205 results about "Fluid joints" patented technology

A composite tissue formed in situ is provided. The composite tissue includes a synovial joint tissue; and a barrier material adhered thereto for sealing the synovial joint tissue against synovial fluid. Also provided is a method for regenerating synovial joint tissue in situ by excluding synovial fluid therefrom. The method includes providing a synovial joint tissue having a defect; and placing a barrier material in intimate contact with the defect for sealing the defect against synovial fluid. The barrier material includes a curable protein copolymer. The method further includes curing the protein copolymer in situ. The barrier material can include a crosslinked network, or a self gelled network of repeating elastin-like and fibroin-like polymer chains.

The invention describes a process for determining a biological state through the discovery and analysis of hidden or non-obvious, discriminatory biological data patterns. The biological data can be from health data, clinical data, or from a biological sample, (e.g., a biological sample from a human, e.g., serum, blood, saliva, plasma, nipple aspirants, synovial fluids, cerebrospinal fluids, sweat, urine, fecal matter, tears, bronchial lavage, swabbings, needle aspirantas, semen, vaginal fluids, pre-ejaculate.), etc. which is analyzed to determine the biological state of the donor. The biological state can be a pathologic diagnosis, toxicity state, efficacy of a drug, prognosis of a disease, etc. Specifically, the invention concerns processes that discover hidden discriminatory biological data patterns (e.g., patterns of protein expression in a serum sample that classify the biological state of an organ) that describe biological states.

Hydrogel devices for surgical implantation to replace damaged cartilage in a mammalian joint (such as a knee, hip, shoulder, etc.) are disclosed, with one or more of the following enhancements: (1) articulating surfaces that have been given negative surface charge densities that emulate natural cartilage and that interact with positively charged components of synovial fluid; (2) anchoring systems with affixed pegs that will lock into accommodating receptacles, which will be anchored into hard bone before the implant is inserted into a joint; (3) a three-dimensional reinforcing mesh made of strong but flexible fibers, embedded within at least a portion of the hydrogel.

The present invention provides a method for inhibiting the formation of scar tissue and/or exogenous bone at a wound site in a body of a patient. The method includes administering an amount of a biologic agent to the wound site, wherein the biologic agent is synovial fluid or cerebrospinal fluid. A viscous substance applied to the wound site, advantageously incorporating the biologic agent, reduces the flow of blood from cut blood vessels, and contributes to a reduction in the formation of adhesions through action of the biologic agent, and through barrier properties introduced by the viscous substance.

The invention discloses a health product for increasing bone density and a preparation method of the health product. Chinese dwarf cherries, Chinese herbal medicine extracts refined by adopting a modern extraction technology and other raw materials having the function of increasing the bone density are scientifically compounded and are scientifically combined omnibearingly to play a synergistic effect, so as to effectively promote the calcium absorption in multiple aspects, repair and reconstruct the cartilago articularis, promote the generation of synovial fluid, promote the synthesis of collagen in cartilago articularis substrates, prevent the further degradation of cartilage, indirectly reduce the osteoclast function, inhibit the re-absorption of bones, increase the content of bone calcium and perfect the biomechanical properties of the bones, so that the product has a good function of increasing the bone density. A microwave drying technology in the preparation method can be used for further improving the integration and biological stability of the health product, and by means of the antioxidant activity of a grape seed extract in the raw materials, the strong adsorption and inclusion functions of modified dietary fibers and the antifungal propertie of the Chinese herbal medicine extracts, an efficient, safe, nutritional and stable health product having the function of increasing the bone density is prepared finally.

The invention herein generally refers to an in situ cartilage repair implant. The implant promotes cartilage repair by providing a sealed barrier that prevents the flow of synovial fluid and inflammatory cytokines into a surgically prepared hole that accommodates the implant. Optionally, additives are associated with the implant to promote cartilage repair.

Abstract of Disclosure A therapeutically effective compound is locally administered by associating the compound with a piece of orthopedic hardware that is implanted at an appropriate site within a body. The compound is adapted, such as through a sustained release device, to administer an effective dosage continuously over an extended period of time. The compound may be administered, for example, to a joint of a mammal by intraarticularly implanting a sustained release device to deliver the therapeutically effective compound within a synovial capsule of the joint, such that synovial fluid concentration of the compound is greater than plasma concentration of the compound. A wide range of orthopedic hardware, such as bone screws and staples, may be adapted to use in the systems described herein to provide treatment for a variety of medical conditions.

The present invention relates to an oral formulation comprising a hyaluronic acid-phospholipid complex, and to use of a hyaluronic acid-phospholipid complex for the manufacture of a joint function-improving and protecting agent for oral administration which can alleviate the arthritic symptoms in patients with arthritic conditions, increase the concentration of hyaluronic acid in synovial fluid, improve the lubrication of joints, as well as maintain and enhance the normal functions of joints.

A ball joint or cap for an artificial hip joint is described that is suitable for carrying out a rotating or pivoting motion in an artificial hip joint socket, with a gap being provided for a natural fluid film (synovial fluid) between itself and the artificial hip joint socket, and with regular depressions without interconnecting channels between them being recessed in areas of its surface. It is proposed that its surface in the polar area is smooth and without depressions, that an area is provided in an intermediate area between the smooth polar area and its equator, in which depressions are recessed with hole widths between 1.0 mm to 3.0 mm, that adjacently in the intermediate area in the direction of its base edge, further depressions are recessed, the hole widths of which become steadily smaller, the closer they lie to the base edge, with hole widths between 0.5 mm and 1.0 mm.

The invention discloses a two-fluid atomization nozzle which comprises a fluid joint, a liquid spinning disk, a two-fluid atomization cavity and a sprayer, wherein the sprayer is internally provided with a hollow cavity; one end of the hollow cavity is provided with an opening and the other end of the hollow cavity is provided with spray holes; the two-fluid atomization cavity, the liquid spinning disk and the fluid joint are sequentially assembled towards the opening in the hollow cavity; the two-fluid atomization cavity is internally provided with a first gas runner and a first liquid runner; an atomization cavity is formed at the junction of the first gas runner and the first liquid runner and is communicated with the spray holes; the liquid spinning disk is arranged at the liquid inlet end of the first liquid runner; the liquid joint is internally provided with a second gas runner and a second liquid runner. Therefore, the two-fluid atomization nozzle is formed by detachably assembling multiple split components, so that the replaceability of local atomization components is realized and the maintenance and replacement costs are lowered; furthermore, the two-fluid atomization nozzle can well ensure the high atomization rate and atomization degree of liquids.

Disclosed is a bearing material of a medical implant comprising a polymer such as UHMWPE and a surface active agent that is not covalently bonded to the polymer. The surface active agent includes a hydrophilic moiety or segment, such as an ethoxylated moiety, and a hydrophobic moiety or segment, such as an alkanol, alkenol, aromatic alcohol, alkylamine, alkenyl amine, alkyl aromatic alcohol, alkanoic acid, alkenoic acid, or any combination thereof. The bearing material has a reduced wear rate. Also disclosed is a method of reducing the wear rate of a polymeric bearing material of a medical implant when it articulates against a hard counterface in the presence of synovial fluid, the method comprising providing a surface active agent in the synovial fluid in close proximity to the bearing surface, the hard counterface, or both.

The present invention is directed to a method of altering the amount or composition of synovial fluids secreted from joints in a subject in need of such treatment. The method comprises administering to a subject a pharmaceutical composition comprising a P2Y purinergic receptor agonist in an amount effective to alter the amount or composition of synovial fluids. The P2Y purinergic receptor agonist is administered in an amount effective to stimulate secretion of synovial fluid, lubricin, hyaluronic acid, or surface-active phospholipids; to enhance joint lubrication; or to treat osteoarthritis. The pharmaceutical compositions useful in the present invention comprise a P2Y purinergic receptor agonist of Formula I and include, but are not limited to: uridine-, adenosine-, cytidine-5′-di- or triphosphates, dinucleoside polyphosphates, and analogs thereof. The invention is useful for treating conditions associated with reduced joint lubrication and joint stiffness, such as osteoarthritis.

A coupling assembly for releasably interconnecting a fluid joint is provided where the fluid joint includes confronting ends of a pair of fluid conveying members, each of which has a ferrule fixedly attached thereto, and a sleeve circumferentially surrounding the ferrules. The coupling assembly includes a pair of coupling members, each of which has a first end and a second end, a hinge assembly configured to hingedly connect the first ends of the coupling members to permit them to rotate relative to each other between an open position and a closed position where the coupling members surround the sleeve, a pair of bonding wires, each of which is coupled to a respective coupling member and configured to electrically bond the respective coupling member to the ferrules of respective fluid conveying members, and a releasable latching assembly configured to releasably secure the second ends of the coupling members together when they are in their closed position. Optionally, the coupling assembly includes a pair of bonding members, each of which is externally mounted to a respective coupling member and configured to electrically bond the respective coupling member to the sleeve and/or a latch indicator configured to be moved to a closed position over the releasable latching assembly only when the second ends of the coupling members are secured together by the releasable latching assembly.

A series of beverages and/or foods, which have protecting and enhancing effects on human's joints and bones and can therefore prevent and treat osteoarthritis, is provided. The beverages and/or foods comprise one or more cartilage- and synovial fluid-enhancing active ingredients or combinations of these ingredients with bone-enhancing calcium and phosphorus additives. Active ingredients in these beverages and/or foods are taken in liquid forms. So they can be easily absorbed and utilized thoroughly by human body.

A method of treatment of osteoarthritis is described, where a therapeutically effective amount of a composition having biodegradable microparticles in an aqueous vehicle is delivered into the intra-articular space of a joint. In one aspect, the microparticle-containing composition is injected into the synovial fluid-containing portion of an affected joint.

An intra-articular device comprises a membrane shaped like a cap having a peripheral geometry similar to that of a head of a bone for a joint to be restored and an open end sized to be applied over the bone proximate the head, so that the open end can be stretched over the head of the bone and held in position on the bone interposed between the head and its corresponding articular component of the joint. The membrane is made of a polyether-urethane-urea material selected to have a property of absorbing the joint's own synovial fluid so as to swell and have a viscoelastic property similar to the body's own articular hyaline cartilage. In a preferred embodiment, the membrane cap is adapted for use on a femoral bone for restoring a hip joint. A related method of installing an intra-articular device as artificial cartilage comprises forming a membrane cap to be applied over the head of the bone of the joint, surgically exposing the head of the bone, installing the membrane cap over the head of the bone, then repositioning the capped head of the bone back in its place in the joint with the membrane interposed as artificial cartilage.

A method for distinguishing erythroblasts from bacteria by automated hematology analyzers, such as, for example, the CELL-DYN® 4000 automated hematology analyzer and the CELL-DYN® Sapphire™ automated hematology analyzer. Bacterial cells scatter light and fluoresce differently than do red blood cells, white blood cells, erythroblast nuclei, and platelets. Signals generated by bacteria are distinguishable from those of erythroblasts because the signals generated by erythroblast nuclei are sufficiently unique that erythroblast nuclei can be distinguished from signals generated by bacteria. Signals generated by platelets, lysed red blood cell ghosts, and other cell debris are blocked by the triple-trigger circuitry of the hematology analyzer, because all of the signals generated by noise are below the AND/OR thresholds. Algorithm(s) in the software of the system detect and count signals generated by bacteria by means of the location and the shape of the signals generated by bacteria and calculate the concentration of bacteria per unit of body fluid. In addition, certain body fluids, such as, for example, synovial fluid, can be pretreated with a viscosity reducing agent for a short period of time to reduce the viscosity of the body fluid prior to analyzing a sample of the body fluid by an automated hematology analyzer.

A method and device that can deliver a time-varying electric field non-invasively inside of biological tissue and/or biological fluid such as blood and/or lymph and/or synovial fluid and/or interstitial fluid and/or other fluids in-vivo and with magnitudes that do not cause a tolerable amount of neural motor and sensory action potential generation and frequency components below the megahertz range by means of the placement of more than one electrode on the skin with or without some intermediate biological, synthetic, or natural agent or substance between the electrode and the skin and/or by induction by means of a time-varying magnetic field or both with the novel purpose of activation and/or potentiation and/or normalization and/or regulation and/or stimulation and/or signaling and/or increase and/or regulation of the alertness and/or self tuning of the immune system or any of its parts or components directly or indirectly, locally and/or globally with the purpose of pathogen load reduction and/or reduction of the disease symptoms and/or clinical improvement and/or tumor size reduction and/or malignancy reduction or amelioration and/or improvement of the effects of an autoimmune disorder or any other related condition that could be treated or remised by its effects.

A gasket assembly has at least one fluid-conveying opening and at least one bolt hole. The gasket includes PEEK material that may be applied as a layer to at least a portion of a metal core of the gasket. A layer of elastomeric sealing material is applied to at least a portion of the PEEK material.