141 results about "Screening tool" patented technology

A non-invasive, early stage method to obtain quantitative measures of mild cognitive impairment useful in diagnosing and following degenerative brain disease or closed head injuries by utilizing the image data from individual patient positron emission tomographic scans to construct a cognitive decline index that serves as a diagnostic and screening tool to reveal the onset of mild cognitive impairment and nervous system dysfunction which are sequelae of degenerative brain diseases and closed head injury. The method involves using weighted values of brain region intensities derived from comparing scans of normal subjects to a scan of the patient to calculate a cognitive decline index that is useful as a diagnostic tool for mild cognitive impairment. The weights for the intensity values for each region are derived from the differences of intensity values from regions of the brain of the patient selected by comparing the patient to normal control subjects.

A heart monitor for use as a non-invasive screening tool for identifying potential atrial fibrillation in patients comprises a sensor for producing an output waveform of the patient's actual sinus rhythm, a processing unit arranged to store the normalised waveform of an ideal sinus rhythm and to compare the actual and ideal sinus rhythm waveforms and to produce an output dependant on the difference on a display. The value of the output is indicative of whether the patient is atrial fibrillation or other cardiac arrhythmia.

The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular, methods of using agonists and antagonists of TGF-β superfamily members to modulate the expression or activity of hepcidin, a key regulator of iron metabolism, are described. The inventive methods find applications in the treatment of diseases associated with iron overload, such as juvenile hemochromatosis and adult hemochromatosis, and in the treatment of diseases associated with iron deficiency, such as anemia of chronic disease and EPO resistant anemia in end-stage of renal disease. The present invention also relates to screening tools and methods for the development of novel drugs and therapies for treating iron metabolism disorders.

A testing system and method for screening and evaluation of cognitive function is provided. The system and method may be used in a waiting area prior to examination by a clinician, thus providing information to the clinician as well as maximizing time spent waiting. The system includes a device for input and output of information, from which a report can be generated. The report is provided in electronic or paper format to the clinician, and further evaluation is at least partially based on the report.

A convenient screening tool and a convenient screening method for obtaining an agent for treating diabetes, a pharmaceutical composition for treating diabetes, and a process for manufacturing the pharmaceutical composition are disclosed. The screening tool is a G protein-coupled receptor, a variation functionally equivalent thereto, or a homologous polypeptide thereof which promotes insulin secretion under a high glucose concentration by activation, or cells transformed with an expression vector comprising a polynucleotide encoding the above polypeptide and expressing the polypeptide.

Disclosed are methods of purifying compounds that reduce or prevent an inflammatory response in a mammal, use of such compounds in treating a mammal having or being at risk of developing inflammation, as well as serum containing such purified compounds. Also disclosed are animal models that are more representative of humans in the study of inflammatory responses or as screening tools for discovering or developing new therapeutics or lead candidate compounds for inhibition of an inflammatory response.

The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular, methods of using agonists and antagonists of TGF-β superfamily members to modulate the expression or activity of hepcidin, a key regulator of iron metabolism, are described. The inventive methods find applications in the treatment of diseases associated with iron overload, such as juvenile hemochromatosis and adult hemochromatosis, and in the treatment of diseases associated with iron deficiency, such as anemia of chronic disease and EPO resistant anemia in end-stage of renal disease. The present invention also relates to screening tools and methods for the development of novel drugs and therapies for treating iron metabolism disorders.

The invention relates to, in part, secreted proteins of bacterial pathogens and methods for their use. More specifically, the invention provides in part several new common secreted proteins for A / E pathogens. In some embodiments of the invention, these polypeptides and nucleic acid molecules encoding these polypeptides, or portions thereof, are useful as vaccines, diagnostics, or drug screening tools for A / E pathogenic infections, or as reagents.

The invention relates to Ab2-type anti-idiotypic antibodies and fragments thereof which mimic HVI-1 epitopes that are otherwise cryptic to the immune system and which antibodies or fragments thereof are directed against potently neutralizing anti-HIV-1 antibodies. The invention further relates to a hybridoma cell line 3H6 expressing the anti-idiotypic antibody and to pharmaceutical compositions containing the antibody or fragment thereof. The invention also relates to HIV-1 neutralizing Ab3-type antibodies elicited upon administration of the Ab2-type anti-idiotypic antibody or fragment thereof and to pharmaceutical compositions containing them. The invention also relates to the use of the present antibodies or fragments thereof as screening tools or as diagnostic or therapeutic agents.

A pseudo-virus packaging system of coronaviruses comprises a vesicular stomatitis virus (VSV) vector with a Fluc and EGFP double reporter gene replacing a GP gene and an assembly cell expressing coronavirus spike protein S. The double reporter gene is selected from luciferase and fluorescent protein, and the luciferase reporter gene is preferably a Fluc gene. The fluorescent protein reporter geneis preferably an EGFP gene, and the assembly cell is preferably 293T. The invention further relates to a one-step packaging method of the packaging system; a pseudo-virus with single-cycle infection,low background value and high titer can be quickly packaged through simple, convenient and rapid operation, and the packaging system has the characteristic of being rapid in detection compared with aslow virus mediated pseudo-virus system; the one-step packaging method can be used for researching COVID-19, SARS, MERS and other coronaviruses and other viruses, provides a powerful screening tool for evaluation of antiviral preparations and vaccine, and has wide application value.

A continuously variable screening tool is used to generate a unique texture pattern for every color in a multicolor image. The continuously variable screening tool allows a single colorant version of the image to be generated with less information loss than typically suffered in the multicolor to single color transformation process. The continuously variable screening tool is generated by blending patterns from a set of reference screens. The reference screens are associated with selected reference colors in, for example, a machine independent color space. A calculated screen is generated through a weighted blend of reference screens located near the arbitrary color in the machine independent color space. Typically, the weights depend on the distance the arbitrary color is from each of the reference colors. The screens consist of arrays of threshold values. Each threshold value is associated with a dot position and an image pixel. Where a pixel value exceeds the associated threshold value, provision is made to place a mark in the associated dot position. An image processor operative to carry out the method comprises a continuously variable screening tool generator. An embodiment of the image processor includes a reference screen storage device and a screen blender.

The invention discloses a double-reporter-gene skeleton vector. Double reporter genes of the double-reporter-gene skeleton vector are selected from luciferase and fluorescein, the fluorescein reportergene is preferably an mGFP gene, and the luciferase reporter gene is preferably a Fluc gene. A double-reporter-gene four-plasmid pseudovirus packaging system comprises the double-reporter-gene skeleton vector and three eukaryotic expression packaging plasmids which are respectively integrated with a slow virus gag-pol gene, a slow virus rev gene and an envelope protein gene containing a target virus. A packaged COVID-19 pseudovirus comprises the double-reporter-gene four-plasmid pseudovirus packaging system and a host cell, wherein the host cell is preferably selected from 293T-hACE2 cells. According to the invention, SARS-CoV-2 is specifically implemented, the pseudovirus with single-cycle infection and higher safety can be rapidly packaged, and the vector and the system can be used forresearching coronaviruses such as SARS-Cov2 and the like, provide a powerful screening tool for evaluation of antiviral preparations and vaccines, and have wide application value.

The invention provides an automatic screening and propelling method and system with a high matching degree for managing a user and confidential information. The method comprises the following steps: a step A: self-defining and screening out a target option to be screened according to a screening model of the target option; a step B, establishing a first scoring mechanism of the screening model for scoring the target option to be screened; a step C: capturing the information associated with the target option from a first database according to the scored result, and showing the scored information from high to low in sequence according to the scores; and a step D: propelling the user information to the selected target option according to the self-defined propelling mechanism. According to the automatic screening and propelling method and system provided by the invention, the conational screening tool is improved; the user-defining and quantifying function is additionally added; self-defining treatment to a plurality of objects on the basis of protecting information privacy is carried out; and all operation processes and data are stored in the central database of the system. The automatic screening and propelling method and system are suitable for high-precision matching of market development, company merger and acquisition, investment banking and commercial procurement, and even a plurality of fields such as personal employment and education, marriage dating and the like.

The invention relates to an E-mental symptom fast screening and self-checking system for assisting diagnosis and treatment. The system comprises an initial interface, a scale selecting interface, a scale assessing interface and a detecting result interface. The scale selecting interface comprises four selectable scales including a QIDS-SR 16, an HCL-32, an MDQ and a PHQ-9, and the four scales are self-rating depression scales. The detecting result interface comprises grades, condition description, clinic prompt and an instruction. By means of the testing result, a patient can be guided to pertinently see a doctor, and the doctor can be assisted to carry out the diagnosis and treatment. The system can serve as a screening tool for bipolar disorder and other diseases and can also serve as a tool for monitoring the illness. The tablet personal computer technology serves as the basis, the system is simple in structure, and operation is easy and convenient due to the fact that input is achieved through a touch screen and a computer keyboard.

Compositions and methods disclosed concern an isogenic population of in vitro human embryonic stem cells comprising a disease form of the Huntingtin gene (HTT) at the endogenous HTT gene locus in thegenome of the cell; wherein the disease form of the HTT gene comprises a polyQ repeat of at least 40 glutamines at the N-terminus of the Huntingtin protein (HTT). The cell lines of the disclosure comprise genetically-defined alterations made in the endogenous HTT gene that recapitulate Huntington's Disease in humans. Furthermore, the cell lines have isogenic controls that share a similar genetic background. Differentiating cell lines committed to a neuronal fate and fully differentiated cell lines are also provided and they also display phenotypic abnormalities associated with the length of the polyQ repeat of the HTT gene. These cell lines are used as screening tools in drug discovery and development to identify substances that fully or partially revert these phenotype abnormalities.

A method is provided for screening anti-adenovirus agents. The method includes reducing the activation of the immune system of a small mammal, administering a human adenovirus vector to the small mammal, monitoring the tumor cells in the mammal, and analyzing infectious virus units within the tumor cells and the organs of the small mammal. Specifically, the immune system of the small mammal is suppressed using cyclophosphamide. The small mammal may be, but is not limited to, one of the following: mice, rabbits, cotton rats, hamsters, rats, and other small rodents.

The invention relates to an implementation method for debugging information output in an embedded system, comprising the following steps: a screening tool screens an engineering source code to generate the corresponding relation of debugging positioning information and debugging information; when the embedded system operates the engineering source code and needs to output the real-time debugging information, output information with the debugging positioning information is transmitted to debugging control output equipment; the debugging control output equipment obtains the debugging positioning information and finds the debugging information according to the corresponding relation of the debugging positioning information and the debugging information; and the debugging control output equipment displays the debugging information. The implementation method for debugging information input in the embedded system greatly reduces the system expenditure of a debugging output module of the embedded system and saves bandwidth occupied by the debugging information data on a universal serial bus to bring convenience for the transmission of other data. The method has simple and convenient process, stable and reliable working performance and wide applicable range, thus bringing great convenience for debugging the embedded system.

T.E.S.S. is a Teacher Evaluation Assessment Software which evaluates the teacher / candidate based on a series of pre-designed questions that probe teaching styles, traits, strengths & weaknesses as related to the vocation of teaching. Results determine teaching styles / archetypes (The Discoverer, The Sage, The Counselor and The Motivator), in addition to learning styles associated, methods to assist the client, qualities & characteristics adaptable to the profession, a movie reference that fits learner style, tools for teachers, need to knows and a supervisory portion if requested by administrator for client to assist in supervising to their preferred teaching style. Employers / Clients are provided pdf / word document of results. Used for development of faculty / staff and as a screening tool for schools and universities for teacher candidates.

The invention discloses a yellow mealworm and pupa separation method and relates to the technical field of separation devices. The yellow mealworm and pupa separation method comprises the steps that firstly, a screening tool is manufactured, wherein the screening tool is a long-strip-shaped mesh screen separator; secondly, yellow mealworms and pupas are placed in the screening tool manufactured in the first step to be screened; thirdly, the pupas will stay on a mesh screen and the yellow mealworms will drop from a screen mesh after screening, so that yellow mealworm and pupa separation is achieved. According to the yellow mealworm and pupa separation method, separation is rapid and accurate, time and labor are saved, and operation is convenient.

The invention provides a method for screening out drought tolerant paddy rice through a dynamic ion flow based on NMT. According to the method, a micro-dynamic ion flow detection technology is utilized to detect the K<+> absorption capability of paddy rice roots, and the K<+> absorption change of seedlings before and after the processing by a PEG6000 solution is detected to screen out the drought tolerant paddy rice. The method allows lossless, rapid and in vivo detection of the drought tolerance of paddy rice to be realized, the detection time to be about 10-15min, the consumed time to be short, the detection accuracy to be high, the contrast difference between static ion flows of drought tolerant seedlings and non-drought tolerant drought seedlings to be obvious, and the evaluation method to be simple and reliable, so a direct and rapid screening tool is provided for the paddy rice drought tolerance breeding and the paddy rice field production.

A dual energy x-ray densitometer is incorporated into a standard patient examination table to provide improved access to this screening tool during regular examinations. A repositionable scanning head allows the table to remain unobstructed when scanning is not occurring and a limited scanning area allows the examination table to retain standard examination table features such as table extensions, foot end drawers, trays and stirrups, and a step for access to the high examination table surface.

The invention relates to a screening and computing system for parenteral nutrition. The system comprises a nutrition screening tool subsystem and a nutrition demand amount computing subsystem. The nutrition screening tool subsystem is used for system users to select different screening tools according to different individual situations, input individual tissue condition relevant attribute values, compute individual nutrition scores, and output corresponding nutrition condition evaluation and suggestions according to the individual nutrition scores; and the nutrition demand amount computing subsystem is used for computing individual nutrition demand amounts according to the individual tissue condition relevant attribute values, selecting different nutrition preparations according to the individual nutrition demand amounts and outputting nutrition plans formulated by system users. According to the screening and computing system for parenteral nutrition, system users only need to input or select individual corresponding parameters, the system can compute corresponding results automatically, and accordingly, computing errors are eradicated, and the work amount of system users is reduced simultaneously.

The present invention relates to a method for cell culture, more precisely small scale cell culture. In the present invention a screening tool is used which comprises particulate matter or microcarriers, such as beads, attached to a solid support, such as a microtiter plate, for the cultivation of cells on said microcarriers. The microcarriers are preferably cultivation beads, such as CYTODEX™. According to the invention, this small scale format for cell cultivation may be used for any testing involving cells, for example testing of optimal growth conditions for a specific type of cell, such as stem cells. Another use is cell expansion.

One aspect of the present invention is to assess the performance of automated analysis of blood oxygen saturation (SpO2) recordings as a screening tool for OSAHS. As an initial step, statistical, spectral and nonlinear features are estimated to compose an initial feature set. Then, a fast correlation-based filter (FCBF) is next applied to search for the optimum subset. Finally, the discriminationpower of three pattern recognition algorithms is assessed: linear discriminant analysis (LDA), quadratic discriminant analysis (QDA) and logistic regression (LR). According to another aspect of the invention, oximetry is used to determine the OSAHS severity in children. Single-channel Sp02 recordings from 176 children were divided into three severity groups according to the apnea- hypopnea index (AHI): AHI<1 events per hour (e / h), l<AliI<5 e / h, and Alii >= 5 e / h. For testing the severity of OSAHS, first spectral analysis is conducted to define and characterize a frequency band of interest in SpO2. Then the spectral data is combined with 3% oxygen desaturation index (ODI3) by means of a multi-layer perceptron (MLP) neural network, in order to classify children into one of the three OSAHS severity groups.

A computer-based screening instrument system and method comprising a patient interactive device coupled with a data network and an administrative server, the administrative server operatively connected to a database and a printer, wherein the administrative server is configured to serve as a screening instrument to the patient interactive device and to receive responsive information from the patient interactive device; and a triage module, wherein the screening instrument comprises a plurality of issues, an issue having a patient prompt and one or more patient selectable responses, wherein the patient interactive device, for each issue in the screening instrument, displays the related patient prompt, receive an indication of a patient selection of a related patient selectable response and transmit information representing the indication to the administrative server; wherein the administrative server receives the information and stores a patient response record comprising the information received; wherein the triage module compares a particular patient's response record with a set of triage rules and performs at least one of the following: (1) generate and transmit a triage message indicating a patient exigency to a communication device of a member of the patient's professional health care team, and (2) generate and transmit a message indicating the patient's request to discuss an issue with a member of the patient's professional health care team to the communication device.

The invention discloses a method for predicting complex diseases and phenotypic related metabolites based on Mendel randomization analysis. The method comprises the following steps: (1) collecting andsorting blood metabolite whole genome association research data; (2) screening tool variables and removing multiple effects; and (3) performing double-sample Mendel randomization analysis according to the screened tool variables, and obtaining metabolites related to diseases or phenotypes by integrating judgment of effect values and sensitivity analysis of multiple analysis methods. According tothe method, the influence of 363 blood metabolites on complex diseases and phenotypes is predicted through double-sample Mendel randomization analysis in combination with screening and discriminationof multiple methods, and an important foundation is laid for subsequent searching of drug targets for the blood metabolites and nutrition intervention.

The invention discloses a kit and a detection method for a detecting porcine reproductive and respiratory syndrome virus. An enzyme-linked reaction plate, an enzyme label conjugate, a concentration washing solution, a substrate solution, a developing solution, a concentrated sample diluents, and a stop buffer are arranged in a kit body; the kit is characterized in that the enzyme-linked reaction plate coats a polyclonal antibody of porcine reproductive and respiratory syndrome virus N protein; the enzyme label conjugate is an enzyme label conjugate of the polyclonal antibody of the porcine reproductive and respiratory syndrome virus N protein and is marked by horseradish peroxidase. By means of the sensitivity, specificity, practicability and economical efficiency of a rapid immune detection technology, the kit disclosed by the invention mainly has the advantages of being simple, convenient and fast to operate, and objective and reliable in result judgment, and as a convenient early screening tool, the sensitivity of the kit can reach 90% of the gold standard method PCR.

The present invention relates to the discovery of novel receptors for the signaling of PTH and / or fragments of PTH, and the role of cPTH in bone development. The novel PTH receptors identified are selected from the group consisting of LRP5 / 6, TGFβRII, BMPRII (long form and short form), ActRIIA, and ActRIIB. Specifically, the present invention provides a novel screening tool for identifying compounds that improve bone mass by affecting certain pathways that promote or downregulate bone-forming activity. This promotion of bone-forming activity could provide for treatments for bone-loss or bone density disorders and / or kidney disease. The invention further encompasses the compounds, PTH ligands, and fragments of PTH ligands described herein; pharmaceutical compositions comprising the compounds, PTH ligands, or fragments of PTH ligand; and methods of increasing bone density using the compounds, PTH ligands, or fragments of PTH ligands.