53 results about "Trabecular bone" patented technology

The invention relates to the field of disease animal model construction, and particularly discloses a postmenopausal osteoporosis and knee osteoarthritis co-disease animal model construction method which comprises the following steps: selecting a female animal as an experimental subject; the selected female animals are injected with a GnRH agonist, meanwhile, low-calcium feed feeding and oxidative stress stimulation are conducted, and feeding is conducted for a preset time; detecting bone mineral density and bone trabecula parameters of the fed female animals, and screening qualified female animals meeting set standards; performing meniscus tearing operation on the qualified female animal, and implanting sustained release microspheres loaded with inflammatory factors at the torn part during the operation; carrying out weight-bearing training on the female animal after the operation, and continuing for a set time length; and performing health detection on the female animals at different time points. According to the method, through multi-factor collaborative induction of the PMOP, minimally invasive construction of the KOA and multi-dimensional health detection, accurate simulation of a co-disease pathological process and clinical characteristics is realized, and the authenticity and stability of the model are improved.

The invention discloses a titanium-magnesium hollow screw system capable of promoting fracture healing and a manufacturing method. The titanium-magnesium hollow screw system comprises a titanium-based supporting structure and a magnesium filling layer. The titanium-based supporting structure comprises a main body part, the surface of the main body part is provided with an imitated bone trabecula part, and a plurality of bone gaps are formed in the imitated bone trabecula part; wherein bone gaps are filled with the magnesium filling layer, and the magnesium filling layer is combined with the titanium-based supporting structure in a physical embedding mode; the titanium-based supporting structure bears and maintains initial fixation and long-term bearing, so that the strength and the stability of the screw are ensured; the surface imitated bone trabecula and the communicated bone gaps increase the surface area and provide a physical channel for vascularization and bone tissue ingrowth, so that synostosis is promoted; the magnesium filling layer releases magnesium ions after being locally controllably degraded, so that osteogenesis and angiogenesis are favorably stimulated, the local biological environment is improved, instant mechanical support after an operation is ensured, bone healing is promoted through local biological activity release and structural orientation, the healing time is favorably shortened, and the healing quality is favorably improved.

CT images from the neck, lung, cardiac, abdominal, pelvis, hip, spine or lower extremity areas are obtained and analyzed by a computer to measure trabecular bone density on each level it is available, in the spine and hip. Any bone tissue associated with vertebrae that is fractured is excluded, along with Schmorl's nodes, large blood vessels, and cortical bone, to accurately average the trabecular bone density on a scan. The density of fat, heart, and muscle tissue of a subject is used to calibrate the results. That data may be input to an absolute fracture risk model (Fracture Risk Algorithm calculator). Information such as bone density, T score, Z score, fracture risk, and identification of vertebral fractures (if present) may be determined and reported.

A method and system for analysis of medical images is presented in the field of analysis of medical images. The method and systems is provided to determine one or more parameters of bones in medical images. The method and system may be characterized as an advancement in analysis of medical images to ascertain bone health and discern pathologies in bone. Specifically, a system and method is disclosed for analysing medical images showing at least a portion of a bone to determine one or more bone parameters for the at least one portion of a bone. Steps taken by the system and method include: determining a region of interest of the medical image; identifying a boundary of at least one of an inner edge and an outer edge of cortical bone of the at least one portion of the bone within the region of interest; identifying at least one boundary of trabecular bone of the at least one portion of the bone within the region of interest; utilising the identified boundaries to determine at least one of the following bone parameters: orientation, bone mineral density, length, width of trabecular structure, for the at least one portion of bone within the region of interest.

The invention discloses a bone trabecular bionic implant, and relates to the field of bone trabecular bionic planting, the bone trabecular bionic implant comprises a bone trabecular bionic body, the lower end of the bone trabecular bionic body is fixedly connected with a fixed threaded part, and a reserved filling cavity is formed in the bone trabecular bionic body; an external threaded piece is arranged at the lower end of the bone trabecula bionic body. According to the bone trabecular bionic implant, the whole bone trabecular bionic body is made of a tantalum metal material, the tantalum metal has bone healing force and supporting strength, and the surface of the bone trabecular bionic body is of a porous structure, so that attachment and ingrowth of muscle fulcrums are facilitated, fulcrums are provided for long-term stability of nodules and muscles, exertion of muscle force is facilitated, and the bone trabecular bionic implant has a good application prospect. The bone trabecula bionic body is filled with gel biological factor substances through a reserved filling cavity, the bone trabecula bionic body is mainly applied to implant operation after femoral head necrosis in early and middle stages and drilling decompression, and other drugs can be plugged into micropores in the surface of the bone trabecula bionic body and are slowly released.

Described herein are three-dimensional scaffold compositions and methods for bone repair or regeneration. In some embodiments, the disclosed scaffolds comprise a core portion mimicking a native trabecular bone structure that is surrounded by an exterior portion mimicking a native cortical bone structure. In some embodiments, the scaffolds may be functionalized by mineralization and / or pre-vascularization to promote bone and blood vessel formation.

This invention is based on the creation of a polymer scaffold structure as a result of the proportional combination of β-Tricalcium Phosphate (β-TCP) that will increase the 3D and osteoconductive effect allowing / supporting cell infiltration by using extrusion deposition, in other words, added manufacturing process, and with physiological buffered HA solution with the Deep Coating Method and by increasing the transmission rate of growth factors as a result of coating and expanding their areas with the biological tissue implant, which allows its use with titanium mesh plates or contoured structures.

An implant device configured to be at least partially in contact with bone on implantation has an improved osteoinductive feature to enhance new bone formation. The implant device has one or more bone growth surfaces extending from a structurally solid feature of the implant device. The one or more bone growth surfaces are configured to mimic adult trabecular bone by having trenches, grooves or surface recesses or prominences exhibiting numerous structural elements or walls not perpendicular to the surface that are non-coplanar or arched extending 20 to 500 microns in depth having an increasing inclination from the surface extending inwardly and not parallel to opposing or adjacent walls forming a random or non-random network. The one or more bone growth surfaces configured to mimic trabecular bone have discernable nano features on the structural elements or walls exhibiting nano scale features of less than 200 nano meters within the network.

The present application relates to a kind of trabecula-cement composite finite element model construction method, method includes obtaining trabecula microimage data;Reconstruct the three-dimensional structure of trabecula in the region of interest;The trabecula in the three-dimensional structure image of trabecula is polished and smoothed;Convert to entity after being wrapped using fluid domain;Two-dimensional surface mesh subdivision is carried out to fluid domain, and three-dimensional body mesh division is carried out after subdivision to fluid domain;Trabecula is divided into three-dimensional body mesh;With fluid domain as cement, obtain the trabecula-cement composite of preset filling depth, respectively give cement, trabecula grid corresponding material attribute and material parameter, set boundary condition, load and the contact type between cement and trabecula, obtain trabecula-cement composite finite element model.The method of the present application omits the process of traditional construction trabecula-cement composite sample, and the finite element model established is high in accuracy, low in cost and easy to popularize.

The present application relates to a kind of biomimetic reticular nanofiber composite coating and its preparation method and infectious bone defect repair application, belong to biomedical material field.The present application is aimed at solving the technical problem of the poor bone integration of implant in infectious bone defect.The present application provides a kind of biomimetic reticular nanofiber composite coating, which is formed by layer-by-layer self-assembly on the surface of implant by lysozyme amyloid fiber and polyphenols (such as tannin etc.) Form reticular structure, then prepared with bioactive metal ions coordination;The number of coating layers is 4-8 layers.Preparation method includes lysozyme fiberization, alternate deposition and ion loading steps.The composite coating of the present application has broad-spectrum antibacterial, antioxidant stress and promotes osteogenesis function;In animal model, bacterial load is reduced by 80%, bone volume fraction and trabecular bone parameters are significantly improved, and can realize anti-bacterial biofilm infection-antioxidant stress-angiogenesis-promote bone regeneration synergy.

This application relates to the field of medical device technology, and in particular to a modular bio-ring reconstruction integrated device for the acetabulum, comprising a combined reconstruction ring and a bio-reconstruction support. The combined reconstruction ring is embedded in the acetabular fossa and forms a metal trabecular bone to reconstruct a complete acetabular fossa. The bio-reconstruction support is connected to the combined reconstruction ring and is used to connect the combined reconstruction ring to the acetabulum. This application has the effect of improving the inability to provide effective support and stable reconstruction for the acetabulum.

This invention discloses a biomimetic helical chiral porous bone repair and bone augmentation scaffold, comprising: a scaffold body composed of an array of multiple lattice units, each lattice unit being a biomimetic trabecular bone cell; the lattice units follow the natural helical arrangement of human bone trabeculae, forming a continuous and interconnected helical channel network within the scaffold body; the lattice units are distributed in a helical gradient along the radial direction of the scaffold body, and the outer wall of the scaffold body has a protruding structure integrally formed with the lattice units. This invention, through the deep coupling of the biomimetic helical chiral structure and cellular fluid dynamics, overcomes the limitations of traditional scaffolds with "static channels," forming a composite flow field of "high-speed guidance - low-speed vortex," effectively solving the problem of "nutrient islands," and significantly improving the survival rate and quality of osteoblasts in the central region.

The invention discloses application of quercidic acid in preparation of a medicine or a medicine composition for preventing or treating diseases or symptoms related to excessive glucocorticoid. According to the application disclosed by the invention, the protective effect of the quercidic acid on the GIONFH is verified through a preclinical model, and evidence that the quercidic acid can be applied to prevention or treatment of the GIONFH is provided. Animal experiments prove that the quercidic acid can inhibit methylprednisolone-induced rat GIONFH, and the action mechanism is related to inhibition of osteoclasts. The medicine or the medicine composition described by the invention can obviously improve the formation of necrotic fossa in femoral head of GIONFH, bone loss of bone trabecula, CTSK positive cell expression, osteoclast formation, bone resorption protein expression and osteoclast overactivity at a lower dosage, and provides a potential prevention and treatment scheme for treatment of GIONFH.

The present disclosure discloses an osteoporosis treatment system, apparatus, and method. According to the present disclosure, the osteoporosis treatment system includes: a solid gel pad that has a groove formed to be inclined in consideration of a main direction of trabeculae for an osteoporosis treatment area of a patient obtained using an imaging device; and a fixing part that fixes the solid gel pad to skins near treatment areas of each patient, wherein a probe of low-intensity pulsed ultrasound is inserted into the groove of the solid gel pad so that pulsed ultrasound applied by the low-intensity pulsed ultrasound amplifies movement of fluid inside a trabecular bone to maximize a response of osteoblasts distributed on a surface of the trabeculae.

The invention relates to application of ergothioneine in preparation of a preparation for improving an ovarian reserve function. The invention creatively discovers that the ergothioneine has the function of improving the ovarian reserve function, and the obvious clinical value of the ergothioneine for people with the serum AMH level of 1.0-3.0 ng / mL in the key'window phase 'is defined for the first time. The ergothioneine not only can improve the serum AMH level and the sinus follicle count (AFC), but also can significantly reduce the abnormally increased FSH and LH levels. Meanwhile, aiming at bone loss caused by ovarian reserve function decline, the ergothioneine shows an excellent bone quality protection effect, the bone density can be improved, and the thickness and number of bone trabecula can be increased. In addition, the ergothioneine can improve climacteric symptoms, effectively maintain the nutritional state of target organs such as uterus, delay atrophy and regulate menstrual cycle disorder.

The invention relates to application of a TRMT10C agonist TM3 in preparation of a medicine for treating senile osteoporosis, and belongs to the technical field of biological medicines. According to the invention, the TRMT10C agonist TM3 is used for treating senile osteoporosis for the first time. A mouse experiment verifies that the TRMT10C agonist TM3 can inhibit bone loss of a mouse with osteoporosis, increase the bone density, the number of bone trabecula and the volume fraction of the bone trabecula, reduce the separation degree of the bone trabecula and promote bone formation. It is fully proved that the TRMT10C agonist TM3 can be used for treating the senile osteoporosis caused by the fact that the osteogenesis rate is remarkably reduced due to age increase, and therefore the TRMT10C agonist TM3 can be used for preparing the medicine for treating the senile osteoporosis and has important significance in clinical treatment of the senile osteoporosis in the future.

The present disclosure relates to a novel (Lactococcus lactis subsp. cremoris HEM 20103 strain useful for promoting intestinal absorption of calcium, and uses thereof. The novel Lactococcus lactis HEM 20103 strain of the present invention was confirmed to exhibit acid resistance, bile resistance, and intestinal cell adhesion ability and to have an excellent effect of promoting intestinal absorption of calcium. In addition, by increasing bone mineral content, the strain was confirmed to increase calcium metabolism, bone density, bone volume per unit volume, and cortical bone thickness and to significantly improve trabecular bone thickness, trabecular number per unit area, and trabecular spacing in osteoporosis model mice. Therefore, the strain of the present invention is expected to be widely used as a health functional food composition, a feed composition, a feed additive, and the like for promoting intestinal absorption of calcium and to have an excellent effect of preventing or treating intestinal absorption-related diseases of calcium such as osteoporosis or osteopenia.

The invention provides a tribenzoyl substituted vakognavine type diterpenoid alkaloid, a preparation method and application of the tribenzoyl substituted vakognavine type diterpenoid alkaloid, and a pharmaceutical composition. After rats are treated by the tribenzoyl substituted vakognavine type diterpenoid alkaloid provided by the invention, the quality reduction trend is obviously relieved, and the foot swelling degree and the arthritis score are obviously reduced; bone loss induced by AIA can be effectively inhibited, and the structural integrity of bone trabecula is protected; cartilage matrix degradation can be inhibited, and cartilage erosion damage is relieved; the anti-inflammatory effect can be achieved by inhibiting the expression of key proinflammatory factors in bone tissues.

The invention discloses an intramedullary nail for outer side wall smashing type femoral intertrochanteric fracture, and belongs to the field of medical instruments, the intramedullary nail comprises a main nail, the main nail is connected with a tension bolt through a duct adjusting mechanism, and the main nail is provided with a lock nail; the hole channel adjusting mechanism is arranged on the main screw and used for adjusting the neck-shaft angle of the lag screw, the hole channel adjusting mechanism adjusts and changes the installation angle of the lag screw on the main screw through the structure of the hole channel adjusting mechanism, and then adjustment of the neck-shaft angle of the lag screw is achieved. The lag screw can cross the outer side wall to crush a fracture line, the problem of supporting failure caused by the fact that the screw penetrates through the fracture line in traditional fixation is avoided, meanwhile, the tip end of the lag screw is more accurately embedded into a main pressure bone small beam column (PCS) at the proximal end of the femur, and the holding force of the screw to the femoral head is improved; the main nail and the femoral shaft are tightly fixed through transverse locking, and rotation and axial displacement of the main nail in the medullary cavity are limited.

A method for analyzing a texture of a bone, including: receiving an input x-ray image showing an input bone, and a bone score analysis of the received input x-ray image by a bone score artificial intelligence implemented by a technical element. The bone score artificial intelligence provides as a result of this bone score analysis: a global score depending at least on a trabecular bone score depending on a texture of the trabecular part of the input bone showed on the received input x-ray image, and / or a trabecular bone score depending on a texture of the trabecular part of the input bone showed on the received input x-ray image. Also, a corresponding device for carrying out the method.

The invention discloses an application of a bone marrow mesenchymal stem cell outer vesicle for inhibiting miR-221-3p and a preparation method of the bone marrow mesenchymal stem cell outer vesicle. Rat bone marrow mesenchymal stem cell outer vesicles (rBMSCs-EVs) are extracted, rBMSCs-EVs (miR-221-3pin-EVs are used for cells, and antiagomiR-221-3p-EVs are used for animals) for inhibiting miR-221-3p are prepared, and in-vitro osteogenic induction differentiation experiments define that the miR-221-3pin-EVs can remarkably inhibit fluorine-induced osteogenic differentiation enhancement. Meanwhile, the fact that the antagomiR-221-3p-EVs can improve the phenomena of bone mineral density increase, bone trabecula number increase, bone trabecula thickening and the like of a sclerotic bone fluorosis rat model in vivo is further proved, and the antagomiR-221-3p-EVs has important significance on clinical treatment of a patient with the bone fluorosis.

The present application belongs to the technical field of natural active peptides, and particularly relates to a crab shell polypeptide as well as a preparation method and application thereof. The preparation method provided by the present application takes crab shells as raw materials, extracts crab shell polypeptides by using a hydrolysis, enzymolysis and alcohol precipitation method, controls the hydrolysis, enzymolysis and alcohol precipitation conditions in the extraction process, and makes the prepared crab shell polypeptides mainly composed of low-molecular-weight peptides and rich in glutamic acid, aspartic acid and lysine. Experiments prove that the crab shell polypeptide provided by the present application can enhance calcium deposition, improve OB activity, improve bone density, restore trabecular bone structure, maintain the integrity of bone tissue, inhibit OC function, has no obvious systemic toxicity, and can reestablish the osteoblast / osteoclast balance at the molecular level and restore calcium-phosphorus homeostasis, and therefore can be used for preparing medicines for preventing and treating osteoporosis or health-care foods for improving bone density, and has a good application prospect.

The present application relates to the technical field of medical devices, and discloses a knee joint prosthesis, which comprises a trabecular bone type, one side of the trabecular bone type is provided with a front condyle side, the other side of the trabecular bone type is provided with a notch, both ends of the trabecular bone type notch are provided with distal end sides, the upper surface of the distal end side is provided with a trabecular column, one side of the distal end side is provided with a rear condyle side, the side wall of the trabecular bone type is provided with a femoral condyle body, the inside of the trabecular column is provided with a column, one side of the rear condyle side is provided with a femoral component surface, and the outer wall of the femoral component surface is provided with. The femoral side prosthesis realizes better fusion of the femoral side prosthesis and bone tissue, promotes bone ingrowth, and achieves the effect of long-term stable fixation. The problems of poor long-term stability, easy loosening and easy wear of the friction interface of the traditional femoral side prosthesis are solved, and the service life of the prosthesis and the life quality of the patient are improved.

The invention provides Haitesan type diterpenoid alkaloid as well as a preparation method, application and a pharmaceutical composition thereof. After rats are treated by the Haitesan diterpenoid alkaloid provided by the invention, the quality reduction trend is obviously relieved, and the foot swelling degree and the arthritis score are obviously reduced; bone loss induced by AIA can be effectively inhibited, and the structural integrity of bone trabecula is protected; cartilage matrix degradation can be inhibited, and cartilage erosion damage is relieved; the anti-inflammatory effect can be achieved by inhibiting the expression of key proinflammatory factors in bone tissues.

This invention discloses the application of PT-129 in the preparation of drugs for treating rheumatoid arthritis (RA), belonging to the field of RA treatment. This invention is the first to demonstrate that the compound PT-129 can target and intervene in the synovial microenvironment, effectively inhibiting the abnormal activation behaviors of RA fibroblast-like synovial cells (FLS) such as proliferation, migration, and invasion, and downregulating the expression of N-cadherin and MMP3 proteins in synovial tissue. This invention provides a combined drug formulation containing PT-129 and RGFP966. This composition exhibits a significant synergistic effect in vivo, effectively relieving joint swelling, increasing bone density and trabecular bone thickness, reducing trabecular bone separation, thereby inhibiting cartilage degradation and bone destruction. This invention provides a novel targeted drug and combination therapy with definite efficacy for the clinical intervention of RA, possessing extremely high clinical application development value.

This invention provides the application of Neoruscogenin in the preparation of anti-osteoporosis drugs, belonging to the field of pharmaceutical biotechnology. It was found that Neoruscogenin can significantly increase bone volume fraction, bone surface area to tissue volume ratio, bone mineral density, trabecular bone number, and trabecular bone thickness in osteoporotic mice, while significantly reducing trabecular bone separation; that is, Neoruscogenin can alleviate low bone mass in postmenopausal osteoporotic mice. Furthermore, Neoruscogenin treatment for 8 weeks did not significantly affect the major organs of mice, suggesting the biocompatibility of Neoruscogenin.

This invention comprises base plate and glenosphere designs, as well as cutting guides and holder instruments, developed to provide stronger fixation with a more minimally invasive approach to the shoulder in patients undergoing reverse shoulder arthroplasty for any reason. This newly developed technique allows for surgical operation in a more confined space, particularly in challenging cases such as tight shoulders. In addition, it offers advantages such as being usable as an alternative technique in osteoporotic patients with high cortical fixation and in revision surgeries or in cases with reduced bone stock due to various reasons. In standard base plate designs, it is known that fixation is predominantly achieved in the trabecular bone by screws inserted from the reamed peripheral bone surface surrounding the implant. However, in osteoporotic patients, trabecular bone becomes weakened and the bone stock may not provide sufficient support. Furthermore, version differences related to anatomical variations of the glenoid seen among patients may cause problems in component placement and screw insertion if proper preoperative assessment is not performed. Moreover, in classical component design, in order to send the guidewire in the correct direction corresponding to the surface where the central peg will be applied, soft tissue dissection exposing the entire glenoid must be performed. Performing this dissection may pose challenges for the surgeon in tight shoulders, increase the duration of surgery, and carry risks of complications such as instability or injury to neurovascular structures. In addition, in classical component design, the acceptable threshold of contact between the glenoid and base plate is considered to be 80%. If this is not achieved, implant failure may occur after prosthesis application. When the contact surface between the glenoid and base plate falls below 50%, graft application becomes indicated. Although it is a successful method, it is technically demanding, and in cases of graft non-union, alternative options are limited. Another method is the use of augment components for the defective area. This application not only presents high technical difficulty but also requires well-prepared three-dimensional preoperative planning. Custom-made implants are another option and are technically the most laborious and expensive to manufacture. With this invention, compared to previous techniques, the management of glenoid defect and excessive version problems can be achieved by providing higher cortical fixation with anterior-weighted support.

This invention relates to the field of medical imaging analysis and discloses a method and system for constructing trabecular bone features. The method includes: firstly extracting vulnerable regions from acquired vertebral body image sequences to generate an initial feature set characterizing fine-grained structural stability; performing a coherent comparison of the initial feature set across slice dimensions to obtain a composite feature vector reflecting the structural vulnerability level; based on the composite feature vector, using multi-layer progressive clustering to extract the connectivity change curves of trabecular bone under loading conditions, marking candidate trabecular bone units with potential micro-damage trends; classifying the candidate trabecular bone units according to risk gradients to reconstruct a local trabecular bone topology network with weighted hierarchies; and identifying high-risk nodes exhibiting imbalance tendencies within a specific mechanical simulation cycle based on the local topology network, generating a final feature construction path for microfracture risk prediction. This invention has the advantage of improving the sensitivity of microfracture risk prediction.

The invention provides C20 type diterpenoid alkaloid, a preparation method and application thereof and a pharmaceutical composition. After rats are treated by the C20 type diterpenoid alkaloid provided by the invention, the quality reduction trend is obviously relieved, and the foot swelling degree and the arthritis score are obviously reduced; bone loss induced by AIA can be effectively inhibited, and the structural integrity of bone trabecula is protected; cartilage matrix degradation can be inhibited, and cartilage erosion damage is relieved; the anti-inflammatory effect can be achieved by inhibiting the expression of key proinflammatory factors in bone tissues.

This application discloses an automatic analysis method for CT images of long bones in mice and rats, relating to the field of image processing technology. The method includes: acquiring a CT image sequence of the target long bone, extracting the three-dimensional spatial distribution of bone tissue, and performing pose alignment and three-dimensional cropping to obtain a standardized bone image sequence; then constructing candidate depth intervals based on butterfly-shaped anatomical features and key points of growth plate strip-shaped gaps, respectively, and obtaining a fine search range through intersection operation; subsequently identifying candidate slices of triangular fractures and determining the anatomical zero point; finally, mapping the target analysis region based on the anatomical zero point, completing cortical bone segmentation, medullary cavity segmentation, and trabecular bone extraction under closed mask constraints, and outputting quantitative parameters of bone tissue. This application achieves accurate positioning of the growth plate and unified analysis region mapping in long bone CT images, improving the accuracy of trabecular bone extraction and the consistency of bone tissue quantification results.