91 results about "Screening tool" patented technology

The invention relates to the technical field of agricultural biology, discloses a soybean shade-tolerant gene GmUGT73C2 as well as a molecular marker and application thereof, and is characterized in that the gene GmUGT73C2 which has a remarkable regulation effect on the plant height and shade tolerance of soybeans is obtained through screening and verification; the plant height of the wild soybean is remarkably reduced and the shade tolerance of the soybean is improved by overexpression of the gene in the soybean plant. A novel gene and a novel method are provided for construction of dwarf and shade-tolerant soybean plants. Meanwhile, an SNP locus corresponding to the gene is found, a corresponding molecular marker is developed, and an efficient screening tool is provided for construction of dwarf and shade-tolerant plants.

The present disclosure provides peptides, chimeric molecular constructs, and compositions thereof, that can bind volatile organic compounds (VOCs) and be utilized to distinguish VOC profiles, e.g., indicative of disease, as well as related methods. A VOC-based gas sensing approach described in the present specification can be an effective screening tool, due, at least in part, to its speed, ease of use, sensitivity, specificity, and because it does not rely on binding to specific nucleic acid fragments or proteins to function.

The utility model relates to the technical field of cement negative pressure screen analysis instruments, and discloses a full-automatic cement negative pressure screen analysis instrument which comprises a machine body, a fixing plate is fixedly connected to the top of the inner wall of the machine body, a first stepping motor is fixedly connected to the center of the bottom of the fixing plate, and the output end of the first stepping motor is fixedly connected with a lead screw. A lifting rod is in threaded connection with the outer ring of the lead screw, a lifting frame is fixedly connected to the top of the lifting rod, a screening tool is arranged on one side of the inner ring of the lifting frame, a screen is arranged at the bottom of the inner wall of the screening tool, and a linear bearing penetrates through and is fixedly connected to the center of the bottom of the fixing plate. The left side of the bottom of the fixing plate is fixedly connected with a second stepping motor. According to the vibrating screen, the bearing frame is driven by the first stepping motor, the lifting frame, the screen tool, the screen cover, the vibrator and the second stepping motor to rotate, materials are weighed, the first stepping motor is started to work, the lead screw is driven to rotate, and the screen tool is driven to move downwards.

The invention relates to the field of computational biology and bioinformatics, in particular to an RNA (Ribonucleic Acid) sequence screening and promoter function predicting and screening method based on machine learning, which comprises the following steps of: firstly, adopting a novel sequence algorithm based on a sliding window and a position weight matrix, and combining technologies such as k-mer frequency analysis and conservative motif recognition; candidate RNA sequences are efficiently identified from genomic sequences. Then, an integrated prediction model fusing deep learning and traditional machine learning is established, and multi-dimensional information such as sequence features, structural features, functional features and evolution features is extracted; and carrying out batch prediction on the candidate RNA sequences, outputting a function intensity score and providing credibility evaluation. And finally, screening an RNA sequence with an optimal prediction result based on a multi-objective optimization strategy, and designing an experimental verification scheme. According to the method, the prediction accuracy and the screening efficiency are improved, the experiment cost can be remarkably reduced, and an efficient promoter screening tool is provided for the fields of synthetic biology, gene therapy, biological pharmacy and the like.

Methods of analyzing the presence or absence of immune cells capable of binding to an antigen peptide in a sample from one or more individuals are provided. Also provided are methods of detecting or treating cancer or a tumor, a pathogen infection, or an autoimmune disease. A display moiety is provided having particles associated with a plurality of MHC-peptide complexes, where at least two MHC-peptide complexes are different. Also provided are bait compositions having a plurality of display portions and methods of analyzing immune cells by using the display portions or bait compositions as screening tools.

The present application belongs to the technical field of artificial intelligence assisted drug screening, and particularly relates to a method for screening active molecules against carbapenem-resistant enterobacteriaceae based on a LightGBM algorithm, a medium and an apparatus. The method constructs a LightGBM integrated learning framework, fuses ADME rules optimized for the outer membrane barrier characteristics of gram-negative bacteria and multi-target molecule docking verification, effectively solves the problem of data imbalance caused by the scarcity of active samples and the huge compound library, and significantly improves the hit rate of screening. The present application also provides a computer readable storage medium and an electronic device. By storing and executing the above program, the present application can quickly and standardizedly identify anti-CRE candidate molecules from a large number of compounds, greatly reducing the computing power cost and time cycle of new drug research and development. The present application is designed to overcome the bottleneck of gram-negative bacterial outer membrane permeation, and provides an efficient, accurate and intelligent screening tool for combating CRE super-bacterial infections.

This utility model discloses a bolt screening fixture, relating to the field of bolt screening technology. It includes a base plate with a frame fixedly connected to it. An electric cylinder is fixedly installed at the top of the frame. A rotating block is rotatably installed on the inner side of the frame. One end of the rotating block is fixedly connected to a placement seat. A screening mechanism is provided on the upper side of the placement seat. The screening mechanism includes a fixed frame with a first gear rotatably installed inside. A first slide rail is provided on the left side of the first gear, and a second slide rail is provided on the right side. A first rack and a second rack are slidably installed in the first and second slide rails, respectively. A pointer and a judgment mark are provided on the fixed frame. Driven by the electric cylinder, the fixed frame, the first gear, the first rack, and the second rack all move downwards. If there is a height difference between two bolts, the rack on one side will drive the first gear to rotate, and simultaneously drive the pointer to rotate. By observing the position of the pointer on the judgment mark, it is determined whether the bolt to be tested meets the standard.

The invention relates to the technical field of slide block measurement and model selection, in particular to a slide block steel ball rapid screening method, a tool block and a calibration block are prepared, the outer contour of the tool block is completely consistent with the size after a standard track and target value steel balls are combined, and a plurality of secondary gas channels are formed in the tool block; the plurality of secondary gas channels are respectively opposite to the plurality of channels on the calibration block, and the calibration block is a sliding block and is matched with the tool block for use to obtain a judgment reference of a steel ball mounting gap; the calibration block and the to-be-measured sliding block are sequentially installed on the tool block, ventilation is conducted on the multiple secondary gas channels through the pneumatic measuring instrument, the gas supply pressure is measured, the gap h (mesh) between the tool block and the upper channel of the calibration block and the gap h (real) between the to-be-measured sliding block and the upper channel of the calibration block are judged through the gas supply pressure, and therefore the size of the assembled steel ball is obtained. The tool block is designed, a pneumatic gauge is adopted to directly read a pressure signal to calculate the channel spacing, the detection time can be greatly shortened, and on-site rapid application is facilitated.

The invention relates to the technical field of gene editing, and discloses an sgRNA activity prediction method and device based on deep features and automatic machine learning. The method comprises the following steps: acquiring sgRNA training data with editing efficiency labels and discretizing the sgRNA training data into classification labels; after the sgRNA and the PAM sequence are spliced, inputting the spliced sgRNA and PAM sequence into a pre-training depth sequence model to extract high-dimensional features; obtaining a low-dimensional feature vector through nonlinear dimensionality reduction; an automatic machine learning framework is combined with cross validation, and a prediction model is automatically trained and optimized based on low-dimensional features; and finally, carrying out activity prediction and sorting screening on candidate sgRNA by utilizing the model. According to the method, through fusion of deep semantic extraction, nonlinear structure maintenance and a full-automatic modeling process, the accuracy, robustness and development efficiency of sgRNA activity prediction are effectively improved, and an efficient pilot screening tool is provided for a gene editing experiment.

The application discloses a lung nodule metabolic marker and a screening method and a construction method and application of a screening model. Specifically disclosed are the application of metabolic markers and / or reagents for detecting the metabolic markers in the preparation of products for lung nodule screening; the metabolic markers include hypoxanthine, L-ornithine, decanoyl-L-carnitine, dehydroepiandrosterone sulfate and bethanidine. The application further discloses a method for constructing a lung nodule screening model. The metabolic markers and the lung nodule screening model constructed by using the metabolic markers can effectively screen out individuals with lung nodules from healthy people, have very high sensitivity and good specificity, are fast, accurate, non-invasive and non-radiation, are suitable for wide promotion, can be used as a pre-screening tool of LDCT, are used for the preliminary screening of lung nodules of a large-scale population, and have important significance for the early discovery of lung cancer and the improvement of the prognosis of patients.

An apparatus for culturing cells includes a bioreactor with a fluid reservoir and a fixed bed, as well as a portion associated with the fluid reservoir and adapted for preventing cells from settling therein. The bioreactor may include a first vessel including the fluid reservoir and a second vessel with the fixed bed for the cell culture, which may be directly connected to the first vessel by a frangible connection to facilitate disassembly, such as for sampling. A conduit may be provided for connecting the first vessel to the second vessel, so as to establish fluid communication there between. A pump may also be provided for pumping fluid from the first vessel to the second vessel, such as though the conduit if present. Use of the apparatus as a screening tool for a large-scale bioreactor, in a kit, and related methods are also disclosed.

The utility model provides an air resistance consistency screening tool for a flow sensor of a breathing machine, which relates to the technical field of flow detection and comprises a controller, a fan, the flow sensor, a connecting pipeline and an air resistance detection component used for placing an air resistance device, and an air outlet of the fan is connected and communicated with one end of the air resistance detection component through the connecting pipeline. The flow sensor is fixedly connected in the connecting pipeline, and the fan, the flow sensor and the air resistance detection assembly are electrically connected with the controller; according to the air resistance consistency screening tool for the flow sensor of the breathing machine, actual airflow testing can be directly carried out on air resistance devices so as to screen the air resistance devices.

This invention discloses a method for identifying intrahepatic cholangiocarcinoma (ICC) based on serum peptide characteristics and its application. The invention collects serum samples from three groups: individuals with ICC, those with benign liver disease, and healthy controls. Peptide characteristic peaks associated with ICC are screened, and a model is constructed using a logistic regression algorithm. This model demonstrates excellent discriminative ability on both the training and independent test sets, with AUCs reaching 0.986 and 0.963, respectively, significantly outperforming traditional tumor markers CA19-9 and CEA. The peptide characteristic peak combination and the discriminative model constructed based on it can be used for early detection of ICC, differentiation between benign and malignant cases, and screening of high-risk populations. It offers advantages such as rapid detection, standardized procedures, strong early ICC identification capability, and low false positive rate, providing a highly sensitive, specific, and widely applicable non-invasive screening tool for clinical use.

The invention provides a method and device for determining a target group, electronic equipment and a storage medium, and relates to the technical field of artificial intelligence, in particular to the fields of large models, generative models, resource recommendation and the like. The specific implementation scheme is as follows: determining at least one target screening tool in a plurality of candidate screening tools and at least one reference screening rule for the at least one target screening tool by utilizing a large model according to description information of the plurality of candidate screening tools and a historical context comprising demand information; calling at least one target screening tool by utilizing at least one reference screening rule to obtain at least one label expression; according to combinational logic, processing each label in the at least one label expression into a target screening rule; and determining a target group from the plurality of candidate objects according to a target screening rule.

Provided is a system and method for de-personalized security data file sharing using passenger list information messages, the method including: obtaining from an electronic passenger list information message, passenger data for passengers, the passenger data including a unique passenger identifier (UPID) assigned by a Departure Control System (DCS) of an originating airline for each of the plurality of passengers; and, for each of the passengers: depersonalizing the passenger data; retrieving a security screening image (SSI) representative of contents of the luggage item; converting the SSI and the UPID into SSI file sharing data for a security screening tool; transmitting the SSI file sharing data to a secure system associated with a border crossing airport to be used in a security screening process on the checked-in luggage item using the security screening tool; receiving a first screening message with a result of the screening process; and causing the result to be displayed, wherein the result includes one of: a first result representative of cleared security screening; or a second result representative of failed security screening, wherein one or more of the passenger or the checked-in luggage item that failed the security screening are flagged for further security inspection.

The invention relates to a GNN-RNN hybrid network-based small sample serum toxicity parameter prediction method and application, and the prediction method comprises the steps: inputting an SMILES character string of a to-be-detected compound, processing the character string through a trained serum toxicity parameter prediction model, and outputting a predicted toxicity parameter dichotomy result, the step of training the serum toxicity parameter prediction model comprises the steps of obtaining descriptor features, obtaining graph features, obtaining sequence features, fusing multi-modal features and training and optimizing the model. The prediction method and application provided by the invention are a calculation method for performing small sample learning by using a graph neural network, a recurrent neural network and meta learning. The method can predict abnormal conditions of specific serum toxicity parameters possibly caused by small molecule compounds in vitro or in vivo, and can be used as an efficient and low-cost virtual screening tool in the early stage of drug research and development.

The utility model provides a projector lens assembly imaging effect screening tool. The screening tool comprises a shell, a light source, a reflection cup, a light-transmitting plate and a placement frame. The shell is provided with an installation opening for installing a lens assembly, the light source, the reflection cup, the placing frame and the light-transmitting plates are all located in the shell, the placing frame is used for placing the light-transmitting plates, and light rays of the light source sequentially pass through the reflection cup and the light-transmitting plates and finally pass through the installation opening. According to the screening tool, the optical devices needed by imaging are arranged in the shell, the lens assembly can be subjected to an imaging test by installing the lens assembly on the installation opening of the shell, and therefore the lens assembly meeting the imaging requirement can be screened out in advance, the first pass yield and quality of product production are improved, and the maintenance time and cost are reduced.

This application discloses a search method and related apparatus. Based on acquired search terms, a search filtering tool is displayed, providing filter items that match the search terms. These filter items reflect the user's search preferences. Then, a target filter value is set to obtain the final degree of search preference. Based on the search terms and the target filter value, a target search result matching the user's search preferences is determined and provided to the user. This solution significantly narrows the search scope, greatly reducing the user's workload in judging search results, providing more accurate results, reducing time consumption, and improving search efficiency and experience.

The utility model discloses a crayfish catching and screening tool which comprises an outer frame, a holding handle is fixedly connected to one side of the outer frame, after a person directly holds the holding handle, the outer frame is immersed into a water area for catching, caught crayfishes are stored to the top of a coarse filter screen on the inner side of an inner frame, then the device is taken out from water, and the device is used for catching crayfishes. Water is leaked back to a water area from the coarse filter screen and the fine filter screen again, then the holding handle is continuously held to shake, the small-size crayfishes naturally fall to the top of the fine filter screen from gaps of the coarse filter screen due to the difference between the sizes of the crayfishes, screening of the crayfishes is completed, then a knob is pinched to rotate screw rods on the two sides, and the crayfishes are screened. One end of the screw rod is separated from the inner frame, the inner frame and the coarse filter screen are taken out after the buckling hole is buckled, and the crayfishes are respectively retained at the tops of the coarse filter screen and the fine filter screen according to different sizes, so that the condition that personnel need to screen the crayfishes one by one can be effectively reduced, and the subsequent processing efficiency is guaranteed.

The present invention relates to the study of biological mechanisms and belongs to the field of biomedicine. The present invention synthesizes a dual-labeled probe based on coumarin-conjugated bridge-aromatic receptor. The probe molecule can simultaneously and accurately target mitochondria and lipid droplet components with a single molecule. It can be used to fluorescently track the physiological activities of lipid droplets and mitochondria during ferroptosis, achieving the increase in lipid droplet polarity, mitochondrial fibrosis, and ONOO during cell ferroptosis. ‑ This technology allows for the visualization and detection of multiple ferroptosis-related biological information, including lipid content, reduced lipid droplet-mitochondrial contact, and gel-like formation of lipid droplets. This solution addresses the inability of ferroptosis-related drugs to report multiple internal microenvironments of lipid droplets and mitochondria, as well as the connection between organelle microdynamics and ferroptosis, at the organelle level, leading to the inability to visualize and evaluate clinical efficacy. It achieves the potential for evaluating the activity of ferroptosis-inducing drugs and provides an accurate screening tool for the development of drugs that induce ferroptosis mechanisms.

The invention discloses a method for screening edible and medicinal fungi with high yield of microbial proteins and target active components and a kit thereof, and belongs to the technical field of microbial screening. The method comprises the following steps: carrying out primary culture screening on a culture medium containing a specific precursor; performing safe primary screening; carrying out miniaturized culture and rapid protein detection on the safe strains to evaluate the protein potential, and meanwhile, carrying out visual activity screening by utilizing a report system based on functional characteristics of target active ingredients; and finally, carrying out performance verification on the optimized strain. According to the method disclosed by the invention, high-throughput and synchronous evaluation of the protein yield and the active component synthesis potential of the strain is realized, the bottlenecks of low throughput and single target of a traditional method are solved, the excellent edible and medicinal fungus strain with double effects of one strain can be quickly screened, and a core strain screening tool is provided for efficient production of sustainable protein and natural active components.

The embodiment of the invention provides a system for detecting a trade state. Comprising a preset self-made crawler tool used for collecting restriction list data to generate a restriction list file; the calculation engine is used for acquiring the restriction list file so as to convert the restriction list file into a restriction list of which the data format is structured data and write the restriction list into the trade compliance screening system; the business system is used for managing main data and document information of each trade object and pushing the main data and the document information to the trade compliance screening system; a trade compliance screening system includes a search engine for providing DSL queries; the timing screening tool is used for screening and matching a restriction list with main data and document information of each trade object based on DSL query so as to determine the trade state of each trade object; and when the matching degree of any trade object and the restriction list reaches a first value, determining that any trade object exists in the restriction list, and determining that the trade state of any trade object is trade restriction.

The invention discloses a BRCA gene mutation prediction method and system based on multi-modal data, and belongs to the field of medical artificial intelligence. Performing tissue region identification and segmentation on the image, and segmenting the image into image blocks; extracting image block features through a BEPH model; using a CLAM model to aggregate into full slice features; fusing the image features with the clinical features; and a mutation prediction result is output through a Balanced Bagging Classifier (Balanced Bagging Classifier). According to the method, the prediction speed is high, special gene sequencing equipment is not needed, the detection cost is greatly reduced, the detection efficiency is improved, BRCA gene mutation screening can be popularized to basic medical institutions, meanwhile, the high recall rate is guaranteed, an efficient and economical BRCA gene mutation primary screening tool is provided for clinic, and the important clinical application value is achieved.

The invention discloses an oil spill degradation intermediate product in-situ detection kit and a use method thereof, and belongs to the field of environmental monitoring, the kit comprises an alkane degradation indication module, an aromatic hydrocarbon degradation indication module and a total petroleum hydrocarbon residue detection module, the alkane degradation indication module utilizes fatty alcohol dehydrogenase to catalyze a reaction between fatty alcohol and NAD, and the total petroleum hydrocarbon residue detection module is used for detecting total petroleum hydrocarbon residues. NADH reduces tetrazole salt to generate a purple formazan compound for colorimetric detection, and the aromatic hydrocarbon degradation indication module utilizes catechol dioxygenase to catalyze ring opening of catechol to generate a yellow semialdehyde compound for colorimetric detection. According to the total petroleum hydrocarbon residue detection module, fluorescence quenching is caused by an inclusion compound formed by fluorescein labeled cyclodextrin and petroleum hydrocarbon, the kit is matched with a portable photometer and data processing software, detection can be completed within 15 minutes on site, an evaluation index of the oil spill degradation efficiency can be calculated, the detection sensitivity reaches 5 milligrams per liter, and the detection time is short. And a rapid screening tool is provided for oil spill bioremediation engineering.

The present invention provides biomarkers for predicting immune-related myasthenia gravis, myocarditis, and myositis. The key locus HLA-DQB1 * 03: 03 is obtained through HLA typing, and the method has a good prediction value on whether tumor patients subjected to ICI treatment suffer from irMG and / or myositis and myocarditis or not. The invention provides a screening tool which can identify a potential high-risk irAE patient before ICI treatment, and provides inspiration for preventive treatment development of irMG susceptible people.

The invention discloses an MphR protein mutant and an erythromycin whole-cell biosensor constructed based on the MphR protein mutant. The amino acid sequence of the MphR protein mutant is as shown in SEQ ID NO: 5, SEQ ID NO: 7 or SEQ ID NO: 9. Experiments prove that the MphR protein mutant can be used for preparing erythromycin whole-cell biosensors of which the sensitivity is reduced by about 2.5 times, 10 times or even 100 times compared with the sensitivity of an original erythromycin whole-cell biosensor Top10 / pSense, and the erythromycin whole-cell biosensors can be used as high-throughput screening tools, and can be used for preparing a high-throughput screening kit. The method is applied to erythromycin detection or screening of erythromycin industrial strains with different initial yields, so that the screening flux and breeding speed of the erythromycin industrial strains are greatly improved. The method has an important application value.

EnzyFloss is an innovative interdental cleaning device that integrates diagnostic and oral health functionality into a standard dental flosser. The floss string is coated with a unique combination of enzymes: amylase, protease, and lipase, long with a pH-sensitive dye and candelilla wax, enabling the detection of early oral health issues such as plaque accumulation, bacterial activity, or imbalanced oral pH. The biodegradable handle is ergonomically designed and inscribed with inspirational scripture for user encouragement. This multifunctional design advances the art by transforming flossing into a proactive oral health screening tool, unlike traditional flossers which only provide mechanical cleaning.

The utility model provides a primary polycrystalline silicon powder automatic screening tool for single crystal drawing, which comprises a base, a primary polycrystalline silicon powder screening device, a primary polycrystalline silicon powder screening device and a primary polycrystalline silicon powder screening device, the turntable is arranged at the end part of the output shaft of the motor, and the turntable and the output shaft of the motor are coaxially arranged; the crank-link mechanism is in power connection with the turntable; the screening basket is connected with the other end of the crank connecting rod mechanism, and the screening basket can be driven by the crank connecting rod mechanism to do reciprocating motion in the horizontal direction; wherein the screening basket is at least provided with two screens with different screen hole sizes, and the screen with the larger screen hole size is located above the screen with the smaller screen hole size. According to the tool, inconvenience existing in the manual operation process can be reduced, the operation intensity is effectively reduced, and in the screening process, it can be avoided that too much dust is raised, and the surrounding environment is affected.

The utility model belongs to the technical field of fish screening tools, and provides a fish screening balance which comprises a balance ruler provided with scales used for length measurement, hanging grooves are symmetrically formed in the two sides of the balance ruler, and a round hole is formed in one side of the balance ruler; a groove hole is fixedly formed in the side, close to the balance ruler, of the handle, a connecting rod is movably connected between the handle and the balance ruler, the two ends of the connecting rod are each sleeved with a connecting ring, the connecting rings are connected to the inner sides of the round holes and the groove hole in a sleeved mode, and the connecting rings are in loose fit with the round holes and the groove hole; through the integrated design, the length measurement function and the weight comparison function are integrated, and the high-precision scales are arranged on the balance ruler, so that a fisherman does not need to additionally use a measuring tape, the fish body length can be measured only by aligning a fish mouth to the scale 0 of the ruler body and reading the scale at the tail part, the process is simple and rapid, and the operation time is greatly saved.

Engineered tissue models based on three-dimensional (3D) scaffolds, also referred to herein as tissue-engineered 3D models, can be used as in vitro diagnostic and drug screening tools for predicting, preventing and / or treating cancer metastases.