65 results about "Screening tool" patented technology

The utility model relates to the technical field of cement negative pressure screen analysis instruments, and discloses a full-automatic cement negative pressure screen analysis instrument which comprises a machine body, a fixing plate is fixedly connected to the top of the inner wall of the machine body, a first stepping motor is fixedly connected to the center of the bottom of the fixing plate, and the output end of the first stepping motor is fixedly connected with a lead screw. A lifting rod is in threaded connection with the outer ring of the lead screw, a lifting frame is fixedly connected to the top of the lifting rod, a screening tool is arranged on one side of the inner ring of the lifting frame, a screen is arranged at the bottom of the inner wall of the screening tool, and a linear bearing penetrates through and is fixedly connected to the center of the bottom of the fixing plate. The left side of the bottom of the fixing plate is fixedly connected with a second stepping motor. According to the vibrating screen, the bearing frame is driven by the first stepping motor, the lifting frame, the screen tool, the screen cover, the vibrator and the second stepping motor to rotate, materials are weighed, the first stepping motor is started to work, the lead screw is driven to rotate, and the screen tool is driven to move downwards.

Methods of analyzing the presence or absence of immune cells capable of binding to an antigen peptide in a sample from one or more individuals are provided. Also provided are methods of detecting or treating cancer or a tumor, a pathogen infection, or an autoimmune disease. A display moiety is provided having particles associated with a plurality of MHC-peptide complexes, where at least two MHC-peptide complexes are different. Also provided are bait compositions having a plurality of display portions and methods of analyzing immune cells by using the display portions or bait compositions as screening tools.

The present application belongs to the technical field of artificial intelligence assisted drug screening, and particularly relates to a method for screening active molecules against carbapenem-resistant enterobacteriaceae based on a LightGBM algorithm, a medium and an apparatus. The method constructs a LightGBM integrated learning framework, fuses ADME rules optimized for the outer membrane barrier characteristics of gram-negative bacteria and multi-target molecule docking verification, effectively solves the problem of data imbalance caused by the scarcity of active samples and the huge compound library, and significantly improves the hit rate of screening. The present application also provides a computer readable storage medium and an electronic device. By storing and executing the above program, the present application can quickly and standardizedly identify anti-CRE candidate molecules from a large number of compounds, greatly reducing the computing power cost and time cycle of new drug research and development. The present application is designed to overcome the bottleneck of gram-negative bacterial outer membrane permeation, and provides an efficient, accurate and intelligent screening tool for combating CRE super-bacterial infections.

This utility model discloses a bolt screening fixture, relating to the field of bolt screening technology. It includes a base plate with a frame fixedly connected to it. An electric cylinder is fixedly installed at the top of the frame. A rotating block is rotatably installed on the inner side of the frame. One end of the rotating block is fixedly connected to a placement seat. A screening mechanism is provided on the upper side of the placement seat. The screening mechanism includes a fixed frame with a first gear rotatably installed inside. A first slide rail is provided on the left side of the first gear, and a second slide rail is provided on the right side. A first rack and a second rack are slidably installed in the first and second slide rails, respectively. A pointer and a judgment mark are provided on the fixed frame. Driven by the electric cylinder, the fixed frame, the first gear, the first rack, and the second rack all move downwards. If there is a height difference between two bolts, the rack on one side will drive the first gear to rotate, and simultaneously drive the pointer to rotate. By observing the position of the pointer on the judgment mark, it is determined whether the bolt to be tested meets the standard.

The invention relates to the technical field of slide block measurement and model selection, in particular to a slide block steel ball rapid screening method, a tool block and a calibration block are prepared, the outer contour of the tool block is completely consistent with the size after a standard track and target value steel balls are combined, and a plurality of secondary gas channels are formed in the tool block; the plurality of secondary gas channels are respectively opposite to the plurality of channels on the calibration block, and the calibration block is a sliding block and is matched with the tool block for use to obtain a judgment reference of a steel ball mounting gap; the calibration block and the to-be-measured sliding block are sequentially installed on the tool block, ventilation is conducted on the multiple secondary gas channels through the pneumatic measuring instrument, the gas supply pressure is measured, the gap h (mesh) between the tool block and the upper channel of the calibration block and the gap h (real) between the to-be-measured sliding block and the upper channel of the calibration block are judged through the gas supply pressure, and therefore the size of the assembled steel ball is obtained. The tool block is designed, a pneumatic gauge is adopted to directly read a pressure signal to calculate the channel spacing, the detection time can be greatly shortened, and on-site rapid application is facilitated.

The invention relates to the technical field of gene editing, and discloses an sgRNA activity prediction method and device based on deep features and automatic machine learning. The method comprises the following steps: acquiring sgRNA training data with editing efficiency labels and discretizing the sgRNA training data into classification labels; after the sgRNA and the PAM sequence are spliced, inputting the spliced sgRNA and PAM sequence into a pre-training depth sequence model to extract high-dimensional features; obtaining a low-dimensional feature vector through nonlinear dimensionality reduction; an automatic machine learning framework is combined with cross validation, and a prediction model is automatically trained and optimized based on low-dimensional features; and finally, carrying out activity prediction and sorting screening on candidate sgRNA by utilizing the model. According to the method, through fusion of deep semantic extraction, nonlinear structure maintenance and a full-automatic modeling process, the accuracy, robustness and development efficiency of sgRNA activity prediction are effectively improved, and an efficient pilot screening tool is provided for a gene editing experiment.

An apparatus for culturing cells includes a bioreactor with a fluid reservoir and a fixed bed, as well as a portion associated with the fluid reservoir and adapted for preventing cells from settling therein. The bioreactor may include a first vessel including the fluid reservoir and a second vessel with the fixed bed for the cell culture, which may be directly connected to the first vessel by a frangible connection to facilitate disassembly, such as for sampling. A conduit may be provided for connecting the first vessel to the second vessel, so as to establish fluid communication there between. A pump may also be provided for pumping fluid from the first vessel to the second vessel, such as though the conduit if present. Use of the apparatus as a screening tool for a large-scale bioreactor, in a kit, and related methods are also disclosed.

The utility model provides an air resistance consistency screening tool for a flow sensor of a breathing machine, which relates to the technical field of flow detection and comprises a controller, a fan, the flow sensor, a connecting pipeline and an air resistance detection component used for placing an air resistance device, and an air outlet of the fan is connected and communicated with one end of the air resistance detection component through the connecting pipeline. The flow sensor is fixedly connected in the connecting pipeline, and the fan, the flow sensor and the air resistance detection assembly are electrically connected with the controller; according to the air resistance consistency screening tool for the flow sensor of the breathing machine, actual airflow testing can be directly carried out on air resistance devices so as to screen the air resistance devices.

This invention discloses a method for identifying intrahepatic cholangiocarcinoma (ICC) based on serum peptide characteristics and its application. The invention collects serum samples from three groups: individuals with ICC, those with benign liver disease, and healthy controls. Peptide characteristic peaks associated with ICC are screened, and a model is constructed using a logistic regression algorithm. This model demonstrates excellent discriminative ability on both the training and independent test sets, with AUCs reaching 0.986 and 0.963, respectively, significantly outperforming traditional tumor markers CA19-9 and CEA. The peptide characteristic peak combination and the discriminative model constructed based on it can be used for early detection of ICC, differentiation between benign and malignant cases, and screening of high-risk populations. It offers advantages such as rapid detection, standardized procedures, strong early ICC identification capability, and low false positive rate, providing a highly sensitive, specific, and widely applicable non-invasive screening tool for clinical use.

Provided is a system and method for de-personalized security data file sharing using passenger list information messages, the method including: obtaining from an electronic passenger list information message, passenger data for passengers, the passenger data including a unique passenger identifier (UPID) assigned by a Departure Control System (DCS) of an originating airline for each of the plurality of passengers; and, for each of the passengers: depersonalizing the passenger data; retrieving a security screening image (SSI) representative of contents of the luggage item; converting the SSI and the UPID into SSI file sharing data for a security screening tool; transmitting the SSI file sharing data to a secure system associated with a border crossing airport to be used in a security screening process on the checked-in luggage item using the security screening tool; receiving a first screening message with a result of the screening process; and causing the result to be displayed, wherein the result includes one of: a first result representative of cleared security screening; or a second result representative of failed security screening, wherein one or more of the passenger or the checked-in luggage item that failed the security screening are flagged for further security inspection.

The invention relates to a GNN-RNN hybrid network-based small sample serum toxicity parameter prediction method and application, and the prediction method comprises the steps: inputting an SMILES character string of a to-be-detected compound, processing the character string through a trained serum toxicity parameter prediction model, and outputting a predicted toxicity parameter dichotomy result, the step of training the serum toxicity parameter prediction model comprises the steps of obtaining descriptor features, obtaining graph features, obtaining sequence features, fusing multi-modal features and training and optimizing the model. The prediction method and application provided by the invention are a calculation method for performing small sample learning by using a graph neural network, a recurrent neural network and meta learning. The method can predict abnormal conditions of specific serum toxicity parameters possibly caused by small molecule compounds in vitro or in vivo, and can be used as an efficient and low-cost virtual screening tool in the early stage of drug research and development.

This application discloses a search method and related apparatus. Based on acquired search terms, a search filtering tool is displayed, providing filter items that match the search terms. These filter items reflect the user's search preferences. Then, a target filter value is set to obtain the final degree of search preference. Based on the search terms and the target filter value, a target search result matching the user's search preferences is determined and provided to the user. This solution significantly narrows the search scope, greatly reducing the user's workload in judging search results, providing more accurate results, reducing time consumption, and improving search efficiency and experience.

The utility model discloses a crayfish catching and screening tool which comprises an outer frame, a holding handle is fixedly connected to one side of the outer frame, after a person directly holds the holding handle, the outer frame is immersed into a water area for catching, caught crayfishes are stored to the top of a coarse filter screen on the inner side of an inner frame, then the device is taken out from water, and the device is used for catching crayfishes. Water is leaked back to a water area from the coarse filter screen and the fine filter screen again, then the holding handle is continuously held to shake, the small-size crayfishes naturally fall to the top of the fine filter screen from gaps of the coarse filter screen due to the difference between the sizes of the crayfishes, screening of the crayfishes is completed, then a knob is pinched to rotate screw rods on the two sides, and the crayfishes are screened. One end of the screw rod is separated from the inner frame, the inner frame and the coarse filter screen are taken out after the buckling hole is buckled, and the crayfishes are respectively retained at the tops of the coarse filter screen and the fine filter screen according to different sizes, so that the condition that personnel need to screen the crayfishes one by one can be effectively reduced, and the subsequent processing efficiency is guaranteed.

The invention discloses a method for screening edible and medicinal fungi with high yield of microbial proteins and target active components and a kit thereof, and belongs to the technical field of microbial screening. The method comprises the following steps: carrying out primary culture screening on a culture medium containing a specific precursor; performing safe primary screening; carrying out miniaturized culture and rapid protein detection on the safe strains to evaluate the protein potential, and meanwhile, carrying out visual activity screening by utilizing a report system based on functional characteristics of target active ingredients; and finally, carrying out performance verification on the optimized strain. According to the method disclosed by the invention, high-throughput and synchronous evaluation of the protein yield and the active component synthesis potential of the strain is realized, the bottlenecks of low throughput and single target of a traditional method are solved, the excellent edible and medicinal fungus strain with double effects of one strain can be quickly screened, and a core strain screening tool is provided for efficient production of sustainable protein and natural active components.

The invention discloses a BRCA gene mutation prediction method and system based on multi-modal data, and belongs to the field of medical artificial intelligence. Performing tissue region identification and segmentation on the image, and segmenting the image into image blocks; extracting image block features through a BEPH model; using a CLAM model to aggregate into full slice features; fusing the image features with the clinical features; and a mutation prediction result is output through a Balanced Bagging Classifier (Balanced Bagging Classifier). According to the method, the prediction speed is high, special gene sequencing equipment is not needed, the detection cost is greatly reduced, the detection efficiency is improved, BRCA gene mutation screening can be popularized to basic medical institutions, meanwhile, the high recall rate is guaranteed, an efficient and economical BRCA gene mutation primary screening tool is provided for clinic, and the important clinical application value is achieved.

The invention discloses an oil spill degradation intermediate product in-situ detection kit and a use method thereof, and belongs to the field of environmental monitoring, the kit comprises an alkane degradation indication module, an aromatic hydrocarbon degradation indication module and a total petroleum hydrocarbon residue detection module, the alkane degradation indication module utilizes fatty alcohol dehydrogenase to catalyze a reaction between fatty alcohol and NAD, and the total petroleum hydrocarbon residue detection module is used for detecting total petroleum hydrocarbon residues. NADH reduces tetrazole salt to generate a purple formazan compound for colorimetric detection, and the aromatic hydrocarbon degradation indication module utilizes catechol dioxygenase to catalyze ring opening of catechol to generate a yellow semialdehyde compound for colorimetric detection. According to the total petroleum hydrocarbon residue detection module, fluorescence quenching is caused by an inclusion compound formed by fluorescein labeled cyclodextrin and petroleum hydrocarbon, the kit is matched with a portable photometer and data processing software, detection can be completed within 15 minutes on site, an evaluation index of the oil spill degradation efficiency can be calculated, the detection sensitivity reaches 5 milligrams per liter, and the detection time is short. And a rapid screening tool is provided for oil spill bioremediation engineering.

The present invention provides biomarkers for predicting immune-related myasthenia gravis, myocarditis, and myositis. The key locus HLA-DQB1 * 03: 03 is obtained through HLA typing, and the method has a good prediction value on whether tumor patients subjected to ICI treatment suffer from irMG and / or myositis and myocarditis or not. The invention provides a screening tool which can identify a potential high-risk irAE patient before ICI treatment, and provides inspiration for preventive treatment development of irMG susceptible people.

EnzyFloss is an innovative interdental cleaning device that integrates diagnostic and oral health functionality into a standard dental flosser. The floss string is coated with a unique combination of enzymes: amylase, protease, and lipase, long with a pH-sensitive dye and candelilla wax, enabling the detection of early oral health issues such as plaque accumulation, bacterial activity, or imbalanced oral pH. The biodegradable handle is ergonomically designed and inscribed with inspirational scripture for user encouragement. This multifunctional design advances the art by transforming flossing into a proactive oral health screening tool, unlike traditional flossers which only provide mechanical cleaning.

The utility model belongs to the technical field of fish screening tools, and provides a fish screening balance which comprises a balance ruler provided with scales used for length measurement, hanging grooves are symmetrically formed in the two sides of the balance ruler, and a round hole is formed in one side of the balance ruler; a groove hole is fixedly formed in the side, close to the balance ruler, of the handle, a connecting rod is movably connected between the handle and the balance ruler, the two ends of the connecting rod are each sleeved with a connecting ring, the connecting rings are connected to the inner sides of the round holes and the groove hole in a sleeved mode, and the connecting rings are in loose fit with the round holes and the groove hole; through the integrated design, the length measurement function and the weight comparison function are integrated, and the high-precision scales are arranged on the balance ruler, so that a fisherman does not need to additionally use a measuring tape, the fish body length can be measured only by aligning a fish mouth to the scale 0 of the ruler body and reading the scale at the tail part, the process is simple and rapid, and the operation time is greatly saved.

This invention discloses a rapid on-site HPV genotyping method based on one-pot RPA-Cas12a, belonging to the field of molecular biology diagnostic technology. This invention utilizes the automated target screening tool AutoCORDS to design specific crRNAs and RPA primers for different HPV subtypes. Combined with RPA amplification and CRISPR-Cas12a, it achieves highly sensitive, highly specific, efficient, and convenient HPV genotyping detection. This method requires no complex instruments and has advantages such as simple operation, fast analysis speed, and independence from expensive equipment. It can accurately detect genotypes of 14 high-risk HPV types and is suitable for screening and diagnosis of HPV infection in resource-scarce areas.

The application provides a screening method and device for ore blending schemes, relates to the technical field of steel smelting, and is applied to electronic equipment. The electronic equipment is configured with a screening tool. The architecture of the screening tool comprises a main process and N initial sub-processes. The method comprises the following steps: the main process acquires M candidate ore blending schemes and ore blending constraints; the main process preheats the environment of the N initial sub-processes according to the ore blending constraints, and obtains N target sub-processes; the main process distributes the M candidate ore blending schemes to the corresponding target sub-processes, so that the N target sub-processes process the corresponding candidate ore blending schemes in parallel; after the N target sub-processes are processed in parallel, the main process receives M processing results corresponding to the M candidate ore blending schemes from the N target sub-processes; and the main process screens a target ore blending scheme from the M candidate ore blending schemes based on the M processing results and a preset screening standard.

The utility model discloses an alloy steel shot granulating device, which relates to the technical field of granulating machines, and comprises a granulating machine and a screening mechanism at the upper end of the granulating machine, the screening mechanism comprises a separation assembly, a box body arranged on one side of the granulating machine and vertically slidably mounted on one side of the granulating machine, an upper grating and a guide rod fixed on the inner wall of the box body, and a lower grating fixed on the inner wall of the box body, a guide plate is transversely installed on the guide rod in a sliding mode, a lower grating is fixed to the upper end of the guide plate, gaps between the lower grating and the upper grating are arranged at intervals in a staggered mode, an inclined groove is formed in the lower end of the guide plate, and a transverse block is installed in the inclined groove in a sliding mode; the adjusting assembly is arranged at the front end of the box body and used for pushing the transverse block to move along the track of the inclined groove in the guide plate; and the screening component is arranged on one side of the granulator and is used for driving the box body to move up and down. The problems that most screening mechanisms of existing alloy steel shot granulation devices are difficult to directly adjust the screening particle size according to needs, related personnel need to replace screening tools during specific application, and time and labor are wasted are solved.

The invention discloses a recombinant feline infectious peritonitis double-layer vesicle tracer virus as well as a construction method and application thereof, and belongs to the technical field of bioengineering. A CRISPR / Cas9 mediated homologous recombination technology is used, on the basis of a reverse genetic manipulation platform, an Nsp3 region of plasmid pBAC-FIBV-791146 is replaced with a reporter gene sequence, then the feline infectious peritonitis virus is rescued, and the recombinant feline infectious peritonitis bilayer vesicle tracer virus is formed. The biological characteristics of the strain and the tracing effect of the double-membrane vesicles are measured, it is proved that insertion of the ZsGreen gene does not affect virus proliferation, but the recombinant virus has the characteristic of tracing the double-membrane vesicles, and the recombinant virus can serve as a research tool for monitoring the forming mechanism of the double-membrane vesicles and a drug screening tool for resisting the feline infectious peritonitis virus.

The invention discloses a Y chromosome detection fluorescent probe kit based on SRY and TSPY1 double genes and an application method, and belongs to the technical field of molecular biological detection. The kit comprises a primer pair and a fluorescence labeling probe which are used for specifically amplifying and detecting an SRY gene and a TSPY1 gene on a Y chromosome, and a primer pair and a fluorescence labeling probe of a GAPDH gene serving as an internal reference. Two Y chromosome functional genes which are crucial to male gonad development are synchronously detected in a reaction system through a multiplex fluorescent PCR technology. The kit is mainly used for (1) auxiliary diagnosis of Y chromosome linked genetic diseases; (2) evaluating the integrity of the key gene region of the Y chromosome of the fetus, and providing non-invasive prenatal risk evaluation for sexual development related diseases (such as gonadal insufficiency); and (3) the kit is used as an auxiliary screening tool for male infertility factors. Through double-site detection, the accuracy and reliability of detection are effectively improved, and the limitation of single-site detection is avoided.

A tool and method for screening cryogenic electron microscopy (cryo-EM) sample grids using vacuum ultraviolet (VUV) illumination in two configurations. First configuration directly images cryo-EM grids using bright-field optical microscopy employing VUV wavelengths and specialized VUV optics. Second configuration converts transmitted VUV radiation from the cryo-EM grid to visible or near-UV light with a scintillator positioned by the grid. The resultant luminescent high-resolution shadow image is viewed using more conventional microscope optics. In both configurations, individual micron-scale grid holes are imaged to determine ice thickness and quality from the optical absorption of ultrathin vitrified water layers with a precision of a few nanometers. Longer wavelengths can be used to independently view protein concentration and distribution within the ice layer. This tool greatly increases yield of high-quality grids before cryo-EM analysis and is compatible with Single Particle Analysis (SPA) and other cryo-EM methods including cryo-electron Tomography and microcrystal electron diffraction.

This invention discloses a system for early screening of neurodevelopmental delay in mid-to-late-term preterm infants. Based on the expression levels of two mRNAs, APOE and CST3, in the placenta, this invention establishes a "2-mRNA Panel" classification model for early screening of neurodevelopmental delay in mid-to-late-term preterm infants. The area under the receiver operating characteristic curve (AUC) for gross motor delay, fine motor delay, and personal-social functional delay reaches 86.1%, 82.2%, and 83.3%, respectively. Therefore, APOE and CST3 mRNAs in the placenta can serve as biomarkers for neurodevelopmental delay in mid-to-late-term preterm infants, providing a valuable supplement to the development of early screening tools for neurodevelopmental delay. This invention has significant application value.

The application provides a kind of Alzheimer's disease risk prediction system based on brain image, comprising: brain image receiving unit, for receiving the brain image of subject;Temporal muscle thickness acquisition unit, for obtaining the temporal muscle thickness of subject according to brain image;Alzheimer's disease risk analysis unit, for comparing gender-specific cutoff value according to the temporal muscle thickness of subject, predict the result of subject suffering from Alzheimer's disease;Specific cutoff value is: male 8.40mm, female 7.51mm;When the temporal muscle thickness is less than or equal to the cutoff value, the subject is at high risk of suffering from Alzheimer's disease;When the temporal muscle thickness is greater than the cutoff value, the subject is at low risk of suffering from Alzheimer's disease.The application can solve the technical problem of lack of non-invasive, simple and easy-to-promote early screening tool for Alzheimer's disease in the prior art.

This utility model belongs to the technical field of soil testing, specifically relating to a layered sieving tool for soil pest detection. It includes a base plate, with a motor fixedly mounted on the upper end of the base plate. The motor's output shaft is fixedly connected to a rotating rod. This utility model, through the cooperation of the motor, rotating rod, circular turntable, T-shaped push-pull plate, concave plate, sliding support rod, fixed frame, mounting components, and mounting blocks, can drive two sieving frames to sway left and right. At this time, under the action of the sieving meshes at the bottom of both sieving frames, a layered sieving process is achieved, ensuring that the sieved soil meets the requirements for soil testing. The cooperation between the electric telescopic rod, fixed seat, support rod, and connecting plate drives several inserted rods to move out from the corresponding insertion holes inside the mounting blocks, allowing the sieving frames to be easily removed from the device after use.

This invention discloses a strain for the efficient synthesis of D-tagatose, its preparation method, and its applications. Through strategies such as the discovery of novel galactitol dehydrogenase and promoter engineering, this invention initially increased tagatose yield by 28.48%. Simultaneously, a highly efficient and sensitive tagatose biosensor was developed, which was used as a screening tool for xylose reductase. Ss XR molecularly modified the strain to obtain the F128M-Q219K double mutant, which achieved a tagatose yield of 5.39 g / L in the producing strain. Based on this, amino acid complementation optimization was performed on the high-yielding strain, and the final engineered strain achieved a tagatose yield of 44.61 g / L in a 5 L bioreactor. This study provides a new strategy and core technology support for the efficient biosynthesis of tagatose.

The invention discloses application of plasma CXCL16 as a marker in evaluation of pulmonary arterial hypertension, and the application comprises the following specific steps: S1, treating a plasma sample; s2, detecting the concentration of CXCL16 in the blood plasma by using an ELISA (enzyme-linked immunosorbent assay) method; s3, comparing the CXCL16 concentration with a healthy control group, a CTEPD non-pulmonary arterial hypertension group and other types of pulmonary arterial hypertension groups; s4, the CXCL16 concentration is associated with hemodynamic parameter changes before and after BPA treatment, the detection operation is non-invasive, convenient and safe, a part of invasive examination can be replaced to serve as a preliminary screening tool, the method is suitable for grass-roots popularization and large-scale population screening, and the medical cost and the patient diagnosis and treatment risk are reduced.