542 results about "Lesion site" patented technology

The invention discloses an automatic segmentation method and device for a focus area in an ultrasonic image, a medium and a product, and relates to the field of intelligent medical treatment. The method comprises the following steps: firstly, acquiring an original ultrasonic image shot at a lesion part of a patient and preprocessing the original ultrasonic image, then labeling the preprocessed ultrasonic image, and storing the labeled image and the ultrasonic image in a one-to-one correspondence manner to form a sample data set; performing coarse segmentation on a foreground and a background in the ultrasonic image through an automatic threshold segmentation method to obtain a binary mask of the foreground as a coarse mask; the rough mask is converted into multi-mode cue word information; training an improved SAM large model by using the sample data set and the multi-modal cue word information, and using the improved SAM large model as a focus region segmentation model after training is completed; the to-be-segmented ultrasonic image and the cue word information thereof are obtained and input into the lesion region segmentation model, so that the lesion region can be automatically segmented, and the efficiency, accuracy and intelligent level of segmentation of the lesion region in the ultrasonic image are remarkably improved.

The invention relates to a visualization method of an electronic medical record system and a visual medical record system. The method comprises the following steps: constructing a system main page; providing entry options, basic information corresponding to the patient, chief complaint information and current medical history information in the navigation bar area; loading and displaying the three-dimensional human body model in the three-dimensional human body model display area; in response to analysis of the electronic medical record information of the patient, automatically identifying and extracting lesion part information described in the medical record information; performing visual labeling on the mapped diseased region on the three-dimensional human body model; setting human body system options in the three-dimensional human body model display area; and in response to the operation that the mouse of the user hovers on the lesion part label on the three-dimensional human body model, displaying an examination result and abnormal index information related to the lesion part. According to the invention, the defects of an existing electronic medical record system in the aspects of information acquisition efficiency, spatial information presentation and information interaction modes can be effectively overcome, and the readability of medical record information and the diagnosis and treatment efficiency of doctors are remarkably improved.

An electronic device according to one embodiment can acquire a first trendline related to vessels from a medical image; determine lesion candidates among the vessels on the basis of the first trendline; acquire a second trendline on the basis of a reference point selected in the vicinity of the lesion candidates; and determine a lesion site among the lesion candidates on the basis of the acquired second trendline.

The utility model provides a blade, a cutting balloon and a balloon catheter system. The blade comprises a cutting edge part and a cutter body part connected with the bottom of the cutting edge part. The blade part comprises a plurality of three-dimensional tooth block structures which are continuously arranged; the cutter body part comprises two fixed ends located at the two ends respectively and a middle part between the two fixed ends. The blade is high in cutting capacity for a diseased region, and the blade can be reliably fixed on the main body. The sacculus body of the cutting sacculus provided with the blade is provided with the groove, the blade is provided with the continuous cutting edge portion of the three-dimensional tooth block structure, the flexibility and cutting force of the cutting sacculus are enhanced, the turning performance of the cutting sacculus in a blood vessel and the cutting performance of the sacculus on lesion are improved, the blade is fixed to the groove through the blade body portion, and the cutting sacculus is fixed to the blade body portion. And the probability that the cutting balloon slips and is nested in plaques during cutting is greatly reduced.

The invention discloses a bionic nano-composite, a preparation method thereof and application of the bionic nano-composite in preparation of a product for treating atherosclerosis, and belongs to the technical field of medicine preparation. The bionic nano compound is a metal nano enzyme Ir-TiO2 coated by an M2 macrophage cell membrane. According to the invention, the surfaces of Ir-TiO2 nanoparticles are coated with M2 macrophage membranes, so that the nanocomposite with a bionic structure is prepared. After intravenous injection, the formed bionic nanocomposite can actively target endothelial cells in atherosclerotic lesions, and release Ir-TiO2 antagonism to endothelial cells in plaques and cytoplasm of inflammatory macrophages. After the Ir-TiO2 reaches the diseased region, the Ir-TiO2 can play an enzyme role to achieve an anti-inflammatory effect, and can promote inflammatory cells such as macrophages and smooth muscle cells at the diseased region to discharge cholesterol, reduce lipid deposition in the cells, reduce the generation of foam cells and promote the growth of plaques. The nanotherapy can effectively prevent the progress of atherosclerosis lesion inflammation and relieve atherosclerosis.

The invention discloses a fuzzy edge enhanced skin lesion image segmentation method and system. The method comprises the steps of S110-S140: S110: collecting clinical skin lesion image data; s120, constructing a fuzzy edge segmentation network ResPDCNet of the residual error pixel differential convolution; s130, carrying out training on the constructed ResPDCNet (Registered Packet Data Convergence Network And S140, according to a network training result, giving a skin lesion region segmentation result. The invention provides a fuzzy edge enhanced skin lesion image segmentation method based on residual pixel difference convolution. According to the method, detail edge details of a target lesion area are extracted through a residual pixel convolution block, the problem that the pixel difference between a foreground area and a background area in a clinical medical image is small is solved, and then space and channel feature extraction is carried out through a residual attention block to perceive the size and position of a lesion part. The problems of different sizes of lesion parts and difficulty in positioning the lesion positions are solved.

The present invention relates to a medical image processing method and an image processing system, and relates to the technical field of medical image processing, wherein the method comprises: acquiring multiple medical images of a patient's lesion site; determining a reference medical image from the multiple medical images based on relevant information of the patient's lesion site; performing multi-modal spatial position registration on the multiple medical images based on the reference medical image, and generating multiple medical images after multi-modal spatial position registration; determining a fusion weight corresponding to each medical image based on relevant information of the patient's lesion site; and fusing the multiple medical images after multi-modal spatial position registration based on the fusion weight corresponding to each medical image, and generating a fused medical image, which has the advantage of improving the fusion quality of multi-modal medical images.

The invention discloses a preparation method of artemisia apiacea extracellular vesicles, which comprises the following steps: step 1, pre-treating artemisia apiacea, carrying out primary centrifugal treatment, removing large plant tissues and cell debris, carrying out secondary centrifugal treatment, filtering by a needle filter, and collecting; step 2, transferring the filtered suspension to a sucrose density gradient solution, then carrying out third centrifugal treatment, collecting the solution with the concentration of 30% in the layer, and carrying out fourth centrifugal treatment to obtain artemisia apiacea extracellular vesicles; the invention further discloses an artemisia apiacea extracellular vesicle, a pharmaceutical composition for treating cerebral apoplexy, a medicine and application of the artemisia apiacea extracellular vesicle in preparation of the medicine for treating cerebral apoplexy. The naturally-sourced vesicle delivery system provided by the invention is expected to have higher safety and lower toxic and side effects, and the enrichment concentration of the therapeutic component at the focus part of cerebral apoplexy is improved, so that the bioavailability and the treatment efficiency of the medicine are remarkably improved.

The invention discloses a preparation method and application of a diABZI-loaded targeted nano preparation, and relates to the technical field of biological medicines.The diABZI-loaded targeted nano preparation combines a stem cell membrane and a targeted peptide pHLIP, and the targeting property of the nano preparation to colorectal cancer cells can be enhanced; the stem cells are used as a coating material of the nanoparticles, and the stem cell membrane has excellent biocompatibility and biological activity, so that the stability and biological activity of the nanoparticles in vivo are enhanced. DiABZI is an effective medicine for treating colorectal cancer. By loading the diABZI into nanoparticles and preferentially delivering the diABZI to a diseased region, effective enrichment of the diABZI in colorectal cancer can be realized, so that the therapeutic effect of the diABZI is exerted, and the inflammatory response of a body is reduced. According to the diABZI-loaded stem cell membrane bionic targeting nano preparation prepared by the invention, a new method is provided for accurate treatment of colorectal cancer through targeting delivery and effective enrichment strategies, the treatment effect and the biological safety are improved, and the important technical progress in the field is marked.

The invention discloses an intelligent massage method and system and a computer readable storage medium, which are applied to the field of massage health care, and comprise the following steps: obtaining a target heat distribution diagram of a target object; identifying and analyzing the target heat distribution diagram to obtain a lesion identification result of the target object; obtaining depth image information corresponding to the lesion part based on the lesion recognition result; the diseased region is positioned based on the lesion recognition result and the depth image information, and a massage component is controlled to massage the diseased region according to the positioning result. The target heat distribution diagram is recognized and analyzed to obtain the lesion recognition result, the depth image information corresponding to the lesion part is obtained according to the lesion recognition result, then the lesion part is positioned and massaged according to the lesion recognition result and the depth image information, the recognition and positioning precision can be improved, and the massage effect is improved. Manual operation is reduced, and massage efficiency is improved.

The invention relates to a breast tumor lesion part ultrasonic image segmentation method based on an SAM-VMama model. The method comprises the steps of obtaining a breast ultrasonic image set and performing preprocessing; the method comprises the following steps: constructing an SAM-VMama model, wherein the SAM-VMama model comprises a first encoder, a second encoder, a prompt encoder and a mask decoder; obtaining a trained model; obtaining a preprocessed breast ultrasound image to be segmented; and obtaining a segmentation result of the breast lesion tumor. According to the method, the local features are extracted through the first extraction, the global features are extracted through the second encoder, the interactive prompt information processed by the prompt encoder is combined, and the precise segmentation mask is generated through the mask decoder; the method not only retains the flexibility of SAM interactive segmentation, but also improves the long-sequence data processing capability and calculation efficiency through a Mamba structure, effectively adapts to the characteristics of uneven gray scale, multiple artifacts and the like of the ultrasonic image, and achieves the balance of high precision and high efficiency.

The invention relates to double-encapsulated lipid nanoparticles entering brain through nose and a preparation method and application thereof, the double-encapsulated lipid nanoparticles comprise lipid nanoparticles, drugs in the lipid nanoparticles and rana odorata lectin coupled to the surfaces of the lipid nanoparticles, and the drugs comprise hydrophilic drugs and hydrophobic drugs. According to the invention, the rana odorata lectin and the lipid nanoparticles are coupled, and the rana odorata lectin can be specifically combined with L-fucose residues expressed by olfactory epithelial cells, so that the adhesion of the lipid nanoparticles to olfactory epithelium during nasal administration is enhanced, and the brain entering efficiency of the lipid nanoparticles is finally improved. After entering the brain, the lipid nanoparticles respond to diseased regions with high active oxygen content so as to release drugs. In addition, double-drug encapsulation can target different pathogenesis of central nervous system diseases, and the limitation that a traditional treatment drug is single in action target is improved.

The invention provides a thrombus aspiration catheter with the variable inner diameter of the far end, and belongs to the technical field of interventional surgical instruments.The catheter comprises an interventional catheter, an operating handle and a collecting component, and the interventional catheter is used for moving along a blood vessel to be close to the thrombus position; the operating handle is arranged at the near end of the interventional catheter and is used for providing suction force for the interventional catheter; the collecting part is arranged at the far end of the interventional catheter, the near end of the collecting part is communicated with the interventional catheter, and the far end is open and adjustable in diameter; when the interventional catheter moves along the blood vessel to be close to the thrombus, the diameter of the collecting part is in a contracted state and is not larger than that of the interventional catheter, and after the collecting part is in place, the collecting part expands to increase the diameter of the far end so as to integrally suck the thrombus; the thrombus aspiration catheter is mainly used for solving the technical problems that in the prior art, a small-caliber thrombus aspiration catheter is insufficient in aspiration force, repeated aspiration is needed, thrombus escape is easily caused, and a large-caliber catheter is poor in passing ability and difficult to reach a diseased region.

The intelligent gynecological flushing system comprises a gynecological flushing platform, a colposcope image guiding system, a self-adaptive flushing execution system and an evaluation feedback optimization system, and the gynecological flushing platform is used for supporting a patient to conduct gynecological flushing; the colposcope image guiding system is used for collecting colposcope image data, identifying lesion characteristics based on an image identification technology, and transmitting an identification result to the self-adaptive flushing execution system; the self-adaptive flushing execution system is used for carrying out self-adaptive gynecological flushing on the focus part by utilizing flushing fluid according to the guidance of the colposcope image guidance system and based on the basic information of the patient; and the evaluation feedback optimization system is used for collecting the components of the flushing fluid after flushing and the reaction of the flushing part, performing quantitative evaluation on the flushing effect, feeding back the evaluation result to the self-adaptive flushing execution system, and optimizing the self-adaptive flushing parameters of the self-adaptive flushing execution system. According to the invention, the stability and accuracy of the flushing process can be ensured.

A mark that identifies a lesion site is displayed on a tomographic image. A two-dimensional map and a graph are displayed regardless of whether or not the mark is displayed. The two-dimensional map represents lesion site probability distribution. The graph represents temporal change of lesion site probabilities.

The invention belongs to the technical field of medical nano-materials, and particularly relates to a lactoferrin nano-material for sonodynamic regulation and control of blood-brain barrier permeability as well as a preparation method and application of the lactoferrin nano-material. The nanomaterial is nanoparticles LCe6 formed by self-assembly of lactoferrin and chlorin e6, can target brain microvascular endothelial cells, and can temporarily, reversibly and targeting open BBB by using the sonodynamic effect of the LCe6 in combination with transcranial ultrasonic stimulation, so that the accumulation of the nanoparticles LCe6 at a focus part is improved; in addition, the nanoparticle LCe6 also has a targeting property on brain tumor cells, the tumor cells can be accurately killed by utilizing the sonodynamic effect of the nanoparticle under secondary transcranial ultrasound, and the effect of sonodynamic treatment on brain glioma is exerted to the maximum extent; the nanoparticles LCe6 have excellent biocompatibility and low toxicity; according to the invention, the intracerebral delivery efficiency of the drug can be obviously improved, and a novel method for targeting open brain disease BBB is provided.

The invention discloses an intelligent analysis system and method for rehabilitation treatment of lumbar intervertebral disc herniation, and relates to the field of intelligent analysis. Abstract clinical information amounts such as lesion part features, pain perception description and movement function requirements are converted into high-dimensional vectors by adopting a semantic coding technology based on deep learning; the system can more accurately understand and simulate the condition of a patient in a multi-dimensional space, further, a dynamic mapping mechanism between a rehabilitation starting point and a target is established to capture non-linear correlation between the current state of the patient and an ideal rehabilitation target, and intelligent derivation of a rehabilitation path is achieved based on the non-linear correlation. Through the dynamic analysis of the multi-dimensional information of the patient, the system can better understand the unique demand of each patient, the matching precision of the rehabilitation treatment scheme is improved, and the treatment is more personalized and effective.

The invention discloses a capsule medicament for endoscopic treatment of ulcerative colitis and a preparation method thereof, and belongs to the technical field of biological medicine, the capsule medicament is composed of a capsule matrix and a drug matrix; by adopting a dual control mechanism of an enteric layer coating and a pH response layer coating, accurate release of a medicine at a colon diseased region is ensured, medicine waste of the stomach and the small intestine is reduced, the medicine concentration at a focus is improved, mesalazine or budesonide is combined with the composite composition for treatment, inflammatory response is rapidly inhibited, acute symptoms are controlled, and the curative effect is good. A multi-mechanism synergistic treatment mode is adopted, the anti-inflammatory and repairing effects are enhanced, the clinical remission rate and the mucous membrane healing rate are remarkably improved, the pH response layer is dissolved in a colon alkaline environment, and the MMP-9 peptide cross-linking agent is subjected to enzymolysis at an inflammation part, so that the medicine is continuously released at a focus, the administration frequency is reduced, the compliance of a patient is improved, and the curative effect is good. In addition, the spherical gel particles in the medicament can prevent the medicament from being disintegrated too early in the intestinal tract, and the long-acting effect can be maintained.

A method for evaluating plaque load based on OCT images is characterized in that fitting is carried out through the far end and the near end of a blood vessel lumen of the OCT images, a reference lumen at a plaque is fitted out, and then a middle membrane area and a plaque area can be calculated, so that the plaque load condition is evaluated; the imaging length of the intravascular OCT is usually 50-80 mm, the intravascular OCT generally comprises a far end, a lesion part and a near end, and the image of the near end is close to a coronary artery opening and has a larger diameter; the distal end is far away from the coronary opening, the diameter is relatively small, and the diameter of the healthy blood vessel from the proximal end to the distal end generally decreases linearly; when a blood vessel has plaque, the space-occupying effect causes the diameter of the lumen of the blood vessel at the plaque to become smaller. The invention can acquire the real plaque load through the conventional OCT image, provides basis for diagnosis and is beneficial to expanding the scope and quality of OCT diagnosis.

The invention discloses a lightweight hysteroscope image diseased region detection model construction method, which comprises an input layer, a multi-scale feature pyramid module, a lightweight backbone network module, a target detection head module and an output layer, performing hierarchical feature extraction and cross-layer feature fusion through a multi-scale feature pyramid module to obtain fused feature maps of different scales; the fused feature maps are input into a lightweight backbone network module and are further processed through a deep separable self-association mechanism and a dynamic region attention mechanism, and the capturing capability of the features of the lesion site is enhanced; the processed feature map is input into a target detection head module, multi-scale feature matching detection and self-adaptive anchor frame generation are carried out, and the category and the position of the diseased region are predicted; finally, the output layer outputs a detection result of the lesion part, and the detection result comprises lesion types and corresponding bounding box information.

The invention provides a multifunctional needle inserting device for percutaneous lung puncture under the guidance of a CT image, and relates to the technical field of medical instruments. A motor base is installed at the left end of the base plate through bolts, a first motor is installed on the motor base through bolts, a chain wheel is fixed to an output shaft of the first motor, and a rotating column is installed on the base plate through a bearing. The front-back position of a puncture needle is adjusted by operating a third motor, the orientation of the puncture needle can be adjusted by operating a fourth motor, the height of the puncture needle can be adjusted by operating a fifth motor, a fifth hydraulic rod is stretched out and drawn back to enable a sliding seat to drive a rotating rod to rotate, and adjustment of the puncture elevation angle of the puncture needle is achieved; the sixth motor is operated to enable the moving seat to move on the mounting seat, so that the puncture needle punctures the diseased region, and the flexibility is high; a first hydraulic rod extends to enable a first rotating ring to drive six sets of movable seats to move, six sets of clamping plates clamp the puncture needle, and the first hydraulic rod retracts to quickly disassemble the puncture needle.

The intelligent haemorrhoids ligation device comprises a gun body, a quick-change connector, a pull strip, a push block, a rotary cutter, a battery, a first control circuit board, a motor, a lead screw, a rotary encoder, a sliding block and a second control circuit board, the pull strip is clamped in the push block, the push block is clamped on a push pipe, the rotary cutter is fixed to the front end of the push block, and a tensioning knot of a ligation ring penetrates through the rotary cutter and then is clamped on the pull strip; the battery is connected with the first control circuit board and the second control circuit board, the first control circuit board is connected with the motor, the motor is connected with the lead screw, the lead screw is clamped with the sliding block, and the sliding block is connected with the push pipe. The second control circuit board is connected with a rotary encoder, and the rotary encoder is fixed to the lead screw. The sliding block is connected with the rear end of the brace, and when the lead screw pushes the sliding block to slide front and back, the brace moves front and back. The intelligent haemorrhoids loop ligature device can realize automatic control of lesion site adsorption, lesion site loop ligature, loop ligature ring tightening and loop ligature ring cutting.

A method for providing primary therapy to restore functional blood flow to a back of an eye may include advancing a guidewire through an access site in a subject to an ostium of an ophthalmic artery (OA) via an internal carotid artery (ICA), advancing a microcatheter to the ostium of the OA, retracting the guidewire into the microcatheter, such that a distal tip of the microcatheter assumes a pre-shaped configuration, advancing the microcatheter to cannulate a short limb of the OA, advancing the guidewire to a position approximately at or beyond a central carotid artery (CRA) branch of the OA, removing the microcatheter, advancing a treatment device over the guidewire to a lesion site in the OA of the subject, performing a treatment with the treatment device, and removing the treatment device and the guidewire from the subject.

The invention belongs to the technical field of medical instruments, and discloses a digestive endoscopy diseased region accurate positioning and marking device which comprises a controller, an endoscope hose is fixedly connected to the bottom of the controller, and an instrument insertion opening is formed in the right side of the controller. Through the arrangement of the sleeve, the dye tube, the pressurization air bag and the baffle, after an operator observes a diseased region through the endoscope hose, the operator only needs to align the endoscope hose to the diseased region, and by pressing the pressurization air bag, air in the pressurization air bag enters the dye tube through the inner hose; the baffle can be pushed to rotate outwards under the action of air pressure, meanwhile, methylene blue in the dye tube is sprayed out under the action of air flow, a diseased region is marked, the methylene blue can be absorbed by normal mucous membrane cells, and diseased tissue shows dyeing difference due to abnormal cell function and poor absorption capacity, so that the diseased region is marked. Therefore, the effect of accurate positioning is achieved.

The invention belongs to the technical field of biological medicines, and particularly relates to nasal temperature-sensitive hydrogel with immunoregulation and anti-inflammatory functions as well as a preparation method and application of the nasal temperature-sensitive hydrogel. The preparation method of the nasal temperature-sensitive hydrogel with the immunoregulation and anti-inflammatory functions comprises the following steps: preparation of hydroxybutyl chitosan (HBC), preparation of levodopa-hydroxybutyl chitosan (LHBC), and preparation of CELHBC composite hydrogel. The novel temperature-sensitive hydrogel composite material of the composite hydrogel loaded with the chlorella / exosome can be used for the focus position of allergic rhinitis, and enrichment and retention of active ingredients are achieved; the chlorella is combined with the exosome, so that the inflammatory response of nasal mucosa can be relieved, the damaged nasal mucosa can be repaired, and the immune imbalance of Th1 / Th2 cells can be reversed, thereby improving the treatment effect of allergic rhinitis.

The invention belongs to the technical field of biomedicine, and particularly relates to a bionic PLGA composite nano-material and a preparation method and application thereof.The bionic PLGA composite nano-material is characterized in that after curcumin and iloumab are co-loaded and packaged through a polylactic acid-glycolic acid copolymer, a bionic membrane is disguised on the outer layer of the polylactic acid-glycolic acid copolymer; and modifying the surface of the biomimetic membrane with phosphatidylated hyaluronic acid. According to the biomimetic PLGA composite nano-material disclosed by the invention, by utilizing the design characteristics of biomimetic membrane and hyaluronic acid modification and combining two anti-atherosclerosis effects of curcumin and iloumab with different mechanisms, the specific aggregation and permeation of a drug at a diseased region are realized, and the bioavailability of a target cell to the drug is improved; the purpose of treating atherosclerosis through synergistic interaction is achieved.

The invention relates to an exosome-coated responsive drug-loaded dendrimer nanogel system as well as a preparation method and application thereof. The preparation method comprises the following steps: grafting a drug on the surface of a phenylboronic acid modified third-generation PAMAM (Polyamidoamine) dendrimer through a boric acid ester bond; then, synthesizing active oxygen sensitive drug-loaded nanogel by using a cross-linking agent containing a double-selenium bond through a reversed-phase microemulsion method, and wrapping the surface of the drug-loaded nanogel with exosome through a physical effect. The drug-loaded nanogel system prepared by the invention can effectively improve the bioavailability of small-molecule drugs, realizes targeted delivery and responsive release of the drugs at focus parts, shows an excellent synergistic treatment effect in an acute lung injury model, and has a good application prospect.

The invention discloses a nano-drug delivery system for treating myocardial fibrosis as well as a preparation method and application of the nano-drug delivery system, and belongs to the technical field of biological medicines. According to the system, ZIF-8 is taken as a core carrier, the loading efficiency of pirfenidone is improved through high specific surface area and adjustable aperture, PCM myocardial targeting peptide is covalently coupled on the surface, and the limitation of tissue selectivity is broken through. Through coordination complexation, pi-pi conjugate accumulation and electrostatic interaction synergy, stable drug loading and microenvironment response release are guaranteed; a one-pot method and a carbodiimide method are adopted to wrap PFD and modify PCM on the surface of ZIF-8 to form a nano-drug delivery system; according to the system, the fibrosis process is intervened through multiple mechanisms, the enrichment degree and the acting time of the medicine at the diseased region are improved, the prepared medicine integrates the carrier structure advantage and the targeting peptide function, efficient medicine carrying, precise delivery and controllable release are achieved, a new scheme is provided for myocardial fibrosis treatment, and the system has wide application prospects.

The inhalation suspension preparation containing the SGC receptor stimulant comprises the SGC receptor stimulant with an effective therapeutic dose or pharmaceutically acceptable salt of the SGC receptor stimulant, and pharmaceutically acceptable auxiliary materials of the suspension preparation, the pharmaceutically acceptable auxiliary materials of the suspension preparation comprise at least one of a surfactant, a pH regulator, an osmotic pressure regulator and a metal complexing agent; the inhalation suspension preparation containing the riociguat shows good lung absorption efficiency, is beneficial to reaching the same or better treatment level by reducing the administration dosage, can directly act on a diseased region through an administration route, takes effect more quickly compared with oral administration of the riociguat, and has a good application prospect. Gastrointestinal discomfort and systemic hypotension side effects caused by gastrointestinal tract contact and absorption entering a circulatory system can be avoided, the treatment cycle of an oral dosage form dosage titration administration scheme is shortened, and a better treatment scheme is provided for relieving dyspnea and syncope symptoms of pulmonary hypertension patients treated at home.

Systems, catheter and methods for treating Atrial Fibrillation (AF) are provided, which are configure to illuminate a heart tissue having a lesion site; obtain a mitochondrial nicotinamide adenine dinucleotide hydrogen (NADH) fluorescence intensity from the illuminated heart tissue along a first line across the lesion site; create a 2-dimensional (2D) map of the depth of the lesion site along the first line based on the NADH fluorescence intensity; and determine a depth of the lesion site at a selected point along the first line from the 2D map, wherein a lower NADH fluorescence intensity corresponds to a greater depth in the lesion site and a higher NADH fluorescence intensity corresponds to an unablated tissue. The process may be repeated to create a 3 dimensional map of the depth of the lesion.