260 results about "Bacterial activity" patented technology

The present invention relates to a biopolymer covering for a tissue surface including, for example, a dressing, a bandage, a drape such as a bandage contact lens, a composition or covering to protect tissue, a covering to prevent adhesions, to exclude bacteria, to inhibit bacterial activity, or to promote healing or growth of tissue. An example of such a composition is an amniotic membrane covering for an ocular surface. Use of a covering for a tissue surface according to the invention eliminates the need for suturing. The invention also includes devices facilitating the fastening of a membrane to a support, culture inserts, compositions, methods, and kits for making and using coverings for a tissue surface and culture inserts. Compositions according to the invention may include cells grown on a membrane or attached to a membrane, and such compositions may be used as scaffolds for tissue engineering or tissue grafts. A method of preparing and using an amniotic membrane covering for a tissue surface as a controlled release drug delivery vehicle is also disclosed.

Novel protected cyclopeptide intermediates are prepared from polymyxin B are used to synthesize new peptide antibiotics. Intermediates are readily derivatized and deprotected to provide new families of antibiotics, which have potent anti-bacterial activity against gram-negative bacteria; but also are useful and potent against gram-positive bacteria.

A novel cephem compound of the formula:wherein R1 is a phosphono group or a group convertible to a phosphono group; R2 is a hydrogen atom or a group having a linkage through a carbon atom; each of Q and X is a nitrogen atom or CH; Y is S, O or CH2; n is 0 or 1; one of R3 and R4 is a pyridinium group which may be substituted and the other is a hydrogen atom or hydrocarbon group which may be substituted, or R3 and R4 taken together may form a quaternalized nitrogen-containing heterocyclic ring which may be substituted, or its ester or its salt, which has a superior anti-bacterial activity, stability, absorbability, etc., a production thereof and a pharmaceutical composition containing it, is provided.

The invention discloses a high-efficiency multi-bacterial activity biogas residue biofertilizer and a preparation method thereof, and relates to the field of farm fertilizers. The biofertilizer is prepared by mixing and granulating 44 to 54 weight parts of biogas residue, 10 to 15 weight parts of potassium chloride, 10 to 15 weight parts of humic acid, 0.4 to 0.6 part of secondary and micro-element, 0.4 to 0.6 weight part of microbe, 5 to 10 weight parts of urea, 10 to 15 weight parts of monoammonium phosphate and 5 to 10 weight parts of ammonium chloride. The high-efficiency multi-bacterial activity biogas residue biofertilizer has the characteristics of better multiple bacteria co-existing environment, stronger bioactivity, higher fertilizer efficiency, complete organic matters, effective micropopulations and chemical nutrients, controlled-release effect and the like, can be used as a fertilizer for rice, also can be used as a fertilizer for Upland food crops, vegetables, melons and fruits and fruit trees, and can improve the fertility of land and the utilization rate of the fertilizer, improve the quality of agricultural products, enhance plant diseases and insect pest resistance and drought resistance, purify and repair soil and the like after being applied.

A system and method for the purification and biodeodorizing of a gas are disclosed. The system is highly adaptable and capable of operating in a variety of modes to tailor performance of the system to specific odor control applications. The scrubber stages of the system may each be maintained at different conditions to selectively promote bacterial activity that targets a variety of odorous constituents. The pH level of the irrigation fluid provided to each scrubber stage may be controlled.

The use of a composition containing at least one not easily water-soluble calcium salt and / or the composite material thereof, to protect and / or therapeutically treat and / or preventively treat teeth and / or bones in case of damage or prevent damage resulting from external influences, especially biological, chemical, physical, and / or microbiological influences, particularly to prevent and repair bone and tooth erosion, especially the enamel, maintain the enamel, protect teeth from aggressive acids, particularly caused by bacterial activity or the effect of acids contained in food, protect teeth from demineralizing, seal cracks, provide protection against and / or repair primary lesions and / or initial cavities in the enamel, smooth the tooth surface, prevent cavities make it easier to clean teeth, improve the mechanical resistance of teeth, and generally keep teeth healthy.

Provided herein is a placental membrane product comprising an immunocompatible amniotic membrane. Such placental membrane products can be cryopreserved and contain therapeutic factors and viable cells after thawing. The placental membrane products are useful in wound healing and tissue repair / regeneration as they are capable of promoting angiogenesis, reducing inflammation, inhibiting proteases and free radical oxidation, reducing scar formation, and other methods that promote healing. The present technology relates to products to protect injured or damaged tissue, or as a covering to prevent adhesions, to exclude bacteria, to inhibit bacterial activity, and / or to promote healing or growth of tissue. The field also relates to methods of manufacturing and methods of use of such membrane-derived products.

Provided herein is a placental membrane product comprising an immunocompatible chorionic membrane. Such placental membrane products can be cryopreserved and contain therapeutic factors and viable cells after thawing. The placental membrane products are useful in wound healing or tissue repair / regeneration as they are capable of promoting angiogenesis, reducing inflammation, reducing scar formation, and other methods that promote healing. The present technology relates to products to protect injured or damaged tissue, or as a covering to exclude bacteria, to inhibit bacterial activity, or to promote healing or growth of tissue. The field also relates to methods of manufacturing and methods of use of such membrane-derived products.

Compounds of formula (I)in which R1, R2, R3, R4 and R5 are hydrogen atoms or chromogenic substituents and X is hydroxyl, OR6 wherein R6 is selected from the group consisting of C1-C4 alkyl, or O-Me+ wherein Me+ is a cation derived from an organic or inorganic base; these compounds do not exhibit significant fluorescence but are capable of being cleaved by phosphatidyl-inositol-specific phospholipase C, an enzyme which is indicative of bacterial activity; the umbelliferyl moity resulting from such cleavage is a strong fluorogen thus providing effective test methods for various pathogenic bacteria, such as Listeria, Staphylococcus and Clostridium species. Also disclosed are plating media for detection of microorganisms that are capable of metabolic generation of a phosphatidyl inositol-specific phospholipase C (PI-PLC). The plating medium can be in a dry, liquid, or semi-liquid form, depending upon its water content, and comprise at least one compound capable of forming an aqueous gel when in contact with water; at least one nutrient capable of supporting growth of said microorganism; and at least one indicator compound of formula I and / or IV, notably 4-methylumbelliferyl myo-inositol-1-phosphate or salts thereof and 5-bromo-4-chloro-3-indoxyl myo-inositol-1-phosphate or salts thereof. PI-PLC generated by the microorganisms of interest leads to cleavage of the indicator compounds causing formation of fluorescence and / or color suitable for identification of type and count of such hygienically and pathologically important microorganisms as Listeria species.

The present invention describes a container end closure which utilizes a material that is adapted to provide a visible indicator when the internal pressure of the contents increase to a predetermined level. In one embodiment, an interruption in a reinforcing bead incorporated in the end closure is deformed to visually notify a consumer of spoilage due to bacterial activity and to substantially prohibit the use of traditional can openers to access the spoiled contents within the container.

An airborne-bacteria filter arrangement is used with an apparatus that has an internal airflow. The airflow passes through a fibrous filter arrangement that has, on its fibres, a highly toxic bacteria-killing substance which entraps and kills bacteria in the airflow. A charcoal-infused filter removes the toxic substance from the airflow, and further filters can effuse beneficial substances to the airflow. The filter arrangement is sealed from germ intrusion. The filter arrangement is used in hand dryers and other apparatus such that the airflow can be sterilised to the extent of achieving 100% bacteria removal.

The present invention provides solution to the problem involved in preparation of metal nanosponges using templates and polymers. The instant invention is successful in providing a simple, template free single step process for the preparation of metal nanosponges having porous low density and high surface area. These metal nanosponges were found to be good self-supported substrates for surface-enhanced Raman spectroscopy (SERS) and have shown significant anti-bacterial activity.

The invention discloses a method for preparing organic bacteria liquid, the organic bacteria liquid prepared by the method, and an application of the organic bacteria liquid. The organic bacteria liquid is prepared by breeding bacteria from industrial and agricultural wastes which are rich in organic materials, such as plant ash, furfural residue, excrement, activated sludge, and crop straw, and screening, expanding and propagating the bred bacteria. The organic bacteria liquid has the characteristic of high bacterial activity, and can be used as a mother culture in the production of a microbial fertilizer or directly used as a seed-dressing agent.

Chromogenic 3-Indoxyl choline phosphate compounds of formula (I):wherein R is selected from the group consisting of hydrogen and C1-4 alkyl, such as methyl, ethyl, propyl and butyl while R<1>, R<2>, R<3>, and R<4 >are independently selected from the group consisting of hydrogen, halogen, cyano, nitro, carboxy, amino, amino substituted with one or two C1-4 alkyl groups, aminomethyl, hydroxy, C1-4 alkoxy, carboxyalkyl, and sulphonyl. These compounds are capable of being cleaved by lecithinase C leading to products which are calorimetrically detectable. The invention provides safe and sensitive detection of potentially pathogenic bacterial activity of such microbes as Clostridium perfringens, Bacillus cereus, Bacillus anthracis, Pseudomonas aeruginosa, Listeria monocytogenes, Heliobacter pylori, Legionella pneumophila, and others in material which may contain such activity typically including physiological samples, goods for consumption, such as food and beverages, and any other potentially infected objects or articles.

The present invention relates to a compound of formula (I)or a pharmaceutically acceptable salt thereof wherein X and R are as defined herein. The compounds of formula (I) are useful as gyrase and / or topoisomerase IV inhibitors for treating bacterial infections. The compounds of formula (I) either possess a broad range of anti-bacterial activity and advantageous toxicological properties or are prodrugs of compounds having said activity.

A ferritic stainless steel sheet. An first embodiment of the ferritic stainless steel sheet contains 0.1 to 5.0 mass% inclusive of Cu and has a Cu-rich layer on the surface thereof, wherein the maximum concentration of Cu (Cm) in the Cu-rich layer is 10.0 mass% or more and the Fe / Cr ratio at a position at which the maximum concentration of Cu (Cm) is stood at, as observed from the surface of the steel sheet in the thickness direction, is 2.4 or more. A second embodiment of the ferritic stainless steel sheet contains 0.1 to 5.0 mass% inclusive of Cu and has a Cu-rich layer on the surface thereof, wherein the maximum concentration of Cu (Cm) in the Cu-rich layer is 18.0 mass% or more.

The invention discloses an Arthrinium sp. strain which is preserved in China General Microbiological Culture Collection Center on June 8th, 2007 and has the preservation name of Arthrinium sp. strain Phl012 and the preservation number of CGMCC 2082. The Arthrinium sp. strain can be used for preparing 2,3beta-dihydroxy bostrycin which is a nontoxic red pigment with antibacterial activity.

The present invention relates to a compound of formula (I)or a pharmaceutically acceptable salt thereof wherein X and R are as defined herein. The compounds of formula (I) are useful as gyrase and / or topoisomerase IV inhibitors for treating bacterial infections. The compounds of formula (I) either possess a broad range of anti-bacterial activity and advantageous toxicological properties or are prodrugs of compounds having said activity.

There is provided a nanoparticle-containing hydrogel comprising metal nanoparticles and at least one peptide. The nanoparticle-containing hydrogel may possess antibacterial activity. There is also provided a method for preparing the nanoparticle-containing hydrogel, and compositions and uses thereof.

The invention discloses a berberine azole compound shown in general formulas such as I-IV, and a pharmaceutically acceptable salt thereof, and also discloses a preparation method of the compound, which comprises the following steps that: a compound VI and an azole compound HIm or 1H-2-mercaptobenzimidazole are reacted to obtain an intermediate VII or VIII, and then the obtained intermediate is reacted with a compound V to obtain the berberine azole compound shown in general formulas such as I or II; and the compound V and a compound IX or XI are reacted to obtain an intermediate X or XII, and then the obtained intermediate is reacted with the azole compound Him to obtain the berberine azole compound shown in general formulas such as III or IV. The berberine azole compound has a certain inhibitory activity on Gram-positive bacteria, Gram-negative bacteria and fungi, the anti-bacterial activity of part of the compounds is equal to or even stronger than that of chloramphenicol or norfloxacin, the antifungal activity of part of the compounds is equal to or even stronger than that of fluconazole, and the berberine azole compound can be used for preparing anti-microbial drugs.

The invention discloses the application of a flow cytometry method to vaccine production real-time monitoring. The application is to apply the flow cytometry method to the vaccine production process, and monitor the viable bacteria count in real time during the vaccine production process. The application comprises the steps of dyeing bacterial cell through fluorescent dye, detecting the change of bacteria fluorescence signals through a flow cytometer, and obtaining an FCM diagram with at least two types of the following parameters by measuring the change of the bacteria fluorescence signals: viable bacteria count, dead bacteria count and total bacteria count, obtaining the ratio of the viable bacteria count according to the FCM diagram, obtaining the concentration of target bacteria solution through an absolute counting method, and obtaining the viable bacteria amount and the dead bacteria amount of target bacteria according to the ratio of the viable bacteria count and the concentration of the target bacteria solution. The invention provides a convenient, rapid and reliable bacterial activity monitoring method for the vaccine production process and is convenient and easy, the operation time is only 30 minutes, and the quality of the vaccine production process can be accurately controlled.

The invention discloses a bactericidal odor removing agent in the chemical mixture agent field, and is characterized by comprising the components, in percentage by weight: (A) 0.25 to 5% of an organic silicon quaternary ammonium salt; (B) 0.1 to 2% of an organic silicon coupling agent; (C) 0.2 to 2% of a stabilizing agent; and (D) the balance being deionized water. The bactericidal odor removing agent has antibacterial, mildewproof, odor-removing and deodorant effects, has lastingly bacteriostatic effect and widely bacteriostatic range, simultaneously is safe and reliable for any product, and does not pollute the environment. The organic silicon quaternary ammonium salt has bactericidal and bacteriostatic effects, and non-toxic, gentle, soft and smooth properties of the organic silicon quaternary ammonium salt to human bodies are utilized, so the bactericidal odor removing agent is prepared into a spray medicament form, is used for disinfectant and bactericidal treatment of various traumatic infections and skin infections, can have rapidly bactericidal antipruritic effect for the various skin infections, and can kill bacteria and inhibit bacterial activity.

A method of detecting a phosphatidylinositol-specific phospholipase C enzyme by means of a substrate which is cleaved by said enzyme and yields a dye when the chromophoric portion of the substrate is dimerized and oxidized; the invention teaches using in such method, as a novel substrate, a 3-indoxyl-myo-inositol-1-phosphate compound of formula (I) wherein R is selected from the group consisting of hydrogen and C1-4 alkyl, while R1, R2, R3, and R4 are radicals selected from the group consisting of hydrogen, halogen, cyano, nitro, carboxy, amino, alkyl-substituted amino and sulphonyl; or of a salt of said formula I compound. The invention provides for a safe and sensitive method of detection of potentially pathogenic bacterial activity of such microbes as Bacillus cereus, B. Thuringiensis, Staphy lococcus aureus and various Listeria strains in potentially infected materials including physiological samples or consumable goods such as foods and beverages.

The invention discloses a technology for preparing an intestinal flora preparation in fecal microbiota transplantation clinic treatment. The technology comprises the following steps: collecting feces,preparing intestinal flora, and filling the intestinal flora preparation, wherein the step of collecting feces includes fecal collection and anaerobic transportation, the step of preparing the intestinal flora preparation includes stepwise filtration under aerobic and anaerobic conditions, centrifuging and mixing, and the step of filling the intestinal flora preparation adopts storage using a glycerol protection solution and a cryopreservation technology. A novel aerobic and anaerobic separation method is adopted in the separation process of an intestinal flora solution, the aerobic and anaerobic separation method selected according to the characteristics of the living environment of intestinal florae can maximally protect the flora diversity of aerobic bacteria and anaerobic bacteria inthe intestinal tract, and an added glycerol protection agent maintains the bacterial activity within a certain period of time and improves the effect of the intestinal flora preparation.

The invention discloses a substituted nitroaniline compound. The structure of the compound is represented by formula I, and all substituents in the formula I are defined in the specification. The compound of the general formula I has a very good bacterial activity in the agricultural field, and especially has a very good control effect on rice blast, cucumber downy mildew, cucumber gray mold, wheat powdery mildew and corn rust at a low dosage.

The invention discloses a scylla paramamosain anti-bacterial polypeptide Sp-NPFin and its application. A molecular formula is C227H373N71O62S1, and its amino acid sequence is shown as SEQ ID NO: 01. The scylla paramamosain anti-bacterial polypeptide Sp-NPFin has strong antibacterial activity and antifungal activity, good antibacterial effect, wide antibacterial spectrum and fast sterilization rate. The scylla paramamosain anti-bacterial polypeptide Sp-NPFin is derived from crustaceans and can be applied to aquatic feed additives, can be developed to anti-mold preservatives, antibacterial agents and antibacterial drugs, and has broad application prospects.

A method for controlling the activity of sulfate reducing bacteria or methanogenic archaea (or both) in environments containing such organisms comprises treating the environment with free nitrous acid (HNO2) or with a solution containing nitrite (NO2 -) having a pH of less than 7 or by adding nitrite to the environment and having a pH of less than 7 in the environment. The method can also disrupt biofilms.

The invention provides compounds of formula (I) in which R1, R2, R3, R4 and R5 are independently selected from hydrogen and chromogenic substituents, and X is selected from the group consisting of hydroxyl; OR6 wherein R6 is selected from the group consisting of C1-C4 alkyl; and O-Me+ wherein Me+ is a cation derived from an organic or inorganic base. A preferred species of formula (I) is 4-Methylumbelliferyl myo-inositol-1-phosphate and salts thereof with an organic or inorganic base. The invention also provides fluorogenic methods for detecting various pathogenic bacteria, e.g., Listeria, Staphylococcus and Clostridium species, using substrates containing at least one formula (I) compound. A kit for detecting a phosphatidyl-inositol-specific phospholipase C enzyme as an indication of bacterial activity is disclosed.