249 results about "Oral Cancers" patented technology

Methods and device for detecting the presence of tumor biomarkers in oral squamous cell carcinoma. A membrane based cell capture device allows deliver of cell samples and reagents to the membrane

The present invention provides a novel oral cancer and periodontal disease salivary metabolome for use in the diagnosis or for providing a prognosis for oral cancer and periodontal disease in an individual. The present invention also provides novel methods of diagnosing or providing a prognosis for oral cancer or periodontal disease by detecting metabolites found in the saliva of an individual. Finally, the present invention provides kits for the detection of salivary metabolites useful in the diagnosis or prognosis of oral cancer and periodontal disease in an individual.

Methods of monitoring the expression of genes in malignant oral cells is disclosed. Gene expression profiles are used to identify markers associated with malignant oral cells and to diagnose oral cancer.

The present invention provides for pharmaceutical compositions comprising carvedilol for treatment of cancer. More particularly the invention relates to the use of carvedilol for treatment of cancers of the colon, ovary, breast, prostate, pancreas, lung, melanoma, glioblastoma, oral cancer and leukemias. Although not bound to any theory, the anticancer activity of carvedilol appears to be attributed to the inhibition of Epidermal Growth Factor and Platelet derived growth factor dependent proliferation of cancer cells. Further, carvedilol exerts anticancer effect by inhibition of the Protein kinase C (PKC) activity and that of the cyclooxygenase 2 enzyme. The invention also relates to the anticancer activity of the optically pure isomers S(-) and R(+) of carvedilol and the use of carvedilol and its isomers in pharmaceutical compositions for the treatment of cancer.< / PTEXT>

A gene marker for the detection of oral cancer, comprising methylated CpG sites in target genes, is provided. The CpG sites in the target genes are selected from a group consisting of the following CpG sites: FLT4_E206_F, ASCL1_E24_F, KDR_E79_F, TFPI2_P9_F, TERT_E20_F, ADCYAP1_P455_R, MT1A_P49_R, and combinations thereof. A method for the detection of oral cancer, comprising the following steps is also provided: a) providing a sample to be examined from an individual; b) detecting a methylation state of at least one CpG site in a target gene on the genomic DNA from cells of the sample, wherein the CpG site in the target gene is selected from a group consisting of the following CpG sites: FLT4_E206_F, ASCL1_E24_F, KDR_E79_F, TFPI2_P9_F, TERT_E20_F, ADCYAP1_P455_R, and MT1A_P49_R; and c) determining if the individual has oral cancer based on the methylation state of the selected CpG site in the target gene.

An oral cancer screening device 10 used for the detection of pre-cancerous and cancerous tissue has a power supply 100, an illumination source 200, a selector switch 300 that enables the activation of a specific wavelength of light from the illumination source 200, an electrical system 400 in communication with the selector switch 300 and the illumination source 200, a heat sink 500 in thermal communication with the illumination source, a filter or cover 600 to protect the illumination source, and a transparent sheath 700 for providing a sanitary shield for the device when it is brought into contact or close proximity with the patient oral cavity. The sheath may optionally have an angled mirror incorporated at a distal end of the sheath to provide the operator with a reflected image of the illuminated tissue 900. The operator will optionally utilize head mounted lenses 800 to assist the operator's visualization of the light from the illuminated oral cavity.

An oral screening toothbrush is provided for screening for oral diseases such as oral cancer and dental caries. The toothbrush emits blue light into the oral cavity and captures an image of the reflection of blue light. Image processing techniques are used to analyze the images to screen for oral diseases. Further, the toothbrush is comprised in a system including a data transfer medium (i.e. “smartphone”) and the Cloud, which allows for data transfer between multiple platforms from the toothbrush. The oral screening toothbrush and extended system provide for in-home oral screening and interaction with health professionals.

The invention relates to application of differential expression of a gene in oral cancer diagnosis, and particularly relates to application of differential expression of LRRC26 gene in oral squamous cell carcinoma diagnosis. Transcriptome deep sequencing analysis is performed by virtue of a high-throughput sequencing platform to preliminarily screen the gene LRRC26 with remarkable differential depression in oral squamous cell carcinoma tissues, para-carcinoma tissues and normal tissues; and the RT-PCR experiment further proves that the LRRC26 gene has low expression with oral squamous cell carcinoma tissues, can be used for preparing oral squamous cell carcinoma auxiliary diagnosis or prognosis preparations, and has an important clinical practical application value.

Methods and systems related to detecting disease, such as oral cancer, in a patient, using a viewing scope to investigate a patient's tissues. The systems and methods excite and detect fluorescence from the tissue. The fluorescence can then be evaluated, and the possibility of certain diseases such as cancer can be determined. The devices include an ambient light management system (ALMS, often referred to as a “vestibular device”) that manages background light in the health practitioner's office. This device can be used with scope systems for fluorescence based detection of abnormal tissue.

A method of providing a risk evaluation and diagnosis of human oral cancer, by examining at the presence in human saliva sample of a combination of particulate nucleic acids from bacteria, virus, as well as human, and / or the presence of particulate biochemical volatile organic compounds, which are indicative of an increased risk of oral cancer.

A medical X-ray tube system for dental diagnosis and oral cancer therapy based on nano-material is disclosed. The medical X-ray tube system may include a body and an X-ray emission module emitting X-rays using a cathode having a chipped nano-structured material. The X-ray emission module may be separable from the body. The medical X-ray tube system may be formed as a pen that can be inserted in the oral cavity for displaying an accurate image of an inner location of the oral cavity needing a diagnosis. For treatment of oral cancer requiring an appropriate amount of radiation therapy, brachytherapy may be conducted without concern of exposure of normal tissues to radiation because radiation can be directly irradiated to a diseased part. The X-ray emission module may use a chipped nano-structured material, for example, a carbon nanotube.

The invention discloses a novel acyl aniline compound. The novel acyl aniline compound has the structure shown in the specification. Experiments prove that the novel acyl aniline compound can be used for preventing and treating clinical symptoms triggered by HPV (Human Papillomavirus) infection, in particular, verruca vulgaris, verruca plana, verruca plantaris, vulvar cancer, penile cancer, anal epidermoid cancer, prostatic cancer, bladder cancer, cervical cancer, rectal cancer, oral cancer, tonsil cancer, and the like. The novel acyl aniline compound provided by the invention has the advantages such as simple preparation method, low production cost and prominent HPV resisting effect, and has a significant potential application value in the aspect of developing HPV-resisting drugs.

The invention relates to application of LCE3E to diagnosis and treatment of an oral cancer. According to the application, transcriptome deep sequencing analysis is performed through a high-throughput sequencing platform to preliminarily screen out LCE3E genes obvious in differential expression in oral squamous cell carcinoma tissue and normal tissue, a further RT-PCR experiment proves high expression of the LCE3E genes in the oral squamous cell carcinoma tissue, and an siRNA interference experiment shows that interference to expression of the LCE3E genes can effectively suppress proliferation of oral cancer cells. Oral cancer molecular markers in the application have significant clinical practical application value.

The invention discloses a water-soluble fullerene nano-material as well as a preparation method and an application thereof. A general structural formula of the water-soluble fullerene nano-material is shown as C2n(OH)x(Amino Acid)y, wherein n is less than or equal to 60 and is greater than or equal to 20, x is less than or equal to 50 and is greater than or equal to 0, y is less than or equal to 20 and is greater than or equal to 0 and Amino Acid is water-soluble amino acid. The nano-material provided by the invention is applied to preparation of medicines for treating tumors, wherein the tumors include at least one of liver cancer, lung cancer, colorectal cancer, renal cancer, pancreatic cancer, cancer in bones, breast cancer, ovarian cancer, prostatic cancer, esophagus cancer, gastric cancer, oral cancer, nose cancer, laryngeal cancer, cancer of biliary duct, cervical cancer, uterine cancer, testicle cancer, meningeoma, skin cancer, melanoma and sarcoma. The nano-material profvided by the invention is good in water solubility, good in affinity with organisms and low in preparation cost, and the nano-material can obviously block off tumor vessels and rapidly cut off nutrition supply to tumor tissues.

The present invention relates to applying an existing carbon nanotube X-ray tube for a dental X-ray imaging system that can replace a carbon nanotube electron emission source installed in a cathode portion. An X-ray tube system formed in a pen according to the present invention can be inserted in the oral cavity due to its thin thickness, thereby displaying an accurate image of an inner location of the oral cavity needing a diagnosis. For therapy of oral cancer requiring an appropriate amount of radiation therapy, since radiation can be directly irradiated to a diseased part, brachytherapy is enabled without concern of exposure dose of normal tissues. Therefore, when the system is commercialized, a great amount of distribution effect may be expected. The X-ray tube system that can be used for medical services such as a dental service includes an X-ray emission module emitting X-rays using a chipped nano-structured material, for example, carbon nanotube. The X-ray emission module is separable from a body in order to replace a cathode portion that is included in the X-ray emission module and is based on the nano-structured material.

Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to stage-specific embryonic antigen 4 (SSEA-4) are disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as breast cancer, lung cancer, esophageal cancer, rectal cancer, biliary cancer, liver cancer, buccal cancer, gastric cancer, colon cancer, nasopharyngeal cancer, kidney cancer, prostate cancer, ovarian cancer, cervical cancer, endometrial cancer, pancreatic cancer, testicular cancer, bladder cancer, head and neck cancer, oral cancer, neuroendocrine cancer, adrenal cancer, thyroid cancer, bone cancer, skin cancer, basal cell carcinoma, squamous cell carcinoma, melanoma, and / or brain tumor.

The invention relates to a terahertz non-bianisotropic metamaterial unmarked sensor, and a preparation method and a use thereof, and belongs to the biotechnical field. The unmarked sensor comprises aflexible substrate polyimide, a metal layer is arranged on the flexible substrate polyimide, the metal layer comprises a lower titanium metal layer having a thickness of 20 nm and an upper gold metallayer having a thickness of 200 nm, the titanium metal layer is arranged on the flexible substrate polyimide, and the metal layer is a metal resonance ring with two openings. The asymmetric metal resonance ring with two openings is designed to realize electromagnetic induction of a transparent formant, the surface of a metamaterial is inoculated with cells through cell culture, the resonance frequency shift of a device is detected in a back transmission manner, and the theoretic sensitivity reaches up to 455 GHz / RIU, so the concentration of cancer cells can be rapidly preliminarily detected inan unmarked manner, and the apoptosis trend of oral cancer cells HSC3 under different anticancer drug action times is obtained.

The present invention discloses a nutritional composition for improving oral health. The nutritional composition comprises the following raw materials in parts by weight: 5-30 parts of probiotics, 20-80 parts of prebiotics and 0.1-2 parts of epigallocatechin gallate; the probiotics are selected from at least one of lactobacillus rhamnosus, lactobacillus reuteri, lactobacillus helveticus, and lactobacillus salivarius; and the prebiotics are selected from at least one of inulin, oligofructose, galactooligosaccharide, xylooligosaccharide, stachyose, oligoisomaltose, raffinose, trehalose, and lactitol. At the same time, the present invention also provides a use of the nutritional composition in preparations of oral health-care products. The provided nutritional composition can inhibit colonization of caries inducing streptococcus mutans, reduces adhesion of subgingival gingiva pathogenic bacteria, inhibits bad breath, promotes the proliferation of the oral probiotics, prevents the occurrence and development of dental erosion and oral cancers, and can effectively solve the oral problems caused by alcoholism, smoking, staying up late, irregular diet, long-term consumption of acidic substances, etc.

A point of care diagnostic test, device and disposables for determining a patient risk for oral cancer in the same visit that a sample is collected.

Neural net method of computing oral cancer risk based on inputs such as age, gender, smoking status, morphological characteristics of sampled cells, and levels of biomarkers in samples cells.

The present invention relates to the identification of novel oral cancer and periodontal disease biomarkers. Further, the present invention provides novel methods of diagnosing and for providing a prognosis for oral cancer and periodontal disease. The present invention additionally provides novel methods of distinguishing between oral cancer and periodontal disease. Finally, kits are provided that find use in the practice of the methods of the invention.

Treating oral cancer with an anti-IL-20 antibody.

An oral screening toothbrush is provided for screening for oral diseases such as oral cancer and dental caries. The toothbrush emits blue light into the oral cavity and captures an image of the reflection of blue light. Image processing techniques are used to analyze the images to screen for oral diseases. Further, the toothbrush is comprised in a system including a data transfer medium (i.e. “smartphone”) and the Cloud, which allows for data transfer between multiple platforms from the toothbrush. The oral screening toothbrush and extended system provide for in-home oral screening and interaction with health professionals.

The invention discloses a cycloalkane thiophthene derivative and pharmaceutically acceptable salts, metabolic products or prodrugs thereof. A compound can be used for treating diseases related with STAT3 (Signal Transducer and Activator of Transcription 3) activation, such as ovarian cancer, endometrial cancer, cervical cancer, breast cancer, colon cancer, pancreatic cancer, lung cancer, brain cancer, prostate cancer, kidney cancer, liver cancer, bladder cancer, oral cancer, sarcoma, prostate cancer, head and neck squamous cell carcinoma, neuroglioma, melanoma, lymphoma, leukemia, and renal fibrosis, pulmonary fibrosis, rheumatoid arthritis, hair growth, arthritis, psoriasis, lupus erythematosus, inflammatory lung diseases and inflammatory bowel diseases. (The formula is shown in the description.).

A pharmaceutical composition including oleoylethanolamide (OEA) is administered to inhibit tumor / cancer cell proliferation. The pharmaceutically composition may additionally include vitamin A, carotenoids, ω-3 polyunsaturated fatty acid, ω-6 polyunsaturated fatty acid and / or conjugated linolenic acid. The tumor / cancer may be colorectal cancer, lung adenocarcinoma, breast cancer, hepatoma, oral cancer and / or stomach adenocarcinoma.

The invention belongs to the field of medicines, and relates to an application of a method for degrading all carbohydrate chains in the blood to be monosaccharide and detecting the monosaccharide in cancer detection. A sample in the method for degrading the blood to obtain the monosaccharide and detecting the monosaccharide is the blood, and the cancer includes lung cancer, gastric cancer, ovarian cancer, penis cancer, esophagus cancer, oral cancer, biliary duct cancer, breast cancer, adenocarcinoma perampullaire, rectal cancer and bladder cancer. The method has the characteristics of simplicity and easiness in operation steps, easiness in popularization, short detection time, low requirement on the instrument, low detection cost, less consumption of blood and the like. The result displays that based on the content of eight monosaccharides in the blood, not only can a normal person and a cancer patient be distinguished, but also different cancers can be distinguished. The method for simplifying glycomics knowledge and applying in the detection of the biomarker of blood is first created in the world.

The invention discloses a compound having the following general formula (I), wherein K is selected from a cycloalkane group shown in the following formula. The invention also discloses an indoleamine-2,3-dioxygenase inhibitor comprising the compound and an application of the compound in preparation of drugs for treating cancer. The compound of the invention can effectively inhibit cell proliferation, has a good therapeutic effect on various diseases such as cancer, has significant therapeutic effects on breast cancer, cervical cancer, colon cancer, lung cancer, stomach cancer, rectal cancer, pancreatic cancer, brain cancer, skin cancer, oral cancer, prostatic cancer, bone cancer, kidney cancer, ovarian cancer, bladder cancer, liver cancer, fallopian tube tumor, ovarian tumor, peritoneal tumor, stage IV melanoma, glioma, glioblastoma, hepatocellular carcinoma, mastoid renal tumor, head and neck tumor, leukemia, lymphoma, myeloma, non-small cell lung cancer, and the like, and has very broad application prospects.

Methods and kits for assessing the presence of, and for detecting cancer, notably oral cancer, are disclosed. Such methods and kits use one or more lectins operably linked to a fluorophore, wherein the lectin binds differentially to cancerous and non-cancerous tissues, and wherein the fluorophore facilitates visualizing the differential binding. The lectins are applied to the oral mucosa of a subject, the fluorophore is exposed to light, and cancerous regions of the mucosa are visualized. In certain embodiments, the lectin specifically binds to one or more of a β-galactoside, an α- or β-N-acetylglucosamine, or a sialic acid moiety.

The present invention relates to the use of antrodia camphorata in the treatment of skin conditions, allergic rhinitis, diabetes mellitus and its complications, cancer cachexia, hypercholesterolemia, gout in a subject in need of such treatment. The present invention is also directed to the use of antrodia camphorata in the prevention and treatment of oral cancer and arterial restenosis, in a subject in need of such prevention. The methods comprise the steps of: identifying a subject in need thereof, and administering to the subject a formulation comprising an effective amount of antrodia camphorata, whereby the symptoms in the subject are reduced or prevented. The composition can be a pharmaceutical composition or a nutraceutical composition.