has the function of improving the ovarian reserve function, and the obvious clinical value of the ergothioneine for people with the serum AMH level of 1.0-3.0 ng / mL in the key'window phase 'is defined for the first time. The ergothioneine not only can improve the serum AMH level and the sinus follicle count (AFC), but also can significantly reduce the abnormally increased FSH and LH levels. Meanwhile, aiming at bone loss caused by ovarian reserve function decline, the ergothioneine shows an excellent bone quality protection effect, the bone density can be improved, and the thickness and number of bone trabecula can be increased. In addition, the ergothioneine can improve climacteric symptoms, effectively maintain the nutritional state of target organs such as uterus, delay atrophy and regulate menstrual cycle disorder.

The invention relates to application of a TRMT10C agonist TM3 in preparation of a medicine for treating senile osteoporosis, and belongs to the technical field of biological medicines. According to the invention, the TRMT10C agonist TM3 is used for treating senile osteoporosis for the first time. A mouse experiment verifies that the TRMT10C agonist TM3 can inhibit bone loss of a mouse with osteoporosis, increase the bone density, the number of bone trabecula and the volume fraction of the bone trabecula, reduce the separation degree of the bone trabecula and promote bone formation. It is fully proved that the TRMT10C agonist TM3 can be used for treating the senile osteoporosis caused by the fact that the osteogenesis rate is remarkably reduced due to age increase, and therefore the TRMT10C agonist TM3 can be used for preparing the medicine for treating the senile osteoporosis and has important significance in clinical treatment of the senile osteoporosis in the future.

The present disclosure relates to a novel (Lactococcus lactis subsp. cremoris HEM 20103 strain useful for promoting intestinal absorption of calcium, and uses thereof. The novel Lactococcus lactis HEM 20103 strain of the present invention was confirmed to exhibit acid resistance, bile resistance, and intestinal cell adhesion ability and to have an excellent effect of promoting intestinal absorption of calcium. In addition, by increasing bone mineral content, the strain was confirmed to increase calcium metabolism, bone density, bone volume per unit volume, and cortical bone thickness and to significantly improve trabecular bone thickness, trabecular number per unit area, and trabecular spacing in osteoporosis model mice. Therefore, the strain of the present invention is expected to be widely used as a health functional food composition, a feed composition, a feed additive, and the like for promoting intestinal absorption of calcium and to have an excellent effect of preventing or treating intestinal absorption-related diseases of calcium such as osteoporosis or osteopenia.