4 results about "Fibrin adhesive" patented technology

The present invention relates to a composition for transplantation comprising an organoid, and a use of same. According to one example, using collagen, gelatin or fibrin glue as a scaffold for organoid transplantation results in a high transplantation rate and a high survival rate of organoid as well as desirable stability.

The application belongs to the technical field of biological medicine, and discloses application of antibacterial peptide humAMP_23 in preparation of a medicine for treating burn infection, and is used for promoting healing of a burn wound surface. It is found that local application of the antibacterial peptide humAMP_23 can effectively reduce inflammatory reaction and mortality. It is proved by cell experiments that humAMP_23 has no cytotoxicity and good biocompatibility. The application further provides a pharmaceutical composition containing the antibacterial peptide humAMP_23 and a pharmaceutically acceptable local external carrier. The pharmaceutical composition can be prepared into various forms such as gels, creams, ointments, sprays, hydrocolloid dressings or fibrin glue, is convenient to use in medicine, has the advantages of convenient use, high local drug concentration, remarkable effect of promoting wound healing, and is suitable for local administration of burn infection wound, especially burn infection wound caused by Staphylococcus aureus or Pseudomonas aeruginosa.

The invention provides a collagen self-adhesive cartilage repair scaffold as well as a preparation method and application thereof, and relates to the technical field of biomedical materials, the collagen self-adhesive cartilage repair scaffold sequentially comprises a collagen compact layer, a collagen loose layer and a biological adhesive layer covalently crosslinked with the collagen loose layer; the biological bonding layer comprises a multi-arm PEG derivative, and a terminal functional group of the multi-arm PEG derivative is NHS ester. The NHS ester can be subjected to a covalent reaction with amino groups of collagen in cartilage tissue, joint fluid scouring and joint activity shearing force are resisted, the initial adhesion strength and stability of the cartilage repair scaffold in a wet dynamic environment are improved, the postoperative early displacement or falling risk is reduced, and persistent repair of cartilage defects is promoted. The technical problems that in the prior art, due to the fact that a cartilage repair support depends on suture or fibrin glue fixing, surgical operation is complex, initial mechanical stability is insufficient, and the integration failure rate is high are solved.

The invention relates to the technical field of cartilage repair, in particular to a preparation method and application of injectable collagen gel. The method comprises the following specific steps: (1) carrying out low-temperature pretreatment and irradiation sterilization on a collagen solution; (2) mixing the physiological pH buffer solution B with moisturizing, lubricating and repairing components and a composite nutrient solution, and adjusting the pH value to 7.5-8.5 to obtain a neutralization solution A; and (3) mixing and neutralizing the collagen solution and the neutralization solution A to complete collagen self-assembly to form the hydrogel. The physicochemical property and the structure of the gel are more suitable for adhesion, growth, proliferation and differentiation of cartilage cells, and are more suitable for tissue engineering cartilage research. The technology does not need to be combined with a micro-fracture surgery, does not need to be bonded by virtue of fibrin glue, can be directly operated in joint fluid, does not need a dry environment, does not damage subchondral bones, protects the joint structure of a patient, increases the proliferation migration rate of cells, greatly reduces the operation cost, and simultaneously reduces the technical threshold of an operation hospital and an operation doctor.