The invention relates to novel application of an artemisinin ingredient or a composition thereof in oral nursing, namely novel application in the field of mammal oral nursing. The artemisinin ingredient or the composition has a series of advantages of capability of correcting keratinization abnormality, anti-inflammation effect, analgesic effect, hemostasis effect, callus effect, antibacterial effect and antifungal effect, thereby being capable of eliminating or relieving adverse conditions of mammal oral cavities to improve health and beauty of the oral cavities. The advantages are proved by obviously preventing or relieving mammal dental plaque, gingivitis, periodontitis, oral keratoma, tooth sensitivity, oral ulcer, dental decay and oral pathogen proliferation. The advantages are realized by applying the artemisinin ingredient or the composition thereof or oral nursing compositions like health products, daily chemical products, healthcare products or drugs containing the artemisinin ingredient or the composition thereof. Application of the artemisinin ingredient or the composition thereof is expanded to the field of oral nursing, so that the artemisinin ingredient or the composition thereof is enabled to exert higher efficacy for health cause of the public.