12 results about "Bone biomechanics" patented technology

The application discloses a bone health tablet candy rich in marine peptide calcium chelate and a preparation method thereof, and belongs to the technical field of polypeptides, wherein the calcium chelate peptide provided by the application has an amino acid sequence as shown in SEQ ID No.1, and the specific sequence is GETGPA (F21-1), and the calcium binding capacity of the calcium chelate peptide is 4.72±1.06 μg / mg. The bone health tablet candy provided by the application has good calcium absorption promoting activity. The results of a mouse experiment show that the bone health tablet candy does not cause adverse effects on the growth of mice, can reverse high bone conversion caused by osteoporosis, improves the bone biomechanical properties of osteoporotic mice, and thus achieves the effect of enhancing bone density.

The invention relates to the technical field of bone biomechanical simulation, and discloses a bone biomechanical modeling method and system based on a multi-modal image, and the method comprises the steps: S1, collecting a CT image and an MRI image of a to-be-detected bone structure, and generating a multi-modal image; s2, adopting a depth variation inference algorithm to extract common features of the multi-modal images, adopting a generative adversarial network algorithm to optimize the common features, and performing information fusion on the multi-modal images to generate comprehensive image data; s3, reconstructing a three-dimensional bone structure model based on the comprehensive image data; s4, simulating mechanical property parameters of the three-dimensional bone structure model under different external loads and physiological states by adopting a nonlinear finite element method based on the three-dimensional bone structure model, and outputting mechanical properties of bone tissues; and S5, based on the three-dimensional bone structure model and the mechanical characteristics of the bone tissue, generating a personalized bone biomechanical model by using a depth variation inference algorithm. According to the method, an accurate personalized bone biomechanical modeling scheme can be provided.

The present invention relates to the use of a polysaccharide from pitaya branches, and relates to the field of pharmaceutical technology. The present invention provides a use of a polysaccharide from pitaya branches in the treatment of osteoporosis. The polysaccharide is an extract obtained from pitaya branches by water extraction. The polysaccharide from pitaya branches promotes the proliferation and differentiation of osteoblasts, improves bone biomechanics, and is significantly effective in preventing and treating osteoporosis.

The present invention discloses a preparation method and application of fermented milk rich in osteogenic growth peptide FPPQSVL, and belongs to the technical field of dairy product processing. The present invention prepares Lactobacillus helveticus fermented milk rich in osteogenic growth peptide FPPQSVL by inoculating Lactobacillus helveticus CCFM1263 into skimmed milk for fermentation. The fermented milk has the functions of significantly enhancing bone density, significantly increasing the number and thickness of trabeculae, significantly increasing bone volume fraction, significantly enhancing the bone biomechanics of rats, and significantly reducing the content of bone turnover biomarkers TRAP, CTX-1, and DPD in serum, while significantly increasing the content of BALP. The Lactobacillus helveticus fermented milk rich in osteogenic growth peptide FPPQSVL provided by the present invention can effectively prevent or treat osteoporosis, promote bone health, and is of great significance to the development of health products and medicines that promote bone health.

The present invention belongs to the technical field of bioactive peptide processing, and particularly relates to fresh bovine bone collagen peptide for supplementing joint nutrition and increasing bone density and a preparation method thereof. The preparation method includes enzymatic hydrolysis, and the enzymatic hydrolysis uses a compound protease including carboxypeptidase, aminopeptidase, neutral protease, phytase and trypsin; the mass ratio of the carboxypeptidase, aminopeptidase, neutral protease, phytase and trypsin is 0.5-1:0.5-1:2-4:1-3:1-3. The molecular weight of the collagen peptide prepared by the present invention is less than 5000 daltons, and this collagen peptide can effectively improve bone density, bone mineral content, bone biomechanical properties and bone metabolism indexes, and has good health care and therapeutic effects on elderly osteoporotic fracture patients.

The present invention relates to the field of bone biomechanics simulation technology, and discloses a bone biomechanics modeling method and system based on multimodal images. The method includes: S1: Collecting CT images and MRI images of the bone structure to be measured to generate multimodal images; S2: Using a deep variational inference algorithm to extract the common features of the multimodal images and using a generative adversarial network algorithm to optimize the common features, performing information fusion on the multimodal images to generate comprehensive image data; S3: Reconstructing a three-dimensional bone structure model based on the comprehensive image data; S4: Based on the three-dimensional bone structure model, using the nonlinear finite element method to simulate the mechanical property parameters of the three-dimensional bone structure model under different external loads and physiological states and output the mechanical properties of the bone tissue; S5: Based on the three-dimensional bone structure model and the mechanical properties of the bone tissue, using the deep variational inference algorithm to generate a personalized bone biomechanics model. The present invention can provide an accurate personalized bone biomechanics modeling solution.

The application discloses application of black corn polysaccharide in preparation of a medicine for preventing or treating senile osteoporosis. The evaluation of the prevention or treatment effect of the black corn polysaccharide on senile osteoporosis includes improvement effects on serum bone metabolism markers, bone microstructure and bone biomechanics. The black corn polysaccharide of the application refers to a polysaccharide powder after water extraction, alcohol precipitation, Sevag method deproteinization, H2O2 method depigmentation and dialysis bag dialysis from dried black corn kernels. The black corn polysaccharide has improvement effects on imbalance of serum bone metabolism markers of senile osteoporosis, deterioration of bone microstructure and decrease of bone strength. The results show that the black corn polysaccharide has great improvement effects on bone loss in preventing senile osteoporosis. Therefore, the black corn polysaccharide has important significance in developing senile osteoporosis in clinic.

The application discloses application of a lignan and flaxseed polysaccharide in preparation of health care products for improving osteoporosis, and belongs to the technical field of health care functions. The postmenopausal osteoporosis model is established by ovariectomized rats, and the comparison of the lignan and flaxseed polysaccharide on bone metabolism, related bone conversion indexes, bone microstructure, bone biomechanics and intestinal flora of the rats is systematically studied, so that the dominant material for improving osteoporosis of the lignan and flaxseed polysaccharide is explored, and a more effective theoretical basis is provided for development of functional food of flaxseed.

The invention discloses a bone parameter inversion method and device based on a bone biomechanics multi-scale model, and the method comprises the steps: selecting a to-be-tested animal bone, preparing the to-be-tested animal bone into a compression sample, and carrying out a uniaxial compression experiment, so as to obtain a first stress-strain curve; establishing a representative volume element model based on the porosity and bone mineral density of the animal skeleton to be measured, performing grid division, and performing offline analysis and online analysis to obtain a second stress-strain curve; and finally, based on the first stress-strain curve and the second stress-strain curve, Bayesian inference is adopted to obtain skeleton parameters. According to the method, Bayesian inference, bone biomechanical experiments and multi-scale model finite element simulation are combined, the problem that physical significance and interpretability are insufficient when finite element simulation is conducted only based on theoretical numerical values traditionally is solved, the cost for obtaining bone mechanical parameters is greatly reduced, and the research efficiency is improved.

A rib implant structure with gradient mechanical transition, design method and application thereof, belonging to the technical field of artificial prostheses; the rib implant structure is a spring-like rib structure, which sequentially includes a costal cartilage part, a gradient rib part and a rib part along the length direction. The outer end of the costal cartilage part is connected to the sternum implant, and the outer end of the rib part is connected to the missing end of the human rib; the gradient rib part is connected between the costal cartilage part and the rib part to realize the mechanical gradient transition of the implanted rib from a low modulus to a high modulus structure. By calculation, a reasonable range of structural parameters conforming to the biomechanics of natural ribs is obtained; according to the different elastic moduli of ribs and costal cartilages, a gradient transition is adopted to design a gradient mechanical spring-like rib implant for the 2nd to 6th ribs, which plays a major role in respiratory function, and has the functions of both the costal cartilage part and the rib part at the same time. The invention solves the problem that the elastic moduli of rib implants, costal cartilages and ribs are inconsistent and cannot meet the normal breathing of patients after surgery.

The present application provides a Chlorella pyrenoidosa calcium-chelating peptide and a Chlorella pyrenoidosa peptide calcium-chelate prepared by using the Chlorella pyrenoidosa calcium-chelating peptide; the prepared Chlorella pyrenoidosa peptide calcium-chelate can enhance the maximum load and structural strength of the tibia of an osteoporosis mouse. The Chlorella pyrenoidosa calcium-chelating peptide provided by the present application combines with calcium ions to form a peptide calcium-chelate, and experiments on animals prove that the peptide calcium-chelate can significantly improve the maximum load and structural strength of the tibia of an osteoporosis mouse, and has a good effect of improving the bone biomechanical properties of an osteoporosis mouse.

The invention provides a traditional Chinese medicine composition for preventing or treating osteoporosis. The colla corii asini polypeptide composition is prepared from colla corii asini polypeptide, cornu cervi pantotrichum, eurycoma longifolia, mulberries and dried blood oranges according to a specific proportion, through the synergistic effect of multiple traditional Chinese medicines, the bone mineral density, bone microstructure and bone biomechanical properties are remarkably improved, and the colla corii asini polypeptide composition is suitable for preventing or treating osteoporosis of middle-aged and elderly people.