3 results about "Fibrin adhesive" patented technology

The present invention relates to a composition for transplantation comprising an organoid, and a use of same. According to one example, using collagen, gelatin or fibrin glue as a scaffold for organoid transplantation results in a high transplantation rate and a high survival rate of organoid as well as desirable stability.

The application belongs to the technical field of biological medicine, and discloses application of antibacterial peptide humAMP_23 in preparation of a medicine for treating burn infection, and is used for promoting healing of a burn wound surface. It is found that local application of the antibacterial peptide humAMP_23 can effectively reduce inflammatory reaction and mortality. It is proved by cell experiments that humAMP_23 has no cytotoxicity and good biocompatibility. The application further provides a pharmaceutical composition containing the antibacterial peptide humAMP_23 and a pharmaceutically acceptable local external carrier. The pharmaceutical composition can be prepared into various forms such as gels, creams, ointments, sprays, hydrocolloid dressings or fibrin glue, is convenient to use in medicine, has the advantages of convenient use, high local drug concentration, remarkable effect of promoting wound healing, and is suitable for local administration of burn infection wound, especially burn infection wound caused by Staphylococcus aureus or Pseudomonas aeruginosa.

The invention provides a collagen self-adhesive cartilage repair scaffold as well as a preparation method and application thereof, and relates to the technical field of biomedical materials, the collagen self-adhesive cartilage repair scaffold sequentially comprises a collagen compact layer, a collagen loose layer and a biological adhesive layer covalently crosslinked with the collagen loose layer; the biological bonding layer comprises a multi-arm PEG derivative, and a terminal functional group of the multi-arm PEG derivative is NHS ester. The NHS ester can be subjected to a covalent reaction with amino groups of collagen in cartilage tissue, joint fluid scouring and joint activity shearing force are resisted, the initial adhesion strength and stability of the cartilage repair scaffold in a wet dynamic environment are improved, the postoperative early displacement or falling risk is reduced, and persistent repair of cartilage defects is promoted. The technical problems that in the prior art, due to the fact that a cartilage repair support depends on suture or fibrin glue fixing, surgical operation is complex, initial mechanical stability is insufficient, and the integration failure rate is high are solved.