The present invention belongs to the technical field of rotation speed, acceleration speed measurement and inertial navigation, and relates to a quantum inertial sensor capable of measuring six-parameter inertial parameters and a measuring method thereof. The quantum sensor capable of measuring the six-parameter inertial parameters comprises two-dimensional microcrystalline glass vacuum chambers, a three-dimensional microcrystalline glass vacuum chamber, differential pumping tubes and alkali metal sources, the two two-dimensional microcrystalline glass vacuum chambers are connected with three-dimensional microcrystalline glass vacuum chamber by the differential pumping tubes, and respectively with the alkali metal sources, in addition, and the differential pumping tubes are prepared from microcrystalline glass same as the material of microcrystalline glass of the two-dimensional microcrystalline glass vacuum chambers and the three-dimensional microcrystalline glass vacuum chamber. By use of a scheme of counter-throwing of cold atomic groups and combination of manipulation of the cold atomic groups by Raman beams in different directions, and measurement of six-axis-space inertial parameters can be achieved. Based on low-temperature bonding technique, microcrystalline glass is used for constructing the vacuum chambers, so that the quantum inertial sensor has better light transmitting property, is more compact in structure, higher in thermal and magnetic stability and impact resistance, and more conducive to miniaturization.