42 results about "Microbial adhesion" patented technology

Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents.

A non-food anti-microbial-adhesion and aggregation composition comprising a suitable carrier and an effective amount of an adhesion inhibitory fraction isolated from juice from berries of the Vaccinium plant genus. In an embodiment the anti-aggregation and adhesion fraction is isolated from cranberry juice. It is characterized as being polymeric and having a molecular weight ≧14,000; an elemental analysis of carbon 43-51%, hydrogen 4-5%, no nitrogen, no sulfur and no chlorine; a nuclear magnetic resonance (NMR) line spectrum as set forth in FIGS. 2A and 2B; and an ultraviolet spectrum with an absorption peak at 280 nm in neutral or acidic pH solution which is absent in alkali solutions. This fraction exhibits adhesion inhibitory activity against P fimbriated bacteria, oral bacteria and Helicobacter pylori.

Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and/or a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents.

The present invention is directed to absorbable polyether esters that have been found to reduce bacterial adhesion to materials such as medical devices and implants. More specifically, the invention is directed to novel amorphous co-polymers comprising polyethylene diglycolate (PEDG) copolymerized with lactide-rich monomers.

The invention relates to the technical field of sewage purifier processing, and in particular, relates to porous sewage purifying bamboo balls and a processing method thereof. The purified bamboo balls are porous balls with a diameter of 15-18 mm. The purified bamboo balls are prepared by mixing and processing bamboo powder particles, green steel shot and mixed cement in a ratio of (15-25):(2-5):(1-3); with use of the bamboo ball characteristics of good hydrophilicity and good microbial adhesion power, the bamboo balls are used as the main raw material and processed into the porous sewage purifying bamboo balls with the density of 1.1-1.3 g/cm<3> under the adhesion of mixed cement and green steel shot; the bamboo balls are inoculated with suitable microorganisms, the bamboo balls inoculated with the microorganisms are put into sewage to be treated, so as to purify the sewage by the microorganisms; air is blown into the sewage, so that the put bamboo balls can float up and down in the sewage, and the microorganisms adhering to the surface of the bamboo balls can fully play a role in purifying a water body. With up-and-down floating of the bamboo balls, the microorganism carriers areprevented from standing at the water bottom for a long time effectively, and the effect of microorganism purification of the sewage is prevented from being weakened.

The invention discloses a suspending filter material having a trace element self-release function. The suspending filter material comprises polyurethane sponge, and a trace element releaser is embedded in the polyurethane sponge. The filter material is suitable for a biochemical function of a suspending rapid filter, has good intercepting and adsorbing effect on suspending pollutants and has goodmicrobial adhesion, bio-film formation and bio-film protection effect, thereby being capable of better playing a role in quick filtering and biochemical treating; the trace element releaser can provide needed trace elements for microorganisms to grow, so that microbial adhesion and bio-film formation are better facilitated.

The invention relates to application of a non-release type antimicrobial adhesion coating in an antibacterial pipe. The main component of the coating is composed of a copolymer of two monomers, namely bornyl acrylate (BA) and polyethylene glycol diacrylate (PEGDA), and the amphiphilic three-dimensional chemical antibacterial polymer coating is constructed; and the coating has good anti-microbial adhesion. A preparation method of the coating mainly comprises the following steps: 1, fixing a photoinitiator on the surface of a high polymer material; and 2, carrying out surface free radical-initiated polymerization on the monomers to realize grafting and copolymerization. The preparation method of the coating is simple, and the obtained grafted coating is safe and stable; respective advantages of the bornyl polyacrylate and the polyethylene glycol diacrylate can be fully exerted, and microbial adhesion can be synergistically prevented; and the coating can be applied to surface modification of most high polymer materials, and the structure flatness of the grafted coating can be ensured.

The invention relates to application of a non-release type anti-microbial adhesion coating in antibacterial medical instruments, the main component of the coating is composed of copolymers of two monomers of bornyl acrylate (BA) and polyethylene glycol diacrylate (PEGDA), an amphiphilic three-dimensional chemical antibacterial polymer coating is constructed, and the coating has good anti-microbial adhesion. The preparation method of the coating mainly comprises the following steps: 1, fixing a photoinitiator on the surface of a medical instruments; and 2, carrying out surface radical-initiated polymerization on a monomer to realize grafting and copolymerization. The preparation method of the coating is simple, and the obtained grafted coating is safe and stable; respective advantages of the bornyl polyacrylate and the polyethylene glycol diacrylate can be fully exerted, and microbial adhesion can be synergistically prevented; the coating can be applied to modification of the surface of a medical instrument, and the structure flatness of the grafting coating can be ensured.

The invention discloses a modifier for a microbial adhesion rate and application thereof, and relates to the technical field of biology. The modifier for the microbial adhesion rate is suitable for regulating the adhesion rate of microorganisms with the mucous membranes or the skin, and contains a surfactant, and the concentration of the surfactant is lower than the critical micelle concentration (CMC) of the surfactant. The modifier for the microbial adhesion rate can increase the probability and speed of the contact of the microorganisms and the mucosal cells or skin cells. Meanwhile, by the adoption of the surfactant, the cell-surface hydrophobicity of the microorganisms is changed, the microbial adhesion rate of the beneficial microorganisms with the mucosal epithelial cells or the skin cuticle is increased, the microorganisms are easily colonized on the mucous membranes or the skin, the microorganisms can continuously take effect for a long time, the modifier has broad application prospects.

The invention relates to medical equipment for treatment, specifically medical equipment for extracting and draining fluids contained in the bladder of a patient. The Foley catheter according to the invention comprises tubing, with at least two lumens, made of a biocompatible polymer material with a length of between 100 and 400 mm and outer diameters of between 1 and 15 mm. The surface of the tubing has a high-relief texture with a maximum height of 30 micrometers and patterns designed to generate the property of hydrophobicity and to reduce the adhesion of bacteria to said surface. A collecting funnel with at least two channels, made from medical-grade polymer material, is fixed to the distal end of the tip of the tubing, while the tip of the tubing is closed in such a way that it forms a rounded tip. A flexible inflatable balloon is arranged upstream of the tip, for the anchoring of the catheter.

The invention relates to a method for preparing a pressure retarded osmosis membrane modified by a zwitterionic random copolymer. The method comprises the steps that methyl-2-[methyl-(4-pyridine)dithiocarbonate]propionate is used as a chain transfer agent, azobisisobutyronitrile is used as an initiator, N-vinylimidazole and an N-vinylphthalimide monomer containing an amino protecting group are subjected to random copolymerization; a poly N-vinylimidazole chain segment is subjected to quaternization under the action of propane sultone and 4-bromobutyric acid separately; under the action of hydrazine hydrate, a poly(N-vinylphthalimide)chain segment is subjected to amino deprotection to obtain a zwitterionic polymer; and the zwitterionic polymer is prepared into an aqueous solution to be grafted and modified on a porous support layer of an osmosis composite membrane. A comonomer used in the method is simple and easy to obtain, the random copolymer is convenient to synthesize, the condition is mild, and realization is easy; the chemical stability and water solubility of a graft polymer are improved, and the cost is greatly reduced; and excellent anti-protein and microbial adhesion areachieved.

The invention relates to a non-release type antimicrobial adhesion coating and a preparation method thereof. A polymer forming the coating is formed by copolymerization of two monomers, namely bornyl acrylate and polyethylene glycol diacrylate; and the coating has good antimicrobial adhesion. The preparation method of the coating mainly comprises the following steps: firstly, preparing a solution with a certain concentration from the monomers and a photoinitiator, and then carrying out two-step modification on a high polymer material by using a photo-grafting method, wherein in the first step, the is photoinitiator fixed on the surface of the high polymer material, and in the second step, surface free radical-initiated polymerization is conducted on the monomers to realize grafting. The preparation method of the coating is simple, and the obtained grafted coating is safe and stable; respective advantages of the bornyl polyacrylate and the polyethylene glycol diacrylate can be fully exerted, and microbial adhesion can be synergistically prevented; and the coating can be applied to surface modification of most high polymer materials, and the structural flatness of the grafted coating can be ensured.

A composition includes a surfactant that is a linear alkylbenzene sulfonate, an acid thereof, or a combination thereof and that is present in an amount of from about 5 to about 30 weight percent actives based on a total weight of the composition and has the structure:

wherein each m is independently a number of from 0 to 16, each n is independently a number of from 0 to 16, the sum of each m+n is a number of from 4 to 16, and X is a counter ion. The composition also includes a defoamer in an amount of from about 1 to about 20 weight percent actives based on a total weight of the composition, a thickening agent in an amount of from greater than zero to an amount of about 3 weight percent actives based on a total weight of the composition, and water.

The invention belongs to the technical field of functional coatings, and particularly discloses a durable inorganic super-hydrophilic coating as well as a preparation method and application thereof. The durable inorganic super-hydrophilic coating is prepared from the following raw materials in percentage by mass: 30 to 60 percent of silicate, 5 to 25 percent of zinc oxide, 10 to 40 percent of water and 0.1 to 5 percent of a wetting agent. A coating layer formed by the durable inorganic super-hydrophilic coating prepared by the invention is a flat rigid coating layer, has good appearance, excellent antifouling self-cleaning and anti-microbial adhesion properties, and also has the characteristics of long-term underwater stability and high mechanical strength. The paint can be used for building outer walls, household inner walls and the like by utilizing the antifouling and self-cleaning characteristics of the paint, has excellent underwater oleophobic performance, and can be used in the fields of oil fields and oil-water separation.