Traditional Chinese medicine compound preparation for treating osteoporotic fractures and preparation method and application thereof

Abstract

The invention discloses a traditional Chinese medicine compound preparation for treating osteoporotic fractures. The compound preparation is prepared from traditional Chinese medicine for strengthening the spleen and reinforcing the kidney and pharmaceutical excipients, wherein the traditional Chinese medicine for strengthening the spleen and reinforcing the kidney is prepared, by weight, 6-30 parts of codonopsis pilosula, 6-30 parts of acanthopanax senticosus, 6-30 parts of drynaria rhizome, 6-30 parts of epimedium, 6-15 parts of salvia miltiorrhiza and 3-12 parts of angelica pubescens. According to the traditional Chinese medicine compound preparation for the treating osteoporotic fractures, a formula for strengthening the spleen and reinforcing the kidney is based on a spleen-kidney-related theory that the kidney is a congenital origin and the spleen is an acquired foundation, through animal experiments, it is found that the formula for strengthening the spleen and reinforcing the kidney can significantly promote healing of bone calluses in different periods of ovariectomized mice suffering from the osteoporotic fractures, the bone mass and biomechanical strength of the bone calluses are improved, the expression of beta-catenin in fractured bone end muscles and bone calluses is promoted, the number of muscle-derived stem cells in the fractured bone end muscles is increased, the proliferative activity is promoted, the muscle-derived stem cells are promoted to migrate to the bone calluses, and therefore osteogenic differentiation is simulated, and healing of the osteoporotic fractures is accelerated. The invention further discloses a preparation method and medicinal application of the traditional Chinese medicine compound preparation.

Description

technical field [0001] The invention relates to a traditional Chinese medicine compound preparation for treating osteoporotic fractures. In addition, the invention also relates to a preparation method and medical application of the traditional Chinese medicine compound preparation. Background technique [0002] Osteoporotic fracture is a serious complication of osteoporosis. It often causes fractures in various parts of the body under the action of a slight external force, mostly in the spine, hip and distal radius and ulna. Fractures are also prone to occur in other parts. It can cause pain, deformity, and dysfunction at the fracture site. Spinal fractures can also cause short stature, hunchback, etc. [0003] With the aging of my country's population, the incidence of primary osteoporosis also shows a clear upward trend, resulting in more and more osteoporotic fractures. The treatment of osteoporotic fractures is mainly divided into non-surgical and surgical treatments. H...

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Problems solved by technology

However, since osteoporotic fractures mostly occur in middle-aged and elderly people, the important principle of non-surgical treatment is long-term immobilization, which increases the risk of c

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