11 results about "Biodegradable scaffold" patented technology

Implant materials fabricated from citrate-based materials are disclosed, which have particular applicability in the formation of biodegradable scaffolds and generally comprise compositions including (i) a citrate component, (ii) a polyol, and (iii) a particulate inorganic material.

Medical stent designs are disclosed. An example stent includes a tubular scaffold having a proximal end and a distal end. The tubular scaffold includes a first filament extending between the proximal end and the distal end, the first filament including a first biodegradable region positioned adjacent to a second biodegradable region. Further, the first biodegradable region includes a first biodegradable material, the first biodegradable material having a first rate of degradation. The second biodegradable region includes a second biodegradable material, the second biodegradable material having a second rate of degradation, wherein the first rate of degradation is different from the second rate of degradation.

A biodegradable scaffold and methods of vessel preparation and drug delivery using the biodegradable scaffold are described. The biodegradable scaffold may be used to treat vessel dissection, restore vessel elasticity, and to provide long term release of drugs to prevent smooth muscle cell proliferation.

This invention relates to the development of a biodegradable scaffold containing growth factor and antibiotic loaded nanoparticulate systems with the aim of enabling the regeneration of the pulp-dentin complex of immature permanent teeth with necrotic pulp damaged due to infection, trauma, or developmental anomalies.

The invention discloses a tumor organoid chip and application thereof in tumor organoid culture, the tumor organoid chip comprises a plurality of microfluidic units, the microfluidic units are used for simulating different tumor microenvironments, each microfluidic unit comprises a plurality of microchannels, an inlet and outlet channel and a microfluidic system, the conveying device is used for accurately conveying culture media, drugs, cell factors and growth factors; the 3D culture module adopts a nano-scale porous material and a biodegradable bracket to simulate a three-dimensional structure of a tumor tissue, and due to the design of the 3D culture module, the tumor-like organs can be self-assembled into a multi-layer tissue structure similar to a human tumor. By introducing a multi-cell co-culture system and a microfluidic technology, the tumor organ-like chip can simulate complex in-vivo microenvironments, including immune escape, angiogenesis, inter-tumor heterogeneity and the like, of tumors. Interaction among different cell types can be accurately controlled in the chip, so that tumor organs are closer to the physiological state of human tumors.

A synthetic rotator cuff repair scaffold / patch system fabricated from citrate-based materials is provided. The biodegradable scaffold / patch system includes (i) a citrate component and / or other carboxylic acid components, (ii) a polyol, and (iii) particulate inorganic material. The patch system includes a patch that defines a patch thickness and may define a porosity gradient across the patch thickness.

This invention belongs to the field of bone replacement material technology, specifically relating to a porous biodegradable bone replacement scaffold and its preparation method. The porous biodegradable scaffold of this invention consists of pillars, each pillar having an outer shell and a core. The outer shell comprises ZnO, and the core comprises Zn. The porous biodegradable bone replacement scaffold of this invention has a nano- to millimeter-level hierarchical pore structure, which is more similar to the structure of human bone. Furthermore, its degradation performance, antibacterial properties, and biocompatibility are superior to existing biodegradable metallic bone implant materials (zinc and its alloys), which helps promote osteogenic differentiation.

Disclosed herein are compositions of biodegradable scaffolds combined with mesenchymal stem cells and methods of use thereof for the regeneration of cranial sutures and treatment of craniosynostosis, which can help reverse increased intracranial pressure and skull and neurocognitive abnormalities.

The present invention provides a degradable stent for promoting artificial vascular tissue regeneration and a method for preparing the same. The degradable stent is a three-layer tubular stent constructed from a degradable polymer. The middle layer is a nanofiber layer. The inner and outer tube walls contain a large number of micropores, which are interconnected in series and extend from the inside outward to form a beaded structure. The beaded structure extends from the lumen to the outer surface and forms microchannels for cell migration. Cells can secrete extracellular matrix within the tube wall, thereby promoting the regeneration of new tissue. At the same time, the nanofiber layer separates the microporous channels of the inner and outer layers, allowing different cells to grow in the inner and outer layers respectively. Secondly, the pores in the nanofiber layer do not allow cells to pass through, but do allow nutrients and growth factors secreted by cells to pass through, thereby promoting information exchange between cells on both sides, regulating cell behavior, and further accelerating vascular remodeling.

A bioengineered endothelial stent designed for implantation in Schlemm's canal enhances aqueous humor outflow and restores physiological intraocular pressure regulation. Unlike conventional devices, this stent integrates transplanted Schlemm's canal endothelial cells (SCECs) to restore mechanosensitive outflow regulation. The stent features a biocompatible or biodegradable scaffold with an endothelial cell-seeding system to support integration into the Schlemm's canal inner wall. This regenerative approach maintains physiological resistance and prevents excessive drainage, offering a stable, cell-based alternative to conventional glaucoma stents.

A synthetic rotator cuff repair scaffold / patch system fabricated from citrate-based materials is provided. The biodegradable scaffold / patch system includes (i) a citrate component and / or other carboxylic acid components, (ii) a polyol, and (iii) particulate inorganic material. The patch system includes a patch that defines a patch thickness and may define a porosity gradient across the patch thickness.