The invention discloses anti-caries and anti-allergy polishing paste and a preparation method of the anti-caries and anti-allergy polishing paste. The anti-caries and anti-allergy polishing paste is prepared from the following components in percentage by weight: 0.5% of quaternary ammonium salt, 2% of a nonionic surfactant, 0.25% of sodium pyrophosphate, 0.85% of CMC, 0.5% of sodium benzoate, 5% of sediment amino calcium formate, 45% of hydrogen phosphate dehydrate, 22% of glycerol, 0.1-0.3 % of edible essence, 0.1-0.3 % of an edible preservative, 0.2% of a sweetening agent, 0.08-0.2 % of a refreshing agent, and 0.0001-0.0002% of a pigment. Ammonium hexafluorosilicate is taken as the functional material and added into the polishing paste, compared with the existing anti-allergy toothpaste, the anti-caries and anti-allergy polishing paste provided by the invention has the more obvious anti-allergy efficacy, in addition, the anti-caries and anti-allergy polishing paste is good in mouthfeel and contains no alcohol, so that the risk of cancer caused by the alcohol is reduced, and thus the product is safe; no side effects including teeth color change are caused; meanwhile, the anti-caries and anti-allergy polishing paste has the effects of preventing caries and killing bacteria, and can well maintain the health of the oral cavity.