353 results about "Tooth caries" patented technology

The invention provides an intelligent toothbrush based on AI visual identification and an oral health assessment method, and relates to the technical field of artificial intelligence and computer vision. The intelligent toothbrush based on AI visual identification and the oral health assessment method comprise the following steps: S1, based on a built-in multispectral camera of the intelligent toothbrush, dynamically adjusting illumination parameters of different oral regions by adopting a visible light and near-infrared bimodal synchronous acquisition algorithm and through a self-adaptive exposure compensation technology, high-resolution images and transmission data of tooth surfaces and gingival lines are obtained, and a multi-mode oral cavity image data set is generated. Illumination parameters are dynamically adjusted through a multispectral camera to obtain high-resolution bimodal data, the focus detection precision is improved in combination with cross-modal feature fusion, the problem that traditional single-modal imaging is insufficient in early-stage dental caries recognition is solved, and the accuracy of early-stage dental caries recognition is improved based on laser radar point cloud complementation and a three-dimensional surface reconstruction technology. And mapping the two-dimensional focus label into a dynamic three-dimensional plaque distribution model.

The invention discloses a lactobacillus delbrueckii subsp. Lactis TG001 and application thereof in improving oral health, and belongs to the technical field of probiotic application, the preservation number of the lactobacillus delbrueckii subsp. Lactis TG001 is CCTCC NO: M 20241941, the preservation place is China Center for Type Culture Collection in Wuhan, and the preservation date is September 9, 2024. The lactobacillus delbrueckii subsp. Lactis TG001 has a good inhibition effect on common oral pathogens such as streptococcus mutans and porphyromonas gingivalis, particularly can inhibit the growth of cariogenic bacteria streptococcus mutans by generating hydrogen peroxide and remove biofilm formation, and has good tolerance to antibacterial substances in an oral environment. Therefore, the oral cavity diseases such as dental caries, periodontitis and ozostomia can be prevented, the micro-ecological environment of the oral cavity is effectively improved, meanwhile, the peculiar smell of the oral cavity is relieved, and good application prospects are achieved in preparation of products for preventing and / or treating the oral cavity diseases such as dental caries and periodontitis.

The invention relates to the technical field of oral cavity cleaning and nursing materials, and discloses an oral cavity nursing composition containing plant extract components, which comprises plant extract components, inactivated probiotics, prebiotics and fluoride. The preparation method of the toothpaste product comprises the following steps: step 1, weighing corresponding components according to a formula, adding the cortex magnoliae officinalis extract, the lactobacillus paracasei, the fructo-oligosaccharide, the sucralose, the sodium benzoate and the sodium fluoride into the deionized water, stirring to fully dissolve, then adding the glycerol and the sorbitol, and stirring uniformly to obtain a mixture 1; fully mixing silicon dioxide, cellulose gum, hydroxyethyl cellulose and sodium lauryl sulfate to obtain a mixture 2; compared with the prior art, the oral cavity cariogenic bacteria inhibiting composition has the advantages that various oral cavity cariogenic bacteria are inhibited safely and effectively by using plant extract components, and beneficial bacteria proliferation is promoted by inactivating probiotics agglutinating harmful bacteria and prebiotics, occupation in oral mucosa is increased, colonization of harmful bacteria is reduced, so that the anti-sugar effect is achieved, and caries are prevented.

The invention provides an additive composition containing a bioactive enzyme and a preparation method of the additive composition, and belongs to the technical field of biological enzymes. The preparation method comprises the following steps: fixing phytic acid and cyclodextrin on hydroxyapatite, modifying with tannic acid, reacting with dithiothreitol modified lysozyme to prepare an immobilized compound, adding 2, 2-dimethoxy-2-phenylacetophenone and methyl methacrylate, and carrying out irradiation reaction with an ultraviolet lamp to prepare the additive composition containing the bioactive enzyme. The broad-spectrum antibacterial property and the antiviral property of the lysozyme are greatly improved, the sterilization effect on gram negative bacteria is obviously improved, meanwhile, the stability of enzyme is greatly improved, the enzyme is not prone to inactivation, the preservation time of the enzyme is prolonged, the application effect of the enzyme is widened, meanwhile, the lysozyme has good killing capacity on oral bacteria and viruses, the addition of preservatives is reduced, and the cost is reduced. The cleaning effect and stability of the product are improved, tooth demineralization can be prevented, decayed teeth can be prevented, and wide application prospects are achieved.

The invention provides a probiotic composition for preventing and / or inhibiting oral pathogens as well as a derivative product, a preparation method and application of the probiotic composition, and belongs to the technical field of oral care. The probiotic composition comprises the following bacterial strains in parts by mass: 90 to 0.45 part of a lactobacillus rhamnosus bacterial strain A2114, 10 to 0.3 part of a plant lactobacillus bacterial strain A2124, 80 to 0.4 part of a pediococcus pentosaceus bacterial strain A2135, 250 to 0.25 part of a lactobacillus reuteri bacterial strain A21350, and 40 to 0.2 part of a plant lactobacillus bacterial strain A2109. The probiotic composition or the metabolite thereof can effectively inhibit oral pathogens such as streptococcus mutans, porphyromonas gingivalis, helicobacter pylori, escherichia coli and staphylococcus aureus. Therefore, the probiotic composition or the metabolite thereof shows a good application prospect in the aspects of preventing and relieving oral problems such as decayed teeth, periodontitis and ozostomia.

The invention relates to an oral cavity scanner and an oral cavity scanning method, and belongs to the technical field of medical instruments, the oral cavity scanner comprises a host, a handheld scanning gun and a data processing terminal, a main control circuit and a power module are arranged in the host, the handheld scanning gun is connected with the host, and a scanning window is arranged at the front end of the handheld scanning gun. The method comprises the following steps: acquiring three-dimensional shape data of oral tissues through a main white light scanning module; the auxiliary deep hole scanning module is used for carrying out supplementary scanning on optical dead angles such as the edge of a preparation body and a deep caries cavity; lesion information such as decayed teeth and dental plaque is obtained through the fluorescence detection module; data splicing is assisted through the attitude sensing module, the data processing terminal fuses multi-modal data to generate a color digital model with high-precision three-dimensional morphology and pathological information labeling, and real-time guidance and quality evaluation are performed on a scanning process by using an artificial intelligence model. And full-automatic, high-precision and intelligent oral cavity three-dimensional data acquisition is realized.

The invention relates to the technical field of microorganisms, in particular to plant lactobacillus BR32 with functions of preventing decayed teeth and improving inflammation and application of the plant lactobacillus BR32. The plant lactobacillus BR32 with the functions of preventing decayed teeth and improving inflammation, provided by the invention, has the preservation number of CGMCC No.32836, has an inhibiting effect on the growth of oral pathogens such as streptococcus mutans, candida albicans and porphyromonas gingivalis, is high in oxidation resistance, is beneficial to continuous oral cavity stability maintenance through a synergistic effect, also has relatively high hydrophobicity and self-agglutination capability, and can be used for preparing oral cavity health-care products. The compound is low in tooth environment corrosion, high in lysozyme tolerance and good in oral colonization capacity, does not have a hemolysis phenomenon in in-vitro hemolysis culture, is sensitive to common antibiotics and has relatively high food safety. The invention further provides a microbial agent, a probiotic product, a functional food, a fermented product, a bacteriostatic agent and an oral product containing the plant lactobacillus BR32 with the functions of preventing the decayed teeth and improving the inflammation, and the effects of preventing the decayed teeth, improving the inflammation, preventing dental plaque, relieving oral ulcer and the like are achieved.

The invention relates to the technical field of oral care, and in particular to an effective anti-caries mouthwash and a preparation method thereof; the effective anti-caries mouthwash is composed of the following percentage components: 0.1-0.5% sodium fluoride, 0.1-0.5% sodium monofluorophosphate, 0.1-0.5% olafluan, 0.5-1% hydroxyapatite, 0.5-1% lactobacillus, 0.5-1.5% green tea extract, 0.5-1.5% honeysuckle extract, 1.5-2% menthol, 0.5-1% lemon The invention comprises the following components: sodium iodide, 2-3% honey, 1.5-3% licorice extract, 0.5-1.5% lemon extract, 0.5-1.5% ascorbic acid, 2-3% polyoxyethylene hydrogenated eucalyptus oil and water as the balance; the invention has an excellent anti-caries effect, can enhance tooth resistance and inhibit tooth caries, and has excellent ductility and comprehensive protection properties, can quickly cover and fully wrap the tooth surface, can inhibit the growth of bacteria in the oral cavity, reduce the risk of tooth infection and provide a long-term anti-caries effect.

The invention relates to the field of computer vision, in particular to a decayed tooth intelligent identification method and system based on computer vision, and the method comprises the following steps: image collection, image segmentation, bottleneck feature extraction, reconstruction error optimization, diagnosis result generation, diagnosis result feedback, and decayed tooth development prediction. According to the method, a decoder part of U-Net and an encoder part of ConvNeXt are combined into a segmentation model, and a multi-label recall loss function is used for effective identification; a capsule graph network is introduced to serve as a bottleneck layer, and potential spatial relations and high-level dependence of local features in data are captured through a dynamic routing mechanism; and an MFO-SFR-HWACO algorithm is used to optimize the hyper-parameter configuration of the depth auto-encoder. The system comprises a data acquisition module, an image segmentation module, a bottleneck feature extraction module, a reconstruction error optimization module, a diagnosis result generation module, a decayed tooth development prediction module and an intelligent report generation module.

Oral care compositions are disclosed that include a mixture of dentate ligands including mono-, di- and / or tetracarboxylic acid(s) as well as a stannous ion source and a fluoride ions source, such as stannous fluoride. Said oral care compositions show an ability to prevent and / or treat dental erosion and / or caries.

Peptides that bind with high affinity to oral cavity surfaces, such as tooth enamel, have been discovered. The peptides exhibit antibacterial and mineralizing abilities, and are useful in many aspects of oral care. The peptides include the amino acid sequence AKRHHGYKRKFH-SpSp. The peptides can be included in oral care compositions such as toothpastes and mouthwashes. The oral care compositions can be used in methods to treat or prevent diseases or conditions induced by acidophilic oral bacteria. Exemplary methods include reducing or preventing tooth decay or demineralization, biofilm or dental plaque formation, and / or bacterial adhesion to a tooth surface; and promoting mineralization of teeth surfaces.

The invention provides a tooth patch for repairing tooth hardness and a preparation method thereof, the tooth patch comprises a support material and gel, and the gel comprises the following components by mass: 1.5-2 parts of regenerated silicon, 0.5-0.7 part of A200, 1.5-2.5 parts of a thickener, 15-20 parts of a film-forming agent, 4-6 parts of a humectant, and 1-1.5 parts of a gelling agent. The tooth paste can form a hydroxyapatite layer on the tooth surface, repair tooth enamel, promote remineralization of the tooth surface and improve tooth hardness, is alkalescent, and can prevent dental caries; after contacting with saliva, hydroxyapatite crystals can be quickly formed in dentinal tubules to block the dentinal tubules, and the hydrogel can be used for treating tooth sensitivity.

The invention provides toothpaste containing active biological enzyme and a preparation method of the toothpaste, and belongs to the technical field of toothpaste. Comprising the following components in parts by weight: 2 to 15 parts of a biological enzyme additive composition, 20 to 50 parts of a friction agent, 30 to 60 parts of a humectant, 0.7 to 1.5 parts of a thickening agent, 0.1 to 0.3 part of a taste improver, 0 to 0.3 part of an appearance improver, 0.5 to 1.5 parts of perfume, 2 to 4 parts of a surfactant, 0.2 to 2 parts of an acid-base buffer agent, 0.2 to 0.5 part of a preservative, 0.001 to 5 parts of a functional component and 80 to 120 parts of water. On the premise of protecting teeth from being damaged, the toothpaste disclosed by the invention inhibits bacterium breeding, prevents decayed teeth, can reduce the formation of dental plaque and tartar, alleviates halitosis, resists dental calculus, safely and effectively removes stains on the surfaces of the teeth and whitens the teeth, also has the effect of solving oral problems, and has a wide application prospect.

The invention discloses an anti-decayed tooth toothpaste containing sugarcane leaf polysaccharide and a preparation method thereof. The toothpaste is prepared from the following raw materials in parts by weight: 3-6 parts of sugarcane leaf polysaccharide, 0.5-0.8 part of propolis extract, 0.05-0.09 part of antibacterial peptide, 2-5 parts of green tea extract, 80-100 parts of auxiliaries, 5-10 parts of deionized water and 2-4 parts of natural tea tree oil. The preparation method comprises the following steps: uniformly mixing all the raw materials, heating and stirring, and carrying out vacuum degassing to prepare the paste. The toothpaste disclosed by the invention can be used for efficiently inhibiting / killing oral pathogenic bacteria, maintaining the micro-ecological steady state of oral health and reducing erosion of acid substances to enamel, has excellent effects in the aspects of protecting gingiva, resisting inflammation, preventing bacterial breeding and resisting decayed teeth, and keeps lasting efficacy.

The invention belongs to the technical field of biomedical treatment and biological fermentation, discloses a metagen composition for effectively inhibiting oral dental caries and application thereof, and aims to solve the problems of great side effect, weak effect and unknown mechanism of the existing dental caries prevention and treatment means. The composition is prepared by mixing a metagen 1 which is prepared by fermenting lactobacillus salivarius Postbio-YY with a metagen 2 which is prepared by fermenting lactococcus lactis Postbio-F3 and lactobacillus paracasei Postbio-P6 step by step. In the preparation process, the active ingredients are reserved by accurately controlling the fermentation pH, time and pasteurization parameters. The composition can be prepared into multiple dosage forms such as toothpaste and the like, can remarkably inhibit the growth of streptococcus mutans and destroy the thallus structure, inhibits biofilm and exopolysaccharide synthesis by down-regulating fimI, wcaJ and wcae genes, is safe and free of side effects, and provides an efficient scheme for decayed tooth prevention and treatment.

The invention provides a composite Janus particle. The composite Janus particle disclosed by the invention can be used for treating the dentin hypersensitivity, not only can be accurately oriented on the surface of the dentin, but also has the effects of inducing mineralization and inhibiting bacteria on the two sides respectively, and has great application potential for treating the dentin hypersensitivity and preventing decayed teeth.

Oral care compositions are disclosed comprising a mixture of dentate ligands including mono-, di- and / or tetracarboxylic acid(s) as well as a stannous ion source and a fluoride ions source, such as stannous fluoride. Said oral care compositions show an ability to prevent and / or treat dental erosion and / or caries.

Methods and apparatuses for dental caries detection and communication. These methods and apparatuses may be used in real time, as part of an intraoral scanning system, or at any point following intraoral scanning. These methods and apparatuses may use a plurality of different images of the teeth, each having two or more fields (e.g., wavelengths such as visible light, near-infrared, fluorescent, etc.), and may use a trained pattern matching agent to detect possible caries centers from each image, then may project some or all of the possible caries centers onto a 3D model of the teeth to identify consensus caries and caries centers.

Oral care compositions are disclosed that include a mixture of dentate ligands including mono-, di- and / or tetracarboxylic acid(s) as well as a stannous ion source and a fluoride ions source, such as stannous fluoride. Said oral care compositions show an ability to prevent and / or treat dental erosion and / or caries.

The invention relates to the technical field of microorganisms, in particular to a viable bacterium preparation with the effect of preventing or treating decayed teeth as well as a preparation method and application of the viable bacterium preparation. The viable bacterium preparation comprises a lactobacillus paracasei strain and auxiliary materials, and the preservation number of the lactobacillus paracasei strain is CGMCC (China General Microbiological Culture Collection Center) No.27975. The viable bacterium preparation can inhibit the proliferation of streptococcus mutans and significantly inhibit the adhesion of streptococcus mutans on a hydroxyapatite tooth model; the level of producing water-insoluble exopolysaccharides by streptococcus mutans is reduced, the formation of a dental plaque biofilm caused by streptococcus mutans is effectively reduced, the content of a mature dental plaque biofilm is reduced, and the biofilm is not easy to form; the expression quantity of cariogenic genes gtfB, gtfC, gtfD, ftf and LuxS of streptococcus mutans can be obviously reduced.

A sequencing module configured to provide metatranscriptomic reads from an oral sample from a subject; metatranscriptomic reads from the sequencing of oral sample and identify and cluster microbes identified in the oral sample into taxon clusters (TCs) using the metatranscriptomic reads mapped to a metagenomic library; generate TC-specific orthogroups for each of the TCs via protein clustering; determine KEGG orthology for each of the TC-specific orthogroups, or genes directly; generate phylogenomic functional categories (PGFCs) from grouping of gene expression counts by the KEGG modules for each of the TCs; retain the PGFCs having an MCR above an MCR threshold to obtain input data; and identify or predict, using a classifier model including variables selected by a feature selection machine learning algorithm, dental caries in said subject based on the input data.

The present invention relates to improved complexes of amorphous calcium phosphate and / or amorphous calcium fluoride phosphate stabilised by phosphopeptides / phosphoproteins by addition of stannous ions. These complexes have anticariogenic properties useful to protect tooth structures as they remineralize (repair) early stages of dental caries and have other dental / medical applications (including anti-calculus, anti-erosion / corrosion and anti-dentinal hypersensitivity). Methods of making the complexes of the invention and of treatment or prevention of various dental conditions including dental caries, dental calculus, dental erosion / corrosion and dental hypersensitivity are also provided.

The invention discloses a traditional Chinese medicine composite lactobacillus acidophilus NM probiotic preparation for improving oral bacterial flora and a preparation process thereof, and relates to the related field of biotechnology. According to the traditional Chinese medicine composite lactobacillus acidophilus NM probiotic preparation, the synergistic effect of probiotics and traditional Chinese medicine is combined, the traditional Chinese medicine composite lactobacillus acidophilus NM probiotic preparation has the multiple advantages of regulating oral flora, resisting bacteria and diminishing inflammation, resisting oxidation, relieving fatigue and the like, lactobacillus acidophilus NM can tolerate acid and cholate, pathogenic bacteria such as escherichia coli, staphylococcus aureus and salmonella are effectively inhibited, and the traditional Chinese medicine composite lactobacillus acidophilus NM probiotic preparation is suitable for oral administration. The traditional Chinese medicine composition has the advantages that the traditional Chinese medicine composition can be used for reducing dental caries, gingivitis and ozostomia, is free of antibiotic drug resistance and is safer after being used for a long time, radix scutellariae, honeysuckle and green tea extracts are rich in flavonoids and tea polyphenols and can further resist bacteria and inflammation and improve oral health, and meanwhile, the probiotics can reduce blood lactic acid, blood urea nitrogen and blood ammonia, enhance SOD, CAT and GSH-Px vitality and inhibit lipid peroxidation, so that body fatigue is relieved, and the traditional Chinese medicine composition can be used for preventing and treating dental caries, gingivitis and ozostomia. The immunity is improved, and preparation forms are diversified.

The invention discloses an anti-caries early warning method and system based on oral health detection, and belongs to the technical field of data processing. The method comprises the following steps: acquiring and processing target detection data to generate a clear enamel demineralization feature image and a buffer capability score; analyzing pixel-level fluorescence intensity distribution by adopting a convolutional neural network model, determining a quantized value of the enamel demineralization degree, and further determining a comprehensive dental caries risk level category; judging a risk change trend according to the historical target detection data sequence to obtain a dynamic evaluation update value; a data fusion algorithm is adopted to obtain a final decayed tooth risk assessment index, and risk early warning information is generated according to the early warning template; by integrating fluorescence imaging, an image enhancement algorithm, a convolutional neural network, spectral analysis, k-means clustering and time sequence analysis, a complete process from enamel demineralization feature extraction to comprehensive risk assessment is constructed, the accuracy and individuation level of decayed tooth risk assessment are remarkably improved, and a scientific basis is provided for early prevention and intervention.

The invention provides a decayed tooth auxiliary diagnosis system and method for a dental clinic of a community hospital, and the method comprises the steps: obtaining a tooth image to be diagnosed, and dividing the tooth image into a plurality of local tooth regions according to the anatomical structure of teeth; performing multi-scale feature extraction on each local tooth body region to obtain a multi-scale feature map representing texture and structural features under different scales; calculating a lesion perception attention weight of each local tooth body region based on the multi-scale feature map; extracting a feature region related to a decayed tooth lesion in the tooth image, wherein the feature region comprises a demineralization region and a structure damage region; and performing adaptive enhancement on the feature region according to the lesion perception attention weight, and generating an enhanced image for dental caries diagnosis. By adopting the scheme of the invention, local adaptive enhancement of the dental caries lesion feature region in the tooth image can be realized.

The invention relates to the technical field of image data processing, in particular to a decayed tooth visual identification method and system for oral implantation, and the method comprises the steps: screening out a target tooth region from an obtained root tip piece to be identified, carrying out gray distribution analysis processing and brightness analysis processing on a preset neighborhood corresponding to each pixel point in each target tooth region; screening out a suspected caries lesion region; drawing a target central axis of a target tooth area to which each suspected caries area belongs, determining a vertical line of the target central axis as a target vertical line, translating the target vertical line, and forming an intersection point group by intersection points of the target vertical line translated each time and the edge of the suspected caries area; screening out a suspected medullary cavity point group from the intersection point group set corresponding to each suspected caries lesion region; and screening out the target caries damage region according to all the determined medullary cavity possibilities. According to the invention, image data processing is carried out on the to-be-identified root tip piece, so that the accuracy of identifying the caries lesion region is improved.

The invention relates to the technical field of oral medicine and biological information analysis, in particular to an evaluation system for oral microbiological analysis and decayed tooth risk prediction. The system comprises a sample collection module, a microorganism detection module, a data preprocessing module, a microorganism population dynamic analysis module, a multi-dimensional feature extraction module, a decayed tooth risk assessment module and a personalized suggestion generation module. By constructing microbial population evolution analysis based on a Lotka-Volterra competitive model, diversity dynamic change analysis based on Shannon entropy and evolution trend prediction based on a Lyapunov stability theory, the system deeply reveals a dynamic evolution law of an oral micro-ecosystem, and a multi-dimensional feature adaptive weighting mechanism based on mutual information is adopted, so that the dynamic evolution law of the oral micro-ecosystem is improved. Personalized accurate risk assessment is realized, a causal reasoning theory is introduced to generate personalized intervention suggestions with causal support, and the accuracy and the prevention effect of dental caries risk prediction are remarkably improved.

Disclosed are oral care compositions comprising: a tooth ligand mixture comprising a monocarboxylic acid, a dicarboxylic acid, and / or a tetracarboxylic acid; and a stannous ion source and a fluoride ion source, such as stannous fluoride. The oral care compositions show the ability to prevent and / or treat dental erosion and / or dental caries.

Oral care compositions are disclosed comprising a mixture of dentate ligands including mono-, di- and / or tetracarboxylic acid(s) as well as a stannous ion source and a fluoride ions source, such as stannous fluoride. Said oral care compositions show an ability to prevent and / or treat dental erosion and / or caries.