203 results about "Tooth caries" patented technology

The invention provides a probiotic composition for preventing and / or inhibiting oral pathogens as well as a derivative product, a preparation method and application of the probiotic composition, and belongs to the technical field of oral care. The probiotic composition comprises the following bacterial strains in parts by mass: 90 to 0.45 part of a lactobacillus rhamnosus bacterial strain A2114, 10 to 0.3 part of a plant lactobacillus bacterial strain A2124, 80 to 0.4 part of a pediococcus pentosaceus bacterial strain A2135, 250 to 0.25 part of a lactobacillus reuteri bacterial strain A21350, and 40 to 0.2 part of a plant lactobacillus bacterial strain A2109. The probiotic composition or the metabolite thereof can effectively inhibit oral pathogens such as streptococcus mutans, porphyromonas gingivalis, helicobacter pylori, escherichia coli and staphylococcus aureus. Therefore, the probiotic composition or the metabolite thereof shows a good application prospect in the aspects of preventing and relieving oral problems such as decayed teeth, periodontitis and ozostomia.

The invention relates to an oral cavity scanner and an oral cavity scanning method, and belongs to the technical field of medical instruments, the oral cavity scanner comprises a host, a handheld scanning gun and a data processing terminal, a main control circuit and a power module are arranged in the host, the handheld scanning gun is connected with the host, and a scanning window is arranged at the front end of the handheld scanning gun. The method comprises the following steps: acquiring three-dimensional shape data of oral tissues through a main white light scanning module; the auxiliary deep hole scanning module is used for carrying out supplementary scanning on optical dead angles such as the edge of a preparation body and a deep caries cavity; lesion information such as decayed teeth and dental plaque is obtained through the fluorescence detection module; data splicing is assisted through the attitude sensing module, the data processing terminal fuses multi-modal data to generate a color digital model with high-precision three-dimensional morphology and pathological information labeling, and real-time guidance and quality evaluation are performed on a scanning process by using an artificial intelligence model. And full-automatic, high-precision and intelligent oral cavity three-dimensional data acquisition is realized.

Peptides that bind with high affinity to oral cavity surfaces, such as tooth enamel, have been discovered. The peptides exhibit antibacterial and mineralizing abilities, and are useful in many aspects of oral care. The peptides include the amino acid sequence AKRHHGYKRKFH-SpSp. The peptides can be included in oral care compositions such as toothpastes and mouthwashes. The oral care compositions can be used in methods to treat or prevent diseases or conditions induced by acidophilic oral bacteria. Exemplary methods include reducing or preventing tooth decay or demineralization, biofilm or dental plaque formation, and / or bacterial adhesion to a tooth surface; and promoting mineralization of teeth surfaces.

The invention provides a tooth patch for repairing tooth hardness and a preparation method thereof, the tooth patch comprises a support material and gel, and the gel comprises the following components by mass: 1.5-2 parts of regenerated silicon, 0.5-0.7 part of A200, 1.5-2.5 parts of a thickener, 15-20 parts of a film-forming agent, 4-6 parts of a humectant, and 1-1.5 parts of a gelling agent. The tooth paste can form a hydroxyapatite layer on the tooth surface, repair tooth enamel, promote remineralization of the tooth surface and improve tooth hardness, is alkalescent, and can prevent dental caries; after contacting with saliva, hydroxyapatite crystals can be quickly formed in dentinal tubules to block the dentinal tubules, and the hydrogel can be used for treating tooth sensitivity.

The invention belongs to the technical field of biomedical treatment and biological fermentation, discloses a metagen composition for effectively inhibiting oral dental caries and application thereof, and aims to solve the problems of great side effect, weak effect and unknown mechanism of the existing dental caries prevention and treatment means. The composition is prepared by mixing a metagen 1 which is prepared by fermenting lactobacillus salivarius Postbio-YY with a metagen 2 which is prepared by fermenting lactococcus lactis Postbio-F3 and lactobacillus paracasei Postbio-P6 step by step. In the preparation process, the active ingredients are reserved by accurately controlling the fermentation pH, time and pasteurization parameters. The composition can be prepared into multiple dosage forms such as toothpaste and the like, can remarkably inhibit the growth of streptococcus mutans and destroy the thallus structure, inhibits biofilm and exopolysaccharide synthesis by down-regulating fimI, wcaJ and wcae genes, is safe and free of side effects, and provides an efficient scheme for decayed tooth prevention and treatment.

A sequencing module configured to provide metatranscriptomic reads from an oral sample from a subject; metatranscriptomic reads from the sequencing of oral sample and identify and cluster microbes identified in the oral sample into taxon clusters (TCs) using the metatranscriptomic reads mapped to a metagenomic library; generate TC-specific orthogroups for each of the TCs via protein clustering; determine KEGG orthology for each of the TC-specific orthogroups, or genes directly; generate phylogenomic functional categories (PGFCs) from grouping of gene expression counts by the KEGG modules for each of the TCs; retain the PGFCs having an MCR above an MCR threshold to obtain input data; and identify or predict, using a classifier model including variables selected by a feature selection machine learning algorithm, dental caries in said subject based on the input data.

The invention discloses an anti-caries early warning method and system based on oral health detection, and belongs to the technical field of data processing. The method comprises the following steps: acquiring and processing target detection data to generate a clear enamel demineralization feature image and a buffer capability score; analyzing pixel-level fluorescence intensity distribution by adopting a convolutional neural network model, determining a quantized value of the enamel demineralization degree, and further determining a comprehensive dental caries risk level category; judging a risk change trend according to the historical target detection data sequence to obtain a dynamic evaluation update value; a data fusion algorithm is adopted to obtain a final decayed tooth risk assessment index, and risk early warning information is generated according to the early warning template; by integrating fluorescence imaging, an image enhancement algorithm, a convolutional neural network, spectral analysis, k-means clustering and time sequence analysis, a complete process from enamel demineralization feature extraction to comprehensive risk assessment is constructed, the accuracy and individuation level of decayed tooth risk assessment are remarkably improved, and a scientific basis is provided for early prevention and intervention.

The invention provides a decayed tooth auxiliary diagnosis system and method for a dental clinic of a community hospital, and the method comprises the steps: obtaining a tooth image to be diagnosed, and dividing the tooth image into a plurality of local tooth regions according to the anatomical structure of teeth; performing multi-scale feature extraction on each local tooth body region to obtain a multi-scale feature map representing texture and structural features under different scales; calculating a lesion perception attention weight of each local tooth body region based on the multi-scale feature map; extracting a feature region related to a decayed tooth lesion in the tooth image, wherein the feature region comprises a demineralization region and a structure damage region; and performing adaptive enhancement on the feature region according to the lesion perception attention weight, and generating an enhanced image for dental caries diagnosis. By adopting the scheme of the invention, local adaptive enhancement of the dental caries lesion feature region in the tooth image can be realized.

The invention relates to the technical field of oral medicine and biological information analysis, in particular to an evaluation system for oral microbiological analysis and decayed tooth risk prediction. The system comprises a sample collection module, a microorganism detection module, a data preprocessing module, a microorganism population dynamic analysis module, a multi-dimensional feature extraction module, a decayed tooth risk assessment module and a personalized suggestion generation module. By constructing microbial population evolution analysis based on a Lotka-Volterra competitive model, diversity dynamic change analysis based on Shannon entropy and evolution trend prediction based on a Lyapunov stability theory, the system deeply reveals a dynamic evolution law of an oral micro-ecosystem, and a multi-dimensional feature adaptive weighting mechanism based on mutual information is adopted, so that the dynamic evolution law of the oral micro-ecosystem is improved. Personalized accurate risk assessment is realized, a causal reasoning theory is introduced to generate personalized intervention suggestions with causal support, and the accuracy and the prevention effect of dental caries risk prediction are remarkably improved.

Disclosed are oral care compositions comprising: a tooth ligand mixture comprising a monocarboxylic acid, a dicarboxylic acid, and / or a tetracarboxylic acid; and a stannous ion source and a fluoride ion source, such as stannous fluoride. The oral care compositions show the ability to prevent and / or treat dental erosion and / or dental caries.

The invention relates to a flavonoid derivative containing a flavonoid that is coupled to an alkylene group via an ether bond, said alkylene group having an adhesion group for adhesion onto a dental surface. The flavonoid derivative has a long-term suppressing effect on the dental disease-causing formation of biofilm on the dental surfaces treated with the flavonoid derivative. The invention further relates to a kit for producing such a flavonoid derivative, and to the use of same.

The invention belongs to the technical field of biological medicine, and particularly relates to a sophora flower extract for inhibiting formation of an oral biofilm and application thereof. According to the method, the sophora flower extract obtained after alcohol extraction is subjected to specific macroporous resin column elution conditions, the sophora flower extract obtained through enrichment has a very excellent effect of inhibiting oral biofilm formation, and further elution is carried out under specific silica gel column conditions, so that the effect of the obtained sophora flower extract is further improved. The inhibition rate of the obtained sophora flower extract is obviously higher than that of sophora flower extracts prepared by traditional alcohol extraction or other processes, and the sophora flower extract has important application value in preparation of products for inhibiting and / or killing oral microorganisms or biological membranes thereof, and can be used for preventing and / or treating dental bacterial diseases including decayed teeth.

The invention provides an intelligent management system for oral health detection, and the system comprises a data collection module which is used for inputting the personal information of a user, and detecting the oral information of the user through an oral detection device; the data warehouse module is used for storing data in a five-dimensional classification manner according to gender, age, region, activeness and tooth health state; the user classification module is used for generating user health portrait labels through a clustering algorithm; and the intelligent analysis module is used for carrying out differential data analysis based on the user health portrait tag and issuing a data analysis report. The oral health in the region is combined according to the user health portrait label, personal health management and regional public health early warning are combined, data information can be transmitted to the cloud, doctors can conveniently know the oral condition of the user, early warning of high-incidence regions of oral diseases such as decayed teeth can be achieved, targeted treatment can be carried out in time, and the user experience is improved. The oral health of the public can be conveniently improved.

The application discloses a kind of children's toothpaste composition and its preparation method and application, belong to oral care technical field.The composition includes anticaries efficacy component, anti-inflammatory composition, color-changing microcapsule and toothpaste acceptable adjuvant;Anticaries efficacy component is compounded by sodium fluoride, casein phosphopeptide and ten kinds of components, and anti-inflammatory composition is composed of Notopterygium extract, Magnolia officinalis extract, Prunus divaricata extract and kale leaf extract according to specific proportion.Preparation method is completed by water phase preparation, liquid phase deployment, powder mixing, paste machine stirring and vacuum degassing and the like steps, and process is stable and controllable.The toothpaste has anticaries and anti-inflammatory effects, and the color-changing microcapsule can change color during brushing, which improves the brushing interest of children and prompts proper cleaning.The toothpaste is suitable for preparing oral care products for children, and the components are safe and mild, which are suitable for the physiological environment of children's oral cavity.

The present invention relates to a pharmaceutical composition for preventing or treating dental caries and the use thereof. The pharmaceutical composition, according to the present invention, includes a peptide comprising an amino acid sequence of General Formula 1 as an active ingredient:         K-Y-R1-R2-R3-R4-R5-R6-R7-R8     (General Formula 1). In General Formula 1, R1 is arginine (R), lysine (K), or glutamine (Q), R2 is arginine (R) or glutamine (Q), R3, R4, and R5 are each arginine (R) or lysine (K), R6 is asparagine (N) or serine (S), and R7 and R8 are lysine (K) or tyrosine (Y).

This invention discloses a method for preparing prebiotic-containing minced meat canned food, belonging to the field of canned food preparation technology, including the following steps: removing large pieces of fascia and fat from the hind leg meat, and then cutting it into chunks; adding Mixture No. 1 and fructooligosaccharide syrup to the pork hind leg meat and tumbling it with a positive and negative pressure tumbler, then marinating it; cutting the thick layer of skinless pork belly into small pieces, adding salt and mixing evenly, then marinating it; removing the skin from the chicken breast and mincing it; first, pouring the marinated skinless pork belly and skinless chicken breast into a chopping pot and chopping at high speed until the meat particles are the size of rice grains, then adding the hind leg meat and chopping and stirring, then adding soy protein, Mixture No. 2, ice water and corn starch, stirring evenly at low speed, chopping and stirring, then removing from the pot; then mixing in a vacuum mixer; filling, sealing, sterilizing, heat preservation, packaging and warehousing, and the product is obtained. This invention provides canned minced meat that can regulate the ratio of intestinal flora, improve the intestinal environment, and is a good choice for people who like sweets but also want to lose weight; it can also help with calcium absorption and reduce the formation of tooth decay.

The utility model discloses a fluorine coating device for preventing decayed teeth of children in the department of stomatology, which relates to the technical field of fluorine coating devices and comprises a handheld part, a fluorine coating head and a fluorine coating device, a rotating roller is rotationally connected to the bottom of the inner side of the fluorine coating head in an embedded mode, bristles used for coating fluoride are arranged on the surface of the rotating roller, an arc-shaped cavity for containing the rotating roller to rotate is formed in the fluorine coating head, and the bristles are in interference fit with the inner wall of the arc-shaped cavity; a fluorine storage cavity is formed in the top of the fluorine coating head, and the bottom of the fluorine storage cavity is communicated with the rotating roller mounting cavity through a fluorine outlet; the positioning mechanism comprises a plurality of positioning holes and positioning rods, the positioning holes are circumferentially formed in the end face, close to the handheld part, of the rotating roller, the positioning rods can be inserted into the positioning holes, and the positioning rods penetrate through the side wall of the fluorine coating head. And the handheld part is moved to drive the roller brush to uniformly brush the fluoride, so that the brushing uniformity of the fluoride is further improved.

This invention relates to the field of oral care products technology, specifically to an artificial enzyme with antibacterial properties, its preparation method, and its application. This technical solution employs a chemical reduction method, where a palladium source reacts in an environment containing surfactants and reducing agents to obtain palladium nanozymes. The obtained palladium nanozymes exhibit uniform morphology, controllable particle size, good dispersibility in water, and good biocompatibility; they have no significant toxic side effects on human gingival fibroblasts, possess highly efficient catalase activity, and demonstrate strong antibacterial and bactericidal effects against oral pathogens, significantly reducing bacterial drug resistance; they can inhibit acid production by oral bacteria, preventing tooth decay; and they retain their original catalytic activity even after multiple cycles of use. Applying the palladium nanozymes of this solution to the manufacture of oral care products can solve the technical problems of unsatisfactory safety and easy development of drug resistance in existing oral care products using antibacterial and anti-caries methods, showing promising application prospects.

The invention relates to a preparation method and application of a tooth antibacterial and mineralized dual-function anti-caries material. The anti-caries material provided by the invention comprises two components, namely a mineralizing solution I and a mineralizing solution II. The mineralization liquid I contains polyelectrolyte and soluble salt of antibacterial metal cations; and the mineralization liquid II contains phosphate and fluoride. The pH values of the two mineralizing solutions are both 9.5 + / -0.5. During use, the surface of a demineralized tooth is firstly cleaned, the mineralizing liquid I and the mineralizing liquid II are sequentially coated, flushing is performed after each action for 15 minutes, 1-3 cycles are performed every day, and continuous treatment is performed for 7-14 days. Through polyelectrolyte template guiding and antibacterial metal ion doping, a biomimetic mineralization layer with an antibacterial function is formed on the surface of the demineralized tooth, and the dual functions of antibacterial and remineralization are achieved. The material can significantly recover the mechanical properties of teeth, the elastic modulus and hardness recovery rates respectively reach 68.6% and 62.5%, the dental caries score is reduced by 70% or more, and the dental caries prevention material has an excellent dental caries prevention effect and a clinical application prospect.

The invention discloses a buccal element as well as a preparation method and application thereof, and belongs to the technical field of oral cleaning supplies. The method comprises the following steps: firstly, adding 2.8 to 3.5 parts of glacial acetic acid, 0.005 to 0.015 part of sodium benzoate, 0.005 to 0.015 part of sodium cyclamate, 0.08 to 0.12 part of lactic acid and 0.04 to 0.06 part of citric acid into 100 parts of water, and mixing to form acetic acid mother liquor; then, putting 3.7-4.6 parts of sodium bicarbonate and 0.08-0.12 part of calcium carbonate into a container, adding the acetic acid mother solution into the container, and stirring to form a mixed solution; adjusting the pH value of the mixed solution to 6.8-7.2, then sequentially adding 0.08-0.12 part by weight of lovastatin, 0.02-0.04 part by weight of peppermint water and 0.08-0.12 part by weight of a clove extracting solution, and uniformly stirring, so as to obtain the traditional Chinese medicine composition. The method disclosed by the invention is simple, and the prepared buccal essence is non-toxic and non-irritant, is high in decayed tooth inhibition rate and can quickly relieve decayed tooth pain and dentin hypersensitivity.

The application belongs to the technical field of nanomaterials, and particularly relates to a graphene oxide composite nanocoating, application thereof and modified dental metal material. The obtained graphene oxide composite nanocoating overcomes the problem of easy agglomeration of GO alone, has the advantages of long-term antibacterial property, strong corrosion resistance, low toxicity, good remineralization effect on dental enamel, reduced occurrence of dental demineralization and dental caries, effectively reduced friction between dental metal materials, especially between metal materials for orthodontic treatment, is conducive to the sliding between arch wires and bracket grooves in the orthodontic process, and further conducive to improving the efficiency of aligning and flattening the dental arch in orthodontic treatment and shortening the treatment course. In addition, the application has the characteristics of simple operation, low cost and strong controllability, and provides a simple and universal strategy for preparing dental metal materials with long-term antibacterial property, corrosion resistance, low toxicity, good remineralization effect and low friction.

The invention relates to the technical field of biomedical materials, in particular to a COF heterojunction nanosphere with biomimetic mineralization and antibacterial functions and a preparation method and application thereof. The preparation method comprises the following steps: mixing a magnolol solution, a 1, 3, 5-tris (4-aminophenyl) benzene solution, a polyvinylpyrrolidone solution, a 2, 5-dimethoxybenzene-1, 4-dicarboxaldehyde solution and acetic acid, so as to obtain COFDMTP-coated Honokiol nanospheres; the preparation method comprises the following steps: mixing 4, 4 '-((2, 5-diformyl-1, 4-phenylene) bis (oxy)) dibutyric acid, COFDMTP (at) Honokiol nanospheres, acetonitrile and an acetic acid solution, and reacting to obtain the COFFPBA (at) Honokiol heterojunction nanospheres. The heterojunction nanosphere provided by the invention not only can promote the mineralization of acid-etched enamel, but also can effectively inhibit the growth of oral bacteria and reduce the occurrence of decayed teeth.

The invention discloses a dental disease image recognition method and system, computer equipment and a storage medium, and the method achieves the bidirectional interaction knowledge transmission between students and a teacher model through constructing a dynamic agent teacher model and integrating the multi-level features of a teacher network, and solves the problem of knowledge stagnation caused by traditional one-way distillation. A comparison relation distillation module is further designed, the relation between samples is optimized based on a cosine similarity matrix and positive and negative sample masks, feature redundancy is reduced in combination with a covariance regularization technology, and the feature alignment capability of the model is improved. And finally, through joint optimization of interactive distillation loss, comparison loss and covariance loss, a lightweight student model is trained. According to the method, the early classification accuracy of dental diseases such as decayed teeth and gingivitis is remarkably improved while the model calculation complexity and the storage requirement are reduced, and the method is suitable for medical scenes with limited resources and has important clinical application value.

The invention belongs to the technical field of traditional Chinese medicines, and relates to a glycyrrhiza uralensis n-butyl alcohol extract and application of effective components thereof. The invention relates to a glycyrrhiza uralensis n-butyl alcohol extract. The effective components of the glycyrrhiza uralensis n-butyl alcohol extract are prepared from glycyrrhiza uralensis isoflavanone, glycyrrhiza stem alcohol A, licorcidine, dibutyl phthalate, glycyrrhizin I, 3 '-Dimethylallylkievitone, lupinone, glycyrrhiza flavonol, edediol, 1-methoxy phaseolin and isoderrone. The glycyrrhiza uralensis n-butyl alcohol extract is prepared from the following raw materials: glycyrrhiza uralensis, glycyrrhiza uralensis, glycyrrhiza uralensis, glycyrrhiza uralensis, glycyrrhiza uralensis, glycyrrhiza uralensis, glycyrrhiza uralensis, glycyrrhiza uralensis, glycyrrhiza uralensis and glycyrrhiza uralensis, the anti-streptococcus mutans activity of the glycyrrhiza uralensis n-butyl alcohol extract provided by the invention is superior to that of an extract extracted by ethanol in the same extraction method. The method has more advantages in the aspect of preventing streptococcus mutans infection and decayed teeth, and a theoretical basis is provided for research and development of new products.

The present invention discloses a method for dental caries segmentation in oral panoramic films based on semi-supervised multi-level uncertainty perception. The present invention performs iterative training through a student-teacher model, extracts feature maps of different scales from each layer of the decoder for deep supervision, and uses Gaussian noise perturbation and the Monte Carlo method to generate an uncertainty mask matrix, and utilizes the multi-level output of decoders at different layers to assist in the generation of the uncertainty mask. Due to the differences in the receptive fields of each layer, the present method expands the uncertainty mask matrix from two-dimensional space to three-dimensional space, that is, simultaneously utilizes noise perturbation, exponential moving average (EMA) and multi-level features to enrich the reference of the uncertainty mask, thereby helping the model to distinguish between artifacts and dental caries with similar image features in oral panoramic images, and improve the model's recognition performance for dental caries of various sizes, thereby enhancing the medical auxiliary role.

This specification describes a dental imaging and / or curing system and methods of using it, optionally in combination with a fluorescent imaging aid applied to a tooth. In some examples, a system or kit described in this specification combines a fluorescent compound with an intra-oral device. The intra-oral device includes a light source to excite the fluorescent compound. The intra-oral device further includes a sensor to produce an image of fluorescent light emitted from the fluorescent compound. Optionally, the fluorescent compound can include positively charged nanoparticles including a fluorophore, for example fluorescein. Optionally, the intra-oral device can include a blue LED, a bandpass emission filter and a digital camera sensor. This specification also describes an intra-oral device and a method of producing an image of plaque, calculus or active carious lesions in the mouth of a person or other animal.

The invention belongs to the technical field of food additives, and particularly discloses dictyophora rubrovolvata beta-glucan low-calorie hydrophilic colloid and a preparation method and application thereof.The dictyophora rubrovolvata beta-glucan in dictyophora rubrovolvata is extracted through a water extraction and alcohol precipitation method, and the extract has good physiological activities such as blood sugar lowering activity and immunity. And compounding the dictyophora rubrovolvata beta-glucan and erythritol through a series of steps of sol dissolving, decocting and cooling, so as to prepare the dictyophora rubrovolvata beta-glucan low-calorie hydrophilic colloid. The prepared dictyophora rubrovolvata beta-glucan low-calorie hydrophilic colloid is applied to preparation of low-calorie soft sweets, the situation that traditional soft sweets with gelatin as a gelling agent are low in nutritional value and rich in saccharides, and the risk of chronic diseases such as obesity, decayed teeth, hyperglycemia and type II diabetes mellitus can be possibly increased is broken through, and the prepared dictyophora rubrovolvata beta-glucan low-calorie hydrophilic colloid has the advantages of being simple in preparation process, low in cost and the like. And a development direction is provided for researching and developing a novel functional gelling agent into soft sweets.

The utility model provides an anti-caries ointment smearing device which comprises a groove, limiting pieces are arranged at the two ends of the groove, the area defined by the inner side faces of the two adjacent limiting pieces and the inner wall of the groove is filled with a sponge body, the lower end of the sponge body is a tip end, a connecting piece is arranged on one side of the outer surface of the groove, and an extension piece is arranged at the tail end of the connecting piece in a connected mode. The sponge body is in an extrusion form, the tip is tightly attached to the outer surface of a target decayed tooth in an extrusion posture, the inner wall of the groove is tightly attached to the inner side face, the outer side face and the occlusal face of the target decayed tooth through the sponge body in the extrusion posture, and the inner side face of the limiting piece is tightly attached to the adjacent face of the target decayed tooth through the sponge body in the extrusion posture. According to the embodiment, the tip of the cavernous body penetrates into the inner side surface of a target decayed tooth and is tightly attached to the inner side surface of the decayed tooth, the cavernous body, the inner side face of the limiting piece and the side wall of the groove jointly surround the outer surface of the target decayed tooth, saliva can be isolated in the ointment staying process, and the problems that the ointment is swallowed by mistake and the ointment staying amount is insufficient are solved.

The invention relates to anti-caries toothpaste capable of freshening breath and a preparation method of the anti-caries toothpaste. The anti-caries toothpaste comprises disodium dihydrogen pyrophosphate, zinc citrate, a grape seed extract, tetrasodium pyrophosphate, sodium fluoride and synthetic fluorophlogopite. The disodium dihydrogen pyrophosphate, the zinc citrate, the grape seed extract, the tetrasodium pyrophosphate, the sodium fluoride and the synthetic fluorophlogopite are combined, so that a synergistic interaction effect is achieved, decayed teeth can be prevented and treated, and fresh breath is remarkably improved.

Disclosed are a novel Streptococcus salivarius (S. salivarius G7, KCCM13161P) strain, a composition containing the same for prevention or alleviation of an oral disease, and oral probiotics, and specifically, the novel Streptococcus salivarius (S. salivarius G7, KCCM13161P) strain can prevent, treat, and alleviate periodontal diseases through strong antibacterial and antiinflammatory activities against periodontal disease-causing strains, prevents, treat, and alleviates dental caries through strong antibacterial activity against dental caries-causing strains and biofilm formation inhibitory ability, and suppress halitosis caused by oral diseases, thereby contributing to oral health improvement.