104 results about "Tooth enamel" patented technology

The invention relates to a composition with functions of protecting gingiva and repairing enamel and a preparation method of the composition, and belongs to the technical field of oral care. The composition contains a functional additive, a plant compound fermentation extract and the like, the functional additive is a mixture of corn starch, calcium phosphosilicate, hydroxyapatite, ubiquinone, sodium guaiazulene sulfonate, menthol and vitamin E, and the plant compound fermentation extract is obtained by fermenting and purifying honeysuckle flowers, radix polygonati officinalis and dandelions according to a specific proportion. Through the synergistic effect of the fermentation extract and the functional components, the problems that an existing toothpaste body is hardened, the storage stability is poor, the gingival protecting effect is short, and the enamel repairing persistence is insufficient are solved, the gingival protecting effect can be enhanced, the enamel repairing effect can be improved, the stability of the toothpaste body can be optimized, the antibacterial property and the oral mucosa relieving effect are achieved, and the oral cavity repairing effect is achieved. And the preparation process is scientific and reasonable, and is suitable for daily oral care.

The invention relates to the technical field of oral cavities, and discloses an alveolar bone resorption degree detection method, device and equipment and a medium, oral cavity image data of a patient is obtained, and tooth jaw segmentation data extraction is performed on the oral cavity image data to obtain tooth jaw segmentation data; performing three-dimensional space morphological feature analysis on tooth segmentation data in the tooth jaw segmentation data to obtain tooth coordinate azimuth information; calculating periodontal measurement surface information according to the tooth coordinate azimuth information; extracting enamel boundary line data and alveolar bone boundary line data in the dental jaw segmentation data; calculating an alveolar bone resorption degree result according to the enamel boundary line data, the alveolar bone boundary line data and the periodontal measurement surface information; the alveolar bone resorption degree result is calculated through the boundary line data and the measurement surface information, and the accuracy of the result is improved while the resorption degree is accurately quantified.

The invention relates to the technical field of oral biological materials, in particular to a self-adaptive anti-caries coating as well as a preparation method and application thereof. The coating is prepared from random and block polymers, and is specifically prepared by polymerizing acid radical-containing functional monomers, phenylboronic acid and derivatives thereof. Construction of the coating depends on specific coordination of a functional group and Ca < 2 + > in enamel, and stable anchoring on the tooth surface is achieved. The core action mechanism is to introduce phenylboronic acid groups to endow the coating with pH sensitive characteristics: in a cariogenic acid environment, biofilm formation is synergistically inhibited through a plurality of mechanisms such as physical barrier, electrostatic repulsion and inhibition of mucoprotein-mediated adhesion. According to the application, the Ca < 2 + > anchoring monomer, phenylboronic acid and the derivative thereof are copolymerized, design is carried out aiming at two key links of protein adsorption and bacterial adhesion, multi-mechanism synergy and environment dynamic response are integrated, and an integrated anti-caries effect from early intervention to long-term protection is realized.

A dental varnish composition for promoting enamel remineralization may comprise nano-hydroxyapatite particles dispersed in a biocompatible resin matrix that forms an adhesive film on tooth enamel. The composition may include a solvent to facilitate uniform dispersion and one or more additives. The resin matrix may be hydrophilic to enhance adhesion and wetting of enamel microstructures. Contact with saliva triggers controlled, gradual release of nano-hydroxyapatite, providing sustained remineralization benefits and protection against demineralization over an extended period. The nano-hydroxyapatite may penetrate enamel microstructures and repair microlesions, while optionally reducing dentin hypersensitivity. The composition may be fluoride-free and formulated with defined weight ratios of resin, particles, and solvent. A method of treatment includes applying the varnish to tooth surfaces, forming the adhesive film, and allowing slow release of nano-hydroxyapatite to strengthen enamel.

The present application relates to a kind of tooth sample digestion system and method, belong to tooth sample detection field, for solving the tooth sample digestion system in prior art in peeling enamel, using diamond line to cut tooth, after cutting, using scalpel and forceps to separate enamel and dentin, and manually grinding enamel, it is difficult to operate, low efficiency Problem;Including: enamel separation mechanism, enamel grinding mechanism and enamel digestion mechanism.Enamel separation mechanism is provided with grinding separation module, enamel on tooth is directly ground down, enamel is stripped down in small granular or powder form, it is convenient for subsequent enamel grinding mechanism to grind it, after grinding, enamel will become more delicate, digestion effect is better, digestion is more complete.Enamel stripping does not need to cut tooth, can realize automatic operation throughout, high efficiency.

This disclosure relates to systems and methods for the electrokinetic (EKF) delivery of therapeutic and cosmetic agents to oral tissues, including but not limited to enamel, dentin, cementum, gingiva, and mucosa. More specifically, it relates to modular, low-current dental treatment platforms configured to deliver active agents across or into oral tissues using flexible electrodes, voltage ramping logic, and optionally insulating or stabilizing structures.

The application belongs to the technical field of nanomaterials, and particularly relates to a graphene oxide composite nanocoating, application thereof and modified dental metal material. The obtained graphene oxide composite nanocoating overcomes the problem of easy agglomeration of GO alone, has the advantages of long-term antibacterial property, strong corrosion resistance, low toxicity, good remineralization effect on dental enamel, reduced occurrence of dental demineralization and dental caries, effectively reduced friction between dental metal materials, especially between metal materials for orthodontic treatment, is conducive to the sliding between arch wires and bracket grooves in the orthodontic process, and further conducive to improving the efficiency of aligning and flattening the dental arch in orthodontic treatment and shortening the treatment course. In addition, the application has the characteristics of simple operation, low cost and strong controllability, and provides a simple and universal strategy for preparing dental metal materials with long-term antibacterial property, corrosion resistance, low toxicity, good remineralization effect and low friction.

The invention relates to the technical field of biomedical materials, in particular to a COF heterojunction nanosphere with biomimetic mineralization and antibacterial functions and a preparation method and application thereof. The preparation method comprises the following steps: mixing a magnolol solution, a 1, 3, 5-tris (4-aminophenyl) benzene solution, a polyvinylpyrrolidone solution, a 2, 5-dimethoxybenzene-1, 4-dicarboxaldehyde solution and acetic acid, so as to obtain COFDMTP-coated Honokiol nanospheres; the preparation method comprises the following steps: mixing 4, 4 '-((2, 5-diformyl-1, 4-phenylene) bis (oxy)) dibutyric acid, COFDMTP (at) Honokiol nanospheres, acetonitrile and an acetic acid solution, and reacting to obtain the COFFPBA (at) Honokiol heterojunction nanospheres. The heterojunction nanosphere provided by the invention not only can promote the mineralization of acid-etched enamel, but also can effectively inhibit the growth of oral bacteria and reduce the occurrence of decayed teeth.

The invention relates to the technical field of marine microorganisms, in particular to application of lactobacillus salivarius NHNK-603 in preparation of products for improving tooth color and gingivitis. The strain provided by the invention is preserved in the China Center for Type Culture Collection, and the preservation number is CCTCC NO: M 2024416. Experiments show; the NHNK-603 has the effects of inhibiting proliferation and biofilm formation of pigment-generating pathogenic bacteria, agglutinating the pigment-generating pathogenic bacteria, inhibiting melanin generation of the pigment-generating pathogenic bacteria, inhibiting hyaluronidase activity of the pathogenic bacteria, promoting growth of gingival fibroblasts, inhibiting gingival cell inflammation and apoptosis induced by the pigment-generating pathogenic bacteria, and inhibiting melanin generation of the pigment-generating pathogenic bacteria. And the product can be used for preparing products for improving tooth color and gingivitis.

The present application relates to the technical field of oral abrasive, in particular to a pectin-coated volcanic stone oral abrasive loaded with saussurea involucrate extract and a preparation method thereof. The oral abrasive comprises volcanic stone particles, saussurea involucrate extract, calcium pectin and an auxiliary agent. The volcanic stone particles serve as a natural porous abrasive, providing strength support and drug loading; the saussurea involucrate extract serves as an active ingredient, providing anti-inflammatory and antibacterial effects; the calcium pectin serves as a controlled-release agent and coating material, forming a gel network with calcium ions to control the release of the saussurea involucrate extract and wrapping the volcanic stone particles to form a flexible contact, buffering the direct friction of the abrasive on the tooth enamel; the components synergistically achieve the integrated effects of "physical cleaning-gel protection-traditional Chinese medicine treatment", ensuring the cleaning effect while reducing the dentin abrasion value, reducing the damage to the tooth enamel and effectively inhibiting oral pathogenic bacteria. The preparation method of the oral abrasive is simple, low in cost and has a broad application prospect.

The invention relates to the technical field of medical supplies, and discloses an orally disintegrating film for promoting remineralization of enamel and a preparation method thereof.The orally disintegrating film takes hydroxypropyl methyl cellulose, microcrystalline cellulose, starch and the like as film base materials and has the advantages of being thin, light, good in flexibility, free of toxicity and stimulation, good in biocompatibility and biodegradability and the like; and the composition can be quickly dissolved in the oral cavity to take effect. The device has the advantages of quick effect, convenience in carrying, easiness in use and the like. The orally disintegrating film serves as a direct carrier of an inducer for inducing remineralization of enamel, so that the orally disintegrating film becomes a more effective transmission system. A bacteriophage display technology is utilized, a peptide fragment with strong adsorption capacity with HAP is integrated into a carrier bacteriophage DNA, and purification is performed after large-scale amplification, so that the peptide fragment is used as an important effective component of the orally disintegrating film.

The invention discloses nano calcium polyphosphate-containing toothpaste with a repairing effect and a preparation method of the nano calcium polyphosphate-containing toothpaste. The toothpaste is prepared from the following components in percentage by mass: 5 to 15 percent of water, 55 to 75 percent of a polyol humectant, 0.2 to 1 percent of sodium carboxymethyl cellulose, 2 to 8 percent of sodium lauryl sulfate, 15 to 20 percent of silicon dioxide, 0.01 to 0.4 percent of menthol, 0.01 to 0.07 percent of a preservative and 0.01 to 0.1 percent of nano calcium polyphosphate. The nano calcium polyphosphate is introduced into a toothpaste system, and the nano calcium polyphosphate can be effectively attached to and actively repair microscopic defects on the enamel surface by utilizing the high specific surface activity and biomimetic mineralization characteristics of the nano calcium polyphosphate. The toothpaste not only has a conventional cleaning function, but also can remarkably reduce tooth surface roughness, recover microhardness and relieve dentin sensitivity, daily active repair of tooth hard tissue is achieved, and the defect of existing toothpaste in the aspect of direct structural repair is overcome.

The invention discloses an oral care composition and a preparation method thereof. The oral care composition comprises the following components in percentage by weight: 20-30% of abrasive; 15 to 25% of a humectant; 0.8 to 1.5 percent of a surfactant; the biomimetic mineral repairing agent is a biomimetic mineral peptide which can be self-assembled at the enamel defect part and can guide mineral substances to directionally deposit; 1.5-3% of an oral cavity micro-ecology regulating composition, wherein the regulating composition comprises prebiotics and metabiotics; 0.3-1% of a slow-release antibacterial compound, wherein the slow-release antibacterial compound comprises a coating body of a zinc salt and a biocompatible carrier; 0.1 to 0.2 percent of a stable fluorine source; the pH regulator is used for regulating the pH value of the composition to 6.5-7.5; and the balance of deionized water. The hydrated silica with the particle size of 5-20 microns is adopted as the abrasive, so that stains on the surfaces of teeth are effectively removed.

The toothbrush head of the present disclosure comprises two bristle planting pieces which are arranged in sequence along the extension direction of the toothbrush handle, each of the bristle planting pieces comprises tooth surface cleaning bristle planting holes, gum cleaning bristle planting holes and interdental cleaning bristle planting holes, the gum cleaning bristle planting holes are arranged at the left and right ends of the tooth surface cleaning bristle planting holes, and the interdental cleaning bristle planting holes are arranged at the upper end or the lower end of the tooth surface cleaning bristle planting holes.

The invention discloses a low-temperature preparation method of a biomimetic mineralized dental material, which comprises the following steps of: (1) adding a microorganism sporosarcina pasteurii capable of generating calcium carbonate into a microorganism fermentation liquid capable of generating protein fibers for co-culture to obtain a fibrous biofilm containing the sporosarcina pasteurii; (2) adding the biological membrane into a mineralizing solution for biological mineralization; and (3) after mineralization is finished, performing high-temperature sterilization and drying on the material to obtain the biomimetic mineralized dental material. By adopting an in-situ mineralization technology and combining microbial co-culture with a biomineralization assembly technology, the preparation of the super-hard and super-tough bionic ceramic dental material can be realized under the near room temperature condition of 30 DEG C, and the super-high energy consumption of a traditional high-temperature sintering technology is avoided; the Vickers hardness HV value of the dental material prepared by the method is about 300 and is close to that of natural enamel, and the tensile toughness value of the dental material is 18 MJ / m < 3 > and is 10 times of that of natural teeth.

The present invention relates to a method for synthesizing calcium-based biominerals, particularly hydroxyapatite (found in vertebrate bones and teeth) and calcium carbonate (found in plankton and corals). This fully biocompatible mineralization strategy not only offer fundamental insights into the biomineralization process, starting from mineral ions to amorphous precursors and eventually to specific minerals, but also contributes to our scientific understanding of life's origin. Furthermore, it showcases great promise for therapeutic applications, such as actively repairing damaged tooth enamel and promoting bone growth.

The present application relates to the field of tooth whitening, and particularly relates to a tooth whitening and enamel remineralization composition and a use method thereof, the tooth whitening and enamel remineralization composition comprising a CPIC gel and an HP gel; the CPIC gel comprising a composite CPIC, an HP activator and a first pH regulator; the composite CPIC comprising calcium ions, phosphate ions and weakly reducing metal ions; the HP activator comprising a transition metal complex for promoting HP decomposition; the first pH regulator being used for controlling the pH value of the CPIC gel in a weak alkaline range; the HP gel comprising HP, an HP stabilizer and a second pH regulator; the HP stabilizer being used for combining the weakly reducing metal ions in the HP gel to prevent HP decomposition; and the second pH regulator being used for controlling the pH value of the HP gel within 4-6. The composition in the present application comprises the CPIC gel and the HP gel, and can simultaneously realize tooth whitening and enamel remineralization.

The present application relates to the technical field of intelligent lamp mirror, especially to a kind of intelligent lamp mirror for children washing, including mirror module, internal monitoring camera and teeth cleaner, the teeth cleaner is provided with cleaning groove, multiple hardness controllers and multiple cleaning brushes.The present application controls the neatness of cleaning brush by hardness controller, thereby realizing dynamic regulation of friction force, while preventing excessive wear of enamel when removing stubborn stains.On the other hand, the neatness of cleaning brush can be reduced at the missing teeth by hardness controller according to the missing teeth in user's oral cavity, to reduce the irritation to gums at the missing teeth, thereby improving the comfort of cleaning teeth.The present application realizes the functions of monitoring and cleaning, and overcomes the problems of uncontrolled force of traditional teeth cleaning tools, resulting in unsatisfactory cleaning effect and damage to teeth and gums.

The invention belongs to the technical field of oral care, and particularly discloses whitening toothpaste and a preparation method thereof. The whitening toothpaste comprises the following components in percentage by mass: a transparent matrix component, a whitening active component and an auxiliary component. The transparent matrix comprises hydrated silica, sorbitol, cellulose gum and xanthan gum; the whitening active component comprises an optical modifier, an active decolorizing agent and an endogenous inhibitor. Through the synergistic effect of the optical modification component and the bioactive component, exogenous stain decomposition and endogenous pigment inhibition are realized while the high light transmittance of the cream is maintained, the use of peroxide bleaching agents is avoided, and the whitening cream has the advantages of being good in whitening effect, transparent and stable in cream body, small in damage to enamel, safe and comfortable to use and the like.

This disclosure relates to systems and methods for the electrokinetic (EKF) delivery of therapeutic and cosmetic agents to oral tissues, including but not limited to enamel, dentin, cementum, gingiva, and mucosa. More specifically, it relates to modular, low-current dental treatment platforms configured to deliver active agents across or into oral tissues using flexible electrodes, voltage ramping logic, and optionally insulating or stabilizing structures.

An oral liquid dental suspension is disclosed, including (a) a tooth whitening agent; (b) a solvent; and (c) at least one of (i) a resin or (ii) a urethane. The suspension is formulated to be applied to the surface of human teeth, where it rapidly dries—even in the presence of saliva—to form an adherent varnish. This varnish enables prolonged and effective contact between the whitening agent and tooth enamel for enhanced whitening efficacy. The composition may further include one or more optional additives, such as sweeteners, glazing agents, teeth desensitizers, remineralization agents, sequestering agents, complexing agents, or fluoridation agents. Also provided are kits containing the oral liquid dental suspension and one or more applicators, as well as methods of use involving topical application to teeth and subsequent drying to achieve a whitening effect.

The present invention relates to an adhesive oral film strip designed for the controlled release of sodium fluoride and other therapeutic agents to enhance oral health. The strip comprises a polymeric matrix — primarily polyvinyl alcohol (PVA), hydroxypropyl methylcellulose (HPMC), and carboxymethylcellulose (CMC) which provides mechanical integrity, controlled erosion, and sustained release of active ingredients when applied to the teeth. The invention addresses the challenges of traditional fluoride delivery methods by enabling targeted, prolonged, and customizable administration of fluoride and additional agents such as remineralization compounds, desensitizers, antimicrobials, and whitening agents. The strip may feature multilayer constructions, heterogeneous therapeutic agent distribution, and auxiliary components for improved adhesion, user compliance, and safety. The invention further encompasses methods of manufacture, application, and integration into comprehensive dental care kits, offering solutions for diverse populations and oral health needs. This innovation provides a significant advancement in preventive dentistry by improving caries prevention, enamel remineralization, and overall oral hygiene, while minimizing risks such as fluorosis and enhancing user experience.

The invention discloses a tooth whitening strip and a preparation method, and relates to the technical field of oral care. According to the invention, the two key components, namely the adhesive and the desensitization protective agent, of the tooth paste are respectively designed and the synergistic effect of the adhesive and the desensitization protective agent is fully exerted, so that on one hand, the adhesion of the gel layer of the wet tooth paste on the tooth surface and the toughness of the tooth paste are improved, and the gel layer is not easy to fall off or break or remain on the tooth surface; on the other hand, calcium ions, phosphate ions and fluorine ions released by the desensitization protective agent promote generation of acid-resistant fluorapatite and induce remineralization on the enamel surface, and microscopic damage is repaired; and a cross-linked network formed by the adhesive in a gel layer matrix is beneficial to enriching the ions and leading the ions to a to-be-repaired part quickly. The tooth whitening paste can better protect and repair the tooth surface while playing a whitening role, and better oral care experience is provided for a user.

This invention relates to a desensitizing drug for tooth enamel repair and its preparation method, belonging to the field of biomedical technology. The drug comprises a specific ratio of paeonol-dopamine modified chitosan quaternary ammonium salt, enzyme-responsive precursor mineral, polyethylene glycol didopamine modified hydroxyapatite, strontium nitrate, hyaluronic acid-maleimide, L-cysteine, and carbomer. The paeonol-dopamine modified chitosan quaternary ammonium salt is obtained by modifying chitosan quaternary ammonium salt with paeonol and dopamine hydrochloride under tyrosinase catalysis. The enzyme-responsive precursor mineral is obtained by coating nano-calcium pyrophosphate with ε-polylysine. The polyethylene glycol didopamine modified hydroxyapatite is obtained by surface adhesion modification of hydroxyapatite with polyethylene glycol didopamine. This invention yields a restorative desensitizing gel with strong adhesion and enzyme responsiveness. This gel can form a long-lasting protective layer on the tooth surface, simultaneously achieving the triple effects of physical sealing, nerve inhibition, and active mineralization.

This invention discloses a tooth powder with whitening, stain removal, and anti-inflammatory effects, and its preparation method. The tooth powder is a compound of a whitening system, an antibacterial and anti-inflammatory system and a microbiome regulation system, a repair and abrasion system, and a taste-correcting and preservative system. Its core utilizes a specifically formulated biofilm complex enzyme, which can efficiently decompose dental plaque biofilm. Combined with sodium phytate and niacinamide, it achieves gentle whitening and stain removal; with epigallocatechin gallate and baicalin, it achieves targeted antibacterial and anti-inflammatory effects; with probiotic components, it regulates the oral microbiome; and with hydroxyapatite and 45S5 bioactive glass, it repairs tooth enamel. This invention employs customized embedding technology and a graded low-temperature preparation process, significantly improving the storage stability of the active ingredients. The tooth powder of this invention is gentle and non-irritating, does not damage tooth enamel, does not disrupt the oral microecological balance, and has multiple oral care effects with long-lasting and non-rebounding results, making it suitable for large-scale industrial production and long-term use by various population groups.

The invention discloses an intelligent labeling method and system based on an oral cavity CBCT image, and belongs to the technical field of oral cavity medical image processing, and the method comprises the steps: obtaining CBCT voxel data of a target tooth region; performing sliding window analysis on the CBCT voxel data to generate a local gray statistical feature of each sliding window; and for each sliding window, constructing a dual-modulation adaptive threshold function comprising a main threshold and an auxiliary threshold based on the local gray statistical characteristics, and carrying out joint judgment on the CBCT voxel data to form a preliminary tooth region. According to the scheme, through cooperative work of the main threshold value and the auxiliary threshold value, the judgment condition is dynamically adjusted in combination with the gray distribution similarity, the gray overlapping areas of the enamel, the dentin, the alveolar bone and other tissues can be effectively distinguished, and the problems that in the prior art, fixed threshold value segmentation is sensitive to local noise and cannot adapt to gray distribution changes are solved; and the accuracy and robustness of tooth region preliminary labeling are obviously improved.

This invention relates to a whitening and stain-removing toothpaste and its preparation method, belonging to the field of oral care technology. The toothpaste contains 1.5-2.5 parts of plant enzymatic hydrolysate, 15-25 parts of a composite abrasive, and other components. The plant enzymatic hydrolysate is obtained by grinding walnut shell powder, beech, oyster shell, and Manegug glacial mud into powder in a mass ratio of 3:3:2:1, and then mixing and enzymatically hydrolyzing it with a composite enzyme solution. The composite abrasive and chelating agent are substances of specific particle sizes / molecular weights mixed in proportion. It also contains film-forming agents and enamel repair components. The preparation process includes the preparation of the plant enzymatic hydrolysate, the preparation of the mixture, and subsequent stirring, degassing, and filling steps. This toothpaste achieves highly effective whitening and stain removal, antibacterial properties, and long-lasting stain prevention, enamel repair, and antioxidant effects through the synergistic effect of multiple components, solving the problems of incomplete stain removal and enamel damage caused by traditional toothpastes.

The invention belongs to the field of cosmetics, particularly relates to the field of A61K8 / 03, and more particularly relates to multi-effect nursing toothpaste with cream texture and a preparation method thereof. The multi-effect nursing toothpaste with the cream texture is prepared from the following raw materials: a phase A, a phase B and a phase C, wherein the mass ratio of the phase A to the phase B to the phase C is (20-50): (30-50): (0.0001-1); wherein the phase A comprises water and a humectant, and the phase B comprises a thickening agent, a foaming agent, an aromatic, an antibacterial agent, a sweetening agent, an antioxidant, a friction agent and functional inorganic salt; the thickening agent comprises super micro-crosslinked polyquaternium-22, and the molecular weight of the thickening agent is greater than 1000000; the functional inorganic salt at least comprises sodium monofluorophosphate; the C phase includes a colorant. The multi-effect nursing toothpaste with the cream texture, provided by the invention, not only can realize the technical effects of rapid sterilization and long-acting bacteriostasis, but also can repair enamel, improve gingival bleeding and relieve tooth sensitivity, and has more effects and higher cost performance compared with similar products in the market.

The invention discloses a multi-material gradient bionic dental crown and a digital preparation method thereof, and belongs to the technical field of dental restoration materials and digital additive manufacturing. Comprising a dental crown body, the dental crown body is provided with a material structure of which the mechanical property continuously changes in a gradient manner along with the surface of a prepared tooth body, is formed by mixing two basic resin materials through voxel-level gradient in space, and is divided into two functional layers by imitating a double-layer hard tissue physiological structure of a natural tooth; comprising a high-wear-resistance bionic enamel layer used for forming the outer surface of a dental crown body and a high-toughness bionic dentin layer used for forming the dental crown body and connecting the high-wear-resistance bionic enamel layer and the surface of a prepared tooth body. By simulating a gradient structure of a natural tooth and a crack inhibition mechanism of the enamel-dentin boundary (DEJ), the fracture toughness and the anti-fatigue life of the dental crown body are far better than those of a traditional single-layer or layered all-ceramic crown, and thermal stress and mechanical stress are effectively buffered through modulus matching of the high-toughness bionic dentin layer and a resin adhesive.

Aqueous-based compositions for remineralizing dentinal tissues in vivo are disclosed to arrest demineralization and early-stage caries, treat dentin / tooth sensitivity, fix white spot lesions, and strengthen dentinal hard tissues (enamel, dentin, cementum), among others. Methods utilizing the remineralizing composition are also disclosed.