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Constructing method and application for osteoportic fracture disease animal model

A technology of osteoporosis and animal models, applied in the fields of medical evaluation, medical testing, and experimental zoology, can solve the problems of large ligament damage, long operation time, and high technical requirements, achieve less bleeding, shorten operation time, and speed up experiments The effect of the process

Inactive Publication Date: 2018-11-06
FIRST PEOPLES HOSPITAL OF YUNNAN PROVINCE
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Problems solved by technology

In the method of retrogradely inserting intramedullary nails end-to-end of the femur, there are disadvantages such as high technical requirements, difficult operation, long operation time, large incision, frequent bleeding, large damage to soft tissues, blood vessels, nerves, and ligaments, and easy to fall off.

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  • Constructing method and application for osteoportic fracture disease animal model
  • Constructing method and application for osteoportic fracture disease animal model
  • Constructing method and application for osteoportic fracture disease animal model

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Embodiment Construction

[0041] The present invention will be further described below in conjunction with the accompanying drawings and embodiments.

[0042] Embodiment The establishment of animal model of femoral osteoporotic fracture disease in rats

[0043] 1. Establishment of osteoporosis animal model

[0044]Modeling method of osteoporosis model, 62 clean healthy female SD rats, 6 months old, never mated, weighing 350-400g, were divided into osteoporosis group (OVX group, 54 rats) and control group (Sham group , 8 pieces). The OVX group underwent bilateral oophorectomy, specifically fasting for 12 hours before the operation, using 10% chloral hydrate 0.4ml / 100g for general anesthesia, fixed on the operating table after deep anesthesia, hair removal, iodophor disinfection, and strict asepsis in principle. The midline abdominal incision was made (2.0 cm), the ovaries were searched retrogradely along the bilateral fallopian tubes, and bilateral oophorectomy was performed, and the fallopian tubes ...

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Abstract

The invention provides a constructing method and application for an osteoportic fracture disease animal model. According to the provided technical scheme, based on a constructed osteoporosis animal model, thighbone small lateral incision fracture molding of a model animal is conducted, then a femur fractured end bilateral inverse intramedullary nail inserting internal fixation is conducted, and the osteoportic fracture disease animal model is constructed. The method avoids influences of uncontrollable factors on an experimental result, ensures the uniformity of modeling, shortens the molding time, and accelerates the experiment process. The method is applied to the preparation of the osteoportic fracture disease animal model and is beneficial for meeting related requirements of the osteoportic fracture disease animal model, and the osteoportic fracture disease animal model is taken as a study object to study the pathogenesis, prevention and treatment of basic and clinical osteoportic fractures.

Description

technical field [0001] The invention relates to the fields of experimental zoology, medical evaluation and medical detection, in particular to a construction method and application of an animal model of osteoporotic fracture disease. Background technique [0002] Osteoporosis (Osteoporosis, OP) is a systemic metabolic bone disease characterized by decreased bone mass and degeneration of bone tissue fibrous structure, which inhibits the increase in bone fragility and fracture risk. It is estimated that about 200 million people in the world suffer from osteoporosis at present, and osteoporosis has become a global public health problem. [0003] Osteoporotic fracture (Osteoporotic fracture, OPF) is the most serious complication of osteoporosis. There are countless osteoporotic fractures caused by falls and external forces in patients with osteoporosis. From 2011 to 2015 in China, the elderly population over 60 years old has increased from 178 million to 221 million, which has ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61D1/00
CPCA61D1/00
Inventor 赵宏斌
Owner FIRST PEOPLES HOSPITAL OF YUNNAN PROVINCE
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