Mouthwash for preventing oral cancerization

Abstract

The invention discloses a mouthwash for preventing oral cancerization. The mouthwash is prepared from the following raw material components: 8-13 parts of normal saline, 1-3 parts of a rotting agent, 1-2 parts of a sweetening agent, 1-3 parts of an ethanol humectant, 0.1-0.5 part of a surfactant, 0.2-0.6 part of a coloring agent, 0.5-2 parts of a preservative, 1-3 parts of food-grade sodium fluoride, 0.1-0.5 part of food-grade strontium chloride and 75-90 parts of refined water. Sodium fluoride has the effects of increasing density and sterilizing. The protection effect on the tooth glaze can be achieved. The toothpaste has the same effect on oral bacteria fluorine-containing toothpaste. Strontium chloride has the effects of cleaning tooth stains and relieving pains caused by tooth sensitivity. The use method of the mouthwash is simple, and after betel nuts are chewed, the mouthwash is used for cleaning the oral cavity, so that the effect of preventing oral canceration is achieved.

Description

Technical Field

[0001] The invention relates to the technical field of mouthwashes, in particular to a mouthwash for preventing oral cancer. Background Art

[0002] The main function of mouthwash is to remove bad breath. Using mouthwash can make our mouth healthier and less likely to produce unpleasant odors. Therefore, it is recommended that you rinse your mouth frequently. And rinsing your mouth is very simple, and only half a minute is enough.

[0004] 1. Symptoms of the disease

[0005] ① Betel nut consumers are generally sensitive to sour, cold and sweet. Their teeth cannot bear the force after eating.

[0006] ② Excessive dosage will lead to frequent canceration.

[0007] 2. Analysis of lesions

[0008] ① Betel nut is a hard food. Long-term chewing will cause excessive wear on the enamel that protects the teeth, making the teeth sensitive to sensitive objects.

[0009] ② After long-term chewing, the hard thorns will damage the oral mucosa. If it is not cleaned, long-term damage and infection will lead to cancer.

[0010] Considering the convenience of mouthwash and the specific consumer group that consumes betel nut, it can be seen that there is a large application space for combining the two. Summary of the invention

[0011] The purpose of the present invention is to provide a mouthwash for preventing oral cancer, so as to solve the problems mentioned in the technical background.

[0012] A mouthwash for preventing oral cancer, the raw materials of the mouthwash consisting of the following components: 8-13 parts of physiological saline, 1-3 parts of septic agent, 1-2 parts of sweetener, 1-3 parts of ethanol moisturizer, 0.1-0.5 parts of surfactant, 0.2-0.6 parts of colorant, 0.5-2 parts of preservative, 1-3 parts of food-grade sodium fluoride, 0.1-0.5 parts of food-grade strontium chloride and 75-90 parts of purified water.

[0013] Preferably, the sweetener comprises the following components in parts by weight: 2-3 parts of Terminalia chebula extract, 2-3 parts of Olea europaea extract and 1-2 parts of xylitol;

[0014] The terminalia chebula extract is prepared by the following processing technology:

[0015] S1. Raw material pretreatment: selecting fresh and ripe Terminalia chebula fruits, cleaning them, drying them and then crushing them to obtain Terminalia chebula fruit crushed;

[0016] S2, three freeze-thaw cycles: freezing the terminalia chebula fruit pieces for the first time at -10±2°C for more than 6 hours, and thawing at 20±2°C for 2-3 hours; freezing for the second time at -20±2°C for more than 10 hours, and thawing at 25±2°C for 5-6 hours; freezing for the third time at -20±2°C for more than 5 hours, and thawing at 25±2°C for 5-6 hours, to obtain freeze-thawed fruit pieces;

[0017] S3, ultrasonic extraction: mixing the frozen-thawed fruit pieces with water in a mass ratio of 1:14 and performing ultrasonic extraction to obtain terminalia chebula fruit slurry;

[0018] S4, centrifugation: centrifuging the terminalia chebula fruit slurry, taking the supernatant to obtain terminalia chebula fruit liquid;

[0019] S5, vacuum concentration: placing the terminalia chebula fruit liquid in a vacuum vacuum concentrator, and vacuum concentrating at 60-70° C. and a gauge pressure of 0.05-0.08 MPa to obtain the terminalia chebula extract.

[0020] Preferably, the method for preparing the colorant comprises the following steps:

[0021] a. Put green tea into water, heat it to 80±1℃ and keep it boiling for 3±1 hours;

[0022] b. Lower the heating temperature to 45±5℃ to evaporate the excess water and make the tea extract adhere to the tea leaves;

[0023] c. Place the tea leaves with the precipitate in a dryer and dry them at 60±10°C to obtain a colorant.

[0024] Preferably, the preparation method of food grade strontium chloride comprises the following steps:

[0025] A. High purity Sr(OH) 2 8H2O is prepared as Sr(OH) 2 Aqueous solution; the high-purity Sr(OH) 2 8H 2 The purity of O is not less than 99%;

[0026] B. The Sr(OH) 2 Aqueous solution with MgCl 2 The aqueous solutions are mixed to obtain a slurry;

[0027] C. Separate the slurry into solid and liquid to obtain SrCl 2 Aqueous solution;

[0028] D. The SrCl 2The pH of the aqueous solution is adjusted to neutral, and strontium chloride for toothpaste is obtained through concentration, crystallization, solid-liquid separation and drying.

[0029] As a preferred method, high purity Sr(OH) 2 8H 2 O's specific methods include:

[0030] A1. Sr(OH) 2 0~8H 2 O solid is prepared as crude Sr(OH) 2 aqueous solution; said Sr(OH) 2 0~8H 2 O solid is selected from industrial grade Sr(OH) 2 0~8H 2 O, reagent grade Sr(OH) 2 0~8H 2 At least one of O;

[0031] A2, to the crude Sr (OH) 2 Add flocculant to the aqueous solution and react to obtain Sr(OH) 2 The flocculant is a natural organic polymer flocculant, and the mass of the flocculant is not greater than the crude Sr(OH) 2 0.01% of the mass of aqueous solution;

[0032] A3, the Sr (OH) 2 The turbid liquid was separated into solid and liquid to obtain purified Sr(OH) 2 Aqueous solution;

[0033] A4, the purified Sr (OH) 2 The aqueous solution was cold crystallized and solid-liquid separated to obtain Sr(OH) 2 8H 2 O filter cake;

[0034] A5, the Sr (OH) 2 8H 2 Repeat steps A1 to A4 for no more than 3 times until the high-purity Sr(OH) is obtained. 2 8H 2 O.

[0035] Preferably, the preparation method of the mouthwash comprises the following steps:

[0036] (1) adding physiological saline, food-grade sodium fluoride and food-grade strontium chloride to half of the total amount of purified water for extraction, and then adding the remaining soda water to continue extraction to obtain a water extract;

[0037] (2) adding the rotten taste agent, sweetener and surfactant to the ethanol moisturizer, heating and refluxing, and then concentrating under reduced pressure, drying and removing the ethanol to obtain an alcohol extract;

[0038] (3) Add the alcohol extract to the water extract, and then add the colorant and preservative in sequence. After mixing, the mouthwash is obtained.

[0039] Preferably, in step (1), the extraction is carried out at 50-70°C for 1-2 hours; and the continued extraction is carried out at 75-80°C for 20-30 minutes.

[0040] Preferably, in step (2), the heating reflux is carried out at 85-90° C. for 2-3 h.

[0041] Preferably, in step (2), the reduced pressure concentration is carried out at 60-75°C and -0.06-0.08MPa; the drying is carried out in a vacuum drying oven, and the temperature of the vacuum drying oven is set to 40-60°C.

[0042] Compared with the prior art, the present invention has the following beneficial effects:

[0043] (1) The mouthwash provided by the present invention for preventing oral cancer has the effect of increasing density and killing bacteria due to the properties of sodium fluoride. It can protect tooth enamel and has the same effect as fluoride toothpaste on oral bacteria.

[0044] (2) Strontium chloride can clean tooth stains and relieve pain caused by tooth sensitivity.

[0045] (3) Mouthwash is easy to use. After chewing betel nut, use mouthwash to clean your mouth to prevent oral cancer.

[0046] Other advantages and features of the present invention will be partially reflected in the following description, and partly will be understood by those skilled in the art through research and practice of the present invention. The above description is only an overview of the technical solution of the embodiment of the present application. In order to more clearly understand the technical means of the embodiment of the present application, it can be implemented according to the contents of the specification, and in order to make the above and other purposes, features and advantages of the embodiment of the present application more obvious and easy to understand, the specific implementation methods of the present application are specifically cited below. DETAILED DESCRIPTION

[0047] In order to make the purpose, technical solution and advantages of the embodiments of the present application clearer, the technical solution in the embodiments of the present application is clearly and completely described below. Obviously, the described embodiments are part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this application.

[0048] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by technicians in the technical field to which this application belongs; the terms used in the specification of the application are only for the purpose of describing specific embodiments and are not intended to limit this application; the terms "including" and "having" in the specification and claims of this application and any variations thereof are intended to cover non-exclusive inclusions.

[0049] Reference to "embodiments" herein means that a particular feature, structure, or characteristic described in conjunction with the embodiments may be included in at least one embodiment of the present application. The appearance of the phrase "embodiments" in various locations in the specification does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment that is mutually exclusive with other embodiments. It is explicitly and implicitly understood by those skilled in the art that the embodiments described herein may be combined with other embodiments.

[0050] In order to enable those skilled in the art to better understand the solution of the present application, the technical solution in the embodiments of the present application is clearly and completely described below.

[0051] A mouthwash for preventing oral cancer, the raw materials of the mouthwash consisting of the following components: 8-13 parts of physiological saline, 1-3 parts of septic agent, 1-2 parts of sweetener, 1-3 parts of ethanol moisturizer, 0.1-0.5 parts of surfactant, 0.2-0.6 parts of colorant, 0.5-2 parts of preservative, 1-3 parts of food-grade sodium fluoride, 0.1-0.5 parts of food-grade strontium chloride and 75-90 parts of purified water.

[0052] The sweetener comprises the following components in parts by weight: 2-3 parts of terminalia chebula extract, 2-3 parts of dianthus olive extract and 1-2 parts of xylitol; the terminalia chebula extract is prepared by the following processing technology:

[0053] S1. Raw material pretreatment: selecting fresh and ripe Terminalia chebula fruits, cleaning them, drying them and then crushing them to obtain Terminalia chebula fruit crushed;

[0054] S2, three freeze-thaw: freeze the terminalia chebula fruit pieces for the first time at -10±2°C for more than 6 hours, and thaw at 20±2°C for 2-3 hours; freeze for the second time at -20±2°C for more than 10 hours, and thaw at 25±2°C for 5-6 hours; freeze for the third time at -20±2°C for more than 5 hours, and thaw at 25±2°C for 5-6 hours to obtain freeze-thawed fruit pieces;

[0055] S3, ultrasonic extraction: mixing the frozen-thawed fruit pieces with water in a mass ratio of 1:14 and performing ultrasonic extraction to obtain terminalia chebula fruit slurry;

[0056] S4, centrifugation: centrifuging the terminalia chebula fruit slurry, taking the supernatant to obtain terminalia chebula fruit liquid;

[0057] S5, vacuum concentration: placing the terminalia chebula fruit liquid in a vacuum vacuum concentrator, and vacuum concentrating at 60-70° C. and a gauge pressure of 0.05-0.08 MPa to obtain the terminalia chebula extract.

[0058] The preparation method of the colorant comprises the following steps:

[0059] a. Put green tea into water, heat it to 80±1℃ and keep it boiling for 3±1 hours;

[0060] b. Lower the heating temperature to 45±5℃ to evaporate the excess water and make the tea extract adhere to the tea leaves;

[0061] c. Place the tea leaves with the precipitate in a dryer and dry them at 60±10°C to obtain a colorant.

[0062] The preparation method of food grade strontium chloride comprises the following steps:

[0063] A. High purity Sr(OH) 2 8H2O is prepared as Sr(OH) 2 Aqueous solution; the high-purity Sr(OH) 2 8H 2 The purity of O is not less than 99%;

[0064] B. The Sr(OH) 2 Aqueous solution with MgCl 2 The aqueous solutions are mixed to obtain a slurry;

[0065] C. Separate the slurry into solid and liquid to obtain SrCl 2 Aqueous solution;

[0066] D. The SrCl 2 The pH of the aqueous solution is adjusted to neutral, and strontium chloride for toothpaste is obtained through concentration, crystallization, solid-liquid separation and drying.

[0067] High purity Sr(OH) 2 8H 2 O's specific methods include:

[0068] A1. Sr(OH) 2 0~8H 2 O solid is prepared as crude Sr(OH) 2 aqueous solution; said Sr(OH) 2 0~8H 2 O solid is selected from industrial grade Sr(OH) 2 0~8H 2 O, reagent grade Sr(OH)2 0~8H 2 At least one of O;

[0069] A2, to the crude Sr (OH) 2 Add flocculant to the aqueous solution and react to obtain Sr(OH) 2 The flocculant is a natural organic polymer flocculant, and the mass of the flocculant is not greater than the crude Sr(OH) 2 0.01% of the mass of aqueous solution;

[0070] A3, the Sr (OH) 2 The turbid liquid was separated into solid and liquid to obtain purified Sr(OH) 2 Aqueous solution;

[0071] A4, the purified Sr (OH) 2 The aqueous solution was cold crystallized and solid-liquid separated to obtain Sr(OH) 2 8H 2 O filter cake;

[0072] A5, the Sr (OH) 2 8H 2 Repeat steps A1 to A4 for no more than 3 times until the high-purity Sr(OH) is obtained. 2 8H 2 O.

[0073] The preparation method of the mouthwash comprises the following steps:

[0074] (1) adding physiological saline, food-grade sodium fluoride and food-grade strontium chloride to half of the total amount of purified water for extraction, and then adding the remaining soda water to continue extraction to obtain a water extract;

[0075] (2) adding the rotten taste agent, sweetener and surfactant to the ethanol moisturizer, heating and refluxing, and then concentrating under reduced pressure, drying and removing the ethanol to obtain an alcohol extract;

[0076] (3) Add the alcohol extract to the water extract, and then add the colorant and preservative in sequence. After mixing, the mouthwash is obtained.

[0077] In step (1), the extraction is carried out at 50-70°C for 1-2 hours; the continued extraction is carried out at 75-80°C for 20-30 minutes. In step (2), the heating reflux is carried out at 85-90°C for 2-3 hours. The reduced pressure concentration is carried out at 60-75°C and -0.06--0.08MPa; the drying is carried out in a vacuum drying oven, and the temperature of the vacuum drying oven is set to 40-60°C.

[0078] Example 1

[0079] A mouthwash for preventing oral cancer, the raw materials of the mouthwash consisting of the following components: 9 parts of physiological saline, 1.3 parts of septic agent, 1.2 parts of sweetener, 2.0 parts of ethanol moisturizer, 0.3 parts of surfactant, 0.3 parts of colorant, 1.5 parts of preservative, 2 parts of food-grade sodium fluoride, 0.4 parts of food-grade strontium chloride and 85 parts of purified water.

[0080] The sweetener comprises the following components in parts by weight: 2 parts of terminalia chebula extract, 2 parts of dianthus olive extract and 2 parts of xylitol; the terminalia chebula extract is prepared by the following processing technology:

[0081] S1. Raw material pretreatment: selecting fresh and ripe Terminalia chebula fruits, cleaning them, drying them and then crushing them to obtain Terminalia chebula fruit crushed;

[0082] S2, three freeze-thaw: freeze the terminalia chebula fruit pieces for the first time at -10±2°C for more than 6 hours, and thaw at 20±2°C for 2-3 hours; freeze for the second time at -20±2°C for more than 10 hours, and thaw at 25±2°C for 5-6 hours; freeze for the third time at -20±2°C for more than 5 hours, and thaw at 25±2°C for 5-6 hours to obtain freeze-thawed fruit pieces;

[0083] S3, ultrasonic extraction: mixing the frozen-thawed fruit pieces with water in a mass ratio of 1:14 and performing ultrasonic extraction to obtain terminalia chebula fruit slurry;

[0084] S4, centrifugation: centrifuging the terminalia chebula fruit slurry, taking the supernatant to obtain terminalia chebula fruit liquid;

[0085] S5, vacuum concentration: placing the terminalia chebula fruit liquid in a vacuum vacuum concentrator, and vacuum concentrating at 60-70° C. and a gauge pressure of 0.05-0.08 MPa to obtain the terminalia chebula extract.

[0086] Preferably, the method for preparing the colorant comprises the following steps:

[0087] a. Put green tea into water, heat it to 80±1℃ and keep it boiling for 3±1 hours;

[0088] b. Lower the heating temperature to 45±5℃ to evaporate the excess water and make the tea extract adhere to the tea leaves;

[0089] c. Place the tea leaves with the precipitate in a dryer and dry them at 60±10°C to obtain a colorant.

[0090] Preferably, the preparation method of food grade strontium chloride comprises the following steps:

[0091] A. High purity Sr(OH) 2 8H2O is prepared as Sr(OH) 2Aqueous solution; the high-purity Sr(OH) 2 8H 2 The purity of O is not less than 99%;

[0092] B. The Sr(OH) 2 Aqueous solution with MgCl 2 The aqueous solutions are mixed to obtain a slurry;

[0093] C. Separate the slurry into solid and liquid to obtain SrCl 2 Aqueous solution;

[0094] D. The SrCl 2 The pH of the aqueous solution is adjusted to neutral, and strontium chloride for toothpaste is obtained through concentration, crystallization, solid-liquid separation and drying.

[0095] High purity Sr(OH) 2 8H 2 O's specific methods include:

[0096] A1. Sr(OH) 2 0~8H 2 O solid is prepared as crude Sr(OH) 2 aqueous solution; said Sr(OH) 2 0~8H 2 O solid is selected from industrial grade Sr(OH) 2 0~8H 2 O, reagent grade Sr(OH) 2 0~8H 2 At least one of O;

[0097] A2, to the crude Sr (OH) 2 Add flocculant to the aqueous solution and react to obtain Sr(OH) 2 The flocculant is a natural organic polymer flocculant, and the mass of the flocculant is not greater than the crude Sr(OH) 2 0.01% of the mass of aqueous solution;

[0098] A3, the Sr (OH) 2 The turbid liquid was separated into solid and liquid to obtain purified Sr(OH) 2 Aqueous solution;

[0099] A4, the purified Sr (OH) 2 The aqueous solution was cold crystallized and solid-liquid separated to obtain Sr(OH) 2 8H 2 O filter cake;

[0100] A5, the Sr (OH) 2 8H 2Repeat steps A1 to A4 for no more than 3 times until the high-purity Sr(OH) is obtained. 2 8H 2 O.

[0101] The preparation method of the mouthwash comprises the following steps:

[0102] (1) adding physiological saline, food-grade sodium fluoride and food-grade strontium chloride to half of the total amount of purified water for extraction, and then adding the remaining soda water to continue extraction to obtain a water extract;

[0103] (2) adding the rotten taste agent, sweetener and surfactant to the ethanol moisturizer, heating and refluxing, and then concentrating under reduced pressure, drying and removing the ethanol to obtain an alcohol extract;

[0104] (3) Add the alcohol extract to the water extract, and then add the colorant and preservative in sequence. After mixing, the mouthwash is obtained.

[0105] Preferably, in step (1), the extraction is carried out at 50-70°C for 1-2 hours; the continued extraction is carried out at 75-80°C for 20-30 minutes. In step (2), the heating reflux is carried out at 85-90°C for 2-3 hours. The reduced pressure concentration is carried out at 60-75°C and -0.06--0.08MPa; the drying is carried out in a vacuum drying oven, and the temperature of the vacuum drying oven is set to 40-60°C.

[0106] Example 2

[0107] A mouthwash for preventing oral cancer, the raw materials of the mouthwash consisting of the following components: 11 parts of physiological saline, 2.5 parts of septic agent, 1 part of sweetener, 1.5 parts of ethanol moisturizer, 0.4 parts of surfactant, 0.5 parts of colorant, 1.5 parts of preservative, 3 parts of food-grade sodium fluoride, 0.4 parts of food-grade strontium chloride and 80 parts of purified water.

[0108] The sweetener comprises the following components in parts by weight: 3 parts of terminalia chebula extract, 2 parts of dianthus olive extract and 2 parts of xylitol; the terminalia chebula extract is prepared by the following processing technology:

[0109] S1. Raw material pretreatment: selecting fresh and ripe Terminalia chebula fruits, cleaning them, drying them and then crushing them to obtain Terminalia chebula fruit crushed;

[0110] S2, three freeze-thaw: freeze the terminalia chebula fruit pieces for the first time at -10±2°C for more than 6 hours, and thaw at 20±2°C for 2-3 hours; freeze for the second time at -20±2°C for more than 10 hours, and thaw at 25±2°C for 5-6 hours; freeze for the third time at -20±2°C for more than 5 hours, and thaw at 25±2°C for 5-6 hours to obtain freeze-thawed fruit pieces;

[0111] S3, ultrasonic extraction: mixing the frozen-thawed fruit pieces with water in a mass ratio of 1:14 and performing ultrasonic extraction to obtain terminalia chebula fruit slurry;

[0112] S4, centrifugation: centrifuging the terminalia chebula fruit slurry, taking the supernatant to obtain terminalia chebula fruit liquid;

[0113] S5, vacuum concentration: placing the terminalia chebula fruit liquid in a vacuum vacuum concentrator, and vacuum concentrating at 60-70° C. and a gauge pressure of 0.05-0.08 MPa to obtain the terminalia chebula extract.

[0114] The preparation method of the colorant comprises the following steps:

[0115] a. Put green tea into water, heat it to 80±1℃ and keep it boiling for 3±1 hours;

[0116] b. Lower the heating temperature to 45±5℃ to evaporate the excess water and make the tea extract adhere to the tea leaves;

[0117] c. Place the tea leaves with the precipitate in a dryer and dry them at 60±10°C to obtain a colorant.

[0118] The preparation method of food grade strontium chloride comprises the following steps:

[0119] A. High purity Sr(OH) 2 8H2O is prepared as Sr(OH) 2 Aqueous solution; the high-purity Sr(OH) 2 8H 2 The purity of O is not less than 99%;

[0120] B. The Sr(OH) 2 Aqueous solution with MgCl 2 The aqueous solutions are mixed to obtain a slurry;

[0121] C. Separate the slurry into solid and liquid to obtain SrCl 2 Aqueous solution;

[0122] D. The SrCl 2 The pH of the aqueous solution is adjusted to neutral, and strontium chloride for toothpaste is obtained through concentration, crystallization, solid-liquid separation and drying.

[0123] High purity Sr(OH) 2 8H 2 O's specific methods include:

[0124] A1. Sr(OH) 2 0~8H 2 O solid prepared as crude Sr(OH) 2aqueous solution; said Sr(OH) 2 0~8H 2 O solid is selected from industrial grade Sr(OH) 2 0~8H 2 O, reagent grade Sr(OH) 2 0~8H 2 At least one of O;

[0125] A2, to the crude Sr (OH) 2 Add flocculant to the aqueous solution and react to obtain Sr(OH) 2 The flocculant is a natural organic polymer flocculant, and the mass of the flocculant is not greater than the crude Sr(OH) 2 0.01% of the mass of aqueous solution;

[0126] A3, the Sr (OH) 2 The turbid liquid was separated into solid and liquid to obtain purified Sr(OH) 2 Aqueous solution;

[0127] A4, the purified Sr (OH) 2 The aqueous solution was cold crystallized and solid-liquid separated to obtain Sr(OH) 2 8H 2 O filter cake;

[0128] A5, the Sr (OH) 2 8H 2 Repeat steps A1 to A4 for no more than 3 times until the high-purity Sr(OH) is obtained. 2 8H 2 O.

[0129] The preparation method of the mouthwash comprises the following steps:

[0130] (1) adding physiological saline, food-grade sodium fluoride and food-grade strontium chloride to half of the total amount of purified water for extraction, and then adding the remaining soda water to continue extraction to obtain a water extract;

[0131] (2) adding the rotten taste agent, sweetener and surfactant to the ethanol moisturizer, heating and refluxing, and then concentrating under reduced pressure, drying and removing the ethanol to obtain an alcohol extract;

[0132] (3) Add the alcohol extract to the water extract, and then add the colorant and preservative in sequence. After mixing, the mouthwash is obtained.

[0133] In step (1), the extraction is carried out at 50-70°C for 1-2 hours; and the continued extraction is carried out at 75-80°C for 20-30 minutes.

[0134] In step (2), the heating reflux is carried out at 85-90°C for 2-3h. The reduced pressure concentration is carried out at 60-75°C and -0.06--0.08MPa; the drying is carried out in a vacuum drying oven, and the temperature of the vacuum drying oven is set at 40-60°C.

[0135] Example 3

[0136] A mouthwash for preventing oral cancer, the raw materials of the mouthwash consisting of the following components: 12 parts of physiological saline, 3 parts of septic agent, 2 parts of sweetener, 2.5 parts of ethanol moisturizer, 0.4 parts of surfactant, 0.3 parts of colorant, 1.8 parts of preservative, 2 parts of food-grade sodium fluoride, 0.4 parts of food-grade strontium chloride and 88 parts of purified water.

[0137] The sweetener comprises the following components in parts by weight: 2.5 parts of terminalia chebula extract, 3 parts of dianthus olive extract and 2 parts of xylitol; the terminalia chebula extract is prepared by the following processing technology:

[0138] S1. Raw material pretreatment: selecting fresh and ripe Terminalia chebula fruits, cleaning them, drying them and then crushing them to obtain Terminalia chebula fruit crushed;

[0139] S2, three freeze-thaw: freeze the terminalia chebula fruit pieces for the first time at -10±2°C for more than 6 hours, and thaw at 20±2°C for 2-3 hours; freeze for the second time at -20±2°C for more than 10 hours, and thaw at 25±2°C for 5-6 hours; freeze for the third time at -20±2°C for more than 5 hours, and thaw at 25±2°C for 5-6 hours to obtain freeze-thawed fruit pieces;

[0140] S3, ultrasonic extraction: mixing the frozen-thawed fruit pieces with water in a mass ratio of 1:14 and performing ultrasonic extraction to obtain terminalia chebula fruit slurry;

[0141] S4, centrifugation: centrifuging the terminalia chebula fruit slurry, taking the supernatant to obtain terminalia chebula fruit liquid;

[0142] S5, vacuum concentration: placing the terminalia chebula fruit liquid in a vacuum vacuum concentrator, and vacuum concentrating at 60-70° C. and a gauge pressure of 0.05-0.08 MPa to obtain the terminalia chebula extract.

[0143] The preparation method of the colorant comprises the following steps:

[0144] a. Put green tea into water, heat it to 80±1℃ and keep it boiling for 3±1 hours;

[0145] b. Lower the heating temperature to 45±5℃ to evaporate the excess water and make the tea extract adhere to the tea leaves;

[0146] c. Place the tea leaves with the precipitate in a dryer and dry them at 60±10°C to obtain a colorant.

[0147] The preparation method of food grade strontium chloride comprises the following steps:

[0148] A. High purity Sr(OH) 2 8H2O is prepared as Sr(OH) 2 Aqueous solution; the high-purity Sr(OH) 2 8H 2 The purity of O is not less than 99%;

[0149] B. The Sr(OH) 2 Aqueous solution with MgCl 2 The aqueous solutions are mixed to obtain a slurry;

[0150] C. Separate the slurry into solid and liquid to obtain SrCl 2 Aqueous solution;

[0151] D. The SrCl 2 The pH of the aqueous solution is adjusted to neutral, and strontium chloride for toothpaste is obtained through concentration, crystallization, solid-liquid separation and drying.

[0152] High purity Sr(OH) 2 8H 2 O's specific methods include:

[0153] A1. Sr(OH) 2 0~8H 2 O solid is prepared as crude Sr(OH) 2 aqueous solution; said Sr(OH) 2 0~8H 2 O solid is selected from industrial grade Sr(OH) 2 0~8H 2 O, reagent grade Sr(OH) 2 0~8H 2 At least one of O;

[0154] A2, to the crude Sr (OH) 2 Add flocculant to the aqueous solution and react to obtain Sr(OH) 2 The flocculant is a natural organic polymer flocculant, and the mass of the flocculant is not greater than the crude Sr(OH) 2 0.01% of the mass of aqueous solution;

[0155] A3, the Sr (OH) 2 The turbid liquid was separated into solid and liquid to obtain purified Sr(OH) 2 Aqueous solution;

[0156] A4, the purified Sr (OH) 2 The aqueous solution was cold crystallized and solid-liquid separated to obtain Sr(OH) 2 8H 2 O filter cake;

[0157] A5, the Sr (OH) 2 8H 2 Repeat steps A1 to A4 for no more than 3 times until the high-purity Sr(OH) is obtained. 2 8H 2 O.

[0158] The preparation method of the mouthwash comprises the following steps:

[0159] (1) adding physiological saline, food-grade sodium fluoride and food-grade strontium chloride to half of the total amount of purified water for extraction, and then adding the remaining soda water to continue extraction to obtain a water extract;

[0160] (2) adding the rotten taste agent, sweetener and surfactant to the ethanol moisturizer, heating and refluxing, and then concentrating under reduced pressure, drying and removing the ethanol to obtain an alcohol extract;

[0161] (3) Add the alcohol extract to the water extract, and then add the colorant and preservative in sequence. After mixing, the mouthwash is obtained.

[0162] In step (1), the extraction is carried out at 50-70°C for 1-2 hours; and the continued extraction is carried out at 75-80°C for 20-30 minutes.

[0163] In step (2), the heating reflux is carried out at 85-90°C for 2-3h, and the reduced pressure concentration is carried out at 60-75°C and -0.06--0.08MPa; the drying is carried out in a vacuum drying oven, and the temperature of the vacuum drying oven is set to 40-60°C.

[0164] It can be seen from the bactericidal rate (%) of the mouthwash in Table 1 that the mouthwash prepared by the present invention has a good bactericidal effect.

[0165]

[0166] Table 1

[0167] As described above, the above embodiments are only used to illustrate the technical solutions of the present application, rather than to limit them. Although the present application has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present application.

Claims

1. A mouthwash for preventing oral cancer, characterized in that: The raw materials of the mouthwash are composed of the following components: 8-13 parts of physiological saline, 1-3 parts of septic agent, 1-2 parts of sweetener, 1-3 parts of ethanol moisturizer, 0.1-0.5 parts of surfactant, 0.2-0.6 parts of colorant, 0.5-2 parts of preservative, 1-3 parts of food-grade sodium fluoride, 0.1-0.5 parts of food-grade strontium chloride and 75-90 parts of purified water.

2. A mouthwash for preventing oral cancer according to claim 1, characterized in that: The sweetener comprises the following components in parts by weight: 2-3 parts of Terminalia chebula extract, 2-3 parts of Olea europaea extract and 1-2 parts of xylitol; The terminalia chebula extract is prepared by the following processing technology: S1. Raw material pretreatment: selecting fresh and ripe Terminalia chebula fruits, cleaning them, drying them and then crushing them to obtain Terminalia chebula fruit crushed; S2, three freeze-thaw: freeze the terminalia chebula fruit pieces for the first time at -10±2°C for more than 6 hours, and thaw at 20±2°C for 2-3 hours; freeze for the second time at -20±2°C for more than 10 hours, and thaw at 25±2°C for 5-6 hours; freeze for the third time at -20±2°C for more than 5 hours, and thaw at 25±2°C for 5-6 hours to obtain freeze-thawed fruit pieces; S3, ultrasonic extraction: mixing the frozen-thawed fruit pieces with water in a mass ratio of 1:14 and performing ultrasonic extraction to obtain terminalia chebula fruit slurry; S4, centrifugation: centrifuging the terminalia chebula fruit slurry, taking the supernatant to obtain terminalia chebula fruit liquid; S5, vacuum concentration: placing the terminalia chebula fruit liquid in a vacuum vacuum concentrator, and vacuum concentrating at 60-70° C. and a gauge pressure of 0.05-0.08 MPa to obtain the terminalia chebula extract.

3. A mouthwash for preventing oral cancer according to claim 1, characterized in that: The preparation method of the colorant comprises the following steps: a. Put green tea into water, heat it to 80±1℃ and keep it boiling for 3±1 hours; b. Lower the heating temperature to 45±5℃ to evaporate the excess water and make the tea extract adhere to the tea leaves; c. Place the tea leaves with the precipitate in a dryer and dry them at 60±10°C to obtain a colorant.

4. A mouthwash for preventing oral cancer according to claim 1, characterized in that: The preparation method of the food grade strontium chloride comprises the following steps: A. preparing a Sr(OH)2 aqueous solution from high-purity Sr(OH)2·8H2O; wherein the purity of the high-purity Sr(OH)2·8H2O is not less than 99%; B. mixing the Sr(OH)2 aqueous solution and the MgCl2 aqueous solution to obtain a slurry; C. performing solid-liquid separation on the slurry to obtain a SrCl2 aqueous solution; D. The pH of the SrCl2 aqueous solution is adjusted to neutral, and strontium chloride for toothpaste is obtained by concentration, crystallization, solid-liquid separation and drying.

5. A mouthwash for preventing oral cancer according to claim 4, characterized in that: The specific method of high-purity Sr(OH)2·8H2O comprises: A1. Prepare a crude Sr(OH)2 aqueous solution from Sr(OH)2 solid 0-8H2O; the Sr(OH)2 solid 0-8H2O is selected from at least one of industrial grade Sr(OH)2 0-8H2O and reagent grade Sr(OH)2 0-8H2O; A2, adding a flocculant to the crude Sr(OH)2 aqueous solution and reacting to obtain a Sr(OH)2 turbid solution; the flocculant is a natural organic polymer flocculant, and the mass of the flocculant is not greater than 0.01% of the mass of the crude Sr(OH)2 aqueous solution; A3, separating the Sr(OH)2 turbid solution into solid and liquid to obtain a purified Sr(OH)2 aqueous solution; A4, cold crystallizing and solid-liquid separation the purified Sr(OH)2 aqueous solution to obtain a Sr(OH)2·8H2O filter cake; A5. Repeat steps A1 to A4 for no more than 3 times with the Sr(OH)2·8H2O filter cake until the high-purity Sr(OH)2·8H2O is obtained.

6. A mouthwash for preventing oral cancer according to claim 1, characterized in that: The preparation method of the mouthwash comprises the following steps: (1) adding physiological saline, food-grade sodium fluoride and food-grade strontium chloride to half of the total amount of purified water for extraction, and then adding the remaining soda water to continue extraction to obtain a water extract; (2) adding the rotten taste agent, sweetener and surfactant to the ethanol moisturizer, heating and refluxing, and then concentrating under reduced pressure, drying and removing the ethanol to obtain an alcohol extract; (3) Add the alcohol extract to the water extract, and then add the colorant and preservative in sequence. After mixing, the mouthwash is obtained.

7. A mouthwash for preventing oral cancer according to claim 6, characterized in that: In the step (1), the extraction is carried out at 50-70°C for 1-2 hours; and the continued extraction is carried out at 75-80°C for 20-30 minutes.

8. A mouthwash for preventing oral cancer according to claim 6, characterized in that: In the step (2), the heating reflux is performed at 85-90° C. for 2-3 hours.

9. A mouthwash for preventing oral cancer according to claim 6, characterized in that: In the step (2), the reduced pressure concentration is carried out at 60-75°C and -0.06--0.08MPa; the drying is carried out in a vacuum drying oven, and the temperature of the vacuum drying oven is set at 40-60°C.

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