351 results about "Lesion site" patented technology

The invention discloses a preparation method of artemisia apiacea extracellular vesicles, which comprises the following steps: step 1, pre-treating artemisia apiacea, carrying out primary centrifugal treatment, removing large plant tissues and cell debris, carrying out secondary centrifugal treatment, filtering by a needle filter, and collecting; step 2, transferring the filtered suspension to a sucrose density gradient solution, then carrying out third centrifugal treatment, collecting the solution with the concentration of 30% in the layer, and carrying out fourth centrifugal treatment to obtain artemisia apiacea extracellular vesicles; the invention further discloses an artemisia apiacea extracellular vesicle, a pharmaceutical composition for treating cerebral apoplexy, a medicine and application of the artemisia apiacea extracellular vesicle in preparation of the medicine for treating cerebral apoplexy. The naturally-sourced vesicle delivery system provided by the invention is expected to have higher safety and lower toxic and side effects, and the enrichment concentration of the therapeutic component at the focus part of cerebral apoplexy is improved, so that the bioavailability and the treatment efficiency of the medicine are remarkably improved.

The invention relates to a breast tumor lesion part ultrasonic image segmentation method based on an SAM-VMama model. The method comprises the steps of obtaining a breast ultrasonic image set and performing preprocessing; the method comprises the following steps: constructing an SAM-VMama model, wherein the SAM-VMama model comprises a first encoder, a second encoder, a prompt encoder and a mask decoder; obtaining a trained model; obtaining a preprocessed breast ultrasound image to be segmented; and obtaining a segmentation result of the breast lesion tumor. According to the method, the local features are extracted through the first extraction, the global features are extracted through the second encoder, the interactive prompt information processed by the prompt encoder is combined, and the precise segmentation mask is generated through the mask decoder; the method not only retains the flexibility of SAM interactive segmentation, but also improves the long-sequence data processing capability and calculation efficiency through a Mamba structure, effectively adapts to the characteristics of uneven gray scale, multiple artifacts and the like of the ultrasonic image, and achieves the balance of high precision and high efficiency.

The invention relates to double-encapsulated lipid nanoparticles entering brain through nose and a preparation method and application thereof, the double-encapsulated lipid nanoparticles comprise lipid nanoparticles, drugs in the lipid nanoparticles and rana odorata lectin coupled to the surfaces of the lipid nanoparticles, and the drugs comprise hydrophilic drugs and hydrophobic drugs. According to the invention, the rana odorata lectin and the lipid nanoparticles are coupled, and the rana odorata lectin can be specifically combined with L-fucose residues expressed by olfactory epithelial cells, so that the adhesion of the lipid nanoparticles to olfactory epithelium during nasal administration is enhanced, and the brain entering efficiency of the lipid nanoparticles is finally improved. After entering the brain, the lipid nanoparticles respond to diseased regions with high active oxygen content so as to release drugs. In addition, double-drug encapsulation can target different pathogenesis of central nervous system diseases, and the limitation that a traditional treatment drug is single in action target is improved.

The invention provides a thrombus aspiration catheter with the variable inner diameter of the far end, and belongs to the technical field of interventional surgical instruments.The catheter comprises an interventional catheter, an operating handle and a collecting component, and the interventional catheter is used for moving along a blood vessel to be close to the thrombus position; the operating handle is arranged at the near end of the interventional catheter and is used for providing suction force for the interventional catheter; the collecting part is arranged at the far end of the interventional catheter, the near end of the collecting part is communicated with the interventional catheter, and the far end is open and adjustable in diameter; when the interventional catheter moves along the blood vessel to be close to the thrombus, the diameter of the collecting part is in a contracted state and is not larger than that of the interventional catheter, and after the collecting part is in place, the collecting part expands to increase the diameter of the far end so as to integrally suck the thrombus; the thrombus aspiration catheter is mainly used for solving the technical problems that in the prior art, a small-caliber thrombus aspiration catheter is insufficient in aspiration force, repeated aspiration is needed, thrombus escape is easily caused, and a large-caliber catheter is poor in passing ability and difficult to reach a diseased region.

The intelligent gynecological flushing system comprises a gynecological flushing platform, a colposcope image guiding system, a self-adaptive flushing execution system and an evaluation feedback optimization system, and the gynecological flushing platform is used for supporting a patient to conduct gynecological flushing; the colposcope image guiding system is used for collecting colposcope image data, identifying lesion characteristics based on an image identification technology, and transmitting an identification result to the self-adaptive flushing execution system; the self-adaptive flushing execution system is used for carrying out self-adaptive gynecological flushing on the focus part by utilizing flushing fluid according to the guidance of the colposcope image guidance system and based on the basic information of the patient; and the evaluation feedback optimization system is used for collecting the components of the flushing fluid after flushing and the reaction of the flushing part, performing quantitative evaluation on the flushing effect, feeding back the evaluation result to the self-adaptive flushing execution system, and optimizing the self-adaptive flushing parameters of the self-adaptive flushing execution system. According to the invention, the stability and accuracy of the flushing process can be ensured.

The invention discloses a capsule medicament for endoscopic treatment of ulcerative colitis and a preparation method thereof, and belongs to the technical field of biological medicine, the capsule medicament is composed of a capsule matrix and a drug matrix; by adopting a dual control mechanism of an enteric layer coating and a pH response layer coating, accurate release of a medicine at a colon diseased region is ensured, medicine waste of the stomach and the small intestine is reduced, the medicine concentration at a focus is improved, mesalazine or budesonide is combined with the composite composition for treatment, inflammatory response is rapidly inhibited, acute symptoms are controlled, and the curative effect is good. A multi-mechanism synergistic treatment mode is adopted, the anti-inflammatory and repairing effects are enhanced, the clinical remission rate and the mucous membrane healing rate are remarkably improved, the pH response layer is dissolved in a colon alkaline environment, and the MMP-9 peptide cross-linking agent is subjected to enzymolysis at an inflammation part, so that the medicine is continuously released at a focus, the administration frequency is reduced, the compliance of a patient is improved, and the curative effect is good. In addition, the spherical gel particles in the medicament can prevent the medicament from being disintegrated too early in the intestinal tract, and the long-acting effect can be maintained.

A method for providing primary therapy to restore functional blood flow to a back of an eye may include advancing a guidewire through an access site in a subject to an ostium of an ophthalmic artery (OA) via an internal carotid artery (ICA), advancing a microcatheter to the ostium of the OA, retracting the guidewire into the microcatheter, such that a distal tip of the microcatheter assumes a pre-shaped configuration, advancing the microcatheter to cannulate a short limb of the OA, advancing the guidewire to a position approximately at or beyond a central carotid artery (CRA) branch of the OA, removing the microcatheter, advancing a treatment device over the guidewire to a lesion site in the OA of the subject, performing a treatment with the treatment device, and removing the treatment device and the guidewire from the subject.

The invention belongs to the technical field of medical instruments, and discloses a digestive endoscopy diseased region accurate positioning and marking device which comprises a controller, an endoscope hose is fixedly connected to the bottom of the controller, and an instrument insertion opening is formed in the right side of the controller. Through the arrangement of the sleeve, the dye tube, the pressurization air bag and the baffle, after an operator observes a diseased region through the endoscope hose, the operator only needs to align the endoscope hose to the diseased region, and by pressing the pressurization air bag, air in the pressurization air bag enters the dye tube through the inner hose; the baffle can be pushed to rotate outwards under the action of air pressure, meanwhile, methylene blue in the dye tube is sprayed out under the action of air flow, a diseased region is marked, the methylene blue can be absorbed by normal mucous membrane cells, and diseased tissue shows dyeing difference due to abnormal cell function and poor absorption capacity, so that the diseased region is marked. Therefore, the effect of accurate positioning is achieved.

The invention belongs to the technical field of biological medicines, and particularly relates to nasal temperature-sensitive hydrogel with immunoregulation and anti-inflammatory functions as well as a preparation method and application of the nasal temperature-sensitive hydrogel. The preparation method of the nasal temperature-sensitive hydrogel with the immunoregulation and anti-inflammatory functions comprises the following steps: preparation of hydroxybutyl chitosan (HBC), preparation of levodopa-hydroxybutyl chitosan (LHBC), and preparation of CELHBC composite hydrogel. The novel temperature-sensitive hydrogel composite material of the composite hydrogel loaded with the chlorella / exosome can be used for the focus position of allergic rhinitis, and enrichment and retention of active ingredients are achieved; the chlorella is combined with the exosome, so that the inflammatory response of nasal mucosa can be relieved, the damaged nasal mucosa can be repaired, and the immune imbalance of Th1 / Th2 cells can be reversed, thereby improving the treatment effect of allergic rhinitis.

The invention discloses a nano-drug delivery system for treating myocardial fibrosis as well as a preparation method and application of the nano-drug delivery system, and belongs to the technical field of biological medicines. According to the system, ZIF-8 is taken as a core carrier, the loading efficiency of pirfenidone is improved through high specific surface area and adjustable aperture, PCM myocardial targeting peptide is covalently coupled on the surface, and the limitation of tissue selectivity is broken through. Through coordination complexation, pi-pi conjugate accumulation and electrostatic interaction synergy, stable drug loading and microenvironment response release are guaranteed; a one-pot method and a carbodiimide method are adopted to wrap PFD and modify PCM on the surface of ZIF-8 to form a nano-drug delivery system; according to the system, the fibrosis process is intervened through multiple mechanisms, the enrichment degree and the acting time of the medicine at the diseased region are improved, the prepared medicine integrates the carrier structure advantage and the targeting peptide function, efficient medicine carrying, precise delivery and controllable release are achieved, a new scheme is provided for myocardial fibrosis treatment, and the system has wide application prospects.

The inhalation suspension preparation containing the SGC receptor stimulant comprises the SGC receptor stimulant with an effective therapeutic dose or pharmaceutically acceptable salt of the SGC receptor stimulant, and pharmaceutically acceptable auxiliary materials of the suspension preparation, the pharmaceutically acceptable auxiliary materials of the suspension preparation comprise at least one of a surfactant, a pH regulator, an osmotic pressure regulator and a metal complexing agent; the inhalation suspension preparation containing the riociguat shows good lung absorption efficiency, is beneficial to reaching the same or better treatment level by reducing the administration dosage, can directly act on a diseased region through an administration route, takes effect more quickly compared with oral administration of the riociguat, and has a good application prospect. Gastrointestinal discomfort and systemic hypotension side effects caused by gastrointestinal tract contact and absorption entering a circulatory system can be avoided, the treatment cycle of an oral dosage form dosage titration administration scheme is shortened, and a better treatment scheme is provided for relieving dyspnea and syncope symptoms of pulmonary hypertension patients treated at home.

The invention belongs to the field of medical devices, and particularly relates to a soft robot thrombus removing device which comprises a robot body, a minimally invasive thrombus taking head, an external magnetic field control device and an imaging display device. The minimally invasive thrombectomy head comprises a front section thrombectomy part, a middle section positioning part and a tail section control part; a plurality of through hole structures are arranged in the thrombus extraction component; a rotating structure, a suction component and a clamping structure are respectively arranged in a plurality of through hole structures arranged in the thrombus extraction component; a magnetic navigation sensor is arranged in a middle section positioning component of the minimally invasive thrombus extraction head; a control unit electrically connected with the rotating structure, the suction part and the clamping structure is arranged in the control part at the tail section of the minimally invasive thrombus extraction head; the robot body is transported to the position close to the diseased region through the catheter and the puncture needle sheath. The device has the advantages that the device is specially designed for treating vascular embolism, is particularly suitable for removing thrombus of small blood vessels such as cerebral vessels, and has extremely high flexibility and operation precision.

The application provides a multifunctional nano particle for targeting abdominal aortic aneurysm and a preparation method and application thereof, and belongs to the field of nanobiomedicine, wherein polyphenol oxidation self-polymer nanoparticles are used as carriers, doxycycline is loaded, and a targeting ligand cRGD is modified on the surface of the nano carrier; the neovasculature in the media and adventitia of AAA sites helps accumulation of the nanoparticles in the abdominal aortic aneurysm, and the integrin αν3 beta receptor highly expressed on the surface of the diseased cell membrane can recognize the cRGD with high affinity, and then mediate the targeted endocytosis of the nanoparticles; after intravenous injection, the nanoparticles can be effectively enriched in the lesion site and achieve long-term retention, and can release DC in response to the high ROS level in the tumor microenvironment; the drug is rapidly released to take effect, and the non-specific toxic side effects are reduced; the free radical scavenging capacity of the nanoparticles can be synergized with the DC activity to treat AAA through multiple mechanisms such as anti-inflammatory, antioxidant, macrophage repolarization promotion, anti-apoptosis and calcification inhibition, and MMPs inhibition.

The invention discloses a cryoablation catheter system for pulmonary artery stent internal restenosis, and belongs to the field of medical instruments, the cryoablation catheter system comprises a catheter main body arranged on a guide wire, the catheter main body is provided with a treatment assembly, the treatment assembly is located at the far end of the catheter main body, the catheter main body is provided with a control handle, and the control handle is located at the far end of the catheter main body. The control handle is located at the near end of the catheter body, and the treatment assembly comprises a near-end balloon, a far-end balloon and a freezing balloon. When the near-end balloon and the far-end balloon are simultaneously full, a closed treatment cabin isolated from near-end blood flow and far-end blood flow can be formed in a blood vessel of a target treatment section, the freezing balloon is located in the treatment cabin, the closed treatment cabin thoroughly eliminates the blood flow hot pool effect, cold is prevented from being taken away by the blood flow, and the treatment effect is improved. Freezing energy is intensively acted on a diseased region, so that the ablation efficiency and accuracy are improved; meanwhile, thrombus, tissue debris and whole body blood flow which fall off in the treatment process are isolated, the risk of far-end embolism is reduced from the source, and damage to the blood vessel wall is avoided.

The application provides a single-bending-degree support laryngoscope with variable rigidity and a method for using the same. The device comprises a bendable joint, a driving component and a variable rigidity structure. The distal joint, the middle joint and the proximal joint are hollow structures and are in communication with each other to form an operation channel. The variable rigidity structure is installed in the operation channel. The variable rigidity structure comprises a distal rod, a connecting rod, a translation rod, a proximal rod, a horizontal sliding block and a sliding block frame. The driving component comprises a rudder, a front side driving line, a back side driving line, a guide wheel, a limiting wheel, a driving wheel and a tension spring. The application can be freely bent at a certain angle to expose a lesion site and has a larger field of view. The back side driving line is connected in series with the tension spring, so that self-adaptive adjustment is realized, the structural compliance is enhanced, the system is stable, and the robustness is good. The angle adjustment and the rigidity enhancement realized are both stepless adjustment, the adjustment range is large, and the device is suitable for various application requirements.

This invention relates to an acoustic energy guidewire system and an energy guidewire, the energy guidewire comprising a pushing section and a developing section. The first end of the pushing section is connected to a main unit or handle, and the pushing section is made of metal. The developing section includes a mandrel and a covering layer disposed outside the mandrel. One of the mandrel and the covering layer is integrally formed with its second end, while the other is made of a metallic developing material. The elastic modulus of the pushing section is greater than that of the developing section. During operation, the developing section, driven by the pushing section, enters the lesion site and applies its energy to the lesion site, thereby achieving a therapeutic effect. Because one of the mandrel and the covering layer is integrally formed with the second end and the pushing section, the continuous, weld-free, integrated structure reduces stress concentration points in the overall mechanical structure of the product. This prevents rapid failure at stress concentration points, ensuring the energy guidewire can safely and stably transmit mechanical acoustic energy.

The utility model provides a C-shaped curved stepped balloon catheter, which relates to the technical field of kidney intervention.The C-shaped curved stepped balloon catheter comprises a first balloon head end, the side end of the first balloon head end is integrally communicated with a concave bent wrinkled edge, and the side end of the concave bent wrinkled edge is integrally communicated with a second balloon tail end. In a non-working state, the wall of the balloon in the whole structure is folded to be in a straight column shape, a guide wire can conveniently pass through the balloon to reach a diseased region, in a working state, the whole balloon is in a C shape and is divided into two sections, the diameter of the head end of the first balloon ranges from 4 mm to 5 mm, the first balloon crosses an internal fistula anastomotic stoma to be placed in an artery, the diameter of the tail end of the second balloon ranges from 6 mm to be placed in a vein, and after the whole balloon is placed into a target lesion through the guide wire, the whole balloon is placed into the target lesion through the guide wire. The bending direction is adjusted, a pressure pump is connected, pressurization is conducted, the head end of the first balloon, the concave bending wrinkled edge and the tail end of the second balloon are expanded, arteries and veins with different inner diameters are expanded at the same time through radial force, and fracture caused by tearing of anastomotic stoma is avoided.

The invention discloses a prostate therapeutic instrument, and belongs to the technical field of medical instruments. A massage head slides at the front end of the shell, and a plurality of guide sliding grooves are evenly distributed in the massage head. A center column is fixed to the center of the shell, and a first disc body and a second disc body are arranged on the center column. A plurality of sliding sleeves are arranged between the first disc body and the second disc body in a circumferential array mode, connecting blocks are arranged on the multiple sliding sleeves, each connecting block is arranged in the corresponding guide sliding groove, and air cavities are formed in the multiple sliding sleeves; wherein a plurality of stand columns are arranged on the first disc body in the circumferential direction in an array mode, the stand columns are inserted into the corresponding air cavities in a sliding mode respectively, and each stand column is connected with an air pipe. Through an inflation and deflation circulation system driven by a micro air pump, the sliding sleeves can be regularly pushed to reciprocate along the stand columns, and then the massage heads are driven to generate displacement; pulse type mechanical stimulation on a prostate focus part is formed; the dynamic pressing can effectively promote microcirculation of prostate tissues.

The invention discloses application of an ATP (adenosine triphosphate) citrate lyase (ACLY) inhibitor in preparation of a medicine for treating leucoderma, and belongs to the technical field of preparation of medicines for treating leucoderma. Through targeted inhibition of ACLY activity or specific knockout of ACLY in CD8 + T cells, abnormal activation of ACLY and secretion of killing effector molecules (Granzyme B, IFN-gamma, Perforin and the like) are inhibited, and infiltration of the CD8 + T cells to skin lesion parts is reduced, so that melanocytes are protected from immune injury, and the progress of vitiligo is blocked. The application is based on the abnormally high expression of ACLY in CD8 + T cells of vitiligo patients and the close association with disease activity, and a brand new targeted treatment thought and a medicine research and development direction are provided for vitiligo.

The article is a catheter head used with an atherectomy device, or can be permanently attached to the device. While the internal archimedes screw rotates in the atherectomy device to pulverize the lesion and aid in aspiration, the article rotates with the screw to directly engage the lesion.

The invention belongs to the technical field of medical biological detection, and particularly relates to a gene marker combination for oral mucosa leukoplakia canceration risk and application of the gene marker combination. The gene marker combination is a combination of TP53, CASP8 and CYP2B6 genes and is obtained by screening through a WES technology, the predicted AUC of the gene marker combination reaches 0.813 (95% CI: 0.710-0.916), and the performance of the gene marker combination is remarkably superior to that of traditional pathological grading. Through Cox risk regression analysis, a high-risk group as an independent factor has significant statistical significance and is superior to traditional indexes such as age and diseased regions. The invention further provides an oral mucosa leukoplakia canceration risk prediction kit and prediction system derived from the gene combination.

The present invention discloses a method, system and storage medium for visualization of an AI laparoscope based on focus tracking, which relates to the field of medical information recognition and tracking. An AI laparoscope is used to adjust different angles and brightness to generate a full-wide-angle and omnidirectional video of the region of interest; key frame images are extracted from the video of the region of interest, and the key frame images include images of the lesion site and images containing both the AI ​​laparoscope body and surgical instruments; a deep learning algorithm is used to simultaneously extract image features of different scales corresponding to the key frame images, and a lens tracking signal and an obstacle avoidance control signal are generated; the lens tracking signal has a higher priority than the obstacle avoidance control signal to achieve efficient tracking of the lesion site, and the video of the region of interest is reconstructed based on the tracking of the lesion site by the lens tracking signal and the avoidance path of the AI ​​laparoscope to complete the AI ​​laparoscope visualization. The present invention uses AI technology to achieve focus tracking, video splicing, feature extraction and signal generation to make laparoscope visualization more intelligent.

The invention discloses a preparation method and application of polypeptide hydrogel loaded with modified CAR-T cells and CXCL9, and creatively discovers that the combination of the modified CAR-T cells and the CXCL9 has a remarkable synergistic effect on treatment of melanoma for the first time. According to the invention, efficient enrichment of CAR-T cells at a focus part is realized through the hydrogel delivery system, the local curative effect is improved, in addition, the introduction of CXCL9 further enhances the tumor infiltration capability and the treatment effect of the CAR-T cells, a brand new treatment scheme is provided for tumor treatment, and the clinical application prospect is wide.

The invention discloses an esophageal local medicine perfusion balloon catheter, and relates to the technical field of medical instruments, the esophageal local medicine perfusion balloon catheter comprises a main catheter body, a first injection catheter, a second injection catheter and a liquid medicine injection catheter, a first plugging balloon and a second plugging balloon are arranged in the main catheter body, and a gap is arranged between the first plugging balloon and the second plugging balloon; the first blocking balloon is communicated with the first injection catheter, the second blocking balloon is communicated with the second injection catheter, and the liquid medicine injection catheter is communicated with the main catheter body. By means of the arrangement, the double-balloon design is adopted, blocking of the far-end esophageal cavity and the near-end esophageal cavity with the esophageal lesion can be achieved so as to form a closed cavity for medicine perfusion, the catheter can be fixed to the lesion part, and medicine perfusate in the closed cavity can overflow to the far-end gastrointestinal tract or hiccup to the respiratory tract.

The present invention relates to an electronic flexible and rigid endoscope system and method applicable to general practice. The system comprises: a data acquisition system, configured to acquire image data of a lesion site, and a data processing system, configured to process the image data from the data acquisition system. The data acquisition system comprises a handle end and an endoscope end, the endoscope end comprises an imaging insertion end and an operating end, the imaging insertion end enters the lesion site to acquire images of the lesion site, the operating end controls the action of the imaging insertion end, the handle end sends the image data acquired by the endoscope end to the data processing system, the data processing system comprises a data receiving module and an image processing module, and the data receiving module receives the image data acquired by the data acquisition system.

The present invention discloses a magnetically guided sampling capsule robot and a sampling method, which relate to the technical field of capsule robots. A first capsule shell and a second capsule shell interlock to form an internal cavity. An internal magnet is located in the internal cavity. A first soft magnetic film and a second soft magnetic film are located on either side of the internal magnet. In the absence of an external magnetic field, the first soft magnetic film and the second soft magnetic film both protrude toward the internal magnet. A first sampling hole is provided on the first capsule shell, forming a first sampling cavity between the first capsule shell and the first soft magnetic film. A second sampling hole is provided on the second capsule shell, forming a second sampling cavity between the second capsule shell and the second soft magnetic film. The present invention is used for sampling gastric fluid and / or mucosa at a lesion site, can achieve anchored sampling under the action of an external magnetic field, and can achieve a single gastric entry and multiple sampling operations through the design of the symmetrically arranged first and second sampling cavities.

The utility model relates to a tumor-free isolation device for laparoscopic surgery, and belongs to the technical field of medical instruments. The tumor-free isolation device for the laparoscopic surgery comprises a cannula assembly and a tumor isolation assembly, wherein the tumor isolation assembly is arranged in the cannula assembly in a penetrating manner and extends out of the front end of the cannula assembly; the tumor isolation assembly comprises a connecting pipe, a head rod, a tumor isolation bag and a traction rod, the head rod is hinged to the front end of the connecting pipe, the tumor isolation bag is arranged on the head rod, the traction rod slidably penetrates through the connecting pipe, and the front end of the traction rod is hinged to the head rod; when the traction rod moves back and forth, the head rod can be driven to swing up and down, and the included angle between the opening of the tumor isolation bag and the axis of the connecting pipe is changed. According to the tumor-free isolation device for the laparoscopic surgery, the orientation of the opening of the tumor isolation bag can be automatically changed, so that the opening of the tumor isolation bag is aligned with a focus part, the bearing area is larger, and waste tissue or tissue fluid is not prone to escaping.

The invention belongs to the technical field of medical supplies, and particularly relates to an adjustable cervix uteri multi-point micro-injection device which comprises a guide cylinder, an adjusting mechanism is mounted in the guide cylinder, and an injection needle is mounted on the side, extending into a human body, of the adjusting mechanism; the other side of the adjusting mechanism is connected with the carry control mechanism, the rotation control mechanism and the deflection control mechanism through a first connecting rod, a second connecting rod and a third connecting rod. The other side of the adjusting mechanism is further connected with a connecting hose, and the other end of the connecting hose is connected with an injector. Wherein the adjusting mechanism comprises a carry mechanism, a rotating mechanism and a deflection mechanism, the situation that the device pierces other parts of the genital tract of a patient to cause injury before reaching the cervical lesion part can be avoided, and the injection needle can be deflected towards different parts through the adjusting mechanism; according to the device, the injection needle can accurately pierce a diseased region for injection under the condition that the adjustment range in the genital tract of a patient is minimum.

This disclosure discloses a surgical stapler (100) including a stapler body (200). One end of the stapler body is provided with a receiving opening (203) for receiving a lesion (220) of a specimen. A circular base (206) is positioned proximal to the receiving opening (203), and the circular base defines a curved path (202b) structured to guide one staple of a plurality of staples (300) toward an exit end (203b) defined at the receiving opening. A drive mechanism (202) is structured to displace one staple of the plurality of staples. The drive mechanism has a transport member (202a) configured to displace between a first position (A) and a second position (B) relative to the curved path. An actuator (212) is operably connected to the transport member. The deformation module (204) is positioned near the entrance end (203a) of the receiving end and is structured to deform a portion of one staple.

A diagnostic imaging assistance device 1 comprises: a first acquisition unit 10 for acquiring an image of a head through MRI; an image processing unit 11 for extracting a region containing information on a lesion site and the periphery of the lesion site from the acquired image of the head and generating a first image having the extracted region; an extraction unit 12 for extracting a predetermined image feature amount from the first image; a classification unit 14 for determining, on the basis of the image feature amount extracted by the extraction unit 12, the presence or absence of a molecular biomarker associated with the lesion site for classification using a pre-constructed classifier; and a presentation unit 15 for presenting assistance information related to whether or not the lesion site contained in the image of the head has the molecular biomarker, on the basis of the result of the classification by the classification unit 14.