33 results about "Bone biomechanics" patented technology

The invention discloses a health product for increasing bone density and a preparation method of the health product. Chinese dwarf cherries, Chinese herbal medicine extracts refined by adopting a modern extraction technology and other raw materials having the function of increasing the bone density are scientifically compounded and are scientifically combined omnibearingly to play a synergistic effect, so as to effectively promote the calcium absorption in multiple aspects, repair and reconstruct the cartilago articularis, promote the generation of synovial fluid, promote the synthesis of collagen in cartilago articularis substrates, prevent the further degradation of cartilage, indirectly reduce the osteoclast function, inhibit the re-absorption of bones, increase the content of bone calcium and perfect the biomechanical properties of the bones, so that the product has a good function of increasing the bone density. A microwave drying technology in the preparation method can be used for further improving the integration and biological stability of the health product, and by means of the antioxidant activity of a grape seed extract in the raw materials, the strong adsorption and inclusion functions of modified dietary fibers and the antifungal propertie of the Chinese herbal medicine extracts, an efficient, safe, nutritional and stable health product having the function of increasing the bone density is prepared finally.

The invention discloses a bone biomechanical measurement device. The device is used for measuring single parameters of bones such as three mechanical parameters of bone pull pressure, torsion and bending; the fatigue parameter measurement comprises measurement of bone pull pressure, torsion and bending fatigue parameters; and the composite mechanical property measurement is the mechanical property measurement when the bone is subjected to composite stress. The bone biomechanical measurement device comprises a host system and a control system; the host system comprises a host mechanical system, a servo motor controller for driving a servo motor, a pull pressure sensor for measuring pull pressure of the bone, a bending pressure sensor for measuring the bending force of the bone, and a displacement sensor for measuring the pull pressure of the bone to generate pull pressure deformation; and the control system comprises a programmable controller, a data acquisition controller and a measurement control processor. The bone biomechanical measurement device not only realizes the measurement of single mechanical properties when the bone is acted with pull pressure, torsion and bending respectively, but also realizes the fatigue mechanical property measurement of the bone and the composite mechanical property measurement when the bone is acted with pull pressure, torsion and bending at the same time.

The invention discloses a composition for increasing bone mineral density and a preparation method of the composition. Chinese dwarf cherry, a Chinese herbal medicine extract refined by a modern extraction technology and other raw materials with the function of increasing the bone mineral density are scientifically compounded, are scientifically combined in an omnibearing manner, and work together, so as to achieve the effects of effectively promoting absorption of calcium from a plurality of aspects, restoring and rebuilding cartilago articularis, creating synovial fluid, and promoting collagen synthesis in the cartilago articularis, preventing cartilage from further degenerating, indirectly reducing osteoclast action, inhibiting re-absorption of bones, increasing bone calcium content and improving the mechanical property of the bone, so that the product has a good effect of increasing the bone mineral density. The integrating property and the biological stability of the composition can be further improved by a microwave drying technology in the preparation method. Due to the oxidation resistance of a grape pip extract in the raw materials, high adsorption and embedding effects of modified dietary fiber, and antifungal properties of the Chinese herbal medicine extract, the efficient, safe, nutrient and stable composition with the function of increasing the bone mineral density is finally prepared.

The invention provides a prosthetic socket having a deformation adjusting and controlling function. The prosthetic socket comprises an inner cavity and an outer cavity, wherein the inner cavity is made from intelligent deformable materials; the outer cavity is made from polymer structure materials having better carrying capacity; and the thickness ratio of the inner cavity to the outer cavity is 1to (3-5). The inner cavity made from the intelligent deformable materials is introduced into a prosthetic socket through a 4D printing technique to form the prosthetic socket having a deformation adjusting and controlling function, a hard and soft coupled prosthetic socket having human body biological mechanical properties is printed layer by layer according to parameters of three-dimensional pattern data, biological mechanics characteristics of muscle and bone and the like of disabled limbs of a wearer, under the excitation of an outer field, the inner cavity produces intelligent chronologydeformation of expanding, distorting, folding and the like, the shape and the hardness of the inner part of the prosthetic socket are dynamically adjusted, the jointing degree of the prosthetic socketand the disabled limbs of the wearer is improved, the uniformity of pressure distribution between the prosthetic socket and the interface of the disabled limbs of the wearer is strengthened, and thedressing comfortability and the use safety of the wearer are improved.

The invention discloses a traditional Chinese medicine compound preparation for treating osteoporotic fractures. The compound preparation is prepared from traditional Chinese medicine for strengthening the spleen and reinforcing the kidney and pharmaceutical excipients, wherein the traditional Chinese medicine for strengthening the spleen and reinforcing the kidney is prepared, by weight, 6-30 parts of codonopsis pilosula, 6-30 parts of acanthopanax senticosus, 6-30 parts of drynaria rhizome, 6-30 parts of epimedium, 6-15 parts of salvia miltiorrhiza and 3-12 parts of angelica pubescens. According to the traditional Chinese medicine compound preparation for the treating osteoporotic fractures, a formula for strengthening the spleen and reinforcing the kidney is based on a spleen-kidney-related theory that the kidney is a congenital origin and the spleen is an acquired foundation, through animal experiments, it is found that the formula for strengthening the spleen and reinforcing the kidney can significantly promote healing of bone calluses in different periods of ovariectomized mice suffering from the osteoporotic fractures, the bone mass and biomechanical strength of the bone calluses are improved, the expression of beta-catenin in fractured bone end muscles and bone calluses is promoted, the number of muscle-derived stem cells in the fractured bone end muscles is increased, the proliferative activity is promoted, the muscle-derived stem cells are promoted to migrate to the bone calluses, and therefore osteogenic differentiation is simulated, and healing of the osteoporotic fractures is accelerated. The invention further discloses a preparation method and medicinal application of the traditional Chinese medicine compound preparation.

The invention provides pharmaceutical compositions for improving the bone loss of hyperthyroid high-conversion type and the reduction of the biomechanical properties of the bone, and relates to an extract of a Chinese medicinal Danshen, or the formula and the production process of pharmaceutical compositions for improving the bone loss of high-conversion type and the reduction of the biomechanicalproperties of the bone caused by the hypersplenism of the thyroid, which is prepared from the following components in parts by weight: 0.1 to 0.3 g of a danshensu and 5 g of crystalline fructose, thepharmaceutical compositions are characterized by being prepared into an injection. The invention further discloses a formula and production process of the injection, a granule and a non-alcoholic beverage. The high-dose thyroxine-induced hyperthyroid high-conversion bone loss animal model proves that the pharmaceutical composition prepared from the danshensu and the fructose can influence the bone metabolism of the rat, promote the bone formation, inhibit the bone resorption, increase the bone mass, improve the bone mineral density and the bone mineral salt content, and improve the performance of the bone biomechanics, and has a good preventive effect on the damage of the bone biological biomechanical properties of the hyperthyroid osteoporosis.

The invention relates to traditional Chinese medicine composition for treating rheumatoid arthritis and bone destruction and an application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from raw materials in parts by weight as follows: 10-20 parts of Japan sabia, 15-30 parts of malaytea scurfpea fruits, 15-30 parts of fortune's drynaria rhizomes, 9-15 parts of Chinese angelica and 15-20 parts of epimedium herbs. The traditional Chinese medicine composition has a remarkable inhibition function on toe swelling of a rheumatoid arthritis animal model, can remarkably reduce loss of bone mass around an inflammable joint of the rheumatoid arthritis animal model, improves the bone biomechanical parameter and inhibits bone destruction caused by rheumatoid arthritis; the traditional Chinese medicine composition has the advantages that a few raw materials are required, preparation is convenient, the cost is low, and no toxic and side effects are caused.

A traditional Chinese medicine composition is prepared from the following raw material: rehmannia, bamboo leaves, liquorice, eucommia ulmoides, rhizoma drynariae, radix achyranthis bidentatae, fructuspsoraleae, cassia twig, dried ginger, herba epimedii, herba cistanche, schisandra chinensis and rhizoma alismatis. The invention further provides application of the traditional Chinese medicine composition in preparation of a traditional Chinese medicine preparation for treating osteoporosis. The traditional Chinese medicine composition and the traditional Chinese medicine preparation for treatment osteoporosis have the beneficial effects that pathology can be carried out on treatment mechanisms of osteoporosis, kidney essence deficiency, kidney qi deficiency, kidney yang deficiency and kidney yin deficiency, and the traditional Chinese medicine composition and the traditional Chinese medicine preparation are suitable for osteoporosis of various traditional Chinese medicine syndrome types; the traditional Chinese medicine composition is mainly suitable for treating symptoms such as waist and knee aching pain, muscle and bone weakness, muscle and bone weakness, waist and knee pain, walking failure, dizziness, deficiency-heat rushing adverse flow, difficult urination and weak pulse; modern medical research finds that the formula has the effects of improving osteoporosis, increasingthe bone mineral content, improving bone biomechanics, promoting bone formation, inhibiting bone resorption and reducing the high conversion state of bones.

Belonging to the technical field of research on the dose-effect of natural drug prescription compatibility and use, the invention discloses a natural drug composition for treatment of osteoporotic fracture and/or osteoarthritis and application thereof. The natural drug composition comprises, by mass percentage, 73.3%-98.3% of sea buckthorn fruit oil and 1.7%-26.7% of panax notoginseng saponins. The natural drug composition can transform and generate a signal molecule of eicosatrienoic acid, and the signal molecule can activate protein and cyclic nucleotide, calcium ion and other multi-path molecular signal pathways to generate the effect of synergistic amplification of signal molecule; the composition can improve the hematopoietic microenvironment, regulate endocrine, adjust the metabolic balance of osteoclast and osteoblast, reduce alkaline phosphatase, improve serum osteoprotegerin, osteocalcin and other bone metabolism marker indexes, increase the femur, tibia and vertebral bone density, significantly improves the bone remodeled bone shape and bone biomechanical symbolic indexes, and can effectively prevent and treat osteoporotic fracture, osteoarthritis and ostealgia diseases.

The invention discloses a drug with an anti-osteoporosis effect. The drug comprises one, two or more than two of the following components: a compound 1: 5,7,4'-trihydroxyl-3'-methoxy-6,8-dimethyl dihydrhomoisoflavonoid, a compound 2: dihydrhomoisoflavonoid, a compound 3: 6-formyl isoophiopogonone B, a compound 4: 6--formyl isoophiopogonone A, a compound 5: methyl isoophiopogonone B, a compound 6: 5,7,4'-trihydroxyl-6-methyl homoisoflavonoid, a compound 7: 5,7,4'-trihydroxyl-6-methyl dihydrohomoisoflavonoid and a compound 8: methyl dihydrisoophiopogonone A. The drug with the anti-osteoporosis effect provided by the invention has an obvious treatment effect in lowering bone mineral loss of an osteoporosis rat and bone biomechanical strength without an obvious toxic and side effect. The compound source is extensive, not only can be obtained by extracting from the plant, but also can be prepared by adopting an artificial synthesis method.

The invention provides a phosphorylated krill peptide. A preparation method comprises the following steps: (1) degreasing krill powder, then adding a NaOH solution into the krill powder and centrifuging to obtain a supernatant, regulating a pH value of the supernatant until reaching the isoelectric points of protein and centrifuging to obtain a precipitate; (2) preparing the krill protein precipitate into an aqueous solution, adding a phosphate, regulating the pH value of the solution and performing spray drying on the solution so as to obtain krill protein powder; standing the krill protein powder at a high temperature so as to obtain phosphorylated krill protein; (3) repeatedly washing the phosphorylated krill protein with distilled water and centrifuging; and (4) preparing the phosphorylated krill protein into the aqueous solution, adding 2M NaOH, regulating the pH value of the solution, adding a protease into the solution, hydrolyzing for 3 to 6 hours at a proper temperature, heating to 100 DEG C and stopping an enzyme reaction, centrifuging to obtain the supernatant and performing the spray drying on the supernatant so as to obtain the phosphorylated krill peptide. The animal experiment proves that the prepared phosphorylated krill peptide can be used for obviously regulating the bone metabolism level of a model rat with the osteoporosis so as to enhance the bone mineral density and improve the bone biomechanical property, thereby having obvious functions for preventing and treating the osteoporosis.

The invention discloses an application of rare earth alendronate in preparation of an osteoporosis treatment drug. The rare earth alendronate comprises one or more of alendronate lanthanum, alendronate cerium, alendronate praseodymium, alendronate neodymium, alendronate promethium, alendronate samarium, alendronate europium and alendronate gadolinium. The osteoporosis treatment drug prepared from rare earth alendronate has obvious therapeutic action on reduction of osteoblast viability and reduction of bone biochemical strength of a model rat with osteoporosis and does not have obvious toxic and side effects.

The invention provides a formula and production technology of one group of health-care foods and medicines composed of fructose and radix astragali seu hedysari and used for preventing and treating muscle atrophy. Osteoporosis and the muscle atrophy are common symptoms occurred along with human body aging; commonly, legs become old before people get old; the invention discloses one group of the health-care foods and medicines composed of the fructose and the radix astragali seu hedysari and used for preventing and treating the muscle atrophy, and one group of the health-care foods and medicines comprises 7 preparations with different preparation forms and is characterized in that a composition is composed of 12 percent of the fructose and 50 percent of the radix astragali seu hedysari; thecompositions have very good prevention and treatment effects on muscle fatigues, muscle loss, the muscle atrophy and bone biomechanics performance degradation caused by excessive exercise, damages, diseases or ageing; the fructose in the formula can be used for enabling muscle to obtain energy supplementation needed by lives; the fructose can directly enter the muscle, without the need of an insulin way, and is directly transformed into muscle glycogen; metabolic disorders caused by the fact that muscle tissue cells are lack of energy are supplemented in time; meanwhile, the radix astragali seu hedysari can be used for promoting the repairing of muscle tissues and the synthesis of protein, so that the muscle is stronger and more powerful; the fructose and the radix astragali seu hedysariare combined and commonly play a role of strengthening bones and the muscle and preventing and controlling the muscle atrophy.

The invention discloses a pharmaceutical composition for treating osteoporosis and a preparing method thereof. The pharmaceutical composition is prepared from conic gymnadenia rhizome, west szechwan pyrethrum, ginseng, cortex lycii radicis, tinospora sinensis stem, yak bone, rhizoma anemarrhenae and concha margaritifera. The preparing method comprises the steps of smashing concha margaritifera into fine powder and conducting heat extraction on other medicinal materials, combining extracting solutions and conducting concentration to dry, adding the concha margaritifera fine powder, and conducting even mixing. It is found through pharmacological research that aqueous extracts and alcohol extracts, especially acidity alcohol extracts, of the pharmaceutical composition have certain curative effect on the bone mineral density and bone biomechanics index of the thighbone and tibia of an osteoporosis model rat, the indexes of calcium and BGP in serum, and the index of HOP in urine, and the pharmaceutical composition can be used for treating osteoporosis, especially osteoporosis caused by estrogen deficiency.

The invention relates to a traditional Chinese medicine composition for treating deficiency of spleen and stomach qi type postmenopausal osteoporosis, and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from medical raw materials: radix astragali, stir-baked rhizoma dioscoreae, rhizoma atractylodis macrocephalae, radix acanthopanacis semticosi, fructus psoraleae, eucommia ulmoides, sargentodoxa cuneata and radix aucklandiae, and can be prepared into multiple dosage forms. The medicines are organically combined, and have the effects of regulating spleen and stomach, tonifying kidney and nourishing stomach, strengthening tendons and bones, promoting blood circulation to remove meridian obstruction, and relieving pain. The traditional Chinese medicine composition is small in adverse reaction and side effect, is high in treatment rate and effective rate, improves the bone density, increases the bone mineral content, improves the bone biochemistry state, and treats both manifestation and root causes of the deficiency of spleen and stomach qi type postmenopausal osteoporosis while improving the deficiency of spleen and stomach qi type postmenopausal osteoporosis.