48 results about "Cartilage surface" patented technology

Disclosed herein is a method of defining a mating surface in a first side of an arthroplasty jig. The mating surface is configured to matingly receive and contact a corresponding patient surface including at least one of a bone surface and a cartilage surface. The first side is oriented towards the patient surface when the mating surface matingly receives and contacts the patient surface. The method may include: a) identifying a contour line associated with the patient surface as represented in a medical image; b) evaluating via an algorithm the adequacy of the contour line for defining a portion of the mating surface associated with the contour line; c) modifying the contour line if the contour line is deemed inadequate; and d) employing the modified contour line to define the portion of the mating surface associated with the contour line.

The articular cartilage according to the invention is made of pure cartilage and is provided with incisions (12) on the surface facing the bone. The cartilage cells are preferably seeded on the surface provided with incisions (12). The method for producing the articular cartilage comprises the step of collecting cartilage from joints, wherein pure cartilage is collected without bone, and incisions are made on the surface of the cartilage intended to face the bone. It is preferably fresh frozen until use. The device for harvesting articular cartilage, comprises handle and cutting blade, wherein the cutting blade (4) is curvilinear and is provided with spacer elements (5), meanwhile the device for producing incisions in articular cartilages comprises handle (2) and a bridge (3) connected to said handle (2) and being provided with one or more cutting blade(s) (4). During the method for applying the articular cartilage the articular cartilage is fixed by thin surgical yarn stitches, by fibrin glue or by small anchors (FIG. 8).

Osteochondral implants for repair of chondral defects and providing bone fixation through bone ongrowth and / or ingrowth. The implant is provided with a base allowing for bone ongrowth and / or ingrowth and a top attached to the base, the top being formed of a material having a compressive resistance similar to that of the cartilage. The material of the top is polycarbonate urethane, for example. The base may comprise a porous substrate for bony ingrowth formed of metal or PEEK and having a pattern porosity about similar to the porosity of cancellous bone. One side of the top attaches to the base for stability, and the other side of the top forms a surface for articulating with the opposing cartilage surface of the joint.

A method for measuring cartilage defects within a subject includes surgically exposing a joint or cartilage surface. The exposed joint or cartilage surface having at least one defect, and the method may generating a cast of the at least one defect. The method may also include measuring a parameter of the cast, thereby estimating a characteristic of the defect.

Customized hemi-knee joint prosthesis and a preparation method thereof are provided. Firstly, the normal side knee joint femur condyle data of a patient is extracted by CT for the medical image three-dimensional image reconstruction. The three-dimensional anatomy model of patient femur condyle is obtained by an antagonizing model. A metal femur condyle joint is obtained according to the three-dimensional anatomy model. Then, a rolling pillar is arranged in the metal femur condyle joint. The two sides of the rolling pillar are respectively opened with a cylindrical groove. A rolling combined station is sheathed on the rolling pillar. The two sides of the rolling combined station are respectively equipped with a side-push plate with a lug boss. The lug bosses of the side-push plates are inserted in the grooves of the rolling pillars. As the rolling pillar is arranged inside the articular surface of the metal femur condyle of the hemi-knee joint prosthesis, the prosthesis upper part, namely the rolling combined station, and the lower part, namely the articular surface of the metal femur condyle, which are fixed on a femoral shaft move relatively within a certain angle. Being corresponding to a tibia platform, the lower part is static during the period. Therefore, the whole process of the knee joint bending is finished and the abrasion of the prosthesis on the cartilage surface of the joint is reduced.

The invention provides a registration target, a registration method, a registration device, an electronic device and a storage medium. The registration target comprises a fixed part and an acquisitiondevice connected with the fixed part, wherein the acquisition device is used for simultaneously acquiring data of a plurality of points on a to-be-registered object; thus, the registration target provided by the invention can acquire the data of the plurality of points on the cartilage surface and / or the hard bone surface of a to-be-registered bone at one time; and the registration time of the to-be-registered bone is greatly shortened. Meanwhile, point cloud data of the cartilage surface and / or the hard bone surface of the to-be-registered bone can be collected at one time through the registration target provided by the invention, so sampling points are not needed to be selected manually; operation is more convenient; and registration errors are effectively reduced. The registration method provided by the invention can obtain the information of bone surface soft tissues, so effective information is provided for bone ligament balance analysis.

The invention aims to provide a bone surface registration method for a covered cartilage, so as to improve the registration accuracy. Specifically, the method comprises the following steps: the firstbone surface point set S1 of a to-be-registered bone surface sample point in an image coordinate system and the second bone surface point set S2 of the to-be-registered bone surface sample point in aworld coordinate system are obtained respectively; then the cartilage surface point cloud S3 of a to-be-registered bone auxiliary sample point in the world coordinate system is obtained by a positionsensor; next the first bone surface point set S1 and the cartilage surface point cloud S3 are registered to obtain an initial rotation matrix R1 and an initial translation vector T1; the second bone surface point set S2 and the cartilage surface point cloud S3 are registered to obtain a corrected rotation matrix R2 and a corrected translation vector T2; and finally, according to the initial rotation matrix R1, the initial translation vector T1, the corrected rotation matrix R2 and the correct translation vector T2, obtaining the following mapping relationship between the image coordinate system and the world coordinate system: the rotation matrix R=R2R1, and the translation vector T=R2T1+T2.

In accordance with one or more embodiments herein, a system for optimizing a position of an implant having an individually customized implant hat H and at least one implant protrusion P extending from the implant hat H in the direction of an implant axis A in an anatomical joint of a patient is provided. The system comprises a storage media 110 and a processor 120 which is configured to: receive medical image data representing a three dimensional image of the joint from the storage media 110; obtain a three dimensional virtual model of the joint which is based on the received medical image data; identify damage in the joint based on the received medical image data and / or the three dimensional virtual model of the joint; define an implant area that covers at least a major part of the identified damage; position a virtual implant template having an implant hat H corresponding to said implant area in the three dimensional virtual model of the joint; and generate a customized top surface of the implant hat H to correspond to a simulated healthy cartilage surface. The processor is configured to position the virtual implant template by: placing the virtual implant template so that the cross section area of the implant hat H in a direction perpendicular to the implant axis A covers at least a major part of the damage; and optimizing the tilt of the implant axis A, while maintaining the position of the cross section area of the implant hat H in the joint, by minimizing at least one of the maximum penetration depth Dmax into the bone along the circumference of the implant hat H; the total volume of bone and / or cartilage to be removed for implanting the implant; and / or the surface area of the implant penetration into the bone.

The invention relates to a new application of a monomer compound CDCA, and particularly relates to the application of the CDCA in preparation of a drug for treating osteoarthritis and a drug composition for treating the osteoarthritis. The drug composition can be prepared into an injection, a tablet, a capsule, an electuary, a drop, a granule or an ointment by adding general medicinal auxiliary components to the CDCA being not less than 98% in purity. A pharmacological experiment result proves that the CDCA can significantly improve inflammatory cell infiltration, proliferation of fibrous tissue and cartilage surface damage and the like situations in an osteoarthritic location, can reduce the levels of MMP-1, MMP-3, IL-1[beta] and PGE2 in synovial fluid and has a strong osteoarthritis-resistant effect, so that the CDCA can be used for preparing a drug for treating the osteoarthritis. The invention provides a new drug source to treatment of the osteoarthritis.

The invention provides a method for preparing an hBMSCs / hyaline cartilage particle / calcium alginate gel compound. According to the method, the hBMSCs / hyaline cartilage particle / calcium alginate gel compound is prepared by using hyaline cartilage particles having a size of 0.125mm<3> after inducing culture is carried out on hBMSCs and is used for repairing defects on the cartilage surface, a strong subchondral bone support can be reconstructed, a complete and smooth articular cartilage surface can be recovered, the trabecular space of the subchondral bone can be filled, and seamless connection can be formed with adjacent defects. Due to the existence of the hyaline cartilage particles, partial normal-simulated cartilage extracellular matrix and partial normal cartilage cells can be formed in the repaired tissue, so that the reconstruction process can be accelerated, the repaired tissue strength on the surface can be enhanced, double effects can be achieved by adopting hBMSCs, and abrasion of the joint surface and regression near the joint surface can be retarded.

This invention relates to methods of lubrication for biological tissue, especially joint and cartilage surfaces, and to methods of treating osteoarthritis using high molecular weight, hydrophilic polymer brushes, which mimic the structure and activity of lubricin. These synthetic lubricin analog polymer brushes (termed herein graft brush polymers), include poly(acrylic acid) back-bones grafted with polyethylene glycol.

The invention discloses a process for extracting non-denatured II-type collagen from sturgeon cartilage. The process comprises the following steps: cleaning cartilage in sturgeon head and / or fishbonein a NaOH solution to remove adhesive substances on the surface of the cartilage, performing flushing to neutrality, then sending the cartilage after flushing into continuous heating equipment for cooking, performing freezing, then sending the cartilage after freezing into continuous drying equipment for drying, and performing grinding into a powder to obtain a compound containing the non-denatured II-type collagen. According to the preparation process, the non-denatured II-type collagen can be obtained, chondroitin sulfate and hyaluronic acid in the cartilage can be reserved, and the extraction technological process is simple. Compared with the prior art, the process shortens production period, has low input, has high yield, and can achieve large-scale production.

The invention relates to a cartilage thickness measuring method and device, computer equipment and a storage medium. The method comprises the steps that cartilage surface contour information is acquired according to 3D cartilage image data; a first surface and second surface in a cartilage surface are identified according to the cartilage surface contour information; according to the position information of a first point of interest in the first surface, the cartilage thickness of the first point of interest is calculated; and / or according to the position information of a second point of interest in the second surface, the cartilage thickness of the second point of interest is calculated. The method can be adopted for measuring the thickness of any point on the cartilage surface.

The application discloses an osteotome for forming a spine fusion machine transplanting channel in a spine fusion operation, and relates to the technical field of medical apparatuses. The osteotome comprises a handle lever and an osteotome head arranged at one end of the handle lever, wherein the osteotome head forms a cylinder structure of which one end is opened; and an annular cutting edge is arranged at the opening end of the osteotome head, so that the transplanting channel can be formed in one time. According to the osteotome disclosed by the invention, in the spine fusion operation, anupper endplate cartilage surface, a lower endplate cartilage surface and an intervertebral disk can be cut in a quick forming manner, so that the operation efficiency is improved, and a complete spinefusion machine transplanting channel is formed.

This invention relates to methods of lubrication for biological tissue, especially joint and cartilage surfaces, and to methods of treating osteoarthritis using high molecular weight, hydrophilic polymer brushes, which mimic the structure and activity of lubricin. These synthetic lubricin analog polymer brushes (termed herein graft brush polymers), include poly(acrylic acid) backbones grafted with polyethylene glycol.

A method for the ablation of human or animal articular cartilage is disclosed that employs an exogenous absorber, such as a compound having the molecular formula C43H47N2NaO6S2, to coat or color the surface of the articular cartilage. The coated or colored cartilage surface then has an energy absorption peak at a specific wavelength due to the exogenous absorber, which makes it possible to employ a simple and cheap laser diode to generate a pulsed laser beam at the specific wavelength so as to superheat the coated or colored cartilage thereby causing at least partial ablation of cartilage.

The invention discloses a puncture bag for cartilage destruction and sampling of rabbit knee joints. The puncture bag comprises a puncture sleeve, a puncture needle and an injector, wherein the puncture needle can be inserted into the puncture sleeve, the needle tail end of the puncture needle is fixedly sleeved with a puncture needle handle, the needle head end of the puncture needle extends intothe sleeve and penetrates through the sleeve, the needle tail of the puncture needle is connected with a needle plug, a fixing block is fixed to the needle head end, penetrating out of the puncture sleeve, of the puncture needle, a plurality of rotating shafts are fixed to the outer circumferential wall of the fixing block, cartilage surface destroying plates are rotatably connected to the rotating shafts, and a plurality of cartilage surface destroying nail thorns are fixedly connected to the cartilage surface destroying plates. The puncture bag has the beneficial effects that the cartilagesurfaces of the knee joints can be destroyed by opening the umbrella-shaped cartilage surface destroying plates of the cartilage surface destroying nail thorns, the knee joint tissue destroying and sampling efficiency is improved, the minimally invasive operation ensures that the pollution is avoided, meanwhile, the damage area and the material taking size are controllable, and the scientificity and standardization are improved.

The invention discloses a joint injection preparation based on collagen binding polypeptide-modified hyaluronic acid as well as a preparation method and application of the joint injection preparation.The method comprises the following steps: firstly, designing and synthesizing a polypeptide molecule capable of being combined with collagen, then grafting modified hyaluronic acid through amidationreaction, and then embedding the hyaluronic acid to the surface of a cartilage matrix through the specific recognition binding effect of the collagen binding polypeptide and cartilage surface II typecollagen so as to obtain the joint injection preparation based on collagen binding polypeptide-modified hyaluronic acid. The joint injection preparation not only can specifically bind the hyaluronic acid to the surface of damaged cartilage tissue, but also endows the surface of the damaged cartilage with excellent non-specific adsorption resistance and lubricating property, and can be used for preparing cartilage repair materials, treating osteoarthritis and improving anti-inflammatory factors and lubricating property of the surface of the damaged cartilage; and the joint injection preparationcan also be used as a modified material for improving the friction performance of cartilage repair materials.

The invention discloses a collagen mimic peptide modified hyaluronic acid-based joint injection preparation and a preparation method thereof and application of the joint injection preparation. Collagen mimic peptide grafted modified hyaluronic acid is synthesized by an amidation reaction; then collagen mimic peptide is intercalated to the surface of a cartilage matrix under the specific recognition and intercalation action of the collagen mimic peptide and type II collagen on the surface of the cartilage, thereby obtaining the collagen mimic peptide modified hyaluronic acid-based joint injection preparation. The joint injection preparation not only can make hyaluronic acid specifically bound to the surface of damaged cartilage tissue, but also gives the damaged cartilage surface excellentanti-nonspecific adsorption property and lubricating property, can be used for preparing cartilage repair materials and treating osteoarthritis, improves anti-inflammatory factors and lubricating property of the surface of the damaged cartilage, and can also be used as a modified material for improving the friction performance of the cartilage repair materials.

The invention relates to a multi-degree-of-freedom macro-micro driving platform for testing the mechanical properties of an irregular cartilage surface, and belongs to the field of precision driving.The multi-degree-of-freedom macro-micro driving platform comprises a macro-micro driving module, a clamping module and a sensing and detecting module, wherein a six-degree-of-freedom macroscopic rigiddriving structure of the macro-micro driving module is mounted on a base, and a three-degree-of-freedom microcosmic driving flexible spherical hinge structure is connected between the six-degree-of-freedom macroscopic rigid driving structure and the clamping module; through mutual cooperation of the six-degree-of-freedom macroscopic rigid driving structure and the three-degree-of-freedom microcosmic driving flexible spherical hinge structure, rigid-flexible coupling driving of the platform is realized; and the sensing and detecting module is fixedly arranged on an upper moving plate of the six-degree-of-freedom macroscopic rigid driving structure, feeds back accurate regulation and control in real time and locates a micro-area to be tested. The platform has the advantages that under the condition that the probe does not move and does not damage the cartilage structure, the complete microscopic mechanical properties of cartilage, such as distribution characteristics of mechanical properties such as cartilage surface global hardness, Young modulus and friction coefficient, are measured.

The invention belongs to the field of polymer functional materials, and particularly relates to a cartilage targeting zwitterionic polymer and a preparation method and application thereof. The preparation method comprises the steps that firstly, a methacryloyl chloride modified N-hydroxysuccinimide monomer is synthesized and used for achieving efficient chemical grafting of cartilage targeting peptide; secondly, obtaining the cartilage targeted zwitterionic polymer through random copolymerization or RAFT polymerization. The polymer can be targeted to the cartilage surface, the lubricating performance of the articular cartilage is enhanced, abrasion of the articular cartilage in the movement process is avoided, in addition, the anti-pollution performance provided by the zwitter-ion unit can resist damage of degrading enzymes to a cartilage matrix, and then hose protection is achieved. The cartilage targeted zwitterionic polymer has a wide application prospect in bone tissue engineering.

A method for the ablation of human or animal articular cartilage is disclosed that employs an exogenous absorber, such as a compound having the molecular formula C43H47N2NaO6S2, to coat or color the surface of the articular cartilage. The coated or colored cartilage surface then has an energy absorption peak at a specific wavelength due to the exogenous absorber, which makes it possible to employ a simple and cheap laser diode to generate a pulsed laser beam at the specific wavelength so as to superheat the coated or colored cartilage thereby causing at least partial ablation of cartilage.

The ultrasound measurement instrument of the present invention comprises a main body component having a polyhedral shape; a nozzle that is provided in one plane of the main body component, the nozzle and communicating with the main body component via a hollow portion; and a contact component blocking off a face of the nozzle on the opposite side from the main body component in a flat shape such that ultrasonic waves are transmitted. The contact component is inclined with respect to a first axis that is parallel to the plane of the polyhedral body in which the nozzle is provided, and to a second axis that is perpendicular to the first axis and is parallel to the plane. A cartilage surface is inclined with respect to a biological surface, and the contact component is inclined by the same degree in the inclination direction thereof. Therefore, the ultrasonic waves emitted perpendicular to the face of the main body component where the nozzle is located pass through the contact component and proceed perpendicular to the cartilage surface.

The invention belongs to the field of polymer functional materials, and specifically relates to a cartilage-targeting zwitterionic polymer and its preparation method and application. First, a methacryloyl chloride-modified N-hydroxysuccinimide monomer is synthesized for realizing High-efficiency chemical grafting of cartilage-targeting peptides; secondly, cartilage-targeting zwitterionic polymers were obtained by random copolymerization or RAFT polymerization. This polymer can be targeted to the surface of cartilage, enhance the lubricating properties of articular cartilage, and avoid wear during its movement. In addition, the "anti-fouling" performance provided by the zwitterionic unit can resist the damage of degrading enzymes to the cartilage matrix, thereby Achieve hose protection. This cartilage-targeting zwitterionic polymer has broad application prospects in bone tissue engineering.

The invention discloses a design and use method of a personalized patella fracture surgery navigation template. The design and use method is used for improving fracture reduction quality and efficiency of comminuted patella. The method comprises the following steps of importing bilateral patella CT scanning data into a computer, respectively establishing 3D models of bilateral patella, mirroring a3D model of a healthy side patella, assisting virtual restoration of an affected side patella, and on the basis of the virtual restored 3D model of the subchondral bone of the patella, thickening thesubchondral bone of the patella to reach the thickness of a cartilage surface to form a cartilage surface morphology 3D model; and on the basis of the artificial virtual cartilage surface 3D model, thickening the cartilage surface of the patella to the thickness required by the surgical navigation template in a thickening manner, and finally, enabling the patella and the virtual cartilage surfaceto be subtracted in a Boolean subtraction manner, so that the design of the navigation template is completed. For displaced comminuted patella fractures, an upper half patella reduction navigation template, a lower half patella reduction navigation template and a full patella reduction navigation template need to be designed respectively, printed and formed by a 3D printer, disinfected and then used in an operation.

The invention discloses a soft tissue injury simulation testing device. According to the structure of the soft tissue injury simulation testing device, slippage of a soft tissue simulation structure represents friction between joints, and unevenness of the surface represents unevenness of the cartilage surface; a first toughness simulation structure and a second toughness simulation structure arelocated on the two sides of the soft tissue simulation structure respectively and used for simulating connection portions of the joints and the muscle tissue; a first muscle elastic simulation structure and a second muscle elastic simulation structure are located on the other side of the first toughness simulation structure and the other side of the second toughness simulation structure respectively and used for simulating the muscle tissue; the two ends of ligaments are connected with the first and second toughness simulation structures respectively and used for preventing the first and second toughness simulation structures from deforming excessively; an active viscous body fluid is used for simulating the synovial fluid and the inter-tissue fluid. By the adoption of the soft tissue injury simulation testing device, the soft tissue injury condition can be simulated, then, the essential causes of soft tissue injury pain can be elucidated in mechanism by analyzing tissue structure components and mechanical mechanisms of all the components, and thus a testing platform can be provided for acupuncture and acupotomology blind diagnosis and treatment.

To provide an ultrasonic wave analyzing device, an ultrasonic wave analyzing method, and an ultrasonic wave analyzing program that can easily adjust the angle of contact of an ultrasonic probe to a subject. An ultrasonic wave analyzing device 10 comprising: a control unit 12 that controls an ultrasonic wave source so as to cause an ultrasonic signal to be transmitted from the ultrasonic wave source on a prescribed sound axis toward a plurality of mutually different positions on the surfaces of cartilage or the surfaces of subchondral bone of a subject; an echo data input unit 141 that receivesthe input of echo data of an echo signal formed by the ultrasonic signal transmitted by the control unit being reflected inside the subject; a position detection unit 142 that detects the position ofthe ultrasonic wave source and the positions of the mutually different plurality of cartilage surfaces or subchondral bone surfaces; a shape detection unit 143 that detects the shape of the cartilagesurface or the subchondral bone surface on the basis of information from each position detected by the position detection unit; and an angle calculation unit 144 that calculates the angle formed by the sound axis of the ultrasonic signal and the normal direction of the cartilage surface or the subchondral bone surface at the position where the ultrasonic signal is transmitted.