113 results about "Oral Cancers" patented technology

The invention belongs to the technical field of medical image analysis, and relates to a lesion detection method and system based on multi-scan interactive deformable Mama, and the method comprises the steps: 1, image block embedding; 2, multi-scale feature extraction and interaction in the backbone network are scanned in parallel; 3, feature pyramid optimization based on dynamic weighted scanning fusion; 4, performing multi-scale fusion; according to the invention, through the adaptive scanning network and the deformable scanning mechanism, the characterization problem of the morphological heterogeneity of the oral cancer focus and the pulmonary nodule microstructure feature is effectively solved, the double breakthrough of the detection precision and the calculation efficiency is realized, and an efficient and reliable solution is provided for multi-cancer medical image analysis.

The invention discloses an oral cancer early screening multi-parameter joint detection method and system, and relates to the technical field of data analysis, and the method comprises the steps: obtaining oral multi-dimensional data of a target user; wherein the oral cavity multi-dimensional data of the target user comprises oral cavity image data, oral cavity saliva miRNA data and oral cavity multi-frequency impedance data; presetting an oral cancerization suspicious classification lightweight model, preprocessing the oral multi-dimensional data of the target user, and generating an oral multi-modal feature vector and a preliminary screening oral state classification label of the target user; and deploying a Transform multi-mode oral canceration state grading and classification model, and carrying out conjoint analysis on the oral cavity multi-mode feature vector and the preliminary screening oral cavity state classification label of the target user to generate oral canceration state grading and classification of the target user. The oral canceration recognition method has the advantage that the oral canceration recognition accuracy is improved.

The invention provides an intelligent nursing monitor used after an oral cancer fibula skin flap repair operation. The monitor integrates functional modules of skin flap physiological parameter monitoring, oral cavity function evaluation, patient whole body state monitoring, intelligent nursing scheme generation and pushing, data storage, remote medical support and the like. Accurate and real-time multi-parameter monitoring is realized through a high-sensitivity sensor, and data processing and early warning are performed by applying a big data analysis technology and an artificial intelligence algorithm. The invention aims to improve the postoperative care quality and effect of the oral cancer patient, has remote monitoring capability, can break through the regional restriction, and provides technical support for the timely intervention of professional medical resources. The monitor is portable in design and simple and convenient to operate.

The invention relates to the technical field of fluorescence detection, in particular to a positioning fluorescence detection method for an oral cancer incision edge specimen. According to the invention, the nano graphene oxide and the fluorescent targeting peptide are mixed and purified to obtain a fluorescent targeting probe solution with high specificity and stability, and the probe is injected into a specimen tissue by using a microneedle system, so that the consistency of the injection depth and the diffusion range is ensured, and the accuracy and reliability of marking are improved; spatial segmentation and mutation point analysis are carried out through optical signal intensity distribution characteristics, low-intensity and abnormal fluctuation signals are eliminated, a signal region boundary is optimized, multi-site extraction is carried out on cutting edge signals through a convolutional neural network, signal intensity center calculation and spatial mapping are analyzed, and a two-dimensional quantizable point set is generated. According to the method, the signal distribution trend is marked, the consistency of boundaries is calibrated, an incisal edge positioning map with higher space consistency and systematicness is generated, the reliability of incisal edge judgment is improved, the omission risk is reduced, and the precision of operation auxiliary diagnosis is improved.

The invention relates to the technical field of medical care, and particularly discloses an oral cancer perioperative nursing decision method, which comprises the steps of image acquisition, model generation, preoperative evaluation, dynamic nursing, risk evaluation and decision support. According to the scheme, the tumor area is extracted from the three-dimensional image data based on the U-Net model, the tumor area is separated from surrounding healthy tissue, complex tumor forms are automatically processed, higher segmentation precision and robustness are provided, and finally the accurate three-dimensional anatomical model is generated; according to the scheme, the individualized data, the real-time physiological indexes and the treatment progress of the patient are obtained, the intelligent optimization algorithm is used for calculating the priority of each nursing measure, the individualized nursing decision is dynamically generated according to the priority, the most suitable nursing scheme is automatically provided for the patient, and individualized requirements of different patients are better met.

The present invention has ascertained a microbial flora that significantly increases or decreases in saliva of an oral cancer patient compared to a control group, and relates to a composition for diagnosing oral cancer comprising a preparation for detecting the microbial flora, and a method for providing information for diagnosing oral cancer using the same. According to the composition for diagnosing oral cancer and the method for providing information for diagnosis of the present invention, it is possible to simply and accurately perform early diagnosis of the onset of oral cancer or the likelihood of onset of oral cancer by analyzing and confirming the abundance level of microorganisms exhibiting a significant change compared to a normal control group.

The invention relates to the technical field of oral system disease diagnosis, in particular to an oral system onset risk prediction method and system. By combining the five groups of indexes, early evaluation can be effectively performed on the oral cancer, score data reflecting the oral cancer can be obtained, and the grade of the oral cancer and the corresponding deterioration degree can be more intuitively determined through the score data. Compared with an existing method, the method has the advantages that the evaluation result of the patient can be accurately obtained based on a non-needle biopsy means, and the accuracy of the evaluation result is high based on multiple types of indexes.

The invention relates to the field of medical instruments, in particular to a sampling device for auxiliary oral cancer screening, which comprises a handle, a probing rod is fixedly connected to the handle, a telescopic rod is arranged at one end, far away from the handle, of the probing rod, a scraping head is arranged at one end, far away from the probing rod, of the telescopic rod, and a pressure sensor is arranged on the scraping head; an adsorption sleeve is arranged on the probing rod, extends towards the scraping head and is arranged outside the telescopic rod in a sleeving manner, an adsorption opening is formed in the end, close to the scraping head, of the adsorption sleeve, and the adsorption sleeve communicates with a negative pressure adsorption source; the device further comprises a controller which is used for collecting the contact pressure between the scraping head and the side wall of the oral cavity of the patient and controlling the contact pressure between the scraping head and the side wall of the oral cavity of the patient to be within a preset range through the telescopic rod. By the adoption of the technical scheme, the force of the scraper is controlled, and the collecting effect is improved.

The invention discloses a method for constructing a miR-181a-2 knockout mouse animal model based on CRISPR (clustered regularly interspaced short palindromic repeats) / Cas9 and application of the method, and belongs to the technical field of transgenosis. According to the invention, two sgRNAs of a specific targeting non-coding gene miR-181a-2 are designed, the sgRNAs comprise an sgRNA 1 with a nucleotide sequence as shown in SEQ ID NO.2 and an sgRNA 4 with a nucleotide sequence as shown in SEQ ID NO.5, bidirectional knockout is carried out by combining Cas9 protein, and a miR-181a-2 knockout mouse strain capable of stably breeding is obtained. Experimental results show that the knockout method provided by the invention does not generate off-target in preparation of the mouse model, and has the advantages of accuracy, high efficiency, simplicity and convenience. An oral cancer model is constructed by using the knockout strain, so that the modeling time is shortened, the research cost is reduced, and the knockout strain has remarkable advantages in the aspects of scientific research efficiency and achievement transformation and provides great convenience for related treatment of oral cancer.

The invention belongs to the technical field of gas detection, and relates to a portable detection device and method for oral expired gas. Comprising a gas collection end, a transmission pipeline and a micro-integrated gas sensor, the gas collection end is connected with one end of the transmission pipeline, the other end of the transmission pipeline outputs a gas sample, and the output gas sample is used for mass spectrometry detection; the transmission pipeline is internally provided with a plurality of micro-integrated gas sensors, and the micro-integrated gas sensors are used for detecting a target expiration marker; at least one micro-integrated gas sensor is correspondingly arranged for one target expiration marker; mass spectrum detection is combined with a sensor, multi-dimensional richer data information is provided through a mass spectrum, and detection information of the sensor is combined, so that the problems of data interference and signal background noise can be effectively solved, interference of other gas components is avoided, and the recognition accuracy is further improved; compared with a traditional oral cancer screening method, the oral cancer screening method is higher in speed and more efficient.

The invention relates to an application of Avasimibe in preparation of a medicine for treating nasopharynx cancer or oral cancer, and belongs to the field of tumor targeted therapy. An in-vitro cell experiment and an in-vivo animal model experiment verify the anti-tumor effect of the compound. Experiments show that Avasimibe can significantly inhibit the activity, proliferation ability, healing ability and cloning ability of nasopharynx cancer cells and oral cancer cells, can regulate cell cycle arrest in a dose-dependent manner, and induces cell apoptosis. In vivo experiments, the tumor volume of nude mice in an Avasimibe treatment group is remarkably reduced, serum cholesterol is remarkably reduced, and serum biochemical analysis shows that compared with a control group, the Avasimibe treatment group has no statistical difference in indexes such as aspartate transaminase (AST) / glutamic-pyruvic transaminase (ALT) and creatinine (Cr). The invention provides a new indication for resisting nasopharynx cancer and oral cancer for the existing compound Avassimibe, has the clinical advantages of low toxicity and capability of overcoming drug resistance, and provides a new treatment choice for patients with nasopharynx cancer and oral cancer.

Various examples are provided related to functionalization for sensing of antibodies. In one example, a method for functionalizing a test strip includes cleaning a gold surface of an electrode of a test strip; submerging the cleaned gold surface in a 3-Mercaptopropanyl-N-hydroxysuccinimide ester solution; cleaning channels of the test strip; injecting an antibody into the channels; sealing the injected antibody in the test strip; storing the sealed test strip at a controlled temperature; and deactivating unfunctionalized groups. In another example, a method includes connecting a functionalized test strip to a strip connector; generating a test pattern that is passed through the functionalized test strip and input into a gate terminal of a MOSFET in a readout block; converting a readout signal into a frequency signal; and counting the frequency signal at fixed intervals to generate a counter output, and displaying a sample concentration based upon the counter output.

The invention relates to a high frequency magnetic induction device (100). The device (100) comprises magnetic nanosuspension (101) and an AMF generator (103). The AMF generator (103) further comprises copper induction coil (104), work head (105), flexible connector (106), power supply (107), chiller (108), display and control unit (109), fiberoptic thermometer sensors (110a &110b), auto-manual toggle switch (111), USB port (112a &112b) and bed support (113). Tumor site enclosed by the magnetic nanosuspension (101) comprising iron oxide magnetic nanoparticles (102) generates heat when exposed to AMF generated by the AMF generator (103). The heat generated does not cause any harm to the healthy tissues. The AMF generator (103) has precise control over thermal doses generated. The high frequency induction device (100) is safe, effective, non-invasive with mild side-effects.

Oral brush biopsy device for oral cancer

The ester derivatives of brefeldin A represented by Formula (I) in the inhibition of tumor proliferation. The compounds are prominent in the prevention or treatment of hyperproliferative diseases, including liver cancer, leukemia, breast cancer, colon adenocarcinoma, gastric cancer, lung cancer, Bart's esophageal cancer, cervical cancer, pancreatic cancer, endometrial cancer, bone cancer, lymphoma, kidney cancer, brain cancer, nerve cancer, nasopharyngeal cancer, oral cancer and colorectal cancer, and have the potential to be developed as antitumor agents.

The present invention discloses coumarin-3-carboxamide derivatives, their preparation methods, and their use in the preparation of anti-tumor drugs. The coumarin-3-carboxamide derivatives or pharmaceutically acceptable salts thereof have the structural formula shown in Formula (I): wherein R1 is hydrogen, an alkoxy group, or an amine group; R2 is hydrogen or a halogen atom; and m and n are 0 to 5. This invention is based on the development potential and value of coumarin derivatives in tumor treatment. The inventors of the present invention have studied coumarin-based anti-tumor drugs and discovered a series of coumarin derivatives with outstanding anti-tumor activity that can be used to treat breast cancer, oral cancer, or cervical cancer. #imgabs0#

The invention relates to application of lactobacillus muricatum in preparation of a medicine for treating oral cancer, the oral cancer is oral squamous cell carcinoma, a C57BL / 6 mouse tongue squamous cell carcinoma model induced by a 4-NQO water drinking method and a C3H / HeN subcutaneous tumor model inoculated by SCC7 tumor cells are constructed, and the lactobacillus muricatum has a remarkable inhibition effect on the oral cancer; experiments prove that the number / area / volume / weight of tumors is remarkably reduced by the lactobacillus muricatum, tumor marginal infiltration and abnormal karyokinesis are effectively inhibited, the expression quantity of tumor proliferation markers is remarkably reduced, and obvious pathological changes do not appear in main organs (heart, liver, spleen, lung and kidney) of mice. The method for minimally invasive injection of the lactobacillus muricatum into the oral squamous cell cancer tumor is safe, drug resistance is not easily induced, the treatment scheme is standardized, and the method has good clinical application potential.

The invention discloses an oral cancer diagnosis model construction method, which is based on DeepLabv3 +, increases an auxiliary branch to provide position information for a diagnosis model and increases SCConv attention so as to realize segmentation processing of oral cancer multi-tissue category pathological images. The method comprises the following steps: acquiring sample set labeling data sets ORA-TCGA and ORA-Nine for training a diagnosis model, classifying data set tissues into tumors, epithelium, interstitial substances, lymphatic vessels, skeletal muscles and vessels, and performing diagnosis model training and prediction by using OCMS-Net. The diagnosis model is based on OCMS-Net and comprises a main branch A and an auxiliary branch B, the input of the main branch A is an oral cancer pathological image, the output of the main branch A is a segmentation mask, and the segmentation mask represents different tissue types with different colors; the input of the auxiliary branch B is an oral cancer pathological image, and the output of the auxiliary branch B is a binary segmentation map and a nuclear pixel distance map of a cell nucleus.

The invention relates to a method, uses, a system, and a kit for detecting a human papillomavirus (HPV) genotype associated with the development of cervical, oral, or anogenital cancer in a subject and for determining the HPV genotype or genotypes thus detected in the same. Additionally, the present invention relates to uses of direct and / or reverse amplicons or primers generated by multiplex real-time PCR comprising a molecular tag for identifying a marker of human papillomavirus genotypes 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and / or 68.

A pharmaceutical composition comprising a tannin selected from 2-O-digalloyl-1,3,4,6-tetra-O-galloyl-β-D-glucose, 3-O-digalloyl-1,2,4,6-tetra-O-galloyl-β-D-glucose, 6-O-digalloyl-1,2,3,4-tetra-O-galloyl-β-D-glucose, 2,6-bis-O-digalloyl-1,3-di-O-galloyl-β-D-glucose, and 6-O-trigalloyl-1,2,3-tri-O-galloyl-β-D-glucose. The tannin may be derived from Quercus infectoria. The pharmaceutical composition is used in a method of treating cancer, particularly oral cancer.

Methods and systems for detection and diagnosis of oral lesions and application of treatment are described. One example mobile intraoral system includes an intraoral probe with a plurality of windows and a first plurality of light sources positioned in its distal section. The intraoral probe also includes one or more additional light sources operable at one or more wavelengths in the range 600 nm to 700 nm, one or more heat sinks, and one or more optical waveguides coupled to the additional light sources. The mobile intraoral system is selectively operable in a first mode of operation for imaging and diagnosis of suspicious regions in the oral cavity, and a second mode of operation for administering photodynamic therapy (PDT). The intraoral probe's distal section is bendable to allow insertion in the oral cavity and targeting a particular location of the oral cavity for administration of the PDT.

The postoperative oral cavity flushing device comprises an arc-shaped frame and a positioning assembly, the positioning assembly comprises a guide plate connected to the top end of the arc-shaped frame, blocking covers are connected to the two ends of the arc-shaped frame, a bracket is slidably clamped to the outer side of the guide plate, an end plate is arranged at the top end of the bracket, and a moving plate is arranged at the bottom end of the guide plate; a pressing block is arranged on the outer side of the moving plate and pressed on the outer side of the bracket, and the end plate is connected with the moving plate through a spring; the positioning assembly can fix the flushing assembly, help a patient to wear the device and determine the position of the flushing assembly, so that medical staff do not need to repeatedly and manually adjust the flushing position during flushing every time, the flushing efficiency is improved, a flushing cylinder connected to the bottom end of a sliding seat is adjusted to move along the outer side of the mouth of the patient, and the flushing efficiency is improved. When the flushing device moves to different positions, the angle of the flushing cylinder is adjusted, and the interior of the oral cavity of the patient can be flushed.

The present disclosure relates to methods and compositions for quantitative risk assessment of lesions in the oral cavity. The risk assessment tool may be used at a point-of-care facility. The present disclosure provides methods and compositions for effective risk assessment of life-threatening or irreversible decline human diseases or conditions, including oral cancer.

The utility model discloses a storage device for detecting oral cancer markers, which belongs to the field of oral cancer detection and comprises a storage platform. A lifting adjusting mechanism is vertically installed on the upper end face of the storage platform, a connecting base is assembled on the lifting adjusting mechanism, and a packaging limiting frame is installed on the side face of the connecting base. Two sets of elastic limiting assemblies are assembled on the packaging limiting frame. According to the storage device for detecting the oral cancer markers, the packaging limiting frame and the elastic limiting assembly are matched with each other, so that the elastic limiting assembly can effectively fix oral cancer marker packaging test tubes, and the oral cancer marker packaging test tubes are prevented from inclining, sliding or falling off in the storage or transfer process; and meanwhile, the two clamping elastic plates which are elastically arranged can be adjusted according to different diameters of the oral cancer marker packaging test tubes, so that the oral cancer marker packaging test tube storage system is suitable for oral cancer marker packaging test tubes of various specifications, and the flexibility of the storage system is improved.

ARTIFICIAL INTELLIGENCE-BASED DETECTION DEVICE FOR ORAL CANCER

The invention belongs to the technical field of biological medicine, and particularly discloses a combined tumor marker for noninvasive detection of oral cancer and application of the combined tumor marker. The invention provides application of a reagent for detecting a biomarker in preparation of a product for diagnosing or predicting oral cancer. The biomarker is an RBMX gene and / or an NEK2 gene. The invention finds that the two oral cancer carcinogenic key molecules are significantly highly expressed in oral cancer tissues, and the activity, migration and invasion ability of oral cancer cells can be inhibited by knocking down the expression of RBMX or NEK2, and the cis-platinum drug resistance of the oral cancer cells can be inhibited. According to the invention, RBMX or NEK2 is taken as a tumor marker to detect the oral cancer and has good diagnostic efficacy, and the RBMX and the NEK2 are combined for use, so that the sensitivity and the specificity of diagnosis can be further improved, and the risk of the oral cancer can be more comprehensively judged. The invention also provides application of the two pathogenic factors as inhibition targets in preparation of drugs for oral cancer.

Antibody drug conjugate (ADC) comprising a drug moiety conjugated to antibody or antigen binding fragments thereof that bind to TROP2 disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The ADC of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the ADC disclosed herein can include carcinomas, such as lung cancer, breast cancer, head-and-neck cancer, esophagus cancer, stomach cancer, bladder cancer, pancreatic cancer, colorectal cancer, cervix cancer, endometrial cancer, ovarian cancer, laryngeal cancer, prostate cancer, thyroid cancer and oral cancer.

The present invention describes synthesis of Toluidine blue O for a formulation to be used for screening and biopsy site identification in oral cancer. The invention discloses two formulations and a method of delivery of the said formulations via a kit. The method described is a reproducible method of synthesis of pharmaceutical grade Toluidine blue O of acceptable purity and good colorimetric value. The present invention also discloses a kit that includes one formulation of a cleaning solution containing an organic acid and another formulation that is a vital stain formulation. The kit is packaged as a dual chamber sprayer having two pump dispensers, that facilitates ready to use, convenient dental chair side delivery, and allows mass screening.

A pharmaceutical composition comprising a tannin selected from 2-O-digalloyl-1,3,4,6-tetra-O-galloyl-β-D-glucose, 3-O-digalloyl-1,2,4,6-tetra-O-galloyl-β-D-glucose, 6-O-digalloyl-1,2,3,4-tetra-O-galloyl-β-D-glucose, 2,6-bis-O-digalloyl-1,3-di-O-galloyl-β-D-glucose, and 6-O-trigalloyl-1,2,3-tri-O-galloyl-β-D-glucose. The tannin may be derived from Quercus infectoria. The pharmaceutical composition is used in a method of treating cancer, particularly oral cancer.

The invention discloses a method for analyzing and identifying an inflammatory bowel disease related oral cancer biomarker, and belongs to the technical field of bioengineering.The method comprises the following steps that 1, IBD whole genome correlation research summary data is obtained; 2, analyzing a causal relationship between IBD and the oral cancer by using a Mendel randomization method, and determining IBD related genes; 3, collecting an oral cancer tissue sample, and carrying out single-cell RNA sequencing; according to the invention, single-cell RNA sequencing is carried out on an oral cancer specimen, and a cell cluster and a gene expression mode are described. Cell clusters and types are displayed by using t-SNE and UMAP, key modes of gene expression are defined by using a lattice diagram, and pathways related to NFKBIA expression are analyzed through GSEA. The experimental result explains the cell heterogeneity and gene expression kinetics in the oral cancer disease progression process, and reveals possible therapeutic targets related to IBD.