216 results about "Lesion site" patented technology

The invention discloses a preparation method of artemisia apiacea extracellular vesicles, which comprises the following steps: step 1, pre-treating artemisia apiacea, carrying out primary centrifugal treatment, removing large plant tissues and cell debris, carrying out secondary centrifugal treatment, filtering by a needle filter, and collecting; step 2, transferring the filtered suspension to a sucrose density gradient solution, then carrying out third centrifugal treatment, collecting the solution with the concentration of 30% in the layer, and carrying out fourth centrifugal treatment to obtain artemisia apiacea extracellular vesicles; the invention further discloses an artemisia apiacea extracellular vesicle, a pharmaceutical composition for treating cerebral apoplexy, a medicine and application of the artemisia apiacea extracellular vesicle in preparation of the medicine for treating cerebral apoplexy. The naturally-sourced vesicle delivery system provided by the invention is expected to have higher safety and lower toxic and side effects, and the enrichment concentration of the therapeutic component at the focus part of cerebral apoplexy is improved, so that the bioavailability and the treatment efficiency of the medicine are remarkably improved.

The invention relates to a breast tumor lesion part ultrasonic image segmentation method based on an SAM-VMama model. The method comprises the steps of obtaining a breast ultrasonic image set and performing preprocessing; the method comprises the following steps: constructing an SAM-VMama model, wherein the SAM-VMama model comprises a first encoder, a second encoder, a prompt encoder and a mask decoder; obtaining a trained model; obtaining a preprocessed breast ultrasound image to be segmented; and obtaining a segmentation result of the breast lesion tumor. According to the method, the local features are extracted through the first extraction, the global features are extracted through the second encoder, the interactive prompt information processed by the prompt encoder is combined, and the precise segmentation mask is generated through the mask decoder; the method not only retains the flexibility of SAM interactive segmentation, but also improves the long-sequence data processing capability and calculation efficiency through a Mamba structure, effectively adapts to the characteristics of uneven gray scale, multiple artifacts and the like of the ultrasonic image, and achieves the balance of high precision and high efficiency.

The invention discloses a nano-drug delivery system for treating myocardial fibrosis as well as a preparation method and application of the nano-drug delivery system, and belongs to the technical field of biological medicines. According to the system, ZIF-8 is taken as a core carrier, the loading efficiency of pirfenidone is improved through high specific surface area and adjustable aperture, PCM myocardial targeting peptide is covalently coupled on the surface, and the limitation of tissue selectivity is broken through. Through coordination complexation, pi-pi conjugate accumulation and electrostatic interaction synergy, stable drug loading and microenvironment response release are guaranteed; a one-pot method and a carbodiimide method are adopted to wrap PFD and modify PCM on the surface of ZIF-8 to form a nano-drug delivery system; according to the system, the fibrosis process is intervened through multiple mechanisms, the enrichment degree and the acting time of the medicine at the diseased region are improved, the prepared medicine integrates the carrier structure advantage and the targeting peptide function, efficient medicine carrying, precise delivery and controllable release are achieved, a new scheme is provided for myocardial fibrosis treatment, and the system has wide application prospects.

The application provides a multifunctional nano particle for targeting abdominal aortic aneurysm and a preparation method and application thereof, and belongs to the field of nanobiomedicine, wherein polyphenol oxidation self-polymer nanoparticles are used as carriers, doxycycline is loaded, and a targeting ligand cRGD is modified on the surface of the nano carrier; the neovasculature in the media and adventitia of AAA sites helps accumulation of the nanoparticles in the abdominal aortic aneurysm, and the integrin αν3 beta receptor highly expressed on the surface of the diseased cell membrane can recognize the cRGD with high affinity, and then mediate the targeted endocytosis of the nanoparticles; after intravenous injection, the nanoparticles can be effectively enriched in the lesion site and achieve long-term retention, and can release DC in response to the high ROS level in the tumor microenvironment; the drug is rapidly released to take effect, and the non-specific toxic side effects are reduced; the free radical scavenging capacity of the nanoparticles can be synergized with the DC activity to treat AAA through multiple mechanisms such as anti-inflammatory, antioxidant, macrophage repolarization promotion, anti-apoptosis and calcification inhibition, and MMPs inhibition.

The invention discloses a cryoablation catheter system for pulmonary artery stent internal restenosis, and belongs to the field of medical instruments, the cryoablation catheter system comprises a catheter main body arranged on a guide wire, the catheter main body is provided with a treatment assembly, the treatment assembly is located at the far end of the catheter main body, the catheter main body is provided with a control handle, and the control handle is located at the far end of the catheter main body. The control handle is located at the near end of the catheter body, and the treatment assembly comprises a near-end balloon, a far-end balloon and a freezing balloon. When the near-end balloon and the far-end balloon are simultaneously full, a closed treatment cabin isolated from near-end blood flow and far-end blood flow can be formed in a blood vessel of a target treatment section, the freezing balloon is located in the treatment cabin, the closed treatment cabin thoroughly eliminates the blood flow hot pool effect, cold is prevented from being taken away by the blood flow, and the treatment effect is improved. Freezing energy is intensively acted on a diseased region, so that the ablation efficiency and accuracy are improved; meanwhile, thrombus, tissue debris and whole body blood flow which fall off in the treatment process are isolated, the risk of far-end embolism is reduced from the source, and damage to the blood vessel wall is avoided.

The application provides a single-bending-degree support laryngoscope with variable rigidity and a method for using the same. The device comprises a bendable joint, a driving component and a variable rigidity structure. The distal joint, the middle joint and the proximal joint are hollow structures and are in communication with each other to form an operation channel. The variable rigidity structure is installed in the operation channel. The variable rigidity structure comprises a distal rod, a connecting rod, a translation rod, a proximal rod, a horizontal sliding block and a sliding block frame. The driving component comprises a rudder, a front side driving line, a back side driving line, a guide wheel, a limiting wheel, a driving wheel and a tension spring. The application can be freely bent at a certain angle to expose a lesion site and has a larger field of view. The back side driving line is connected in series with the tension spring, so that self-adaptive adjustment is realized, the structural compliance is enhanced, the system is stable, and the robustness is good. The angle adjustment and the rigidity enhancement realized are both stepless adjustment, the adjustment range is large, and the device is suitable for various application requirements.

This invention relates to an acoustic energy guidewire system and an energy guidewire, the energy guidewire comprising a pushing section and a developing section. The first end of the pushing section is connected to a main unit or handle, and the pushing section is made of metal. The developing section includes a mandrel and a covering layer disposed outside the mandrel. One of the mandrel and the covering layer is integrally formed with its second end, while the other is made of a metallic developing material. The elastic modulus of the pushing section is greater than that of the developing section. During operation, the developing section, driven by the pushing section, enters the lesion site and applies its energy to the lesion site, thereby achieving a therapeutic effect. Because one of the mandrel and the covering layer is integrally formed with the second end and the pushing section, the continuous, weld-free, integrated structure reduces stress concentration points in the overall mechanical structure of the product. This prevents rapid failure at stress concentration points, ensuring the energy guidewire can safely and stably transmit mechanical acoustic energy.

The invention discloses application of an ATP (adenosine triphosphate) citrate lyase (ACLY) inhibitor in preparation of a medicine for treating leucoderma, and belongs to the technical field of preparation of medicines for treating leucoderma. Through targeted inhibition of ACLY activity or specific knockout of ACLY in CD8 + T cells, abnormal activation of ACLY and secretion of killing effector molecules (Granzyme B, IFN-gamma, Perforin and the like) are inhibited, and infiltration of the CD8 + T cells to skin lesion parts is reduced, so that melanocytes are protected from immune injury, and the progress of vitiligo is blocked. The application is based on the abnormally high expression of ACLY in CD8 + T cells of vitiligo patients and the close association with disease activity, and a brand new targeted treatment thought and a medicine research and development direction are provided for vitiligo.

The invention belongs to the technical field of medical biological detection, and particularly relates to a gene marker combination for oral mucosa leukoplakia canceration risk and application of the gene marker combination. The gene marker combination is a combination of TP53, CASP8 and CYP2B6 genes and is obtained by screening through a WES technology, the predicted AUC of the gene marker combination reaches 0.813 (95% CI: 0.710-0.916), and the performance of the gene marker combination is remarkably superior to that of traditional pathological grading. Through Cox risk regression analysis, a high-risk group as an independent factor has significant statistical significance and is superior to traditional indexes such as age and diseased regions. The invention further provides an oral mucosa leukoplakia canceration risk prediction kit and prediction system derived from the gene combination.

The invention discloses a preparation method and application of polypeptide hydrogel loaded with modified CAR-T cells and CXCL9, and creatively discovers that the combination of the modified CAR-T cells and the CXCL9 has a remarkable synergistic effect on treatment of melanoma for the first time. According to the invention, efficient enrichment of CAR-T cells at a focus part is realized through the hydrogel delivery system, the local curative effect is improved, in addition, the introduction of CXCL9 further enhances the tumor infiltration capability and the treatment effect of the CAR-T cells, a brand new treatment scheme is provided for tumor treatment, and the clinical application prospect is wide.

The present invention relates to an electronic flexible and rigid endoscope system and method applicable to general practice. The system comprises: a data acquisition system, configured to acquire image data of a lesion site, and a data processing system, configured to process the image data from the data acquisition system. The data acquisition system comprises a handle end and an endoscope end, the endoscope end comprises an imaging insertion end and an operating end, the imaging insertion end enters the lesion site to acquire images of the lesion site, the operating end controls the action of the imaging insertion end, the handle end sends the image data acquired by the endoscope end to the data processing system, the data processing system comprises a data receiving module and an image processing module, and the data receiving module receives the image data acquired by the data acquisition system.

The utility model relates to a tumor-free isolation device for laparoscopic surgery, and belongs to the technical field of medical instruments. The tumor-free isolation device for the laparoscopic surgery comprises a cannula assembly and a tumor isolation assembly, wherein the tumor isolation assembly is arranged in the cannula assembly in a penetrating manner and extends out of the front end of the cannula assembly; the tumor isolation assembly comprises a connecting pipe, a head rod, a tumor isolation bag and a traction rod, the head rod is hinged to the front end of the connecting pipe, the tumor isolation bag is arranged on the head rod, the traction rod slidably penetrates through the connecting pipe, and the front end of the traction rod is hinged to the head rod; when the traction rod moves back and forth, the head rod can be driven to swing up and down, and the included angle between the opening of the tumor isolation bag and the axis of the connecting pipe is changed. According to the tumor-free isolation device for the laparoscopic surgery, the orientation of the opening of the tumor isolation bag can be automatically changed, so that the opening of the tumor isolation bag is aligned with a focus part, the bearing area is larger, and waste tissue or tissue fluid is not prone to escaping.

This disclosure discloses a surgical stapler (100) including a stapler body (200). One end of the stapler body is provided with a receiving opening (203) for receiving a lesion (220) of a specimen. A circular base (206) is positioned proximal to the receiving opening (203), and the circular base defines a curved path (202b) structured to guide one staple of a plurality of staples (300) toward an exit end (203b) defined at the receiving opening. A drive mechanism (202) is structured to displace one staple of the plurality of staples. The drive mechanism has a transport member (202a) configured to displace between a first position (A) and a second position (B) relative to the curved path. An actuator (212) is operably connected to the transport member. The deformation module (204) is positioned near the entrance end (203a) of the receiving end and is structured to deform a portion of one staple.

A diagnostic imaging assistance device 1 comprises: a first acquisition unit 10 for acquiring an image of a head through MRI; an image processing unit 11 for extracting a region containing information on a lesion site and the periphery of the lesion site from the acquired image of the head and generating a first image having the extracted region; an extraction unit 12 for extracting a predetermined image feature amount from the first image; a classification unit 14 for determining, on the basis of the image feature amount extracted by the extraction unit 12, the presence or absence of a molecular biomarker associated with the lesion site for classification using a pre-constructed classifier; and a presentation unit 15 for presenting assistance information related to whether or not the lesion site contained in the image of the head has the molecular biomarker, on the basis of the result of the classification by the classification unit 14.

This invention discloses a biomimetic nanocomposite, its preparation method, and its application in the preparation of products for treating atherosclerosis, belonging to the field of pharmaceutical preparation technology. The biomimetic nanocomposite is an Ir-TiO2 metal nanozyme encapsulated in an M2 macrophage membrane. This invention prepares a structurally biomimetic nanocomposite by coating Ir-TiO2 nanoparticles with an M2 macrophage membrane. After intravenous injection, the formed biomimetic nanocomposite actively targets endothelial cells in atherosclerotic lesions, releasing Ir-TiO2 antagonistically into the cytoplasm of plaque-containing endothelial cells and inflammatory macrophages. Once Ir-TiO2 reaches the lesion site, it exerts an enzymatic effect to achieve anti-inflammatory activity and promotes cholesterol excretion from inflammatory cells such as macrophages and smooth muscle cells at the lesion site, reducing intracellular lipid deposition, reducing foam cell formation, and promoting plaque growth. This nanotherapy can effectively prevent the progression of inflammation in atherosclerotic lesions and alleviate atherosclerosis.

The invention discloses a cathepsin B activated chemiluminescent nanoparticle. The cathepsin B activated chemiluminescent nanoparticle is prepared from cat B-C-550, hypericin and DSPE-mPEG2000 (Distearoyl Phosphate Polyethylene-mPEG (Polyethylene Glycol) 2000 in a self-assembly manner; the structure of the cat B-C-550 is as shown in a formula I in the specification. The invention discloses an application of cat B enzyme activated chemiluminescent nanoparticles in preparation of reagents or drugs for screening or diagnosing tumors. The invention discloses an application of cat B enzyme activated chemiluminescent nanoparticles in preparation of a cancer imaging reagent and / or a medicine for treating tumors. According to the invention, chemiluminescence imaging and in-situ cancer PDT treatment without external exciting light are realized. The cat B enzyme response type chemiluminescent nanoparticles are high in stability and can be effectively targeted and enriched at tumor focus parts.

The application provides a nano-catalytic material system capable of targeting tumors for gene editing, which is obtained by loading a CRISPR / Cas9 plasmid of a gene editing system capable of editing a core protein gene GPX4 related to cell ferroptosis into the pores of an iron single-atom nano-catalyst, and then modifying the cell membrane of a homologous tumor. The nano-catalytic material system provided by the application has excellent Fenton catalytic performance, can accurately edit target genes, induces tumor cells to undergo ferroptosis, and has the advantages of simple synthesis process, low cost, easy batch production, high enrichment degree at a lesion site, good treatment effect, and good clinical application prospect.

The present application relates to the technical field of early cancer risk assessment of digestive tract, and particularly relates to a confocal endoscope early cancer risk assessment method of digestive tract based on artificial intelligence. The method acquires macroscopic images and microscopic images of the digestive tract and a reference position of the confocal probe in the macroscopic images in real time; according to the differences in gray scale and reference position distribution between the macroscopic images at the current moment and the previous adjacent moment and the differences in shape and position distribution of the cell regions in the microscopic images at the current moment and the previous adjacent moment, a comprehensive relative displacement vector of the confocal probe at the current moment is acquired; based on the reference position at the previous adjacent moment of the current moment and the comprehensive relative displacement vector, a corrected reference position of the confocal probe in the macroscopic images at the current moment is acquired. The present application acquires the corrected reference position of the confocal probe in the macroscopic images in real time, and effectively improves the accuracy of the early cancer lesion site positioning of the digestive tract.

The application discloses an amino benzene sulfonamide derivative and application thereof. The structural general formula of the amino benzene sulfonamide derivative is shown in the following formula. The amino benzene sulfonamide derivative has good pepsin inhibitory activity, can effectively block the adhesion and reactivation of pepsin in the pharyngeal mucosa, and has super high selectivity in the internal proteinase family compared with other non-specific protease inhibitors, thereby significantly reducing the off-target risk of normal physiological proteases in the human body. In addition, the compound is particularly suitable for local spray administration in the throat, can maintain a high concentration in the lesion site, and overcomes the defect of traditional oral antacid drugs in the insufficient effect on non-acid reflux, thereby providing a new solution for the treatment of throat reflux diseases.

The application relates to application of a piezoelectric material in preparation of a medicine for treating gout, characterized in that a medicine active ingredient of the medicine comprises the piezoelectric material, the piezoelectric material is barium titanate; the application comprises the following steps: delivering the medicine to a lesion site, applying ultrasonic stimulation to the lesion site, and exciting in-vivo active species degradation of uric acid by the medicine. The piezoelectric material has good piezoelectric catalytic performance, excellent tissue penetration ability, low toxicity and high precision, active species can be controllably excited by means of ultrasonic action at the time of gout attack, uric acid can be efficiently degraded into allantoin which is good in solubility and non-toxic, symptoms can be rapidly relieved, the piezoelectric material can be long-term resident in joints, can keep stable catalytic effect in multiple cycles, and long-term treatment of gout can be realized by single injection, and a new gout treatment scheme which is more effective and more durable is provided.

The present invention relates to a local targeting photodynamic therapy device for treating cancer. In more detail, an endoscope is disposed at the center of the end of a probe for photodynamic therapy, and a plurality of optical fibers are disposed along the edge to irradiate a plurality of lights to a lesion site, wherein the plurality of optical fibers of the probe receive light from independent light sources to independently perform light irradiation. The present invention is a device for minimizing damage to unnecessary normal tissue by adjusting the light irradiation area, i.e., each independent light source determines a light irradiation area including a lesion site in a real-time image provided by an endoscope disposed at the end of the probe, and only causes the independent light source that irradiates the determined light irradiation area to emit light, thereby achieving local light irradiation, etc. The local targeting photodynamic therapy device of the present invention can treat a variety of cancers or tumors, including cervical cancer, female cancers (endometrial cancer, ovarian cancer, breast cancer), skin cancer, brain cancer, etc., which are small and can be treated locally.

This invention provides a thrombus aspiration catheter with a variable distal inner diameter, belonging to the field of interventional surgical instrument technology. The catheter includes an interventional catheter, an operating handle, and a collection component. The interventional catheter is used to move along the blood vessel to approach the thrombus location. The operating handle is located at the proximal end of the interventional catheter to provide suction force. The collection component is located at the distal end of the interventional catheter, with its proximal end communicating with the interventional catheter and its distal end open and adjustable in diameter. When the interventional catheter moves along the blood vessel to approach the thrombus, the diameter of the collection component is in a contracted state and not larger than the diameter of the interventional catheter. After the collection component reaches its position, it expands to increase its distal diameter for overall thrombus aspiration. This invention primarily addresses the technical problems of existing small-diameter thrombus aspiration catheters, which suffer from insufficient suction force, require repeated aspiration, and are prone to thrombus escape, while large-diameter catheters have poor permeability and are difficult to reach the lesion site.

The invention discloses a traditional Chinese medicine preparation for preventing postoperative vascular stenosis and occlusion and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine preparation for preventing postoperative vascular stenosis and occlusion is prepared from a multi-layer assembled amphiphilic polymer, a traditional Chinese medicine compound extract and curcumin, the multi-layer assembled amphiphilic polymer is used as a carrier, curcumin and a traditional Chinese medicine compound extract are effectively loaded in an encapsulation and adsorption mode, the drug loading capacity is improved, the drug concentration of a drug at a vascular focus part can be remarkably improved in a long-circulation, targeting and pH response release precise delivery mode, the bioavailability of the drug is improved, and the bioavailability of the drug is improved. Meanwhile, the precise delivery mode can also reduce the distribution of the medicine in normal tissues, so that the toxic and side effects are reduced, and the treatment safety is improved.

The application discloses a multi-component synovitis treatment composition based on repairing cartilage tissue and application thereof, and relates to the technical field of biological medicine, and the composition is composed of glucosamine hydrochloride, chondroitin sulfate, dimethyl sulfone and graded molecular weight sodium hyaluronate; the application precisely compounding the graded molecular weight sodium hyaluronate with the glucosamine hydrochloride, the chondroitin sulfate and the dimethyl sulfone according to weight parts, constructs a gradient slow-release and target delivery system of synovitis lesions, specifically inhibits the activity of hyaluronidase in the inflammatory joint cavity by using the dimethyl sulfone, greatly reduces the degradation of the sodium hyaluronate, prolongs the residence time of the active ingredients at the lesion site, realizes immediate analgesia and relieves joint stiffness by quickly forming a lubricating protective film by the high molecular weight sodium hyaluronate, the medium and low molecular weight sodium hyaluronate penetrates the synovial membrane barrier and carries the cartilage repair components to enrich in the cartilage defect area, and the synergistic effect of the components is realized.

The invention discloses a multi-modal fusion maternal and child medical image intelligent identification and diagnosis auxiliary system and method, and belongs to the technical field of medical health, and the system comprises a data obtaining module which is used for obtaining a medical image of a related part of a patient, the related part comprises an area corresponding to gland tissue, related processing is carried out on the medical image, and the medical image is obtained; the correlation processing includes distinguishing the medical image into an image corresponding to a gland and an image corresponding to connective tissue. According to the method, by obtaining and distinguishing gland and connective tissue medical images, extracting edge features and monitoring area changes, the lesion site can be accurately judged, the distance change between the blood vessel and the blood vessel group can be quantitatively evaluated, then the lesion development trend is scientifically judged, a comprehensive and objective diagnosis basis is provided for doctors, and the diagnosis efficiency is improved. And the diagnosis accuracy and the clinical decision scientificity are effectively improved.

The exosome-glucan compound preparation provided by the invention comprises a stem cell exosome, the final concentration of the stem cell exosome in the exosome-glucan compound preparation is 1 * 10 < 8 > parts / mL to 1 * 10 < 12 > parts / mL based on particle concentration quantification or 1 mu g / mL to 500 mu g / mL based on exosome total protein quantification, and the final concentration of the stem cell exosome in the exosome-glucan compound preparation is 1 * 10 < 8 > parts / mL to 1 * 10 < 12 > parts / mL based on particle concentration quantification or 1 mu g / mL to 500 mu g / mL based on particle concentration quantification. The dextran is used as a matrix entrapment stem cell exosome, the weight-average molecular weight of the dextran is 10kDa to 5000kD, and the weight / volume percent of the dextran in the exosome-dextran compound preparation is 0.5% to 20%; glucan is used as a biocompatible matrix, and a lipid bilayer structure of the glucan wraps the stem cell exosome to form a physical protection barrier, so that the stem cell exosome is prevented from being degraded and inactivated in an in-vitro storage or in-vivo complex environment; and the degradation rate of the glucan matrix is matched with the wound healing period, so that long-acting slow release of the exosome is realized, and the bioavailability of a focus part is improved.

The application belongs to the technical field of biological medicine, and particularly relates to an ultrathin radioactive patch for skin cancer treatment and a preparation method thereof. The preparation method comprises the following steps: adding a photoinitiator solution into a methyl methacrylate gelatin solution, and performing water bath heating dissolution under light shielding conditions; after the dissolution is completed, mixing the radioactive particles used for external irradiation treatment, stirring to a semi-solid state, smearing to a patch bottom film by using a smearing part, covering the patch anti-adhesion paper on the surface, irradiating and curing by using a light source, and obtaining the ultrathin radioactive patch. The patch prepared by the application can be customized according to the size and shape of a lesion site, a corresponding bottom film is cut out and attached to the lesion site, and smearing is directly performed. Compared with a common radioactive hydrogel, the preparation method is simpler, the preparation time is shorter, and the efficiency is higher.

The invention relates to a traditional Chinese medicine composition for treating ankylosing spondylitis, a medicine and a preparation method, and relates to the technical field of traditional Chinese medicines. The invention provides a traditional Chinese medicine composition for treating ankylosing spondylitis. The traditional Chinese medicine composition is prepared from the following raw materials: garden balsam stem, herb of Chinese rabdosia, spina gleditsiae, pangolin scales, camellia oleifera, radix angelicae, sargentgloryvine stem, folium artemisiae argyi, herba asari, leech, ficus microcarpa, semiliquidambar cathayensis, radix gleditsiae, sarcandra glabra, fructus liquidambaris and senecio scandens. The traditional Chinese medicine composition has the effects of dredging tendons and activating blood circulation, can deeply permeate into the body of a patient, enables swollen and calcified muscles and bones to recover to be normal, enables the skin color of a diseased region to recover to be normal, has a very good treatment effect on ankylosing spondylitis, is a neutral medicine, can be accepted by wet, cold and damp-heat constitutions, and is free of toxic and side effects. And the method has wide acceptability.

This invention discloses a method for fusing intracavitary ultrasound images and CT images based on electromagnetic positioning, comprising the following steps: scanning CT images of the lesion site and extracting a set of CT marker points S1; installing an electromagnetic positioning sensor on the intracavitary ultrasound probe; scanning multiple intracavitary ultrasound images of the lesion site and extracting a set of electromagnetic marker points S2; registering the CT image coordinate system with the electromagnetic positioning system coordinate system based on the CT marker point set S1 and the electromagnetic marker point set S2; and achieving real-time fusion of the CT image and the intracavitary ultrasound image based on the registration result. Using this invention, real-time fusion of intracavitary ultrasound images and CT images is achieved based on an electromagnetic positioning system, fully utilizing the advantages of multiple medical images to provide doctors with rich imaging information about the patient's lesion.

The invention relates to the technical field of capsule preparations, in particular to a medicinal capsule structure, which comprises a mother capsule and a sub-capsule filled in the mother capsule, and two working modes are realized through filling switching of the mother capsule: under the mode A (time sequence release), the mother capsule is filled with a quick-release medicine and the sub-capsule filled with a slow-release medicine at the same time, and under the mode B (time sequence release), the sub-capsule is filled with a slow-release medicine; multi-component off-peak release is realized by utilizing the quick release characteristic of the mother capsule and the slow release characteristic of the ascomycetes; and in the mode B (split swallowing), the mother capsule is only filled with the ascoid to adapt to people with dysphagia, and the ascoid can be taken in a mixed manner after the mother capsule is split, and the function of a medicine coating is reserved. The ascus is composed of a medicine containing cavity, a targeting layer and an anchoring layer, the targeting layer can be made of an arabinoxylan-chitosan compound (colon targeting) or a methacrylic acid copolymer (esophageal targeting), the anchoring layer is made of a hyaluronic acid-chitosan compound, and it is ensured that the ascus is anchored at the focus position. The preparation has multiple functions of sequential release, targeted drug delivery, adaptation to people with dysphagia and the like.