250 results about "Bacterial activity" patented technology

Novel protected cyclopeptide intermediates are prepared from polymyxin B are used to synthesize new peptide antibiotics. Intermediates are readily derivatized and deprotected to provide new families of antibiotics, which have potent anti-bacterial activity against gram-negative bacteria; but also are useful and potent against gram-positive bacteria.

A system and method for the purification and biodeodorizing of a gas are disclosed. The system is highly adaptable and capable of operating in a variety of modes to tailor performance of the system to specific odor control applications. The scrubber stages of the system may each be maintained at different conditions to selectively promote bacterial activity that targets a variety of odorous constituents. The pH level of the irrigation fluid provided to each scrubber stage may be controlled.

Provided herein is a placental membrane product comprising an immunocompatible amniotic membrane. Such placental membrane products can be cryopreserved and contain therapeutic factors and viable cells after thawing. The placental membrane products are useful in wound healing and tissue repair/regeneration as they are capable of promoting angiogenesis, reducing inflammation, inhibiting proteases and free radical oxidation, reducing scar formation, and other methods that promote healing. The present technology relates to products to protect injured or damaged tissue, or as a covering to prevent adhesions, to exclude bacteria, to inhibit bacterial activity, and/or to promote healing or growth of tissue. The field also relates to methods of manufacturing and methods of use of such membrane-derived products.

Provided herein is a placental membrane product comprising an immunocompatible chorionic membrane. Such placental membrane products can be cryopreserved and contain therapeutic factors and viable cells after thawing. The placental membrane products are useful in wound healing or tissue repair/regeneration as they are capable of promoting angiogenesis, reducing inflammation, reducing scar formation, and other methods that promote healing. The present technology relates to products to protect injured or damaged tissue, or as a covering to exclude bacteria, to inhibit bacterial activity, or to promote healing or growth of tissue. The field also relates to methods of manufacturing and methods of use of such membrane-derived products.

The present invention describes a container end closure which utilizes a material that is adapted to provide a visible indicator when the internal pressure of the contents increase to a predetermined level. In one embodiment, an interruption in a reinforcing bead incorporated in the end closure is deformed to visually notify a consumer of spoilage due to bacterial activity and to substantially prohibit the use of traditional can openers to access the spoiled contents within the container.

The invention discloses a method for preparing organic bacteria liquid, the organic bacteria liquid prepared by the method, and an application of the organic bacteria liquid. The organic bacteria liquid is prepared by breeding bacteria from industrial and agricultural wastes which are rich in organic materials, such as plant ash, furfural residue, excrement, activated sludge, and crop straw, and screening, expanding and propagating the bred bacteria. The organic bacteria liquid has the characteristic of high bacterial activity, and can be used as a mother culture in the production of a microbial fertilizer or directly used as a seed-dressing agent.

The present invention relates to a compound of formula (I)

or a pharmaceutically acceptable salt thereof wherein X and R are as defined herein. The compounds of formula (I) are useful as gyrase and/or topoisomerase IV inhibitors for treating bacterial infections. The compounds of formula (I) either possess a broad range of anti-bacterial activity and advantageous toxicological properties or are prodrugs of compounds having said activity.

The invention discloses an Arthrinium sp. strain which is preserved in China General Microbiological Culture Collection Center on June 8th, 2007 and has the preservation name of Arthrinium sp. strain Phl012 and the preservation number of CGMCC 2082. The Arthrinium sp. strain can be used for preparing 2,3beta-dihydroxy bostrycin which is a nontoxic red pigment with antibacterial activity.

The invention discloses a berberine azole compound shown in general formulas such as I-IV, and a pharmaceutically acceptable salt thereof, and also discloses a preparation method of the compound, which comprises the following steps that: a compound VI and an azole compound HIm or 1H-2-mercaptobenzimidazole are reacted to obtain an intermediate VII or VIII, and then the obtained intermediate is reacted with a compound V to obtain the berberine azole compound shown in general formulas such as I or II; and the compound V and a compound IX or XI are reacted to obtain an intermediate X or XII, and then the obtained intermediate is reacted with the azole compound Him to obtain the berberine azole compound shown in general formulas such as III or IV. The berberine azole compound has a certain inhibitory activity on Gram-positive bacteria, Gram-negative bacteria and fungi, the anti-bacterial activity of part of the compounds is equal to or even stronger than that of chloramphenicol or norfloxacin, the antifungal activity of part of the compounds is equal to or even stronger than that of fluconazole, and the berberine azole compound can be used for preparing anti-microbial drugs.

The invention discloses a bactericidal odor removing agent in the chemical mixture agent field, and is characterized by comprising the components, in percentage by weight: (A) 0.25 to 5% of an organic silicon quaternary ammonium salt; (B) 0.1 to 2% of an organic silicon coupling agent; (C) 0.2 to 2% of a stabilizing agent; and (D) the balance being deionized water. The bactericidal odor removing agent has antibacterial, mildewproof, odor-removing and deodorant effects, has lastingly bacteriostatic effect and widely bacteriostatic range, simultaneously is safe and reliable for any product, and does not pollute the environment. The organic silicon quaternary ammonium salt has bactericidal and bacteriostatic effects, and non-toxic, gentle, soft and smooth properties of the organic silicon quaternary ammonium salt to human bodies are utilized, so the bactericidal odor removing agent is prepared into a spray medicament form, is used for disinfectant and bactericidal treatment of various traumatic infections and skin infections, can have rapidly bactericidal antipruritic effect for the various skin infections, and can kill bacteria and inhibit bacterial activity.

The invention discloses a technology for preparing an intestinal flora preparation in fecal microbiota transplantation clinic treatment. The technology comprises the following steps: collecting feces,preparing intestinal flora, and filling the intestinal flora preparation, wherein the step of collecting feces includes fecal collection and anaerobic transportation, the step of preparing the intestinal flora preparation includes stepwise filtration under aerobic and anaerobic conditions, centrifuging and mixing, and the step of filling the intestinal flora preparation adopts storage using a glycerol protection solution and a cryopreservation technology. A novel aerobic and anaerobic separation method is adopted in the separation process of an intestinal flora solution, the aerobic and anaerobic separation method selected according to the characteristics of the living environment of intestinal florae can maximally protect the flora diversity of aerobic bacteria and anaerobic bacteria inthe intestinal tract, and an added glycerol protection agent maintains the bacterial activity within a certain period of time and improves the effect of the intestinal flora preparation.

The invention discloses a scylla paramamosain anti-bacterial polypeptide Sp-NPFin and its application. A molecular formula is C227H373N71O62S1, and its amino acid sequence is shown as SEQ ID NO: 01. The scylla paramamosain anti-bacterial polypeptide Sp-NPFin has strong antibacterial activity and antifungal activity, good antibacterial effect, wide antibacterial spectrum and fast sterilization rate. The scylla paramamosain anti-bacterial polypeptide Sp-NPFin is derived from crustaceans and can be applied to aquatic feed additives, can be developed to anti-mold preservatives, antibacterial agents and antibacterial drugs, and has broad application prospects.

The invention provides compounds of formula (I) in which R1, R2, R3, R4 and R5 are independently selected from hydrogen and chromogenic substituents, and X is selected from the group consisting of hydroxyl; OR6 wherein R6 is selected from the group consisting of C1-C4 alkyl; and O-Me+ wherein Me+ is a cation derived from an organic or inorganic base. A preferred species of formula (I) is 4-Methylumbelliferyl myo-inositol-1-phosphate and salts thereof with an organic or inorganic base. The invention also provides fluorogenic methods for detecting various pathogenic bacteria, e.g., Listeria, Staphylococcus and Clostridium species, using substrates containing at least one formula (I) compound. A kit for detecting a phosphatidyl-inositol-specific phospholipase C enzyme as an indication of bacterial activity is disclosed.

The invention discloses a preparation technology for a standard excrement bacteria solution in excrement bacteria transplantation therapy. The preparation technology comprises the following steps: (1) homogenizing excrement: collecting excrement and preparing an excrement diluent; (2) gradually filtering: filtering the excrement diluent with an 80-mesh standard sieve, a 300-mesh standard sieve, a 20mum filter membrane, a 5mu m filter membrane and a 0.8mu m filter membrane in turn and then collecting a filtrate; and (3) centrifuging, thereby acquiring a suspension. According to the invention, the gradual filtering manner is adopted and the filtering tool is arranged, so that the food residue is effectively filtered, the microbial activity in the excrement bacteria is kept and the viable count is increased; the specific buffer solution is capable of more effectively maintaining the bacterial activity in the filtering process; an experiment proves that the preparation technology is capable of removing the harmful food residue and greatly increasing the extraction ratio and survival rate of the excrement bacteria and the operation is simple and effective.

The invention discloses a method for producing L-valine by combined fermentation of double bacterial strains, which adopts two bacterial strains, one has high bacterial activity and strong acid producing capability, and the other one produces few by-products of impurity acids. The method comprises the following steps: performing seed amplification culture of the two bacterial strains; performing fermentation culture of the bacterial strain with strong acid producing capability; inoculating the bacterial strain with few by-products of impurity acids into the fermentation liquid when the activity decreases, supplementing nutrient solutions, continuing to perform fermentation; and detecting the valine content and amino acid purity by liquid chromatography. Combined fermentation of double bacterial strains improves the fermentation liquid purity and the acid producing amount.

Compounds of formula (I) in which R1,R2,R3,R4 and R5 are hydrogen atoms or chromogenic substituents and X is hydroxyl, OR6 wherein R6 is selected from the group consisting of C1-C4 alkyl, or O-Me+ wherein Me+ is a cation derived from an organic or inorganic base; these compounds do not exhibit significant fluorescence but are capable of being cleaved by phosphatidyl-inositol-specific phospholipase C, an enzyme which is indicative of bacterial activity; the umbelliferyl moity resulting from such cleavage is a strong fluorogen thus providing effective test methods for various pathogenic bacteria, such as Listeria, Staphylococcus and Clostridium species. Also disclosed are plating media for detection of microorganisms that are capable of metabolic generation of a phosphatidyl inositol-specific phospholipase C (PI-PLC). The plating medium can be in a dry, liquid, or semi-liquid form, depending upon its water content, and comprise at least one compound capable of forming an aqueous gel when in contact with water; at least one nutrient capable of supporting growth of said microorganism; and at least one indicator compound of formula I and/or IV, notably 4-methylumbelliferyl myo-inositol-1-phosphate or salts thereof and 5-bromo-4-chloro-3-indoxyl myo-inositol-1-phosphate or salts thereof. PI-PLC generated by the microorganisms of interest leads to cleavage of the indicator compounds causing formation of fluorescence and/or color suitable for identification of type and count of such hygienically and pathologically important microorganisms as Listeria species.